|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
539-853 |
5.83e-173 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
:
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 508.18 E-value: 5.83e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 539 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 612
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 613 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 686
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 687 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqeTANYHPDGTIQVSNGSLAFYPAQTNV 765
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV----VGAYHPDGTIQVSNGHLAFYPAQTNG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 766 FPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYK 843
Cdd:pfam12287 231 FPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNYK 310
|
330
....*....|
gi 1876941617 844 RGGTSGGPRA 853
Cdd:pfam12287 311 RGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
119-234 |
1.99e-51 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
:
Pssm-ID: 436391 Cd Length: 116 Bit Score: 176.25 E-value: 1.99e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 119 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 198
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1876941617 199 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 234
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
917-1042 |
6.08e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
:
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 6.08e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 917 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 996
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1876941617 997 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1042
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| SCP-1 super family |
cl30946 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
7-429 |
5.69e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
The actual alignment was detected with superfamily member pfam05483:
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 50.49 E-value: 5.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 7 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 85
Cdd:pfam05483 286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 86 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 158
Cdd:pfam05483 361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 159 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 230
Cdd:pfam05483 439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 231 GyfESIpvpKNAKEKevplEEEMLIQ----SEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDY 299
Cdd:pfam05483 519 Q--EDI---INCKKQ----EERMLKQienlEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLK 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 300 SNKQGEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 377
Cdd:pfam05483 585 KEKQMKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIE 664
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1876941617 378 KQEISKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQ 429
Cdd:pfam05483 665 DKKISEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQ 699
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
539-853 |
5.83e-173 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 508.18 E-value: 5.83e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 539 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 612
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 613 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 686
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 687 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqeTANYHPDGTIQVSNGSLAFYPAQTNV 765
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV----VGAYHPDGTIQVSNGHLAFYPAQTNG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 766 FPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYK 843
Cdd:pfam12287 231 FPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNYK 310
|
330
....*....|
gi 1876941617 844 RGGTSGGPRA 853
Cdd:pfam12287 311 RGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
119-234 |
1.99e-51 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
Pssm-ID: 436391 Cd Length: 116 Bit Score: 176.25 E-value: 1.99e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 119 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 198
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1876941617 199 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 234
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
917-1042 |
6.08e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 6.08e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 917 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 996
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1876941617 997 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1042
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| C1Q |
smart00110 |
Complement component C1q domain; Globular domain found in many collagens and eponymously in ... |
911-1045 |
1.04e-32 |
|
Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.
Pssm-ID: 128420 Cd Length: 135 Bit Score: 123.57 E-value: 1.04e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 911 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 990
Cdd:smart00110 3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1876941617 991 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 1045
Cdd:smart00110 79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
7-429 |
5.69e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 50.49 E-value: 5.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 7 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 85
Cdd:pfam05483 286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 86 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 158
Cdd:pfam05483 361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 159 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 230
Cdd:pfam05483 439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 231 GyfESIpvpKNAKEKevplEEEMLIQ----SEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDY 299
Cdd:pfam05483 519 Q--EDI---INCKKQ----EERMLKQienlEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLK 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 300 SNKQGEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 377
Cdd:pfam05483 585 KEKQMKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIE 664
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1876941617 378 KQEISKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQ 429
Cdd:pfam05483 665 DKKISEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQ 699
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
566-930 |
1.44e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.93 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 566 AIPTSQPPSATPGSPVAskeqnlssqsdflQEPLQATSSPVTCSSNACLVTT-DQASSGSETEFMTSETPEAAIPPGKQP 644
Cdd:PHA03307 61 ACDRFEPPTGPPPGPGT-------------EAPANESRSTPTWSLSTLAPASpAREGSPTPPGPSSPDPPPPTPPPASPP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 645 SSLASPNPPMAKGSEQGFQSPPASSSSvtintapfqamqtvfnvnAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQC 724
Cdd:PHA03307 128 PSPAPDLSEMLRPVGSPGPPPAASPPA------------------AGASPAAVASDAASSRQAALPLSSPEETARAPSSP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 725 QlPSIHVEQTVHSQETANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFD 804
Cdd:PHA03307 190 P-AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTR 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 805 TYRGLPSISNGNYSQLQFQA---REYSGAPYSQRDnfqqcyKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNSGDSG 881
Cdd:PHA03307 269 IWEASGWNGPSSRPGPASSSsspRERSPSPSPSSP------GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1876941617 882 QGDSRSMTPVDVPVTNPAATilpvhvyPLPQQMRVAFSAARTSNLAPGT 930
Cdd:PHA03307 343 PGPSPSRSPSPSRPPPPADP-------SSPRKRPRPSRAPSSPAASAGR 384
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
49-488 |
2.43e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.52 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 49 KHKIRNIEKK---KLKLEDYKDRL---KSGEHLNPDQLEAVEKYEEVLHNLEF---AKELQKTFSGLSLDLLKAQKKAQR 119
Cdd:PTZ00121 1456 AKKAEEAKKKaeeAKKADEAKKKAeeaKKADEAKKKAEEAKKKADEAKKAAEAkkkADEAKKAEEAKKADEAKKAEEAKK 1535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 120 REHMLKLEaEKKKLRTILQVQYVLQnltQEHVQKdfkgglngavylpskeldylIKFSKLTCPERNESLSVEDQMEQssl 199
Cdd:PTZ00121 1536 ADEAKKAE-EKKKADELKKAEELKK---AEEKKK--------------------AEEAKKAEEDKNMALRKAEEAKK--- 1588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 200 yfwdlLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKtQLSKTESVKESESLMEFA 279
Cdd:PTZ00121 1589 -----AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEENKIK 1662
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 280 QPEIQPQEFLNRRYMTEVdySNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQEsfkswEASGKHQEVSKPAVSLE 359
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA-----EELKKAEEENKIKAEEA 1735
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 360 QRK--QDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKlwpvqlQKEQDPKKQTPKSWTPS 437
Cdd:PTZ00121 1736 KKEaeEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR------RMEVDKKIKDIFDNFAN 1809
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1876941617 438 MQSEQNTTKSWTTPMCEEQDSKQPETPKS----WENNVESQKHSLTSQSQISPKS 488
Cdd:PTZ00121 1810 IIEGGKEGNLVINDSKEMEDSAIKEVADSknmqLEEADAFEKHKFNKNNENGEDG 1864
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
539-853 |
5.83e-173 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 508.18 E-value: 5.83e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 539 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 612
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 613 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 686
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 687 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqeTANYHPDGTIQVSNGSLAFYPAQTNV 765
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV----VGAYHPDGTIQVSNGHLAFYPAQTNG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 766 FPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYK 843
Cdd:pfam12287 231 FPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNYK 310
|
330
....*....|
gi 1876941617 844 RGGTSGGPRA 853
Cdd:pfam12287 311 RGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
119-234 |
1.99e-51 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
Pssm-ID: 436391 Cd Length: 116 Bit Score: 176.25 E-value: 1.99e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 119 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 198
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1876941617 199 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 234
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
917-1042 |
6.08e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 6.08e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 917 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 996
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1876941617 997 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 1042
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| C1Q |
smart00110 |
Complement component C1q domain; Globular domain found in many collagens and eponymously in ... |
911-1045 |
1.04e-32 |
|
Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.
Pssm-ID: 128420 Cd Length: 135 Bit Score: 123.57 E-value: 1.04e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 911 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 990
Cdd:smart00110 3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1876941617 991 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 1045
Cdd:smart00110 79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
490-919 |
8.57e-08 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 56.46 E-value: 8.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 490 GVATASLIPNDQLLPRklNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDlmtqiqgtcNFMQESVLDFDKPSSAIPT 569
Cdd:pfam05109 447 GLPSSTHVPTNLTAPA--STGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD---------NGTESKAPDMTSPTSAVTT 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 570 SQPPSATPGSPVASKEQNLSSqsdflqePLQATSSPVTCssnaclVTTDQASSGSETEFMTSETPEAAIPP-GK-QPSSL 647
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATS-------PTLGKTSPTSA------VTTPTPNATSPTPAVTTPTPNATIPTlGKtSPTSA 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 648 ASPNPPMAKGSEQGFQSPPASSSSVTINTAPFQAMQTVfnvnaplPPRKEQeikeSPYSPGYNQ--SFTTASTQTPP--- 722
Cdd:pfam05109 583 VTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTS-------PPKNAT----SAVTTGQHNitSSSTSSMSLRPssi 651
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 723 -QCQLPSIHVEQTVHSQETANYHPDG---TIQVSNGSLAFYPAQTNV-FPRP-TQPFVNSRGSVRGCTRGGRL-IT---- 791
Cdd:pfam05109 652 sETLSPSTSDNSTSHMPLLTSAHPTGgenITQVTPASTSTHHVSTSSpAPRPgTTSQASGPGNSSTSTKPGEVnVTkgtp 731
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 792 ----NSYRSPGGYKgfdtyRGLPSI-SNGNYSQLQFQAREYSGapYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVS 866
Cdd:pfam05109 732 pknaTSPQAPSGQK-----TAVPTVtSTGGKANSTTGGKHTTG--HGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTS 804
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1876941617 867 SPERDNETFNSGdsgqgdsrsmtpvdvPVTNPAATIlpvhvyPLPQQMRVAFS 919
Cdd:pfam05109 805 SKLRPRWTFTSP---------------PVTTAQATV------PVPPTSQPRFS 836
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
7-429 |
5.69e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 50.49 E-value: 5.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 7 QVNHSQHGESQRaLSPLQSTLSSAASPSQAYEtyiENGLICLKHKIRNIEKKKLKLEDyKDRLKSGEHLNPDQLEA-VEK 85
Cdd:pfam05483 286 ELIEKKDHLTKE-LEDIKMSLQRSMSTQKALE---EDLQIATKTICQLTEEKEAQMEE-LNKAKAAHSFVVTEFEAtTCS 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 86 YEEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG- 158
Cdd:pfam05483 361 LEELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKe 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 159 --LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNS 230
Cdd:pfam05483 439 qeLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKH 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 231 GyfESIpvpKNAKEKevplEEEMLIQ----SEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDY 299
Cdd:pfam05483 519 Q--EDI---INCKKQ----EERMLKQienlEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLK 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 300 SNKQGEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 377
Cdd:pfam05483 585 KEKQMKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIE 664
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1876941617 378 KQEISKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQ 429
Cdd:pfam05483 665 DKKISEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQ 699
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
301-721 |
7.93e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.15 E-value: 7.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 301 NKQGEEQPWEADY---ARKPNLPKRWDMLTEPDGQEKKQESFKSWEASgkhQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 377
Cdd:pfam03154 127 NDEGSSDPKDIDQdnrSTSPSIPSPQDNESDSDSSAQQQILQTQPPVL---QAQSGAASPPSPPPPGTTQAATAGPTPSA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 378 KQEISKSKPSPSQwkqdTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSW--------- 448
Cdd:pfam03154 204 PSVPPQGSPATSQ----PPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 449 ---------------TTPMCEEQDSKQPETPKSWENNVESQKHsltsQSQISPKSWGVATASLIPNDQLLPRKLNTEPKD 513
Cdd:pfam03154 280 hslqtgpshmqhpvpPQPFPLTPQSSQSQVPPGPSPAAPGQSQ----QRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHI 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 514 VPKPvhqpvgsSSTLPKDPVLRKEKLQdlmTQIQGTCNFMQESVLDFD---KPSSAIPTSQPPSATPgSPVaskeqNLSS 590
Cdd:pfam03154 356 KPPP-------TTPIPQLPNPQSHKHP---PHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHP-PPL-----QLMP 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 591 QSDFLQEPlqATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIP--PGKQPSSLASPNPPMAKGSEQGFQSPPAS 668
Cdd:pfam03154 420 QSQQLPPP--PAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1876941617 669 SSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTP 721
Cdd:pfam03154 498 ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
566-930 |
1.44e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.93 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 566 AIPTSQPPSATPGSPVAskeqnlssqsdflQEPLQATSSPVTCSSNACLVTT-DQASSGSETEFMTSETPEAAIPPGKQP 644
Cdd:PHA03307 61 ACDRFEPPTGPPPGPGT-------------EAPANESRSTPTWSLSTLAPASpAREGSPTPPGPSSPDPPPPTPPPASPP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 645 SSLASPNPPMAKGSEQGFQSPPASSSSvtintapfqamqtvfnvnAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQC 724
Cdd:PHA03307 128 PSPAPDLSEMLRPVGSPGPPPAASPPA------------------AGASPAAVASDAASSRQAALPLSSPEETARAPSSP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 725 QlPSIHVEQTVHSQETANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFD 804
Cdd:PHA03307 190 P-AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTR 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 805 TYRGLPSISNGNYSQLQFQA---REYSGAPYSQRDnfqqcyKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNSGDSG 881
Cdd:PHA03307 269 IWEASGWNGPSSRPGPASSSsspRERSPSPSPSSP------GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1876941617 882 QGDSRSMTPVDVPVTNPAATilpvhvyPLPQQMRVAFSAARTSNLAPGT 930
Cdd:PHA03307 343 PGPSPSRSPSPSRPPPPADP-------SSPRKRPRPSRAPSSPAASAGR 384
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
49-488 |
2.43e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.52 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 49 KHKIRNIEKK---KLKLEDYKDRL---KSGEHLNPDQLEAVEKYEEVLHNLEF---AKELQKTFSGLSLDLLKAQKKAQR 119
Cdd:PTZ00121 1456 AKKAEEAKKKaeeAKKADEAKKKAeeaKKADEAKKKAEEAKKKADEAKKAAEAkkkADEAKKAEEAKKADEAKKAEEAKK 1535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 120 REHMLKLEaEKKKLRTILQVQYVLQnltQEHVQKdfkgglngavylpskeldylIKFSKLTCPERNESLSVEDQMEQssl 199
Cdd:PTZ00121 1536 ADEAKKAE-EKKKADELKKAEELKK---AEEKKK--------------------AEEAKKAEEDKNMALRKAEEAKK--- 1588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 200 yfwdlLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKtQLSKTESVKESESLMEFA 279
Cdd:PTZ00121 1589 -----AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEENKIK 1662
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 280 QPEIQPQEFLNRRYMTEVdySNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQEsfkswEASGKHQEVSKPAVSLE 359
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA-----EELKKAEEENKIKAEEA 1735
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 360 QRK--QDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKlwpvqlQKEQDPKKQTPKSWTPS 437
Cdd:PTZ00121 1736 KKEaeEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR------RMEVDKKIKDIFDNFAN 1809
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1876941617 438 MQSEQNTTKSWTTPMCEEQDSKQPETPKS----WENNVESQKHSLTSQSQISPKS 488
Cdd:PTZ00121 1810 IIEGGKEGNLVINDSKEMEDSAIKEVADSknmqLEEADAFEKHKFNKNNENGEDG 1864
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
566-727 |
5.19e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 5.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 566 AIPTSQPPSATPGSPVASkeqnLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPS 645
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVAS----LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPP 2848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 646 SLaSPNPPMAKGSEqgFQSPPASSSSVTINTAPfqAMQTVFNVNAPLPPRKEQEIKESPYSPgynQSFTTASTQTPPQCQ 725
Cdd:PHA03247 2849 SL-PLGGSVAPGGD--VRRRPPSRSPAAKPAAP--ARPPVRRLARPAVSRSTESFALPPDQP---ERPPQPQAPPPPQPQ 2920
|
..
gi 1876941617 726 LP 727
Cdd:PHA03247 2921 PQ 2922
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
382-776 |
1.31e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.83 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 382 SKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTP---------- 451
Cdd:pfam03154 41 SSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPERATAKKSKTQEISRPnspsegeges 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 452 ----------------MCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPnDQLLPRKLNTEPKDVP 515
Cdd:pfam03154 121 sdgrsvndegssdpkdIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASP-PSPPPPGTTQAATAGP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 516 KPVHQPVGSSSTLP-KDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKE--------- 585
Cdd:pfam03154 200 TPSAPSVPPQGSPAtSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 586 QNLSSQSDFLQEPLQATSSPVTCSSNACLV--TTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAK------- 656
Cdd:pfam03154 280 HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVppGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMphikppp 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1876941617 657 -------GSEQGFQSPPASSSSvtintAPFQamqtvFNVNAPLPPRKEQEIKESPYSPgynQSFTTASTQTPPQCQ-LPS 728
Cdd:pfam03154 360 ttpipqlPNPQSHKHPPHLSGP-----SPFQ-----MNSNLPPPPALKPLSSLSTHHP---PSAHPPPLQLMPQSQqLPP 426
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1876941617 729 IHVEQTVHSQeTANYHPDGTIQVSNGSLAFYPAQTnvfPRPTQPFVNS 776
Cdd:pfam03154 427 PPAQPPVLTQ-SQSLPPPAASHPPTSGLHQVPSQS---PFPQHPFVPG 470
|
|
| |
