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Conserved domains on  [gi|1905532654|ref|NP_001004416|]
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uromodulin-like 1 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
993-1233 7.97e-40

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 148.52  E-value: 7.97e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654  993 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1067
Cdd:pfam00100    1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654 1068 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1141
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654 1142 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1215
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 1905532654 1216 KLRVCmESPGATCKINCN 1233
Cdd:pfam00100  238 SVSVC-SSDSNSCGKSCS 254
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 117-157 2.45e-10

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 56.66  E-value: 2.45e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1905532654  117 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:pfam00095    1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
EGF_CA pfam07645
Calcium-binding EGF domain;
507-537 9.09e-07

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.46  E-value: 9.09e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1905532654  507 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 537
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
SEA super family cl02507
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 796-883 3.10e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


The actual alignment was detected with superfamily member smart00200:

Pssm-ID: 470595  Cd Length: 121  Bit Score: 47.41  E-value: 3.10e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654   796 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 871
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90

                            90
                    ....*....|..
gi 1905532654   872 VSAAFLTAFQTV 883
Cdd:smart00200   91 DLLQVIKQAAYS 102
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 398-474 4.92e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


:

Pssm-ID: 460188  Cd Length: 100  Bit Score: 46.46  E-value: 4.92e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532654  398 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 474
Cdd:pfam01390    1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
EGF_CA smart00179
Calcium-binding EGF-like domain;
897-928 5.19e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.19e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1905532654   897 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 928
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
264-294 2.80e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.80e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1905532654   264 DVNECfyEELNACSGRELCANLEGSYWCVCH 294
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 703-772 7.07e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 7.07e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1905532654  703 PVSIGRIMVSNVTSTGFHLAWEADLAMDS-------TFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAK 772
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpitgyvvEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
993-1233 7.97e-40

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 148.52  E-value: 7.97e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654  993 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1067
Cdd:pfam00100    1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654 1068 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1141
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654 1142 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1215
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 1905532654 1216 KLRVCmESPGATCKINCN 1233
Cdd:pfam00100  238 SVSVC-SSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 993-1233 1.41e-30

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 121.72  E-value: 1.41e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654   993 CEIEKVVVAIQKRFLQQESIPESSLYLSHPSCNVSHS--NGTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGII 1070
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTdaTSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLVVSPFHPGFI 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654  1071 HHLKILS-PIYCAFQNDLLTSSGFTLEWGVYTIIEDLhGAGNFVTEMQLFIGD--SPIPQNYSVSASDDVRIEVG-LYRQ 1146
Cdd:smart00241   82 TRDDRAAyHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYVLGDPVYHEWEcDGAD 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654  1147 KSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIE--NGNSNKAQFKLRIFSFINDSIVYLHCKLRVCMESP 1224
Cdd:smart00241  161 DPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPynSNPLHRARFSVKVFKFADRSLVYFHCQIRLCDKDD 240

                           250
                    ....*....|
gi 1905532654  1225 GATCK-INCN 1233
Cdd:smart00241  241 GSSCDgPACS 250
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 117-157 2.45e-10

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 56.66  E-value: 2.45e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1905532654  117 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:pfam00095    1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
EGF_CA pfam07645
Calcium-binding EGF domain;
507-537 9.09e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.46  E-value: 9.09e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1905532654  507 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 537
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 796-883 3.10e-06

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 47.41  E-value: 3.10e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654   796 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 871
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90

                            90
                    ....*....|..
gi 1905532654   872 VSAAFLTAFQTV 883
Cdd:smart00200   91 DLLQVIKQAAYS 102
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 398-474 4.92e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 46.46  E-value: 4.92e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532654  398 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 474
Cdd:pfam01390    1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
EGF_CA smart00179
Calcium-binding EGF-like domain;
897-928 5.19e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.19e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1905532654   897 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 928
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
897-928 1.81e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 1.81e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532654  897 DYDECERKEDDCVPGTSCRNTLGSFTCSCEGG 928
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
509-537 2.52e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.52e-05
                            10        20
                    ....*....|....*....|....*....
gi 1905532654   509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:smart00179    3 DECAS--GNPCQNGGTCVNTVGSYRCECP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-928 4.56e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.56e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532654  897 DYDECERkEDDCVPGTSCRNTLGSFTCSCEGG 928
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 509-537 1.43e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.43e-04
                           10        20
                   ....*....|....*....|....*....
gi 1905532654  509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:cd00054      3 DECAS--GNPCQNGGTCVNTVGSYRCSCP 29
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 117-157 1.75e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 40.90  E-value: 1.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1905532654  117 RPGACPA-EGPEPSTSP--CSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:cd00199     16 KPGRCPMvNPPSLGIPPnrCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP smart00217
Four-disulfide core domains;
117-158 2.20e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 40.05  E-value: 2.20e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1905532654   117 RPGACPAE-----GPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPA 158
Cdd:smart00217    1 KPGSCPWPtiascPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
EGF_CA smart00179
Calcium-binding EGF-like domain;
264-294 2.80e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.80e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1905532654   264 DVNECfyEELNACSGRELCANLEGSYWCVCH 294
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
264-293 3.20e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1905532654  264 DVNECFyEELNACSGRELCANLEGSYWCVC 293
Cdd:pfam07645    1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 703-772 7.07e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 7.07e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1905532654  703 PVSIGRIMVSNVTSTGFHLAWEADLAMDS-------TFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAK 772
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpitgyvvEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
993-1233 7.97e-40

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 148.52  E-value: 7.97e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654  993 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1067
Cdd:pfam00100    1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654 1068 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1141
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654 1142 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1215
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 1905532654 1216 KLRVCmESPGATCKINCN 1233
Cdd:pfam00100  238 SVSVC-SSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 993-1233 1.41e-30

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 121.72  E-value: 1.41e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654   993 CEIEKVVVAIQKRFLQQESIPESSLYLSHPSCNVSHS--NGTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGII 1070
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTdaTSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLVVSPFHPGFI 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654  1071 HHLKILS-PIYCAFQNDLLTSSGFTLEWGVYTIIEDLhGAGNFVTEMQLFIGD--SPIPQNYSVSASDDVRIEVG-LYRQ 1146
Cdd:smart00241   82 TRDDRAAyHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYVLGDPVYHEWEcDGAD 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654  1147 KSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIE--NGNSNKAQFKLRIFSFINDSIVYLHCKLRVCMESP 1224
Cdd:smart00241  161 DPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPynSNPLHRARFSVKVFKFADRSLVYFHCQIRLCDKDD 240

                           250
                    ....*....|
gi 1905532654  1225 GATCK-INCN 1233
Cdd:smart00241  241 GSSCDgPACS 250
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 117-157 2.45e-10

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 56.66  E-value: 2.45e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1905532654  117 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:pfam00095    1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
EGF_CA pfam07645
Calcium-binding EGF domain;
507-537 9.09e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.46  E-value: 9.09e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1905532654  507 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 537
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 796-883 3.10e-06

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 47.41  E-value: 3.10e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532654   796 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 871
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90

                            90
                    ....*....|..
gi 1905532654   872 VSAAFLTAFQTV 883
Cdd:smart00200   91 DLLQVIKQAAYS 102
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 398-474 4.92e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 46.46  E-value: 4.92e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532654  398 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 474
Cdd:pfam01390    1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
EGF_CA smart00179
Calcium-binding EGF-like domain;
897-928 5.19e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.19e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1905532654   897 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 928
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
897-928 1.81e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 1.81e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532654  897 DYDECERKEDDCVPGTSCRNTLGSFTCSCEGG 928
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
509-537 2.52e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.52e-05
                            10        20
                    ....*....|....*....|....*....
gi 1905532654   509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:smart00179    3 DECAS--GNPCQNGGTCVNTVGSYRCECP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-928 4.56e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.56e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532654  897 DYDECERkEDDCVPGTSCRNTLGSFTCSCEGG 928
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 509-537 1.43e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.43e-04
                           10        20
                   ....*....|....*....|....*....
gi 1905532654  509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:cd00054      3 DECAS--GNPCQNGGTCVNTVGSYRCSCP 29
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 117-157 1.75e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 40.90  E-value: 1.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1905532654  117 RPGACPA-EGPEPSTSP--CSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:cd00199     16 KPGRCPMvNPPSLGIPPnrCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP smart00217
Four-disulfide core domains;
117-158 2.20e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 40.05  E-value: 2.20e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1905532654   117 RPGACPAE-----GPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPA 158
Cdd:smart00217    1 KPGSCPWPtiascPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
EGF_CA smart00179
Calcium-binding EGF-like domain;
264-294 2.80e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.80e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1905532654   264 DVNECfyEELNACSGRELCANLEGSYWCVCH 294
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
264-293 3.20e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1905532654  264 DVNECFyEELNACSGRELCANLEGSYWCVC 293
Cdd:pfam07645    1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 517-538 5.66e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 35.65  E-value: 5.66e-03
                           10        20
                   ....*....|....*....|..
gi 1905532654  517 HDCSPAAWCINLEGSYTCQCRT 538
Cdd:pfam12947    6 GGCHPNATCTNTGGSFTCTCND 27
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 703-772 7.07e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 7.07e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1905532654  703 PVSIGRIMVSNVTSTGFHLAWEADLAMDS-------TFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAK 772
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpitgyvvEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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