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Conserved domains on  [gi|307775414|ref|NP_001182728|]
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low-density lipoprotein receptor isoform 3 precursor [Homo sapiens]

Protein Classification

LDLa and Ldl_recept_b domain-containing protein( domain architecture ID 11081348)

protein containing domains LDLa, EGF_CA, Ldl_recept_b, and LY

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 488-528 2.74e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.18  E-value: 2.74e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  488 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 528
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
154-190 8.11e-13

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.04  E-value: 8.11e-13
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 307775414  154 SPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC 190
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-102 9.59e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.95  E-value: 9.59e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 307775414   66 KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 102
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 446-485 3.01e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.71  E-value: 3.01e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  446 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 485
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 398-442 6.90e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 6.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 307775414  398 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 442
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 512-554 8.75e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 8.75e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775414   512 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 554
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 9.08e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 9.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775414   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
194-229 1.19e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.19e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 307775414  194 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 229
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
106-138 1.83e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.83e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 307775414  106 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 138
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-267 3.21e-07

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 3.21e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775414  237 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 267
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 575-615 5.25e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 5.25e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 307775414  575 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLFH 615
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
313-347 3.13e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775414   313 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 347
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 277-305 3.81e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 3.81e-06
                          10        20
                  ....*....|....*....|....*....
gi 307775414  277 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 305
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 630-670 5.95e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 5.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  630 TLSNGGCQYLCLPAPQinphspKFTCACPDGMLLARDMRSC 670
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 378-416 4.73e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 4.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775414   378 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 416
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 488-528 2.74e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.18  E-value: 2.74e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  488 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 528
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
154-190 8.11e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.04  E-value: 8.11e-13
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 307775414  154 SPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC 190
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-102 9.59e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.95  E-value: 9.59e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 307775414   66 KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 102
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 446-485 3.01e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.71  E-value: 3.01e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  446 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 485
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 398-442 6.90e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 6.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 307775414  398 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 442
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 512-554 8.75e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 8.75e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775414   512 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 554
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 9.08e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 9.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775414   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
194-229 1.19e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.19e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 307775414  194 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 229
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
106-138 1.83e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.83e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 307775414  106 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 138
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 156-190 1.89e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.89e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414 156 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC 190
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-102 1.91e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.91e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414  68 CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 102
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 8.38e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 8.38e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414    67 TCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 532-574 9.49e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 9.49e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 307775414  532 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVFE 574
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 195-229 1.79e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.79e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414 195 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 229
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 106-138 2.14e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 2.14e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414   106 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 138
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 426-467 2.46e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 307775414   426 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 467
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 107-139 8.32e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 8.32e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 307775414 107 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW 139
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 156-187 1.08e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.08e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 307775414   156 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDE 187
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 1.11e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 1.11e-08
                         10        20        30
                 ....*....|....*....|....*....|..
gi 307775414  27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 194-226 1.13e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.13e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414   194 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 226
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-58 2.22e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 2.22e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414    26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-267 3.21e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 3.21e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775414  237 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 267
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 575-615 5.25e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 5.25e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 307775414  575 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLFH 615
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 468-508 6.60e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 6.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 307775414   468 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 508
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
EGF_CA smart00179
Calcium-binding EGF-like domain;
313-347 3.13e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775414   313 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 347
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
388-552 3.44e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 388 VVALDTEVASNRIYWSDlsqrmicstqlDRAHGVSSYDTV---ISRDIQA---PDGLAVDWIHSNIYWTDSVLGTVSVAD 461
Cdd:COG3391   70 ADGADAGADGRRLYVAN-----------SGSGRVSVIDLAtgkVVATIPVgggPRGLAVDPDGGRLYVADSGNGRVSVID 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 462 TK-GVKRKTLfrENGSKPRAIVVDPVHGFMYWTDWGTP--AKIkkgglngVDIYSLVTENI-------QWPNGITLDLLS 531
Cdd:COG3391  139 TAtGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI-------VSVIDTATGKVvatipvgGGPVGVAVSPDG 209

                        170       180
                 ....*....|....*....|....*...
gi 307775414 532 GRLY-------WVDSKLHSISSIDVNGG 552
Cdd:COG3391  210 RRLYvanrgsnTSNGGSNTVSVIDLATL 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 277-305 3.81e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 3.81e-06
                          10        20
                  ....*....|....*....|....*....
gi 307775414  277 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 305
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-267 6.26e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 6.26e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 307775414 237 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 267
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 313-345 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.51e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414 313 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 345
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 425-587 3.10e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 425 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 498
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 499 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 563
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240

                        170       180
                 ....*....|....*....|....*
gi 307775414 564 LAHPFSLAVFEDKVFW-TDIINEAI 587
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 237-267 5.12e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 5.12e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 307775414   237 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 267
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 630-670 5.95e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 5.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  630 TLSNGGCQYLCLPAPQinphspKFTCACPDGMLLARDMRSC 670
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
313-341 1.53e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.53e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307775414  313 DIDECQDP-DTCSQ--LCVNLEGGYKCQCEEG 341
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 378-416 4.73e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 4.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775414   378 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 416
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 488-528 2.74e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.18  E-value: 2.74e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  488 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 528
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
154-190 8.11e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.04  E-value: 8.11e-13
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 307775414  154 SPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC 190
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-102 9.59e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.95  E-value: 9.59e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 307775414   66 KTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 102
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 446-485 3.01e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.71  E-value: 3.01e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  446 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 485
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 398-442 6.90e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 6.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 307775414  398 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 442
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 512-554 8.75e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 8.75e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775414   512 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 554
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 9.08e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 9.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775414   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
194-229 1.19e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.19e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 307775414  194 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 229
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
106-138 1.83e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.83e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 307775414  106 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 138
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 156-190 1.89e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.89e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414 156 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC 190
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-102 1.91e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.91e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414  68 CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 102
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 8.38e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 8.38e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414    67 TCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 532-574 9.49e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 9.49e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 307775414  532 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVFE 574
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 195-229 1.79e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.79e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414 195 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 229
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 106-138 2.14e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 2.14e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414   106 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 138
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 426-467 2.46e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 307775414   426 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 467
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 107-139 8.32e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 8.32e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 307775414 107 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW 139
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 156-187 1.08e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.08e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 307775414   156 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDE 187
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 1.11e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 1.11e-08
                         10        20        30
                 ....*....|....*....|....*....|..
gi 307775414  27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 194-226 1.13e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.13e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414   194 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 226
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-58 2.22e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 2.22e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414    26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-267 3.21e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 3.21e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775414  237 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 267
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 575-615 5.25e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 5.25e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 307775414  575 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLFH 615
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 468-508 6.60e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 6.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 307775414   468 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 508
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
EGF_CA smart00179
Calcium-binding EGF-like domain;
313-347 3.13e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775414   313 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 347
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
388-552 3.44e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 388 VVALDTEVASNRIYWSDlsqrmicstqlDRAHGVSSYDTV---ISRDIQA---PDGLAVDWIHSNIYWTDSVLGTVSVAD 461
Cdd:COG3391   70 ADGADAGADGRRLYVAN-----------SGSGRVSVIDLAtgkVVATIPVgggPRGLAVDPDGGRLYVADSGNGRVSVID 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 462 TK-GVKRKTLfrENGSKPRAIVVDPVHGFMYWTDWGTP--AKIkkgglngVDIYSLVTENI-------QWPNGITLDLLS 531
Cdd:COG3391  139 TAtGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI-------VSVIDTATGKVvatipvgGGPVGVAVSPDG 209

                        170       180
                 ....*....|....*....|....*...
gi 307775414 532 GRLY-------WVDSKLHSISSIDVNGG 552
Cdd:COG3391  210 RRLYvanrgsnTSNGGSNTVSVIDLATL 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 277-305 3.81e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 3.81e-06
                          10        20
                  ....*....|....*....|....*....
gi 307775414  277 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 305
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-267 6.26e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 6.26e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 307775414 237 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 267
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 313-345 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.51e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775414 313 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 345
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 425-587 3.10e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 425 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 498
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 499 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 563
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240

                        170       180
                 ....*....|....*....|....*
gi 307775414 564 LAHPFSLAVFEDKVFW-TDIINEAI 587
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 432-572 4.21e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.04  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 432 IQAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTLFRENG---SKPRAIVVDPvHGFMYWTDwGTPAKIKKGGLNG 508
Cdd:cd14962   11 LTRPYGVAADG-RGRIYVADTGRGAVFVFDLPNGKVFVIGNAGPnrfVSPIGVAIDA-NGNLYVSD-AELGKVFVFDRDG 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 307775414 509 VDIYSLVTENIQW-PNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILED---EKRLAHPFSLAV 572
Cdd:cd14962   88 KFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgPGEFNLPTDLAV 155
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 237-267 5.12e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 5.12e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 307775414   237 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 267
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 630-670 5.95e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 5.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775414  630 TLSNGGCQYLCLPAPQinphspKFTCACPDGMLLARDMRSC 670
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 435-584 8.08e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.39  E-value: 8.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 435 PDGLAVDwIHSNIYWTDSVLGTVSVADTKGvKRKTLFRENGSK------PRAIVVDPvHGFMYWTDWGTpAKIKK----- 503
Cdd:cd05819   10 PQGIAVD-SSGNIYVADTGNNRIQVFDPDG-NFITSFGSFGSGdgqfnePAGVAVDS-DGNLYVADTGN-HRIQKfdpdg 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 504 GGLNGVDIYSLVTENIQWPNGITLDLlSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDEKRLAHPFSLAVF-EDKVFW 579
Cdd:cd05819   86 NFLASFGGSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDsDGNIYV 164


                 ....*
gi 307775414 580 TDIIN 584
Cdd:cd05819  165 ADTGN 169
EGF_CA pfam07645
Calcium-binding EGF domain;
313-341 1.53e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.53e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307775414  313 DIDECQDP-DTCSQ--LCVNLEGGYKCQCEEG 341
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 433-576 1.73e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 433 QAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTL----FRENGSKPRAIVVDpvHGFMYWTDWGtPAKIKKGGLNG 508
Cdd:cd14963   56 KYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAID--DGKLYVSDVK-KHKVIVFDLEG 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 307775414 509 VDIYSLVTE-----NIQWPNGITLDlLSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDEKRLAHPFSLAVFEDK 576
Cdd:cd14963  132 KLLLEFGKPgsepgELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELngsPDGKSGFVNPRGIAVDPDG 206
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 323-351 2.50e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.07  E-value: 2.50e-03
                          10        20
                  ....*....|....*....|....*....
gi 307775414  323 CSQLCVNLEGGYKCQCEEGFQLDPHTKAC 351
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 316-347 3.03e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 307775414 316 ECQDPDTCS--QLCVNLEGGYKCQCEEGFQLDPH 347
Cdd:cd00053    1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGDRS 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 311-350 4.30e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 39.68  E-value: 4.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 307775414 311 CEDIDECQD-PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA 350
Cdd:cd01475  184 CVVPDLCATlSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 378-416 4.73e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 4.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775414   378 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 416
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF smart00181
Epidermal growth factor-like domain;
316-347 5.74e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.19  E-value: 5.74e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775414   316 ECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPH 347
Cdd:smart00181   1 ECASGGPCSNgTCINTPGSYTCSCPPGYTGDKR 33
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 396-556 8.89e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.72  E-value: 8.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 396 ASNRIYWSDLsqrmicstqldRAHGVSSYD------TVISRDIQAPDGLAVDWiHSNIYWTDSVLGtVSVADTKGVKRKT 469
Cdd:COG3386   17 PDGRLYWVDI-----------PGGRIHRYDpdggavEVFAEPSGRPNGLAFDP-DGRLLVADHGRG-LVRFDPADGEVTV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775414 470 LFRENGSKPRA---IVVDPvHGFMYWTDwgTPAKIKKGGLngvdiY--------SLVTENIQWPNGITLDLLSGRLYWVD 538
Cdd:COG3386   84 LADEYGKPLNRpndGVVDP-DGRLYFTD--MGEYLPTGAL-----YrvdpdgslRVLADGLTFPNGIAFSPDGRTLYVAD 155

                        170       180
                 ....*....|....*....|..
gi 307775414 539 SKLHSISSIDVNG----GNRKT 556
Cdd:COG3386  156 TGAGRIYRFDLDAdgtlGNRRV 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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