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Conserved domains on  [gi|1061899922|ref|NP_001317952|]
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kelch-like protein 2 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 1-116 1.61e-86

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18512:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 130  Bit Score: 259.58  E-value: 1.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18512    15 MHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEHVR 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1061899922  81 LPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 116
Cdd:cd18512    95 LPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
167-424 5.84e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 175.73  E-value: 5.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 167 WHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM-RDRRSTLGAAVLNGLLYAVGGFDG- 244
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 245 ---STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRqcLSTVECYNATTNEWTYIAEMSTRRS 321
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 322 GAGVGVL-NNLLYAVGGHDGplvrksvevyDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPT 400
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|....
gi 1061899922 401 TDKWTVVSScMSTGRSYAGVTVID 424
Cdd:COG3055   229 TNTWTALGE-LPTPRHGHAAVLTD 251
Kelch smart00612
Kelch domain;
145-187 8.26e-07

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 8.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1061899922  145 VVGGQAPK-AIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAG 187
Cdd:smart00612   4 VVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 1-116 1.61e-86

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 259.58  E-value: 1.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18512    15 MHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEHVR 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1061899922  81 LPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 116
Cdd:cd18512    95 LPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
167-424 5.84e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 175.73  E-value: 5.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 167 WHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM-RDRRSTLGAAVLNGLLYAVGGFDG- 244
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 245 ---STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRqcLSTVECYNATTNEWTYIAEMSTRRS 321
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 322 GAGVGVL-NNLLYAVGGHDGplvrksvevyDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPT 400
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|....
gi 1061899922 401 TDKWTVVSScMSTGRSYAGVTVID 424
Cdd:COG3055   229 TNTWTALGE-LPTPRHGHAAVLTD 251
PHA03098 PHA03098
kelch-like protein; Provisional
 1-407 2.22e-49

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 175.73  E-value: 2.22e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:PHA03098  119 FYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922  81 LPLLPREYLvqrveeEALVKNSSACKDYLIeamkyhllpTEQRILMKSVRTRLRT----PMNLPKLMVVVGGQAP--KAI 154
Cdd:PHA03098  199 ITFLSEEGI------KKLKRWKLRIKKKKI---------VFNKRCIKIIYSKKYNlnkiLPRSSTFGSIIYIHITmsIFT 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 155 RSVECYDFKEERWHQVAELPSRRCrAGMVYMAGLVFAVGGFNGS-LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLN 233
Cdd:PHA03098  264 YNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFN 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 234 GLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG---YDgasrQCLSTVECYNATTNEW 310
Cdd:PHA03098  343 NRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskND----ELLKTVECFSLNTNKW 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 311 TYIAEMSTRRSGAGVGVLNNLLYAVGGH---DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDG 387
Cdd:PHA03098  419 SKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKY 498

                         410       420
                  ....*....|....*....|
gi 1061899922 388 SCNLASVEYYNPTTDKWTVV 407
Cdd:PHA03098  499 EYYINEIEVYDDKTNTWTLF 518
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 1-94 1.61e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 134.60  E-value: 1.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:pfam07707  10 AYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSAVR 89

                          90
                  ....*....|....
gi 1061899922  81 LPLLPREYLVQRVE 94
Cdd:pfam07707  90 LPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 1-92 1.20e-35

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 126.69  E-value: 1.20e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922    1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:smart00875  10 AHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEHVR 89

                           90
                   ....*....|..
gi 1061899922   81 LPLLPREYLVQR 92
Cdd:smart00875  90 LPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
331-377 3.73e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.12  E-value: 3.73e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1061899922  331 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 377
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 319-364 2.41e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.79  E-value: 2.41e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1061899922 319 RRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMN 364
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
145-187 8.26e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 8.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1061899922  145 VVGGQAPK-AIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAG 187
Cdd:smart00612   4 VVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 142-174 2.80e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 2.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1061899922 142 LMVVVGGQ-APKAIRSVECYDFKEERWHQVAELP 174
Cdd:pfam01344  13 KIYVIGGFdGNQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
132-194 4.11e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 38.98  E-value: 4.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061899922 132 RLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG 194
Cdd:COG3055   197 RAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
 
Name Accession Description Interval E-value
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 1-116 1.61e-86

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 259.58  E-value: 1.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18512    15 MHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEHVR 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1061899922  81 LPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 116
Cdd:cd18512    95 LPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 1-116 9.07e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 214.16  E-value: 9.07e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18513    15 VHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLEHMAKLMEHVR 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1061899922  81 LPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 116
Cdd:cd18513    95 LPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 1-100 3.42e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 201.69  E-value: 3.42e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18445    15 LHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKEHLAELLEHVR 94

                          90       100
                  ....*....|....*....|
gi 1061899922  81 LPLLPREYLVQRVEEEALVK 100
Cdd:cd18445    95 LPLLSPEYLVQRVEEEELIK 114
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
167-424 5.84e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 175.73  E-value: 5.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 167 WHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM-RDRRSTLGAAVLNGLLYAVGGFDG- 244
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 245 ---STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRqcLSTVECYNATTNEWTYIAEMSTRRS 321
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 322 GAGVGVL-NNLLYAVGGHDGplvrksvevyDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPT 400
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|....
gi 1061899922 401 TDKWTVVSScMSTGRSYAGVTVID 424
Cdd:COG3055   229 TNTWTALGE-LPTPRHGHAAVLTD 251
PHA03098 PHA03098
kelch-like protein; Provisional
 1-407 2.22e-49

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 175.73  E-value: 2.22e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:PHA03098  119 FYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922  81 LPLLPREYLvqrveeEALVKNSSACKDYLIeamkyhllpTEQRILMKSVRTRLRT----PMNLPKLMVVVGGQAP--KAI 154
Cdd:PHA03098  199 ITFLSEEGI------KKLKRWKLRIKKKKI---------VFNKRCIKIIYSKKYNlnkiLPRSSTFGSIIYIHITmsIFT 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 155 RSVECYDFKEERWHQVAELPSRRCrAGMVYMAGLVFAVGGFNGS-LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLN 233
Cdd:PHA03098  264 YNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFN 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 234 GLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG---YDgasrQCLSTVECYNATTNEW 310
Cdd:PHA03098  343 NRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskND----ELLKTVECFSLNTNKW 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 311 TYIAEMSTRRSGAGVGVLNNLLYAVGGH---DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDG 387
Cdd:PHA03098  419 SKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKY 498

                         410       420
                  ....*....|....*....|
gi 1061899922 388 SCNLASVEYYNPTTDKWTVV 407
Cdd:PHA03098  499 EYYINEIEVYDDKTNTWTLF 518
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
145-384 9.35e-45

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 156.85  E-value: 9.35e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 145 VVGGQAP-KAIRSVECYDFKEERWHQVAELP-SRRCRAGMVYMAGLVFAVGGFNGSLRVRT----VDSYDPVKDQWTSVA 218
Cdd:COG3055    27 VAGGLSGgSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSSTplndVYVYDPATNTWTKLA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 219 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG-LLYAVGGYDGasrqcl 297
Cdd:COG3055   107 PMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNG------ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 298 stvecyNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLvrKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 377
Cdd:COG3055   181 ------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252


                  ....*..
gi 1061899922 378 LLYVVGG 384
Cdd:COG3055   253 KVYVIGG 259
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 2-119 6.88e-39

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 136.76  E-value: 6.88e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18452    16 HNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEEREDYLPELLQYVRL 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1061899922  82 PLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 119
Cdd:cd18452    96 PLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 1-94 1.61e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 134.60  E-value: 1.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:pfam07707  10 AYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSAVR 89

                          90
                  ....*....|....
gi 1061899922  81 LPLLPREYLVQRVE 94
Cdd:pfam07707  90 LPLLSPQYLLNLVE 103
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
145-351 3.74e-38

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 139.14  E-value: 3.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 145 VVGG-----QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVAN 219
Cdd:COG3055    75 VFGGftganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 220 MRDRRSTLGAAVL-NGLLYAVGGFDGSTGlssveaynikSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASrqclS 298
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS----D 220

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1061899922 299 TVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKS----VEVYD 351
Cdd:COG3055   221 EVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPlvtsAEVYD 277
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 1-92 1.20e-35

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 126.69  E-value: 1.20e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922    1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:smart00875  10 AHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEHVR 89

                           90
                   ....*....|..
gi 1061899922   81 LPLLPREYLVQR 92
Cdd:smart00875  90 LPLLSPDYLLEV 101
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 4-93 2.93e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 118.18  E-value: 2.93e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   4 CTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPL 83
Cdd:cd18457    18 CSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREEYLPELLSKVRLPL 97

                          90
                  ....*....|
gi 1061899922  84 LPREYLVQRV 93
Cdd:cd18457    98 LRPQFLTDRV 107
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 2-89 1.42e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 110.88  E-value: 1.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18444    17 QGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLALIRL 96


                  ....*...
gi 1061899922  82 PLLPREYL 89
Cdd:cd18444    97 PLLTPQFL 104
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 1-64 1.90e-25

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 98.63  E-value: 1.90e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHD 64
Cdd:cd18508    14 AHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 2-88 2.85e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 96.22  E-value: 2.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18456    16 HSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVDGRRQHVPRLMKCVRL 95


                  ....*..
gi 1061899922  82 PLLPREY 88
Cdd:cd18456    96 PLLSRDF 102
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 2-84 1.36e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 91.72  E-value: 1.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18459    17 HACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERRPHLPQVLQHVRL 96


                  ...
gi 1061899922  82 PLL 84
Cdd:cd18459    97 PLL 99
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 3-89 2.29e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 90.94  E-value: 2.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   3 ACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLP 82
Cdd:cd18468    16 QCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRKQHIAELLAVVRLP 95


                  ....*..
gi 1061899922  83 LLPREYL 89
Cdd:cd18468    96 FIHPSYL 102
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 1-82 6.35e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 89.67  E-value: 6.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18448    16 QHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQHRKRHLDDLLSQVR 95


                  ..
gi 1061899922  81 LP 82
Cdd:cd18448    96 LP 97
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 2-94 1.19e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 89.45  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18446    16 HSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLPLLPRVLENVRL 95

                          90
                  ....*....|...
gi 1061899922  82 PLLPREYLVQRVE 94
Cdd:cd18446    96 PLLDPWYFVETVE 108
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 1-76 3.29e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 87.35  E-value: 3.29e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLM 76
Cdd:cd18458    16 QHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENRRQYLEALL 91
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 2-89 1.27e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 86.51  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18510    17 QGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQKDLGMLLSYIRL 96


                  ....*...
gi 1061899922  82 PLLPREYL 89
Cdd:cd18510    97 PLLPPQLL 104
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 2-89 8.29e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 83.96  E-value: 8.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18511    17 QGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRRKDLSKLLAYIRL 96


                  ....*...
gi 1061899922  82 PLLPREYL 89
Cdd:cd18511    97 PLLAPQFL 104
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 5-83 2.73e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 79.77  E-value: 2.73e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061899922   5 TDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPL 83
Cdd:cd18485    19 EDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRVQHLVELLKQVRLEL 97
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 2-89 2.75e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 80.07  E-value: 2.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18509    17 QGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAYIRL 96


                  ....*...
gi 1061899922  82 PLLPREYL 89
Cdd:cd18509    97 PLLPPQLL 104
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
141-304 3.00e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.44  E-value: 3.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 141 KLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCR-AGMVYMAGLVFAVGGFNGSLRVrtvdsydpvkDQWTSVAN 219
Cdd:COG3055   123 KIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGSGFS----------NTWTTLAP 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 220 MRDRRSTLGAAVLNGLLYAVGGFDGStgLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCL 297
Cdd:COG3055   193 LPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETkpGVRTPLV 270


                  ....*..
gi 1061899922 298 STVECYN 304
Cdd:COG3055   271 TSAEVYD 277
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 2-84 3.25e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 76.52  E-value: 3.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18467    16 YGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQERQKYLAQLLHCVRL 95


                  ...
gi 1061899922  82 PLL 84
Cdd:cd18467    96 PLL 98
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 10-76 6.19e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 75.82  E-value: 6.19e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1061899922  10 KANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLM 76
Cdd:cd18455    23 VATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEERKVHLKDLM 89
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 4-64 2.04e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 73.80  E-value: 2.04e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061899922   4 CTDLLNKANTYAEQHFADVV-LSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHD 64
Cdd:cd18450    18 CPELERKAYRYILRNFEEVAkDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 2-63 2.22e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 73.58  E-value: 2.22e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNH 63
Cdd:cd18463    17 HSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 4-83 4.87e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 73.16  E-value: 4.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   4 CTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPL 83
Cdd:cd18447    19 CPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPYMVDILAKVRFPL 98
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 3-89 3.22e-15

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 70.97  E-value: 3.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   3 ACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLP 82
Cdd:cd18466    17 ACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRKKHVVEVLEPVRFP 96


                  ....*..
gi 1061899922  83 LLPREYL 89
Cdd:cd18466    97 LLPPQRL 103
Kelch smart00612
Kelch domain;
331-377 3.73e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.12  E-value: 3.73e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1061899922  331 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 377
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 2-88 5.95e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 70.56  E-value: 5.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18469    18 HGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARAAHLPELLSLVHL 97


                  ....*..
gi 1061899922  82 PLLPREY 88
Cdd:cd18469    98 SLLTDQY 104
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 2-85 7.70e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 69.87  E-value: 7.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18514    16 HQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRKDYLPELLRNVRL 95


                  ....
gi 1061899922  82 PLLP 85
Cdd:cd18514    96 ALLP 99
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 1-85 2.43e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 68.63  E-value: 2.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18516    15 LLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTKALPVLLESIR 94


                  ....*
gi 1061899922  81 LPLLP 85
Cdd:cd18516    95 FRLMP 99
Kelch smart00612
Kelch domain;
378-425 6.81e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 65.66  E-value: 6.81e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1061899922  378 LLYVVGGDDGSCNLASVEYYNPTTDKWTVVSScMSTGRSYAGVTVIDK 425
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
188-234 6.94e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 65.66  E-value: 6.94e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1061899922  188 LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNG 234
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 4-85 1.31e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 66.33  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   4 CTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPL 83
Cdd:cd18517    18 CPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENRVKSLGEIFDCIRFRL 97


                  ..
gi 1061899922  84 LP 85
Cdd:cd18517    98 MP 99
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 2-85 1.52e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 66.37  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18464    15 HQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHEVLPELLRSVRL 94


                  ....
gi 1061899922  82 PLLP 85
Cdd:cd18464    95 ALLP 98
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 4-85 1.77e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 66.02  E-value: 1.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   4 CTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPL 83
Cdd:cd18477    18 CPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENRQKALPTVFESIRFRL 97


                  ..
gi 1061899922  84 LP 85
Cdd:cd18477    98 LP 99
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 319-364 2.41e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.79  E-value: 2.41e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1061899922 319 RRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMN 364
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
282-330 2.63e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.73  E-value: 2.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1061899922  282 LLYAVGGYDGAsrQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNN 330
Cdd:smart00612   1 KIYVVGGFDGG--QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 4-82 3.61e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 65.15  E-value: 3.61e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061899922   4 CTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLtISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLP 82
Cdd:cd18476    18 CETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPKARKGYIHDLFKKVRLQ 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 367-411 1.02e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 62.24  E-value: 1.02e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1061899922 367 RRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCM 411
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 5-68 5.38e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 61.19  E-value: 5.38e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1061899922   5 TDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 68
Cdd:cd18480    19 TRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 223-268 6.51e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.93  E-value: 6.51e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1061899922 223 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMN 268
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 2-85 1.89e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 60.37  E-value: 1.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18515    15 HQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHCYLSELLQTVRL 94


                  ....
gi 1061899922  82 PLLP 85
Cdd:cd18515    95 ALLP 98
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 1-81 3.57e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 59.30  E-value: 3.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVR 80
Cdd:cd18479    15 LFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIR 94


                  .
gi 1061899922  81 L 81
Cdd:cd18479    95 I 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 176-221 5.60e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.24  E-value: 5.60e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1061899922 176 RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 221
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 2-61 6.88e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 57.78  E-value: 6.88e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWV 61
Cdd:cd18472    16 ATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 2-83 7.30e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 58.59  E-value: 7.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRL 81
Cdd:cd18462    16 HVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIECAYDLLSSIKL 95


                  ..
gi 1061899922  82 PL 83
Cdd:cd18462    96 DL 97
Kelch smart00612
Kelch domain;
235-272 8.63e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.80  E-value: 8.63e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1061899922  235 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 272
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRS 38
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 17-94 1.47e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 57.72  E-value: 1.47e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061899922  17 QHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVE 94
Cdd:cd18453    22 KKLANKYLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQ 99
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 4-82 3.28e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 56.66  E-value: 3.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   4 CTDLLNKANTY------------AEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQEF 71
Cdd:cd18449     6 CVEIGRIANTYhltevdkyvndfILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD-RMQF 84

                          90
                  ....*....|.
gi 1061899922  72 MARLMEHVRLP 82
Cdd:cd18449    85 AAKLMENIRFP 95
PLN02193 PLN02193
nitrile-specifier protein
 283-409 3.51e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 61.51  E-value: 3.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 283 LYAVGGYDgASRQcLSTVECYNATTNEW---TYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQ 359
Cdd:PLN02193  231 LYVFGGRD-ASRQ-YNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFH 308

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1061899922 360 VA---DMNMCRRNAGVCAVNGLLYVVGGDDGsCNLASVEYYNPTTDKWTVVSS 409
Cdd:PLN02193  309 CStpgDSFSIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVET 360
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 3-86 3.86e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 56.73  E-value: 3.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   3 ACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLP 82
Cdd:cd18460    17 ACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKHRQHFWPELLQHVRLP 96


                  ....
gi 1061899922  83 LLPR 86
Cdd:cd18460    97 FVRR 100
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 6-82 5.95e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 56.02  E-value: 5.95e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061899922   6 DLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEH-VRLP 82
Cdd:cd18483    20 ELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREMHLPEIFAKcIRMP 97
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 1-42 6.53e-09

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 51.51  E-value: 6.53e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 42
Cdd:cd14733    14 LYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 5-89 8.11e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 53.00  E-value: 8.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   5 TDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLtISSEEKVFEAVIAWVNHDKDVRQEfMARLMEHVRLPLL 84
Cdd:cd14822    19 DDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSF-CAPEVDIFNAVRRWCEHNPDSKED-AKEILEAVRLPLM 96


                  ....*
gi 1061899922  85 PREYL 89
Cdd:cd14822    97 SLTEL 101
PHA02790 PHA02790
Kelch-like protein; Provisional
 235-406 1.45e-08

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 56.59  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 235 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASrqclsTVECYNATTNEWTYIA 314
Cdd:PHA02790  273 VVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPT-----SVERWFHGDAAWVNMP 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 315 EMSTRRSGAGVGVLNNLLYAVGGHD------------------GP-------------------LVRKSVEVYDPTTNAW 357
Cdd:PHA02790  348 SLLKPRCNPAVASINNVIYVIGGHSetdttteyllpnhdqwqfGPstyyphykscalvfgrrlfLVGRNAEFYCESSNTW 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1061899922 358 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTV 406
Cdd:PHA02790  428 TLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 17-64 8.01e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 49.43  E-value: 8.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1061899922  17 QHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHD 64
Cdd:cd18474    31 RDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 7-84 1.20e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 49.52  E-value: 1.20e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061899922   7 LLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDkDVRQEFMARLMEHVRLPLL 84
Cdd:cd18465    21 LKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRASASHVLCHIRFPLM 97
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 2-79 1.59e-07

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 49.16  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNL---GIEQVCSliSSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEH 78
Cdd:cd18502    16 MNDSELLQKVDSYIQENIEEVAESKEFLKLprlQIEVILE--SNQELESINERKLCQLVLEWVQRSIEEGGLDLDDLTEK 93


                  .
gi 1061899922  79 V 79
Cdd:cd18502    94 V 94
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 282-317 2.92e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.84  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1061899922 282 LLYAVGGYDGasRQCLSTVECYNATTNEWTYIAEMS 317
Cdd:pfam01344  13 KIYVIGGFDG--NQSLNSVEVYDPETNTWSKLPSMP 46
PHA02713 PHA02713
hypothetical protein; Provisional
 316-398 3.64e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 52.32  E-value: 3.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 316 MSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 395
Cdd:PHA02713  338 MIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVH 417


                  ...
gi 1061899922 396 YYN 398
Cdd:PHA02713  418 HMN 420
Kelch smart00612
Kelch domain;
145-187 8.26e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 8.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1061899922  145 VVGGQAPK-AIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAG 187
Cdd:smart00612   4 VVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02713 PHA02713
hypothetical protein; Provisional
 229-412 8.95e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 51.16  E-value: 8.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 229 AAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQclSTVECYNATT 307
Cdd:PHA02713  299 SAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVE--RTIECYTMGD 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 308 NEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEV------------------YDPTTNAWRQVADMNMCRRN 369
Cdd:PHA02713  377 DKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVHHmnsidmeedthssnkvirYDTVNNIWETLPNFWTGTIR 456

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1061899922 370 AGVCAVNGLLYVVGG--DDGSCNLASVEYYNPTTDKWTVVSSCMS 412
Cdd:PHA02713  457 PGVVSHKDDIYVVCDikDEKNVKTCIFRYNTNTYNGWELITTTES 501
PHA02713 PHA02713
hypothetical protein; Provisional
 164-255 9.43e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 51.16  E-value: 9.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 164 EERWHqvAELP---SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVG 240
Cdd:PHA02713  328 ENKIH--VELPpmiKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIG 405

                          90
                  ....*....|....*
gi 1061899922 241 GFDGSTGLSSVEAYN 255
Cdd:PHA02713  406 GRTEHIDYTSVHHMN 420
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 5-63 1.27e-06

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 45.80  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1061899922   5 TDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNH 63
Cdd:cd18503    19 KDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
PLN02153 PLN02153
epithiospecifier protein
 283-409 1.51e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 283 LYAVGGYDgaSRQCLSTVECYNATTNEWTYIAEMSTR-----RSGAGVGVLNNLLYAVGG------HDGPLVRKSVEVYD 351
Cdd:PLN02153   88 LYIFGGRD--EKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYN 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061899922 352 PTTNAWRQVAD--MNMCRRN-AGVCAVNGLLYVV----------GGDDGSCNlaSVEYYNPTTDKWTVVSS 409
Cdd:PLN02153  166 IADGKWVQLPDpgENFEKRGgAGFAVVQGKIWVVygfatsilpgGKSDYESN--AVQFFDPASGKWTEVET 234
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 1-71 2.68e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 45.34  E-value: 2.68e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061899922   1 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEF 71
Cdd:cd18451    15 MYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAEERERY 85
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 19-61 3.96e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 44.49  E-value: 3.96e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1061899922  19 FADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWV 61
Cdd:cd18493    32 FEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 17-86 6.99e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 44.45  E-value: 6.99e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061899922  17 QHFADVVLSEEFL-NLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQEFMARLMEHVRLPLLPR 86
Cdd:cd18475    31 QNFGTLSFTPDFLqNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPE-RENEAYQVLSNIHFPLIPK 100
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 5-84 7.06e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 44.75  E-value: 7.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   5 TDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWvnH------DKD-VRQEFMARLME 77
Cdd:cd18461    19 THLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY--HytpeqvEKDqVSLQEPPKLLE 96


                  ....*..
gi 1061899922  78 HVRLPLL 84
Cdd:cd18461    97 AVRFPLM 103
PLN02193 PLN02193
nitrile-specifier protein
 160-325 1.21e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 47.26  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 160 YDFKEERWH---QVAELPSRRCRA-GMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQW---TSVANMRDRRSTLGAAVL 232
Cdd:PLN02193  198 FDLETRTWSispATGDVPHLSCLGvRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAAD 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 233 NGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVA-PMN--TRRSSVGVGVVGGLLYAVGGYDGASrqcLSTVECYNATTNE 309
Cdd:PLN02193  278 EENVYVFGGVSATARLKTLDSYNIVDKKWFHCStPGDsfSIRGGAGLEVVQGKVWVVYGFNGCE---VDDVHYYDPVQDK 354

                         170
                  ....*....|....*.
gi 1061899922 310 WTYIAEMSTRRSGAGV 325
Cdd:PLN02193  355 WTQVETFGVRPSERSV 370
Kelch_6 pfam13964
Kelch motif;
229-271 2.34e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.55  E-value: 2.34e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1061899922 229 AAVLNGLLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRR 271
Cdd:pfam13964   7 VVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 17-84 4.24e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 42.20  E-value: 4.24e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922  17 QHFADVVLS--EEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHdkDVRQEFMARLMEHVRLPLL 84
Cdd:cd18471    31 KHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEH--NCRYQYMDELLQYVRFGLM 98
PLN02193 PLN02193
nitrile-specifier protein
 142-272 5.14e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 5.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 142 LMVVVGGQAPKAIRSVECYDFKEERWH---QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVA 218
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKlltPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCS 310

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1061899922 219 NMRDRRSTLGAA---VLNGLLYAVGGFDGSTgLSSVEAYNIKSNEWFHVAPMNTRRS 272
Cdd:PLN02193  311 TPGDSFSIRGGAgleVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQVETFGVRPS 366
Kelch_3 pfam13415
Galactose oxidase, central domain;
283-325 1.93e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.81  E-value: 1.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1061899922 283 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGV 325
Cdd:pfam13415   4 LYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSA 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
304-384 2.41e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 43.08  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 304 NATTNEWTYIAEM-STRRSGAGVGVLNNLLYAVGG-----HDGPL-VRKSVEVYDPTTNAWRQVadmnMCRR------NA 370
Cdd:PRK14131   58 NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSPqVFDDVYKYDPKTNSWQKL----DTRSpvglagHV 133

                          90
                  ....*....|....
gi 1061899922 371 GVCAVNGLLYVVGG 384
Cdd:PRK14131  134 AVSLHNGKAYITGG 147
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 319-363 3.20e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 38.09  E-value: 3.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1061899922 319 RRSGAGVGVLNNLLYAVGGHD--GPLVRKSVEVYDPTTNAWRQVADM 363
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWTEVPRL 47
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 11-81 3.62e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 39.47  E-value: 3.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061899922  11 ANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQEFMARLMEHVRL 81
Cdd:cd18470    25 AQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK-RVKYAADLLSNIRF 94
Kelch_3 pfam13415
Galactose oxidase, central domain;
329-375 5.28e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.65  E-value: 5.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1061899922 329 NNLLYAVGG--HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAV 375
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
163-244 6.52e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 6.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922 163 KEERWHQVAELPS-RRCRAGMVYMAGLVFAVGGF-----NGSLRV-RTVDSYDPVKDQWTSVaNMRDRRSTLGAAVL--- 232
Cdd:PRK14131   60 PSKGWTKIAAFPGgPREQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTNSWQKL-DTRSPVGLAGHVAVslh 138

                          90
                  ....*....|....*..
gi 1061899922 233 NGLLYAVGG-----FDG 244
Cdd:PRK14131  139 NGKAYITGGvnkniFDG 155
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 5-89 7.24e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 38.95  E-value: 7.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   5 TDLLNKANTYAEQHFADVVLSE----EFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQEFMARLMEHVR 80
Cdd:cd18473    19 PDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLNQDES-RLAYANALLSRIR 97


                  ....*....
gi 1061899922  81 LPLLPREYL 89
Cdd:cd18473    98 YGLVPVEEL 106
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 2-71 1.08e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 37.95  E-value: 1.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899922   2 HACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDkltISSEEKVFEAVIAWVNHDKDVRQEF 71
Cdd:cd18481    16 HSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHNKEEREGF 82
Kelch_3 pfam13415
Galactose oxidase, central domain;
376-423 1.98e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1061899922 376 NGLLYVVGGDDGSCNLASVEY--YNPTTDKWTVVSScMSTGRSYAGVTVI 423
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLyvYDLDTNTWTQIGD-LPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
233-273 2.60e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 2.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1061899922 233 NGLLYAVGG--FDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSS 273
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSG 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 142-174 2.80e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 2.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1061899922 142 LMVVVGGQ-APKAIRSVECYDFKEERWHQVAELP 174
Cdd:pfam01344  13 KIYVIGGFdGNQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
132-194 4.11e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 38.98  E-value: 4.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061899922 132 RLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG 194
Cdd:COG3055   197 RAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
Kelch_6 pfam13964
Kelch motif;
366-415 4.72e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 4.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1061899922 366 CRRNAGVCAVNGLLYVVGGDDGSCN-LASVEYYNPTTDKWTVVSScMSTGR 415
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPP-LPTPR 50
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 5-60 5.33e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 35.37  E-value: 5.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1061899922   5 TDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTIsSEEKVFEAVIAW 60
Cdd:cd18494    18 DELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRI-DELDILKAVREW 72
Kelch_6 pfam13964
Kelch motif;
283-320 5.47e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 5.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1061899922 283 LYAVGGYDGASRQcLSTVECYNATTNEWTYIAEMSTRR 320
Cdd:pfam13964  14 IYVFGGYTNASPA-LNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_6 pfam13964
Kelch motif;
327-364 5.52e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 5.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1061899922 327 VLNNLLYAVGGHDGPLVRKS-VEVYDPTTNAWRQVADMN 364
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPLP 47
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 10-84 6.53e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 36.41  E-value: 6.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061899922  10 KANTYAEQHFADVVLSEEFLN-LGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQEFMARLMEHVRLPLL 84
Cdd:cd18454    26 KLDSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDRR-RWRHTDTIIQNIRFCLM 100
Kelch_4 pfam13418
Galactose oxidase, central domain;
319-363 9.34e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 9.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1061899922 319 RRSGAGVGVLNNLLYAVGGHDGPLVR-KSVEVYDPTTNAWRQVADM 363
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTRLGSL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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