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Conserved domains on  [gi|1024249344|ref|NP_001311252|]
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3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform 3 [Homo sapiens]

Protein Classification

3-oxo-5-alpha-steroid 4-dehydrogenase( domain architecture ID 10495092)

3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)) converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 37-186 3.05e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


:

Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 219.97  E-value: 3.05e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  37 KPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGG 116
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344 117 LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 186
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 37-186 3.05e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 219.97  E-value: 3.05e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  37 KPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGG 116
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344 117 LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 186
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
PLN02392 PLN02392
probable steroid reductase DET2
 25-186 7.15e-39

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 133.40  E-value: 7.15e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  25 RCLIYPFLM------RGGKPMPLLACTMAIMFCTCNGYLQSRYLSHcavYADDWVTDP----RFLIGFGLWLTGMLINIH 94
Cdd:PLN02392   92 RTCIYPLRLyrstsqQNTKGFPVSMALLAFGFNLLNAYLQARWVSH---YKDDYEDGGwfwwRFFGGLVVFLWGMRINVW 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  95 SDHILRNLRKPGDtGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKF-EE 173
Cdd:PLN02392  169 SDRVLVGLKREGG-GYKVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKFgED 247

                         170
                  ....*....|...
gi 1024249344 174 YPKFRKIIIPFLF 186
Cdd:PLN02392  248 YPKGRKAVIPFLY 260
COG3752 COG3752
Steroid 5-alpha reductase family enzyme [General function prediction only];
75-143 2.73e-04

Steroid 5-alpha reductase family enzyme [General function prediction only];


Pssm-ID: 442966  Cd Length: 264  Bit Score: 40.20  E-value: 2.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  75 DPRFLIGFGLWLTGMLINIHSDHILRNLRK-PGDTGyKIPRGGLFEYVTAANYFGEIMEWCGYALASWSV 143
Cdd:COG3752   140 GWLDVLGAALWLVGFAFEAVADAQLARFKAdPANKG-KVCDTGLWRYSRHPNYFGEWLVWWGLALFALAA 208
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 37-186 3.05e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 219.97  E-value: 3.05e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  37 KPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGG 116
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344 117 LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 186
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
PLN02392 PLN02392
probable steroid reductase DET2
 25-186 7.15e-39

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 133.40  E-value: 7.15e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  25 RCLIYPFLM------RGGKPMPLLACTMAIMFCTCNGYLQSRYLSHcavYADDWVTDP----RFLIGFGLWLTGMLINIH 94
Cdd:PLN02392   92 RTCIYPLRLyrstsqQNTKGFPVSMALLAFGFNLLNAYLQARWVSH---YKDDYEDGGwfwwRFFGGLVVFLWGMRINVW 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  95 SDHILRNLRKPGDtGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKF-EE 173
Cdd:PLN02392  169 SDRVLVGLKREGG-GYKVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKFgED 247

                         170
                  ....*....|...
gi 1024249344 174 YPKFRKIIIPFLF 186
Cdd:PLN02392  248 YPKGRKAVIPFLY 260
PLN02560 PLN02560
enoyl-CoA reductase
 73-185 7.57e-18

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 79.00  E-value: 7.57e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  73 VTDPRFLIGFGLWLTGMLINIHSDHILRNLRKP-GDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFF 151
Cdd:PLN02560  189 VSETQMKVGFGFGLVCQLANFYCHIILRNLRKPdGKGGYQIPRGFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAV 268

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1024249344 152 TFCFLSGRAKEHHEWYLRKFE------EYPKFRKIIIPFL 185
Cdd:PLN02560  269 AAAIMTNWALAKHRRLKKLFDgkdgrpKYPRRWVILPPFL 308
PLN03164 PLN03164
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional
 80-186 9.41e-12

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional


Pssm-ID: 215610 [Multi-domain]  Cd Length: 323  Bit Score: 62.14  E-value: 9.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  80 IGFGLWLTGMLINIHSDHILRNLRK-PGDTG-YKIPRGGLFEYVTAANYFGEIMEWCGYALAS-------WSVQGAAFAF 150
Cdd:PLN03164  213 IGAAIFLWGWIHQYRCHAILGSLREhKKQADeYVIPYGDWFEMVSCPHYLAEIVIYAGLLIASggtdltiWLLFGFVVAN 292

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1024249344 151 ftfcfLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 186
Cdd:PLN03164  293 -----LTFAAAETHRWYLQKFENYPRNRYAIIPFVY 323
COG3752 COG3752
Steroid 5-alpha reductase family enzyme [General function prediction only];
75-143 2.73e-04

Steroid 5-alpha reductase family enzyme [General function prediction only];


Pssm-ID: 442966  Cd Length: 264  Bit Score: 40.20  E-value: 2.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249344  75 DPRFLIGFGLWLTGMLINIHSDHILRNLRK-PGDTGyKIPRGGLFEYVTAANYFGEIMEWCGYALASWSV 143
Cdd:COG3752   140 GWLDVLGAALWLVGFAFEAVADAQLARFKAdPANKG-KVCDTGLWRYSRHPNYFGEWLVWWGLALFALAA 208
DUF1295 pfam06966
Protein of unknown function (DUF1295); This family contains a number of bacterial and ...
 80-143 2.88e-04

Protein of unknown function (DUF1295); This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.


Pssm-ID: 399743  Cd Length: 235  Bit Score: 40.04  E-value: 2.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1024249344  80 IGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSV 143
Cdd:pfam06966 123 IGIAVWLVGFLFEALADQQLWAFKADPANRGKFCDTGLWRYSRHPNYFGEALIWWGIFLIALNV 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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