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transmembrane and coiled-coil domain-containing protein 3 isoform 3 precursor [Homo sapiens]
Protein Classification
cation:proton antiporter ( domain architecture ID 11111152 )
cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to K(+) efflux antiporters that are involved in K(+) homeostasis and osmotic adjustment
List of domain hits
Name
Accession
Description
Interval
E-value
RosB super family
cl47355 Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
208-581
1.13e-60
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
COG4651 :Pssm-ID: 443689 [Multi-domain]
Cd Length: 564
Bit Score: 211.37
E-value: 1.13e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 208 SD I VT I GM L SLPC G W L CTAIGL P TMF GY IIC GVL L GP SGLNSIKSIVQV E T L G E F GV FFT LF L VGLEFS PEK L RK V W KI S 287
Cdd:COG4651 8 TT I AL I LG L AAVL G L L AQRLRQ P PIV GY LLA GVL I GP FTPGLVADVELI E Q L A E I GV ILL LF G VGLEFS LKD L LA V R KI A 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 288 L Q G PCYMTL L MIAF G LLWGH LL RIKPTQ S VFISTC LSLSST PLVSRF L MGS argd K E G D IDYSTVLL G M L VT QD VQLG L F 367
Cdd:COG4651 88 L P G ALLQIA L TTLL G FGIAL LL GWSLGE S LVFGLA LSLSST VVLLKL L EDR ---- G E L D TLHGRIAV G W L IV QD LAVV L M 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 368 MAVM P T L IQA G AS asssivvevlr I L VLI G QI L FSL A AVFL L C LV IKKYL I GPYYRK lh MESKGNK E ILI L GIS A FIFLM 447
Cdd:COG4651 164 LVLL P A L AGG G GG ----------- L L GTL G LT L LKV A LFVA L M LV VGRRV I PWLLHR -- VARTRSR E LFL L AVL A ICLGV 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 448 LTVTE L LDV S ME LG C FLAG ALVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G LHVF P T F VAYELTVLVF L T L S V VVM K F 527
Cdd:COG4651 231 AYLAA L FGL S FA LG A FLAG MVLAESE -- YSHQA A AELL P L RD AF A VL FF V S V G MLFD P S F LLENPLPVLA L L L I V LIG K P 308
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1167803525 528 L L A A L VLSLI lp RSSQYIKWI V SAG LAQ VS EFSF V L GSRARRA G VI S R E V Y L LI 581
Cdd:COG4651 309 L I A F L IVLAL -- GYPLRTALL V GLS LAQ IG EFSF I L AALGLSL G LL S E E A Y Q LI 360
Name
Accession
Description
Interval
E-value
RosB
COG4651 Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
208-581
1.13e-60
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
Pssm-ID: 443689 [Multi-domain]
Cd Length: 564
Bit Score: 211.37
E-value: 1.13e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 208 SD I VT I GM L SLPC G W L CTAIGL P TMF GY IIC GVL L GP SGLNSIKSIVQV E T L G E F GV FFT LF L VGLEFS PEK L RK V W KI S 287
Cdd:COG4651 8 TT I AL I LG L AAVL G L L AQRLRQ P PIV GY LLA GVL I GP FTPGLVADVELI E Q L A E I GV ILL LF G VGLEFS LKD L LA V R KI A 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 288 L Q G PCYMTL L MIAF G LLWGH LL RIKPTQ S VFISTC LSLSST PLVSRF L MGS argd K E G D IDYSTVLL G M L VT QD VQLG L F 367
Cdd:COG4651 88 L P G ALLQIA L TTLL G FGIAL LL GWSLGE S LVFGLA LSLSST VVLLKL L EDR ---- G E L D TLHGRIAV G W L IV QD LAVV L M 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 368 MAVM P T L IQA G AS asssivvevlr I L VLI G QI L FSL A AVFL L C LV IKKYL I GPYYRK lh MESKGNK E ILI L GIS A FIFLM 447
Cdd:COG4651 164 LVLL P A L AGG G GG ----------- L L GTL G LT L LKV A LFVA L M LV VGRRV I PWLLHR -- VARTRSR E LFL L AVL A ICLGV 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 448 LTVTE L LDV S ME LG C FLAG ALVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G LHVF P T F VAYELTVLVF L T L S V VVM K F 527
Cdd:COG4651 231 AYLAA L FGL S FA LG A FLAG MVLAESE -- YSHQA A AELL P L RD AF A VL FF V S V G MLFD P S F LLENPLPVLA L L L I V LIG K P 308
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1167803525 528 L L A A L VLSLI lp RSSQYIKWI V SAG LAQ VS EFSF V L GSRARRA G VI S R E V Y L LI 581
Cdd:COG4651 309 L I A F L IVLAL -- GYPLRTALL V GLS LAQ IG EFSF I L AALGLSL G LL S E E A Y Q LI 360
Na_H_Exchanger
pfam00999 Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
210-581
2.01e-50
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain]
Cd Length: 377
Bit Score: 178.99
E-value: 2.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 210 IV TIGM L S L PCGW L CTAIG LP TMF G Y II C G V LLGPSGL NS I KSI - VQV E T L GEF G VFFT LFL V GLE FSPEK LRK VWKIS L 288
Cdd:pfam00999 1 IV LLIL L A L LAPL L ARRLK LP PIV G L II A G I LLGPSGL GL I SEV d EDL E V L SNL G LPPL LFL A GLE LDLRE LRK NGGSI L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 289 QGPCYMT L LMIAF -- G LL WGHL L R I KPTQSVFISTC LS LS S TPL V SRF L MGSA R GDK egdi DYS T V LLG ML V TQ D VQLGL 366
Cdd:pfam00999 81 LLALLGV L IPFVL ig L LL YLLG L G I PLLEALLFGAI LS AT S PVV V LAI L KELG R VPE ---- RLG T L LLG ES V LN D GVAVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 367 FM AV MPT L I Q AGASA S S sivvevlri L VLIGQ I LFSL A AVF LL CLVI kkyl IG PYY R KLHMESKGNK E ILI L GISAFIF L 446
Cdd:pfam00999 157 LL AV LLA L A Q GVGGG S D --------- L GWLLL I FLVV A VGG LL LGLL ---- IG WLL R LITRFTDDDR E LEV L LVLLLAL L 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 447 MLTVT E L L D VS ME LG C FLAG ALV S sq GPVVTEEIATSI EP IRDF L AI - V FF ASI GL HVFPTFVAYELTV LV F L T L SVVVM 525
Cdd:pfam00999 224 AALLA E A L G VS GI LG A FLAG LVL S -- EYPFANKLSEKL EP FGYG L FN p L FF VLV GL SLDLSSLLLSVWI LV L L A L VAILL 301
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1167803525 526 KFL L AALV L SLI L PR S SQY i KW I VSA G LA Q VSEF S FV L GSRARRA G V I S RE V Y L L I 581
Cdd:pfam00999 302 GRF L GVFL L LRL L GL S LRE - AL I IGF G GL Q RGAV S LA L AAIGPLL G I I A RE L Y P L L 356
2a37
TIGR00932 transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
220-503
4.98e-31
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273348 [Multi-domain]
Cd Length: 273
Bit Score: 121.99
E-value: 4.98e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 220 CGW L CTAI G L P TMF GY IIC GVL L GPSGL NS I KSIVQ V ET L G EFGV FFTL FL V GLE FSP E K L R K VW K ISL - Q G PCYMTLLM 298
Cdd:TIGR00932 7 AVP L SRRL G I P SVL GY LLA GVL I GPSGL GL I SNVEG V NH L A EFGV ILLM FL I GLE LDL E R L W K LR K AAF g V G VLQVLVPG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 299 IAF GLL W GHLL RIKPTQS V F I STC L S LSST PL V SRF L mgsa RGDKEGDIDYSTVL LG M L VT QD VQLGLFM A VM P T L iqa G 378
Cdd:TIGR00932 87 VLL GLL L GHLL GLALGAA V V I GII L A LSST AV V VQV L ---- KERGLLKTPFGQTV LG I L LF QD IAVVPLL A LL P L L --- A 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 379 A SAS SS ivvevlri L V LIGQI L FSLAAV FLL CLVIKKY L IG P YY R KLH me SKGNK E ILIL G ISAFI F LMLTVTE LL DV SM 458
Cdd:TIGR00932 160 T SAS TE -------- H V ALALL L LKVFLA FLL LVLLGRW L LR P VL R LTA -- ELRPS E LFTA G SLLLM F GSAYFAD LL GL SM 229
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1167803525 459 E LG C FLAG ALV S SQ gp VVTEEIATSI EPI RDF L AIV FF A S I G LH V 503
Cdd:TIGR00932 230 A LG A FLAG VVL S ES -- EYRHKLESDL EPI GGV L LPL FF I S V G MS V 272
PRK03562
PRK03562 glutathione-regulated potassium-efflux system protein KefC; Provisional
226-576
5.48e-21
glutathione-regulated potassium-efflux system protein KefC; Provisional
Pssm-ID: 235131 [Multi-domain]
Cd Length: 621
Bit Score: 96.99
E-value: 5.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 226 AI GL PTMF GY I I C G VLL GP S GL NSIKSIVQVETLG EFGV FFT LF LV GLE FS P EK L rkv WK I -------- S LQ - GP C ym TL 296
Cdd:PRK03562 26 RL GL GSVL GY L I A G CII GP W GL RLVTDVESILHFA EFGV VLM LF VI GLE LD P QR L --- WK L rrsifggg A LQ m VA C -- GG 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 297 L MIA F GL L W G HLLRI kptq SVF I STC L S LSST P ----- LVS R F LM GSAR G DKE gdidystvl LGM L VT QD VQLGLFM A VM 371
Cdd:PRK03562 101 L LGL F CM L L G LRWQV ---- ALL I GLG L A LSST A iamqa MNE R N LM VTQM G RSA --------- FAI L LF QD IAAIPLV A MI 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 372 P T L IQA GAS - ASSSIVVEV L RILVLI gqilfsl A A V F L L clvi KK Y LIG P YY R kl HMESK G NK E I ------- L IL G ISA f 443
Cdd:PRK03562 168 P L L AAS GAS t TLGAFALSA L KVAGAL ------- A L V V L G ---- GR Y VTR P AL R -- FVARS G LR E V ftavalf L VF G FGL - 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 444 if LM ltvt E LLDV SM E LG C FLAG A L VS S qgpvv T E --- EIATS IEP IRDF L AIV FF ASI G LHV - F P T FVAYE L TV L VF L T 519
Cdd:PRK03562 234 -- LM ---- E EVGL SM A LG A FLAG V L LA S ----- S E yrh ALESD IEP FKGL L LGL FF IAV G MSI d F G T LLENP L RI L IL L L 302
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1167803525 520 LSVVVMKFL L AA L VLS L IL PR SSQ yik WIVSAG L A Q VS EF S FV LGSR A RR A G V ISR E 576
Cdd:PRK03562 303 GFLAIKIAM L WL L ARP L GV PR KQR --- RWFAVL L G Q GG EF A FV VFGA A QM A N V LEP E 356
Name
Accession
Description
Interval
E-value
RosB
COG4651 Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
208-581
1.13e-60
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
Pssm-ID: 443689 [Multi-domain]
Cd Length: 564
Bit Score: 211.37
E-value: 1.13e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 208 SD I VT I GM L SLPC G W L CTAIGL P TMF GY IIC GVL L GP SGLNSIKSIVQV E T L G E F GV FFT LF L VGLEFS PEK L RK V W KI S 287
Cdd:COG4651 8 TT I AL I LG L AAVL G L L AQRLRQ P PIV GY LLA GVL I GP FTPGLVADVELI E Q L A E I GV ILL LF G VGLEFS LKD L LA V R KI A 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 288 L Q G PCYMTL L MIAF G LLWGH LL RIKPTQ S VFISTC LSLSST PLVSRF L MGS argd K E G D IDYSTVLL G M L VT QD VQLG L F 367
Cdd:COG4651 88 L P G ALLQIA L TTLL G FGIAL LL GWSLGE S LVFGLA LSLSST VVLLKL L EDR ---- G E L D TLHGRIAV G W L IV QD LAVV L M 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 368 MAVM P T L IQA G AS asssivvevlr I L VLI G QI L FSL A AVFL L C LV IKKYL I GPYYRK lh MESKGNK E ILI L GIS A FIFLM 447
Cdd:COG4651 164 LVLL P A L AGG G GG ----------- L L GTL G LT L LKV A LFVA L M LV VGRRV I PWLLHR -- VARTRSR E LFL L AVL A ICLGV 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 448 LTVTE L LDV S ME LG C FLAG ALVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G LHVF P T F VAYELTVLVF L T L S V VVM K F 527
Cdd:COG4651 231 AYLAA L FGL S FA LG A FLAG MVLAESE -- YSHQA A AELL P L RD AF A VL FF V S V G MLFD P S F LLENPLPVLA L L L I V LIG K P 308
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1167803525 528 L L A A L VLSLI lp RSSQYIKWI V SAG LAQ VS EFSF V L GSRARRA G VI S R E V Y L LI 581
Cdd:COG4651 309 L I A F L IVLAL -- GYPLRTALL V GLS LAQ IG EFSF I L AALGLSL G LL S E E A Y Q LI 360
KefB
COG0475 Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
209-581
3.94e-54
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain]
Cd Length: 384
Bit Score: 189.20
E-value: 3.94e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 209 DIVTIGMLSLPC G W L CTAI GLP TMF GYI IC G V LLGPSGL NS I KSIVQV E T L G E F GV FFT LFL V GLE FSPEK LRK VWKIS L 288
Cdd:COG0475 8 QLGLLLLAAVLA G L L ARRL GLP SVL GYI LA G I LLGPSGL GL I EDSEAL E L L A E L GV VLL LFL I GLE LDLKR LRK MGRRA L 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 289 QGPCYMT LL MIAF G L L WGH LL RIKPTQSV F ISTC L SLS ST PL V SRF L -- M G SARG dkegdi DYSTVL LG MLVTQ D VQLG L 366
Cdd:COG0475 88 GIGLLQV LL PFLL G F L LAL LL GLSLAAAL F LGAA L AAT ST AI V LKV L ke L G LLKT ------ PLGQLI LG VALFD D IAAI L 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 367 FM A VM P T L IQA G AS A S S sivvevlrilvl IGQI L FSLAAVFL L C L VIKK YL IGPYY R kl HMESKGNK E ILI L GISAFIF L 446
Cdd:COG0475 162 LL A LV P A L AGG G SV A G S ------------ LLLA L LKALLFLA L L L LVGR YL LRRLF R -- LVARTRSR E LFL L FALLLVL L 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 447 MLTVT ELL DV S ME LG C FLAG ALVSSQGPV vt E E IATS IEP IR D FLAIV FF A S I GL HVFPTFVAYELTVLVF L T L SVV V M K 526
Cdd:COG0475 228 AAALA ELL GL S AA LG A FLAG LVLAESEYR -- H E LEEK IEP FG D LFLPL FF V S V GL SLDLSALLSNPLLALL L V L AAI V G K 305
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1167803525 527 F L L A A L VLS L I lp RS S QYIKWIVSAG LA QVS EF SF VL G S RARR AG V IS R E VYLLI 581
Cdd:COG0475 306 L L G A Y L AAR L F -- GL S RREALRIGLL LA PRG EF AL VL A S LGLS AG L IS P E LFAAL 358
Na_H_Exchanger
pfam00999 Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
210-581
2.01e-50
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain]
Cd Length: 377
Bit Score: 178.99
E-value: 2.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 210 IV TIGM L S L PCGW L CTAIG LP TMF G Y II C G V LLGPSGL NS I KSI - VQV E T L GEF G VFFT LFL V GLE FSPEK LRK VWKIS L 288
Cdd:pfam00999 1 IV LLIL L A L LAPL L ARRLK LP PIV G L II A G I LLGPSGL GL I SEV d EDL E V L SNL G LPPL LFL A GLE LDLRE LRK NGGSI L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 289 QGPCYMT L LMIAF -- G LL WGHL L R I KPTQSVFISTC LS LS S TPL V SRF L MGSA R GDK egdi DYS T V LLG ML V TQ D VQLGL 366
Cdd:pfam00999 81 LLALLGV L IPFVL ig L LL YLLG L G I PLLEALLFGAI LS AT S PVV V LAI L KELG R VPE ---- RLG T L LLG ES V LN D GVAVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 367 FM AV MPT L I Q AGASA S S sivvevlri L VLIGQ I LFSL A AVF LL CLVI kkyl IG PYY R KLHMESKGNK E ILI L GISAFIF L 446
Cdd:pfam00999 157 LL AV LLA L A Q GVGGG S D --------- L GWLLL I FLVV A VGG LL LGLL ---- IG WLL R LITRFTDDDR E LEV L LVLLLAL L 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 447 MLTVT E L L D VS ME LG C FLAG ALV S sq GPVVTEEIATSI EP IRDF L AI - V FF ASI GL HVFPTFVAYELTV LV F L T L SVVVM 525
Cdd:pfam00999 224 AALLA E A L G VS GI LG A FLAG LVL S -- EYPFANKLSEKL EP FGYG L FN p L FF VLV GL SLDLSSLLLSVWI LV L L A L VAILL 301
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1167803525 526 KFL L AALV L SLI L PR S SQY i KW I VSA G LA Q VSEF S FV L GSRARRA G V I S RE V Y L L I 581
Cdd:pfam00999 302 GRF L GVFL L LRL L GL S LRE - AL I IGF G GL Q RGAV S LA L AAIGPLL G I I A RE L Y P L L 356
2a37
TIGR00932 transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
220-503
4.98e-31
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273348 [Multi-domain]
Cd Length: 273
Bit Score: 121.99
E-value: 4.98e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 220 CGW L CTAI G L P TMF GY IIC GVL L GPSGL NS I KSIVQ V ET L G EFGV FFTL FL V GLE FSP E K L R K VW K ISL - Q G PCYMTLLM 298
Cdd:TIGR00932 7 AVP L SRRL G I P SVL GY LLA GVL I GPSGL GL I SNVEG V NH L A EFGV ILLM FL I GLE LDL E R L W K LR K AAF g V G VLQVLVPG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 299 IAF GLL W GHLL RIKPTQS V F I STC L S LSST PL V SRF L mgsa RGDKEGDIDYSTVL LG M L VT QD VQLGLFM A VM P T L iqa G 378
Cdd:TIGR00932 87 VLL GLL L GHLL GLALGAA V V I GII L A LSST AV V VQV L ---- KERGLLKTPFGQTV LG I L LF QD IAVVPLL A LL P L L --- A 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 379 A SAS SS ivvevlri L V LIGQI L FSLAAV FLL CLVIKKY L IG P YY R KLH me SKGNK E ILIL G ISAFI F LMLTVTE LL DV SM 458
Cdd:TIGR00932 160 T SAS TE -------- H V ALALL L LKVFLA FLL LVLLGRW L LR P VL R LTA -- ELRPS E LFTA G SLLLM F GSAYFAD LL GL SM 229
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1167803525 459 E LG C FLAG ALV S SQ gp VVTEEIATSI EPI RDF L AIV FF A S I G LH V 503
Cdd:TIGR00932 230 A LG A FLAG VVL S ES -- EYRHKLESDL EPI GGV L LPL FF I S V G MS V 272
PRK03562
PRK03562 glutathione-regulated potassium-efflux system protein KefC; Provisional
226-576
5.48e-21
glutathione-regulated potassium-efflux system protein KefC; Provisional
Pssm-ID: 235131 [Multi-domain]
Cd Length: 621
Bit Score: 96.99
E-value: 5.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 226 AI GL PTMF GY I I C G VLL GP S GL NSIKSIVQVETLG EFGV FFT LF LV GLE FS P EK L rkv WK I -------- S LQ - GP C ym TL 296
Cdd:PRK03562 26 RL GL GSVL GY L I A G CII GP W GL RLVTDVESILHFA EFGV VLM LF VI GLE LD P QR L --- WK L rrsifggg A LQ m VA C -- GG 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 297 L MIA F GL L W G HLLRI kptq SVF I STC L S LSST P ----- LVS R F LM GSAR G DKE gdidystvl LGM L VT QD VQLGLFM A VM 371
Cdd:PRK03562 101 L LGL F CM L L G LRWQV ---- ALL I GLG L A LSST A iamqa MNE R N LM VTQM G RSA --------- FAI L LF QD IAAIPLV A MI 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 372 P T L IQA GAS - ASSSIVVEV L RILVLI gqilfsl A A V F L L clvi KK Y LIG P YY R kl HMESK G NK E I ------- L IL G ISA f 443
Cdd:PRK03562 168 P L L AAS GAS t TLGAFALSA L KVAGAL ------- A L V V L G ---- GR Y VTR P AL R -- FVARS G LR E V ftavalf L VF G FGL - 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 444 if LM ltvt E LLDV SM E LG C FLAG A L VS S qgpvv T E --- EIATS IEP IRDF L AIV FF ASI G LHV - F P T FVAYE L TV L VF L T 519
Cdd:PRK03562 234 -- LM ---- E EVGL SM A LG A FLAG V L LA S ----- S E yrh ALESD IEP FKGL L LGL FF IAV G MSI d F G T LLENP L RI L IL L L 302
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1167803525 520 LSVVVMKFL L AA L VLS L IL PR SSQ yik WIVSAG L A Q VS EF S FV LGSR A RR A G V ISR E 576
Cdd:PRK03562 303 GFLAIKIAM L WL L ARP L GV PR KQR --- RWFAVL L G Q GG EF A FV VFGA A QM A N V LEP E 356
PRK03659
PRK03659 glutathione-regulated potassium-efflux system protein KefB; Provisional
228-576
4.48e-20
glutathione-regulated potassium-efflux system protein KefB; Provisional
Pssm-ID: 179625 [Multi-domain]
Cd Length: 601
Bit Score: 94.32
E-value: 4.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 228 G LPTMF GY IIC G VLL GP S GL NS I KSIVQVETLG E F GV F F TL F LV GLE FS P E KL rkv W K is L QGP ------------- CYM 294
Cdd:PRK03659 28 G IGAVL GY LLA G IAI GP W GL GF I SDVDEILHFS E L GV V F LM F II GLE LN P S KL --- W Q -- L RRS ifgvgaaqvllsa AVL 102
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 295 TL L MIAFGLL W ghllrikp TQS V FISTC L SL SST PLVSRFLMGSARGDK E GDIDYST VLL gmlv T QD VQLGLFM A VM P T L 374
Cdd:PRK03659 103 AG L LMLTDFS W -------- QAA V VGGIG L AM SST AMALQLMREKGMNRS E SGQLGFS VLL ---- F QD LAVIPAL A LV P L L 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 375 iq AG ASASSSIVV evlrilvlig Q I LFSLA A VFLL c L VIKK YL IG P YY R kl HMESK G NK E I ------- L I LG ISA F I flm 447
Cdd:PRK03659 171 -- AG SADEHFDWM ---------- K I GMKVL A FAGM - L IGGR YL LR P LF R -- FIAAS G VR E V ftaaall L V LG SAL F M --- 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 448 ltvt EL L DV SM E LG C F L AG A L VSSQG pv VTE E IATS IEP IRDF L AIV FF A S I G LHV - FPTFVAYE L T VL VFLTLS V V V MK 526
Cdd:PRK03659 233 ---- DA L GL SM A LG T F I AG V L LAESE -- YRH E LEIA IEP FKGL L LGL FF I S V G MAL n LGVLYTHL L W VL ISVVVL V A V KG 306
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1167803525 527 FL L AA L VLSLI L p RSS QYIKW iv SAG L A Q VS EF S FVL G S R A RRAGVISRE 576
Cdd:PRK03659 307 LV L YL L ARLYG L - RSS ERMQF -- AGV L S Q GG EF A FVL F S A A SSQRLLQGD 353
PRK10669
PRK10669 putative cation:proton antiport protein; Provisional
234-563
8.81e-17
putative cation:proton antiport protein; Provisional
Pssm-ID: 182633 [Multi-domain]
Cd Length: 558
Bit Score: 83.61
E-value: 8.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 234 GY IIC GVL L GP SGLNSIKSIVQVET L G E F GV FFTL F L VGL E FS PEK L RK V WK I SLQ G PCYMTLLMIAF G LLWGHL L RIKP 313
Cdd:PRK10669 35 GY LLA GVL A GP FTPGFVADTKLAPE L A E L GV ILLM F G VGL H FS LKD L MA V KS I AIP G AIAQIAVATLL G MALSAV L GWSL 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 314 TQSVFIST CLS LS ST ----- P L VS R F L MG S A RG D kegdidyst VLL G M L VTQ D VQLG L FMAVM P TLIQAGASASSSIVVE 388
Cdd:PRK10669 115 MTGIVFGL CLS TA ST vvllr A L EE R Q L ID S Q RG Q --------- IAI G W L IVE D LVMV L TLVLL P AVAGMMEQGDVGFATL 185
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 389 VLRILVL IG QIL fsla A VFLLCLVIKKY L IGPYYRK lh MESK G NK E ILI L GIS A FIF - LMLTVT EL L DVS ME LG C F L AG A 467
Cdd:PRK10669 186 AVDLGIT IG KVI ---- A FIAIMMLVGRR L VPWILAR -- SAAT G SR E LFT L SVL A LAL g IAFGAV EL F DVS FA LG A F F AG M 259
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 468 LVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G L h V F PTFVAYELTVL V FL TL SVV V MKFL LAA LV L SLILPR S SQ y IKW 547
Cdd:PRK10669 260 VLNESE -- LSHRA A HDTL P L RD AF A VL FF V S V G M - L F DPMILIQQPLA V LA TL AII V FGKS LAA FF L VRLFGH S RR - TAL 335
330
....*....|....*.
gi 1167803525 548 IVS A G LAQ VS EF S F V L 563
Cdd:PRK10669 336 TIA A S LAQ IG EF A F I L 351
PLN03159
PLN03159 cation/H(+) antiporter 15; Provisional
230-532
2.66e-05
cation/H(+) antiporter 15; Provisional
Pssm-ID: 215608 [Multi-domain]
Cd Length: 832
Bit Score: 47.19
E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 230 P TMFGY I IC GV L LGPS G L NSIK ---------- S IVQV ET LGEF G VFFT LFLVG L E FSPEKL R KVW K ---- I SLQ G PCYMT 295
Cdd:PLN03159 68 P RVISE I LG GV I LGPS V L GQSE vfantifplr S VMVL ET MANL G LLYF LFLVG V E MDISVI R RTG K kala I AIA G MALPF 147
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 296 LLMI AF GLLWGHLL R I -- KP T QSV F ISTC LS LSST P LVS R F L MGSARGDK E - G D I DY S TV L L gmlvt Q D VQLGLFM A VMP 372
Cdd:PLN03159 148 CIGL AF SFIFHQVS R N vh QG T FIL F LGVA LS VTAF P VLA R I L AEIKLINT E l G R I AM S AA L V ----- N D MCAWILL A LAI 222
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 373 T L IQAGASASS S ivvevlr IL VL IGQIL F S L A avfll C LVIKKYL I GPYY R KLH m E SKGNK E IL I LG I SAFIFLMLTV T E 452
Cdd:PLN03159 223 A L AENDSTSLA S ------- LW VL LSSVA F V L F ----- C FYVVRPG I WWII R RTP - E GETFS E FY I CL I LTGVMISGFI T D 289
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 453 LLDVSMEL G C F LA G a LV SSQ GP VVT eeia T S IE PIR DF ---- L AIV FFA SI GL HVFP T FVAYEL T ---- VLV FLTL S VV - 523
Cdd:PLN03159 290 AIGTHSVF G A F VF G - LV IPN GP LGV ---- T L IE KLE DF vsgl L LPL FFA IS GL KTNV T KIQGPA T wgll VLV IIMA S AG k 364
....*....
gi 1167803525 524 V M KFLLA A L 532
Cdd:PLN03159 365 I M GTIII A F 373
NhaP
COG0025 NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
210-552
2.70e-03
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain]
Cd Length: 506
Bit Score: 40.72
E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 210 I VTIGM L S L PCG WL CTAIG LP TMFGYIIC G V LLGP - S GL NSIKSIVQV E T L G E FGVFFT LF LVG L EFSPEK LR KVWKIS L 288
Cdd:COG0025 7 I LLLLL L G L LSQ WL ARRLK LP APLLLLLA G I LLGP g L GL ELDPELGDL E P L L E LFLPPL LF EAA L NLDLRE LR RNGRPI L 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 289 Q --- GPCYM T L L MI A FGLL W gh LL RIKPTQSVFISTC L SLSSTPL VS R f LMGSARGD K E gdid YS T V L L G -------- M L 357
Cdd:COG0025 87 R lav VGVLL T T L AV A LAAH W -- LL GLPLAAALLLGAI L APTDPVA VS P - ILRRLGVP K R ---- LR T I L E G esllndat A L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 358 V tqdvqlg LF MAVM p TLIQA G ASASSSIVVEV L ri L VLI G Q IL FS L AAVF LL CLVIK kyligpyyrkl HMESKGNKEI L I 437
Cdd:COG0025 160 V ------- LF VLAL - AAALG G GFSLGEALLDF L -- L AIL G G IL VG L LLGW LL GRLLR ----------- RLPDPLLEIL L T 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803525 438 L GISAFIF L mlt VT E L L DV S ME L GCFL AG ALVSSQ G PVVTE ei ATSIEPIRD F ------- L AIVF F ASI G LHV - FPTFV A 509
Cdd:COG0025 219 L ALPFLAY L --- LA E A L HG S GV L AVVV AG LVLGNA G RRSLS -- PETRLQLLE F wetlefl L NSLL F VLL G AQL p LILLG A 293
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1167803525 510 YE L TVLVFLT L SVV V MKF L LAA L V L S L ILP R S S QYIKWIV S A G 552
Cdd:COG0025 294 LG L GGILLVL L ALL V VRP L WVF L S L A L RGS R L S WRERLFL S W G 336
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
