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Conserved domains on  [gi|1480008184|ref|NP_001352977|]
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protein ABHD18 isoform 15 [Homo sapiens]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
11-332 4.00e-138

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member pfam09752:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 352  Bit Score: 395.65  E-value: 4.00e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184  11 LFQFIVPKEW-NSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEaRMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMG 89
Cdd:pfam09752  78 RFAFLLPKKWgDSRKKPVCIHLAGTGDHSYWRRRNLMARPLLKD-GIGSIILENPFYGLRKPKNQWRSSLKNVSDLFVMG 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184  90 GALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTtdsfkmgqefvkhftssa 169
Cdd:pfam09752 157 GALILESRVLLHWLEREGYGPLGITGLSMGGHMASLAASNWPKPLVLVPCLSWSTASVVFTE------------------ 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184 170 dkltnlNLVSRTLNLDisnqVVSQKPADCHNSSKTSVSATseglllqdtskmkrfnqtlstnksgyTSRNPQSYHLLSKE 249
Cdd:pfam09752 219 ------GVISKSLAWD----VLEKQLEDGNYRERLATIRD--------------------------EAAQVESDKLDGAK 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184 250 QSRNSlrKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQG 329
Cdd:pfam09752 263 ERGAT--KEALREMRGLMDSCTHLKNFSVPKDPSLAIFVAAKDDAYVPRESVTTLQQIWPGSEVRWVDGGHVSAYLLHQD 340

                  ...
gi 1480008184 330 LFR 332
Cdd:pfam09752 341 LFR 343
 
Name Accession Description Interval E-value
ABHD18 pfam09752
Alpha/beta hydrolase domain containing 18; This entry represents alpha/beta hydrolase ...
11-332 4.00e-138

Alpha/beta hydrolase domain containing 18; This entry represents alpha/beta hydrolase domain-containing protein 18 (ABHD18). Its function is not clear.


Pssm-ID: 370661 [Multi-domain]  Cd Length: 352  Bit Score: 395.65  E-value: 4.00e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184  11 LFQFIVPKEW-NSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEaRMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMG 89
Cdd:pfam09752  78 RFAFLLPKKWgDSRKKPVCIHLAGTGDHSYWRRRNLMARPLLKD-GIGSIILENPFYGLRKPKNQWRSSLKNVSDLFVMG 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184  90 GALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTtdsfkmgqefvkhftssa 169
Cdd:pfam09752 157 GALILESRVLLHWLEREGYGPLGITGLSMGGHMASLAASNWPKPLVLVPCLSWSTASVVFTE------------------ 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184 170 dkltnlNLVSRTLNLDisnqVVSQKPADCHNSSKTSVSATseglllqdtskmkrfnqtlstnksgyTSRNPQSYHLLSKE 249
Cdd:pfam09752 219 ------GVISKSLAWD----VLEKQLEDGNYRERLATIRD--------------------------EAAQVESDKLDGAK 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184 250 QSRNSlrKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQG 329
Cdd:pfam09752 263 ERGAT--KEALREMRGLMDSCTHLKNFSVPKDPSLAIFVAAKDDAYVPRESVTTLQQIWPGSEVRWVDGGHVSAYLLHQD 340

                  ...
gi 1480008184 330 LFR 332
Cdd:pfam09752 341 LFR 343
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
88-131 4.64e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 38.07  E-value: 4.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1480008184  88 MGGALVLESAALLHWLEREGY---GPLGMTGISMGGHMASLAVSNWP 131
Cdd:COG1506    69 WGGDEVDDVLAAIDYLAARPYvdpDRIGIYGHSYGGYMALLAAARHP 115
 
Name Accession Description Interval E-value
ABHD18 pfam09752
Alpha/beta hydrolase domain containing 18; This entry represents alpha/beta hydrolase ...
11-332 4.00e-138

Alpha/beta hydrolase domain containing 18; This entry represents alpha/beta hydrolase domain-containing protein 18 (ABHD18). Its function is not clear.


Pssm-ID: 370661 [Multi-domain]  Cd Length: 352  Bit Score: 395.65  E-value: 4.00e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184  11 LFQFIVPKEW-NSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEaRMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMG 89
Cdd:pfam09752  78 RFAFLLPKKWgDSRKKPVCIHLAGTGDHSYWRRRNLMARPLLKD-GIGSIILENPFYGLRKPKNQWRSSLKNVSDLFVMG 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184  90 GALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTtdsfkmgqefvkhftssa 169
Cdd:pfam09752 157 GALILESRVLLHWLEREGYGPLGITGLSMGGHMASLAASNWPKPLVLVPCLSWSTASVVFTE------------------ 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184 170 dkltnlNLVSRTLNLDisnqVVSQKPADCHNSSKTSVSATseglllqdtskmkrfnqtlstnksgyTSRNPQSYHLLSKE 249
Cdd:pfam09752 219 ------GVISKSLAWD----VLEKQLEDGNYRERLATIRD--------------------------EAAQVESDKLDGAK 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1480008184 250 QSRNSlrKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQG 329
Cdd:pfam09752 263 ERGAT--KEALREMRGLMDSCTHLKNFSVPKDPSLAIFVAAKDDAYVPRESVTTLQQIWPGSEVRWVDGGHVSAYLLHQD 340

                  ...
gi 1480008184 330 LFR 332
Cdd:pfam09752 341 LFR 343
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
88-131 4.64e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 38.07  E-value: 4.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1480008184  88 MGGALVLESAALLHWLEREGY---GPLGMTGISMGGHMASLAVSNWP 131
Cdd:COG1506    69 WGGDEVDDVLAAIDYLAARPYvdpDRIGIYGHSYGGYMALLAAARHP 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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