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Conserved domains on  [gi|568815719|ref|NP_001275582|]
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clathrin heavy chain 1 isoform 2 [Homo sapiens]

Protein Classification

Clathrin_H_link and CLH domain-containing protein( domain architecture ID 12019188)

protein containing domains Clathrin_propel, Clathrin_H_link, CLH, and Clathrin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1278-1420 5.77e-40

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 145.11  E-value: 5.77e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1278 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1357
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568815719   1358 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIITKVANVELYYRAIQFYLEFKP 1420
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
983-1122 1.31e-34

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 129.70  E-value: 1.31e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    983 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1061
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719   1062 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQK 1122
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1132-1269 1.83e-33

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.23  E-value: 1.83e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1132 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1210
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1211 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEYQAAVDGARKANSTRTWKEVCFACVDGKE 1269
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
690-828 1.25e-32

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.92  E-value: 1.25e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    690 ASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNF-SQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 768
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719    769 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 828
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
837-972 5.24e-32

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 122.38  E-value: 5.24e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    837 ILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNP--ERFLRENPYYDSRVVGKYCE 914
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    915 KRDPH-LACVAYERGQCDLELINVCNENS-LFKSLSRYLVRRKDPELWGSVLLESNPYRR 972
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 360-425 6.65e-32

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 119.24  E-value: 6.65e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568815719   360 NLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 425
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1431-1568 7.29e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.90  E-value: 7.29e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1431 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQN---HNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHE 1507
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719  1508 LIEFRRiaaYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRE 1568
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
545-678 1.06e-29

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.45  E-value: 1.06e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    545 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNrPSEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHIAQLCEKA 624
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568815719    625 GLLQRALEHFTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLRAMLSAN 678
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 335-358 4.18e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 55.91  E-value: 4.18e-10
                           10        20
                   ....*....|....*....|....
gi 568815719   335 EENIIPYITNVLQNPDLALRMAVR 358
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 202-238 2.92e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.18  E-value: 2.92e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568815719   202 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 238
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 260-292 4.84e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.84e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568815719   260 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 292
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 4.88e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.88e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568815719    19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 300-334 1.86e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 1.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568815719   300 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 334
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 152-191 1.68e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.40  E-value: 1.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568815719   152 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 191
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1278-1420 5.77e-40

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 145.11  E-value: 5.77e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1278 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1357
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568815719   1358 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIITKVANVELYYRAIQFYLEFKP 1420
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
983-1122 1.31e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 129.70  E-value: 1.31e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    983 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1061
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719   1062 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQK 1122
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1132-1269 1.83e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.23  E-value: 1.83e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1132 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1210
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1211 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEYQAAVDGARKANSTRTWKEVCFACVDGKE 1269
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
690-828 1.25e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.92  E-value: 1.25e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    690 ASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNF-SQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 768
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719    769 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 828
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
837-972 5.24e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 122.38  E-value: 5.24e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    837 ILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNP--ERFLRENPYYDSRVVGKYCE 914
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    915 KRDPH-LACVAYERGQCDLELINVCNENS-LFKSLSRYLVRRKDPELWGSVLLESNPYRR 972
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 360-425 6.65e-32

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 119.24  E-value: 6.65e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568815719   360 NLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 425
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 983-1123 1.40e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 121.21  E-value: 1.40e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   983 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYINRLDNYDAPDIAN 1061
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719  1062 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKG 1123
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1132-1271 1.81e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 120.82  E-value: 1.81e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1132 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE--SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRC 1209
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719  1210 YDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFR 1271
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1431-1568 7.29e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.90  E-value: 7.29e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1431 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQN---HNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHE 1507
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719  1508 LIEFRRiaaYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRE 1568
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
545-678 1.06e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.45  E-value: 1.06e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    545 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNrPSEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHIAQLCEKA 624
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568815719    625 GLLQRALEHFTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLRAMLSAN 678
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 847-974 6.45e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 107.73  E-value: 6.45e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   847 DELVAEVEKRNRLKLLLPWLEARIHEG-CEEPATHNALAKIYIDSN--NNPERFLRENPYYDSRVVGKYCEKRDPH-LAC 922
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568815719   923 VAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPL 974
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1278-1420 6.58e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 107.73  E-value: 6.58e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1278 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1355
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568815719  1356 AEQAHLWAELVFLYDKYEEYDNAIitMMNHPTDAWKEGQfkDIITKVANVELYYRAIQFYLEFKP 1420
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 692-830 1.25e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 106.96  E-value: 1.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   692 KYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFS--QDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKE 769
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719   770 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSE 830
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 545-682 6.08e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 99.25  E-value: 6.08e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   545 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAP-QVADAILgnQMFTHYDRAHIAQLCEK 623
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   624 AGLLQRALEHFTDLYDIKRAV-VHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQN 682
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1431-1582 4.56e-22

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 93.88  E-value: 4.56e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1431 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNnkSVNESLNNLFITEEDYQALRTSIDAYDNFdnislaqrlekHELIE 1510
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719   1511 FRRIAAYLFKGNNrWKQSVELCKKDSLYKDAMQYASESKdtELAEELLQWFLQEEKRECFGACLFTCYDLLR 1582
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIEHL--GNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 335-358 4.18e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 55.91  E-value: 4.18e-10
                           10        20
                   ....*....|....*....|....
gi 568815719   335 EENIIPYITNVLQNPDLALRMAVR 358
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 202-238 2.92e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.18  E-value: 2.92e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568815719   202 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 238
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1059-1223 9.86e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 9.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1059 IANIAISNELFEEAFAIFRKF----DVNTSAVQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMVK 1126
Cdd:COG2956    82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1127 EAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY-VETELIFALAKTNRLAELEEFI-----N 1195
Cdd:COG2956   162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEALELLrkaleL 241

                         170       180
                  ....*....|....*....|....*...
gi 568815719 1196 GPNNAHIQQVGDRCYDEKMYDAAKLLYN 1223
Cdd:COG2956   242 DPSDDLLLALADLLERKEGLEAALALLE 269
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1065-1189 4.49e-06

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 51.31  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1065 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSS 1140
Cdd:cd22947   324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568815719 1141 YMEVVQAantSGNWEELVKYLQMARKK-----ARESYVET----ELIFALAKTNRLAE 1189
Cdd:cd22947   396 LLLLYSS---TGDKEGLEELAELAEAAgknniAFLAYFLLgdldKCVDLLIKTGRLPE 450
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 260-292 4.84e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.84e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568815719   260 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 292
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 4.88e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.88e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568815719    19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 300-334 1.86e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 1.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568815719   300 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 334
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 152-191 1.68e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.40  E-value: 1.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568815719   152 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 191
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1058-1168 2.69e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1058 DIANIAISNELFEEAFAIFRKF----DVNTSAVQVLIE---HIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1125
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKAleldPDNPEAFALLGEillQLGDLDEAIVLLHEAleldpDEPEARLNLGLALLKAGDY 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568815719 1126 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKA 1168
Cdd:COG4783    89 DEALALLEKAlkldpEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1058-1190 8.55e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 8.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1058 DIANIAISNELFEEAFAIFRKF-DVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1125
Cdd:COG3914   117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLnlgealRRLGRLEEAIAALRRAleldpDNAEALNNLGNALQDLGRL 196

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1126 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAEL 1190
Cdd:COG3914   197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1278-1420 5.77e-40

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 145.11  E-value: 5.77e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1278 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1357
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568815719   1358 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIITKVANVELYYRAIQFYLEFKP 1420
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
983-1122 1.31e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 129.70  E-value: 1.31e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    983 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1061
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719   1062 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQK 1122
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1132-1269 1.83e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.23  E-value: 1.83e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1132 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1210
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1211 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEYQAAVDGARKANSTRTWKEVCFACVDGKE 1269
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
690-828 1.25e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.92  E-value: 1.25e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    690 ASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNF-SQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 768
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719    769 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 828
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
837-972 5.24e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 122.38  E-value: 5.24e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    837 ILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNP--ERFLRENPYYDSRVVGKYCE 914
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    915 KRDPH-LACVAYERGQCDLELINVCNENS-LFKSLSRYLVRRKDPELWGSVLLESNPYRR 972
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 360-425 6.65e-32

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 119.24  E-value: 6.65e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568815719   360 NLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 425
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 983-1123 1.40e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 121.21  E-value: 1.40e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   983 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYINRLDNYDAPDIAN 1061
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719  1062 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKG 1123
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1132-1271 1.81e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 120.82  E-value: 1.81e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1132 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE--SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRC 1209
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719  1210 YDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFR 1271
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1431-1568 7.29e-31

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.90  E-value: 7.29e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1431 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQN---HNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHE 1507
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815719  1508 LIEFRRiaaYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRE 1568
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
545-678 1.06e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.45  E-value: 1.06e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719    545 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNrPSEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHIAQLCEKA 624
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568815719    625 GLLQRALEHFTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLRAMLSAN 678
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 847-974 6.45e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 107.73  E-value: 6.45e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   847 DELVAEVEKRNRLKLLLPWLEARIHEG-CEEPATHNALAKIYIDSN--NNPERFLRENPYYDSRVVGKYCEKRDPH-LAC 922
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568815719   923 VAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPL 974
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1278-1420 6.58e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 107.73  E-value: 6.58e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1278 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1355
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568815719  1356 AEQAHLWAELVFLYDKYEEYDNAIitMMNHPTDAWKEGQfkDIITKVANVELYYRAIQFYLEFKP 1420
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 692-830 1.25e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 106.96  E-value: 1.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   692 KYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFS--QDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKE 769
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719   770 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSE 830
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 545-682 6.08e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 99.25  E-value: 6.08e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   545 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAP-QVADAILgnQMFTHYDRAHIAQLCEK 623
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   624 AGLLQRALEHFTDLYDIKRAV-VHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQN 682
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1431-1582 4.56e-22

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 93.88  E-value: 4.56e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719   1431 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNnkSVNESLNNLFITEEDYQALRTSIDAYDNFdnislaqrlekHELIE 1510
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815719   1511 FRRIAAYLFKGNNrWKQSVELCKKDSLYKDAMQYASESKdtELAEELLQWFLQEEKRECFGACLFTCYDLLR 1582
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIEHL--GNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 335-358 4.18e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 55.91  E-value: 4.18e-10
                           10        20
                   ....*....|....*....|....
gi 568815719   335 EENIIPYITNVLQNPDLALRMAVR 358
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 202-238 2.92e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.18  E-value: 2.92e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568815719   202 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 238
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1059-1223 9.86e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 9.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1059 IANIAISNELFEEAFAIFRKF----DVNTSAVQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMVK 1126
Cdd:COG2956    82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1127 EAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY-VETELIFALAKTNRLAELEEFI-----N 1195
Cdd:COG2956   162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEALELLrkaleL 241

                         170       180
                  ....*....|....*....|....*...
gi 568815719 1196 GPNNAHIQQVGDRCYDEKMYDAAKLLYN 1223
Cdd:COG2956   242 DPSDDLLLALADLLERKEGLEAALALLE 269
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1065-1189 4.49e-06

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 51.31  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1065 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSS 1140
Cdd:cd22947   324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568815719 1141 YMEVVQAantSGNWEELVKYLQMARKK-----ARESYVET----ELIFALAKTNRLAE 1189
Cdd:cd22947   396 LLLLYSS---TGDKEGLEELAELAEAAgknniAFLAYFLLgdldKCVDLLIKTGRLPE 450
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1078-1167 4.95e-06

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 51.08  E-value: 4.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719  1078 KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSS----YMevvqaanTSGN 1153
Cdd:pfam04053  320 RFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKDFDKllllYL-------STGN 384

                           90
                   ....*....|....
gi 568815719  1154 WEELVKYLQMARKK 1167
Cdd:pfam04053  385 MEKLKKLAKIAEKR 398
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1060-1251 2.45e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1060 ANIAISNELFEEAFAIFRK-FDVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMVKE 1127
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEaLELDPETVEAHLalgnlyRRRGEYDRAIRIHQKLlerdpDRAEALLELAQDYLKAGLLDR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1128 AIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARES-YVETELIFALAKTNRLAE----LEEFING- 1196
Cdd:COG2956    95 AEELLEKLleldpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEaieaLEKALKLd 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568815719 1197 PNNAHIQ-QVGDRCYDEKMYDAAKLLY--------NNVSNFGRLASTLVHLGEYQAAVDGARKA 1251
Cdd:COG2956   175 PDCARALlLLAELYLEQGDYEEAIAALeraleqdpDYLPALPRLAELYEKLGDPEEALELLRKA 238
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 260-292 4.84e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.84e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568815719   260 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 292
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 4.88e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.88e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568815719    19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1112-1379 1.28e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1112 WSQLAKAQLQKGMVKEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY-VETELIFALAKTN 1185
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEAleldpETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAeALLELAQDYLKAG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1186 RLAELEEFIN-----GPNNAH-IQQVGDRCYDEKMYDAAKLLYNNVSNFG--------RLASTLVHLGEYQAAVDGARKA 1251
Cdd:COG2956    91 LLDRAEELLEkllelDPDDAEaLRLLAEIYEQEGDWEKAIEVLERLLKLGpenahaycELAELYLEQGDYDEAIEALEKA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1252 NSTRtwkevcfacvdgKEFRLAQMcglhivvhadeleELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKF 1331
Cdd:COG2956   171 LKLD------------PDCARALL-------------LLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKL 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568815719 1332 -KPQKMREHLElfwsrvnipKVLRAAEQAHLWAELVFLYDKYEEYDNAI 1379
Cdd:COG2956   226 gDPEEALELLR---------KALELDPSDDLLLALADLLERKEGLEAAL 265
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 300-334 1.86e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 1.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568815719   300 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 334
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 152-191 1.68e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.40  E-value: 1.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568815719   152 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 191
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1058-1168 2.69e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1058 DIANIAISNELFEEAFAIFRKF----DVNTSAVQVLIE---HIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1125
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKAleldPDNPEAFALLGEillQLGDLDEAIVLLHEAleldpDEPEARLNLGLALLKAGDY 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568815719 1126 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKA 1168
Cdd:COG4783    89 DEALALLEKAlkldpEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1058-1190 8.55e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 8.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1058 DIANIAISNELFEEAFAIFRKF-DVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1125
Cdd:COG3914   117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLnlgealRRLGRLEEAIAALRRAleldpDNAEALNNLGNALQDLGRL 196

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815719 1126 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAEL 1190
Cdd:COG3914   197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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