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Conserved domains on  [gi|1835951063|ref|NP_001369275|]
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coiled-coil domain-containing protein 134 isoform 1 precursor [Homo sapiens]

Protein Classification

ERK-JNK_inhib domain-containing protein( domain architecture ID 10633207)

ERK-JNK_inhib domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ERK-JNK_inhib pfam15002
ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein ...
 29-198 1.65e-72

ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38. CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerization.


:

Pssm-ID: 464435  Cd Length: 197  Bit Score: 219.12  E-value: 1.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835951063  29 DPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHV 108
Cdd:pfam15002  10 ISAEKLYRKLFKRKRKEHKLAVKSLLKIGDYEKRYKLLKLLLKKIFKVLRESRIKLEKAGITPESPFPKDEELKDALSKV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835951063 109 VENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTE 188
Cdd:pfam15002  90 LENTAFFGDLVLHFPDIVHTILKKDRDWKTLVRWALNFTNQSRHFLDDKTEKLLGLMAQELEIIERDPNYVNPYRREEAQ 169

                         170
                  ....*....|
gi 1835951063 189 FIPSTDPFQK 198
Cdd:pfam15002 170 KILEAEPKKR 179
 
Name Accession Description Interval E-value
ERK-JNK_inhib pfam15002
ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein ...
 29-198 1.65e-72

ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38. CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerization.


Pssm-ID: 464435  Cd Length: 197  Bit Score: 219.12  E-value: 1.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835951063  29 DPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHV 108
Cdd:pfam15002  10 ISAEKLYRKLFKRKRKEHKLAVKSLLKIGDYEKRYKLLKLLLKKIFKVLRESRIKLEKAGITPESPFPKDEELKDALSKV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835951063 109 VENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTE 188
Cdd:pfam15002  90 LENTAFFGDLVLHFPDIVHTILKKDRDWKTLVRWALNFTNQSRHFLDDKTEKLLGLMAQELEIIERDPNYVNPYRREEAQ 169

                         170
                  ....*....|
gi 1835951063 189 FIPSTDPFQK 198
Cdd:pfam15002 170 KILEAEPKKR 179
 
Name Accession Description Interval E-value
ERK-JNK_inhib pfam15002
ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein ...
 29-198 1.65e-72

ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38. CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerization.


Pssm-ID: 464435  Cd Length: 197  Bit Score: 219.12  E-value: 1.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835951063  29 DPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHV 108
Cdd:pfam15002  10 ISAEKLYRKLFKRKRKEHKLAVKSLLKIGDYEKRYKLLKLLLKKIFKVLRESRIKLEKAGITPESPFPKDEELKDALSKV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835951063 109 VENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTE 188
Cdd:pfam15002  90 LENTAFFGDLVLHFPDIVHTILKKDRDWKTLVRWALNFTNQSRHFLDDKTEKLLGLMAQELEIIERDPNYVNPYRREEAQ 169

                         170
                  ....*....|
gi 1835951063 189 FIPSTDPFQK 198
Cdd:pfam15002 170 KILEAEPKKR 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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