|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
33-926 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 782.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 33 FQSTVFIPSTTFPTylKPNeVIERDQKIQQ--EANflNLYAWQRKNVKGKE-FVLHDGPPYANGKPHIGHAINKISKDII 109
Cdd:COG0060 1 YKETLNLPKTDFPM--RAN-LPKREPEILKfwEEN--DIYEKSREARAGRPkFVLHDGPPYANGDIHIGHALNKILKDII 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 110 LRSQLIQGRKIHYVPGWDCHGLPIEL-----LALKNVETKNLKPIDIRNKAKNIALSMSKLQKESFKSWGVIGNWENDcY 184
Cdd:COG0060 76 VRYKTMRGFDVPYVPGWDCHGLPIELkvekeLGIKKKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNP-Y 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 185 YTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALAEAELLYVDISSTALTVRFEVV---QNFSSEPVYLLIWT 261
Cdd:COG0060 155 LTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKdekALLLLEDAYLVIWT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 262 TTPWTLPLNKAVYFSNSIKYSLVKISNfSGMYIIASDLIESLQKKLK-QEITIHSNMSCKELEGLSYKHPWD----KNKV 336
Cdd:COG0060 235 TTPWTLPANLAVAVHPDIDYVLVEVTG-GERLILAEALVEAVLKELGiEDYEVLATFKGAELEGLRYEHPFYyvvgYDRA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 337 LKVFESSSVTL-SGTGLLHSVPAHGHEDFVMGLQNNLTPECFVDESGCYTSDLgPPLANLNIFgEGKNTVIKTLSSD--I 413
Cdd:COG0060 314 HPVILGDYVTTeDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEA-PLFAGLFVK-DANPAIIEDLKERgaL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 414 ILSENYTHSYPHDWRTNKPVFIRACEQWFIDTNQLKNKALENLRDS----DTPDKYFQSLIKERPYWCLSRQRTWGVPIP 489
Cdd:COG0060 392 LAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVnwipEWGEGRFGNMLENRPDWCISRQRYWGVPIP 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 490 VFFHKTSRRPLISKSLIHHICQLFESSGSDIWWTGTLEELF-PDKI----CNELFVkreniiRGNDIMDIWFDSGISWSF 564
Cdd:COG0060 472 IWVCEDCGELHRTEEVIGSVAELLEEEGADAWFELDLHRPFlDETLkcpkCGGTMR------RVPDVLDVWFDSGSMHFA 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 565 ALNGRK-----SDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPDTVLngkNALG 639
Cdd:COG0060 546 VLENREelhfpADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI---DKYG 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 640 IDTLRWWVGSHSHNSLVPVSDSILKSefkTVQSIRLI---FRYLLGALNNAR-SKDLLENDDLLTLDKYLLNSCYNFYKS 715
Cdd:COG0060 623 ADILRLWVASSDYWGDLRFSDEILKE---VRDVYRRLrntYRFLLANLDDFDpAEDAVPYEDLPELDRWILSRLNELIKE 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 716 VMHSYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLYCDSQESSRRKACLYTLNSILYTLSYSLAPILPHLVEEVFLHH 795
Cdd:COG0060 700 VTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNL 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 796 PVSSEnKRVFFrkEPW-VPREWWSNDTtdktilLLDNFKK--DIVLDSNFKKMSC--------------TLEVDGENFEE 858
Cdd:COG0060 780 PGEAE-ESVHL--ADWpEVDEELIDEE------LEAKWDLvrEVRSAVLKALEAArkeklirqpleaavVLYADEELAAA 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 859 LKKMQDgnvnsidsELTEILQVAEVKLKMGDG-----------------KVNLNLTDASECPRCRRYT---SPEPERLCV 918
Cdd:COG0060 851 LESLGD--------LLAEELNVSEVELVDDAEdlgkdalkaldvegisvTVEVEKADGEKCERCWHYEvgwTPEHEGLCR 922
|
....*...
gi 212511402 919 RCEDVINN 926
Cdd:COG0060 923 RCVRRVQG 930
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
48-927 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 731.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 48 LKPNEVIeRDQKIQQ--EANflNLYAWQRKNVKGKEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPG 125
Cdd:PLN02843 1 MRANSVT-REPEIQKlwEEN--QVYKRVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 126 WDCHGLPIELLALKNV---ETKNLKPIDIRNKAKNIALSMSKLQKESFKSWGVIGNWENDcYYTFDTNYIINQLQIFWKM 202
Cdd:PLN02843 78 WDCHGLPIELKVLQSLdqeARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENP-YLTLDPEYEAAQIEVFGQM 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 203 YERGLIYYGLKPVFWSPSSKTALAEAELLYVD-ISSTALTVRFEVVqnFSSEP-----------VYLLIWTTTPWTLPLN 270
Cdd:PLN02843 157 FLNGYIYRGRKPVHWSPSSRTALAEAELEYPEgHVSKSIYVAFPVV--SPSETspeeleeflpgLSLAIWTTTPWTMPAN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 271 KAVYFSNSIKYSLVKISNFSGMY-----------------------IIASDLIESLQKKLKQEITIHSNMSCKELEGLSY 327
Cdd:PLN02843 235 AAVAVNDKLQYSVVEVQSFSEDEstsggnkkkrpgnvlkeqqklflIVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 328 KHPWDKNKVLKVFESSSVTL-SGTGLLHSVPAHGHEDFVMGLQNNLTPECFVDESGCYTSDLGpPLANLNIFGEGKNTVI 406
Cdd:PLN02843 315 IHPLYNRESPVVIGGDYITTeSGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAG-QFSGLSVLGEGNAAVV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 407 KTL--SSDIILSENYTHSYPHDWRTNKPVFIRACEQWFIDTNQLKNKALENLRD----SDTPDKYFQSLIKERPYWCLSR 480
Cdd:PLN02843 394 EALdeAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKvkwiPAQGENRIRAMVSGRSDWCISR 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 481 QRTWGVPIPVFFHKTSRRPLISKSLIHHICQLFESSGSDIWWTGTLEELFPDKICNelfvKRENIIRGNDIMDIWFDSGI 560
Cdd:PLN02843 474 QRTWGVPIPVFYHVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRD----KASDYEKGTDTMDVWFDSGS 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 561 SWSFALNGRK-----SDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPDTVLN-G 634
Cdd:PLN02843 550 SWAGVLGSREglsypADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEgG 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 635 KN-----ALGIDTLRWWVGSHSHNSLVPVSDSILKSEFKTVQSIRLIFRYLLGALNNARSKDLLENDDLLTLDKYLLNSC 709
Cdd:PLN02843 630 KNqkqepAYGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPDNAVPYEDLPSIDKYALFQL 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 710 YNFYKSVMHSYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLYCDSQESSRRKACLYTLNSILYTLSYSLAPILPHLVE 789
Cdd:PLN02843 710 ENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAE 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 790 EVFLHHPVS---SENKRVFFRKEPWVPREWWSNDTTDK----TILLL-DNFKKDIVLDSNFKKMSCTLEV-------DGE 854
Cdd:PLN02843 790 DAWQNLPFQedgSAAESVFEAGWPTPNEEWLSFPAEDVdfwsLLLEVrDEVNKVLESARNGKLIGASLEAkvylhasDAS 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 855 NFEELKKMqDGNVNSIDsELTEILQVAEVKL------------------KMGDGKVNLNLT--DASECPRCRRYT----- 909
Cdd:PLN02843 870 LAARLAEL-CGASNGAD-ELRRIFITSQVEVvsseddetaacgsytgeyVEGAGRVWVGVSraDGSKCERCWNYSpavgs 947
|
970
....*....|....*...
gi 212511402 910 SPEPERLCVRCEDVINNN 927
Cdd:PLN02843 948 FSDHPTLCERCYPVVIAQ 965
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
73-815 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 645.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 73 QRKNVKGKEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNV---ETKNLKPI 149
Cdd:TIGR00392 29 KKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHGLPIEHKVEKKLgisGKKEISSL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 150 DI---RNKAKNIALSMSKLQKESFKSWGVIGNWENdCYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALA 226
Cdd:TIGR00392 109 EIeefREKCREFALKQIEEQREQFQRLGVWGDWEN-PYKTMDPSYEESQWWLFKEAHEKGLLYRGLKPVYWSPRCRTALA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 227 EAEL----LYVDISSTALTVRFEVVQ----NFSSEPVYLLIWTTTPWTLPLNKAVYFSNSIKYSLVKISNFSGMYIIASD 298
Cdd:TIGR00392 188 EAEVeykeNYKDVKDPSIYVKFPVKKdkktYLKVKLSSLLIWTTTPWTLPSNLAIAVHPDFEYALVQDNTKVEYFILAKK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 299 LIESLQKKLKQEITIHSNMSCKELEGLSYKHPWD------KNKVLKVFESSSVTL-SGTGLLHSVPAHGHEDFVMGLQNN 371
Cdd:TIGR00392 268 LVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHPLYdfvsqlKEGAPVVIGGDHVTTeDGTGIVHTAPGHGEEDYEIGKKYG 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 372 LTPECFVDESGCYTSDLGP------PLANLNIFGEGKNTVIK-TLSSDIILSENYTHSYPHDWRTNKPVFIRACEQWFID 444
Cdd:TIGR00392 348 LEVLSPVDEKGVYTEGVNDfqgrfvKDADKDIIKANKIIIEQlKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIK 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 445 TNQLKNKALENLRDS----DTPDKYFQSLIKERPYWCLSRQRTWGVPIPVFFHKTSRRPLISKSlIHHICQLFESSGSDI 520
Cdd:TIGR00392 428 TKDIKDQMLEQIKKVnwvpEWGEGRFGNWLENRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGS-IEELIELIELKGIDA 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 521 WWTGTLEELFPD-KICNELFVKrenIIRGNDIMDIWFDSGISWSFAL----------NGRKSDVFLEGKDQFGGWFQSSL 589
Cdd:TIGR00392 507 WFEDLHRDFLDKiTLKSGDGGE---YRRVPDVLDVWFDSGSMPYASIhypfenekfkEVFPADFILEGSDQTRGWFYSSL 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 590 LTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPDTVLngkNALGIDTLRWWVGSHSHNSLVPVSDSILKsefKT 669
Cdd:TIGR00392 584 AIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVI---NKYGADILRLYVASSDPWEDLRFSDEILK---QV 657
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 670 VQSIRLI----FRYLLGALNNARSKDLLENDDLLT---LDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVPNNVSS 742
Cdd:TIGR00392 658 VEKYRKIrwntYRFLLTYANLDKFDPLFNSVAVEKfpeEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSN 737
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212511402 743 RYVSAIKDRLYCDSQESSRRkACLYTLNSILYTLSYSLAPILPHLVEEVFLHHPVSSENKRVFFRKEPWVPRE 815
Cdd:TIGR00392 738 WYIRIIRDRLYCEAKDNDKR-AAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLPGGEEEESVHLNLWPEVDEE 809
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
68-647 |
1.57e-146 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 447.63 E-value: 1.57e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 68 NLYAWQRKNVKGKE-FVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNVETKNL 146
Cdd:pfam00133 10 GYFKPELEKRKGKPsFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLGIKEK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 147 KPI------DIRNKAKNIALSMSKLQKESFKSWGVIGNWENDcYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPS 220
Cdd:pfam00133 90 KTRhkygreEFREKCREWKMEYADEIRKQFRRLGRSIDWDRE-YFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 221 SKTALAEAELLYVDISSTALTVRFEVVqnfSSEPVYLLIWTTTPWTLPLNKAVYFSNSIKYSLVKisnfsGMYIIASDLI 300
Cdd:pfam00133 169 LNTALSNLEVEYKDVKGPSIHVAFPLA---DDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVITG-----EGYILAEALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 301 ESLQKKLkQEITIHSNMSCKELEGLSYKHPWDKNKVLKVFESSSVTLSGTGLLHSVPAHGHEDFVMGLQNNLTPECFVDE 380
Cdd:pfam00133 241 KSLYKKG-TDKKILEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDD 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 381 SGCYTSDlGPPLANLNIFgEGKNTVIKTLSSDIIL--SENYTHSYPHDWRTNKPVFIRACEQWFIDTNQLKNKALENLRD 458
Cdd:pfam00133 320 DGTFTEE-APDFQGVYRF-DARKKIVELLTEKGLLlkIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 459 S----DTPDKYFQSLIKERPYWCLSRQRTWGVPIPVFFHKTSRRPLISKSLIHHICQLFESSGSDIWWTGTLEELFPDki 534
Cdd:pfam00133 398 VqfvpKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHREAKDKLGY-- 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 535 cnelfvKRENIIRGNDIMDIWFDSGiSWSFA-----LNGRK-------SDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFD 602
Cdd:pfam00133 476 ------GKGTLEQDEDVLDTWFSSG-SWPFStlgwpFVNTEefkkffpADMLLEGSDQTRGWFYRMIMLSTALTGSVPFK 548
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 212511402 603 KILTHGFAVDENGKKMSKSVGNVVDPDTVLngkNALGIDTLRWWV 647
Cdd:pfam00133 549 NVLVHGLVRDEQGRKMSKSLGNVIDPLDVI---DKYGADALRLWL 590
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
80-647 |
9.94e-88 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 283.74 E-value: 9.94e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 80 KEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALK------NVETKNLKPIDIRN 153
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKelgisgKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 154 KAKNIALSMSKLQKESFKSWGVIGNWENdCYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWsPssktalaeaellyv 233
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWEN-PYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P-------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 234 disstaltvrfevvqnfssepvyLLIWTTTPWtlplnkavyfsnsikysLVKISNFsgmyiiasdlieslqkklkqeiti 313
Cdd:cd00818 145 -----------------------LIYRATPQW-----------------FIRVTKI------------------------ 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 314 hsnmsckeleglsykhpwdKNKVLKVFESSsvtlsgtgllHSVPAHGHEDFvmglqnnltpecfvdesgcytsdlgppla 393
Cdd:cd00818 161 -------------------KDRLLEANDKV----------NWIPEWVKNRF----------------------------- 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 394 nlnifgegkntviktlssdiilsenythsypHDWrtnkpvfiraceqwfidtnqlknkalenlrdsdtpdkyfqslIKER 473
Cdd:cd00818 183 -------------------------------GNW------------------------------------------LENR 189
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 474 PYWCLSRQRTWGVPIPVFFHKTsrrpliskslihhicqlfessgsdiwwtgtleelfpdkiCNELFVKreniiRGNDIMD 553
Cdd:cd00818 190 RDWCISRQRYWGTPIPVWYCED---------------------------------------CGEVLVR-----RVPDVLD 225
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 554 IWFDSGISWSFALNGR----------KSDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVG 623
Cdd:cd00818 226 VWFDSGSMPYAQLHYPfenedfeelfPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLG 305
|
570 580
....*....|....*....|....
gi 212511402 624 NVVDPDTVLngkNALGIDTLRWWV 647
Cdd:cd00818 306 NYVDPQEVV---DKYGADALRLWV 326
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
61-800 |
5.28e-71 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 256.19 E-value: 5.28e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 61 QQEANFLNLYA------WQRKNVKGK-EFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPI 133
Cdd:PLN02882 12 KQEEKILSLWSeidafkTQLKRTEGLpEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 134 ELLALKNVETKN----LK-PIDIRNKA-KNIALSMSklqKESFKSWGVIGNW---ENDcYYTFDTNYIINQLQIFWKMYE 204
Cdd:PLN02882 92 EYEIDKKLGIKRrddvLKmGIDKYNEEcRSIVTRYS---KEWEKTVTRTGRWidfEND-YKTMDPKFMESVWWVFKQLFE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 205 RGLIYYGLKPVFWSPSSKTALA--EAELLYVDISSTALTVRFEVVQNfsSEPVYLLIWTTTPWTLPLNKAVYFSNSIKYS 282
Cdd:PLN02882 168 KGLVYKGFKVMPYSTACKTPLSnfEAGLNYKDVSDPAVMVSFPIVGD--PDNASFVAWTTTPWTLPSNLALCVNPNFTYV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 283 LVKISNFSGMYIIASDLIESL-------QKKLKQEIT-----IHSNMSCKELEGLSYKHPWD-----KNKVLKVFESSSV 345
Cdd:PLN02882 246 KVRNKYTGKVYIVAESRLSALptakpksKKGSKPENAaegyeVLAKVPGSSLVGKKYEPLFDyfsefSDTAFRVVADDYV 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 346 TL-SGTGLLHSVPAHGHEDFVMGLQNNLTPE-----CFVDESGCYTsDLGPPLANLNIFGEGKNTV--IKTlSSDIILSE 417
Cdd:PLN02882 326 TDdSGTGVVHCAPAFGEDDYRVCLANGIIEKggnlpVPVDDDGCFT-EKVTDFSGRYVKDADKDIIaaIKA-KGRLVKSG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 418 NYTHSYPHDWRTNKPVFIRACEQWFIDTNQLKNKALENLRDSD-TPD----KYFQSLIKERPYWCLSRQRTWGVPIPVFF 492
Cdd:PLN02882 404 SITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYwVPDyvkeKRFHNWLENARDWAVSRSRFWGTPLPIWI 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 493 HKTSRRPLISKSlihhICQLFESSGSDIWwtgTLEELFPDKIC------NELFVKReniiRGNDIMDIWFDSG------I 560
Cdd:PLN02882 484 SDDGEEVVVIGS----IAELEKLSGVKVT---DLHRHFIDHITipssrgPEFGVLR----RVDDVFDCWFESGsmpyayI 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 561 SWSFA-----LNGRKSDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPDTVLngk 635
Cdd:PLN02882 553 HYPFEnkelfEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVI--- 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 636 NALGIDTLRWWVgshsHNSLVPVSDSI-LKSE--FKTVQSIRL----IFRYLlgaLNNARSKDL--------LENDDLLT 700
Cdd:PLN02882 630 DKYGADALRLYL----INSPVVRAEPLrFKEEgvFGVVKDVFLpwynAYRFL---VQNAKRLEVeggapfvpLDLAKLQN 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 701 ----LDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVpNNVSSRYVSAIKDRLYCDSQESSRRKAcLYTLNSILYTL 776
Cdd:PLN02882 703 sanvLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLKGRTGEEDCRTA-LSTLYNVLLTS 780
|
810 820
....*....|....*....|....*...
gi 212511402 777 SYSLAPILPHLVEEVFLH----HPVSSE 800
Cdd:PLN02882 781 CKVMAPFTPFFTEVLYQNlrkvLPGSEE 808
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
40-791 |
3.12e-70 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 249.34 E-value: 3.12e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 40 PSTTFPTYLKPNEVIERDQKIQQEANflnLYAWQRkNVKGKEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRK 119
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEG---TYKFDP-DERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 120 IHYVPGWDCHGLPIELLalknVE-TKNLKPIDI-----RNKAKNIALSMSKLQKESFKSWGVIGNWENDcYYTFDTNYI- 192
Cdd:PRK13208 78 VFFPQGWDDNGLPTERK----VEkYYGIRKDDIsreefIELCRELTDEDEKKFRELWRRLGLSVDWSLE-YQTISPEYRr 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 193 INQLQiFWKMYERGLIYYGLKPVFWSPSSKTALAEAELLYVDISSTALTVRFEVVQNfssEPVYllIWTTTPWTLPLNKA 272
Cdd:PRK13208 153 ISQKS-FLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG---EEIE--IATTRPELLPACVA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 273 VYFS-NSIKYslvkisnfsgmyiiasdlieslqkklkqeitihsnmscKELEGLSYKHPWDKNKVlKVFESSSVTLS-GT 350
Cdd:PRK13208 227 VVVHpDDERY--------------------------------------KHLVGKTAIVPLFGVEV-PILADPLVDPDfGT 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 351 GLlhsvpahghedfVM----GLQN--------NLTPECFVDESGCYTSDLGPpLANLNIFgEGKNTVIKTLSSDIIL--S 416
Cdd:PRK13208 268 GA------------VMictfGDKTdvtwwrelNLPTRIIIDEDGRMTEAAGK-LAGLTIE-EARKKIVEDLKSGGLLgkQ 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 417 ENYTHSYPHDWRTNKPVFIRACEQWFIDTNQLKNKALENLRDSD-TPDKYFQSLIKerpY-------WCLSRQRTWGVPI 488
Cdd:PRK13208 334 EPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINwYPEHMRVRLEN---WieglnwdWCISRQRYFGTPI 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 489 PVFFHKTSRRPLISK--SLIHhicqlfessgsDIWwtgtlEELFPDKICNELFVkrENIIRGNDIMDIWFDSGISWSFAL 566
Cdd:PRK13208 411 PVWYCKDCGHPILPDeeDLPV-----------DPT-----KDEPPGYKCPQCGS--PGFEGETDVMDTWATSSITPLIVT 472
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 567 N-GRKSDVF---------LEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPDTVLNgKN 636
Cdd:PRK13208 473 GwERDEDLFekvfpmdlrPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLE-KY 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 637 alGIDTLRWWVGSHSHNSLVPVSDSILKSEFKTVQSIRLIFRYllgALNNARSKDLLENDDLLTLDKYLLNSCYNFYKSV 716
Cdd:PRK13208 552 --GADAVRYWAASARLGSDTPFDEKQVKIGRRLLTKLWNASRF---VLHFSADPEPDKAEVLEPLDRWILAKLAKVVEKA 626
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212511402 717 MHSYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLYCDSQESSRRKAClYTLNSILYTLSYSLAPILPHLVEEV 791
Cdd:PRK13208 627 TEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGEDEEEEQKSAR-YTLYTVLDTLLRLLAPFLPFITEEV 700
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
5-792 |
1.72e-68 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 249.11 E-value: 1.72e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 5 RRKTFQKIVPKRLYSSKIAVEEKKKSKKFQSTVFIPSTTFPTYLKPNEVIERDQKIQQEANFLNLYAWQRKNVKGKE-FV 83
Cdd:PTZ00427 26 RNGTFFNKRIIRRRGNKAKFTPSNVRIKTMEGAEMVTVTFTGVSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKaYI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 84 LHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALK--NVETKN--LK-PIDIRN-KAKN 157
Cdd:PTZ00427 106 FYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKenNINKKEdiLKmGIDVYNeKCRG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 158 IALsmsKLQKESFKSWGVIGNW---ENDcYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALA--EAELLY 232
Cdd:PTZ00427 186 IVL---KYSNEWVKTVERIGRWidfKND-YKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISnfELNLNY 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 233 VDISSTALTVRFEVVQNFSS------------------EPVY-------------------------LLIWTTTPWTLPL 269
Cdd:PTZ00427 262 KDTPDPSIIISFVLCSDFPKveeecnieedkqllgekySVLYnnkrensnngnnnstnnvcyaqhseILAWTTTPWTLPS 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 270 NKAVYFSNSIKYSLVKISNFSGMYIIASDLIESLQKKLK---QEITIHSNMSCKELEGLSYK----HPWDK----NKVLK 338
Cdd:PTZ00427 342 NLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKELKwnvEDLKIVNRFKGKELKGLRYKplftNFYEKynfkERAYK 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 339 VFESSSVTL-SGTGLLHSVPAHGHEDFVMGLQNN-LTPE-CF----VDESGCYTSDLgPPLANLNIfGEGKNTVIKTLSS 411
Cdd:PTZ00427 422 ILADDFVTDdAGTGIVHCAPTYGEDDFRVCKKNGvIDPEkNIfidpLDANGYFTNEV-EEVQNLYI-KEADNVIKKKLKN 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 412 DIILSENYT--HSYPHDWRTNKPVFIRACEQWFIDTNQLKNKALENlrdSDT--------PDKYFQSLIKERPYWCLSRQ 481
Cdd:PTZ00427 500 ENRLLSNNTivHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKN---NETtywipahiKEKKFHNWIKDAKDWCISRN 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 482 RTWGVPIPVFFHKTSRRPLISKSlIHHICQLfessgSDIWWTGTLEELFPD--KICNELFVKRENIIRGNDIMDIWFDSG 559
Cdd:PTZ00427 577 RYWGTPIPIWADEKMETVICVES-IKHLEEL-----SGVKNINDLHRHFIDhiEIKNPKGKTYPKLKRIPEVFDCWFESG 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 560 ------ISWSFALNGRK------SDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVD 627
Cdd:PTZ00427 651 smpyakVHYPFSTEKEDfhkifpADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPD 730
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 628 PDTVLngkNALGIDTLRWWVgshsHNSlVPVSDSILKSEFKTVQSI--RLI------FRYLLGALNN---ARSKDLLEND 696
Cdd:PTZ00427 731 PLYIL---DKYGADSLRLYL----INS-VAVRAENLKFQEKGVNEVvkSFIlpfyhsFRFFSQEVTRyecLNKKQFLFNT 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 697 DLL-----TLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVpNNVSSRYVSAIKDRLycdsQESSRRKACLYTLNS 771
Cdd:PTZ00427 803 DYIykndnIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI-ENLTNWYIRLNRDRM----RGSLGEENCLQSLCT 877
|
890 900
....*....|....*....|....
gi 212511402 772 I---LYTLSYSLAPILPHLVEEVF 792
Cdd:PTZ00427 878 TyrtLHLFTVLMAPFTPFITEYIY 901
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
44-801 |
1.06e-67 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 243.04 E-value: 1.06e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 44 FPTYLKPNEVIERDQKIQQEANFLnlYAWQRKNvkGKEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYV 123
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFF--KPDGNSN--KPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 124 PGWDCHGLPIELLALKNVETKNLKPIDI-----RNKAKNIALSMSKLQKESFKSWGVIGNWENDcYYTFDTNYIINQLQI 198
Cdd:TIGR00422 77 PGTDHAGIATQVKVEKKLGAEGKTKHDLgreefREKIWEWKEESGGTIKNQIKRLGASLDWSRE-RFTMDEGLSKAVKEA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 199 FWKMYERGLIYYGLKPVFWSPSSKTALAEAELLYVDISSTALTVRFEVvQNFSSEpvYLLIWTTTPWTLPLNKAVyfsns 278
Cdd:TIGR00422 156 FVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPL-ANGSKD--YLVVATTRPETMFGDTAV----- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 279 ikyslvkisnfsgmyiiasdlieslqkklkqeiTIHSNMSckeleglSYKHPWDK-------NKVLKVFESSSVTLS-GT 350
Cdd:TIGR00422 228 ---------------------------------AVHPEDE-------RYKHLIGKkvilpltGRKIPIIADEYVDMEfGT 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 351 GLLHSVPAHGHEDFVMGLQNNLTPECFVDESGcYTSDLGPPLANLNIFgEGKNTVIKTLSSDIIL--SENYTHSYPHDWR 428
Cdd:TIGR00422 268 GAVKVTPAHDFNDYEWGKRHNLEFINILDEDG-LLNENAGKYQGLTRF-EARKKIVEDLKEEGLLvkIEPHTHNVGTCWR 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 429 TNKPVFIRACEQWFIDTNQLKNKALENLRDSD---TPDK----YFQSLIKERPyWCLSRQRTWGVPIPVFFHKTSRRPLI 501
Cdd:TIGR00422 346 SGTVVEPLLSKQWFVKVEKLADKALEAAEEGEikfVPKRmekrYLNWLRNIKD-WCISRQLIWGHRIPVWYCKECGEVYV 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 502 SKSlihhicqlfESSGSDIWWTGTLEELFPDKicnelfvkreniirgnDIMDIWFDSGIsWSFALNG-----------RK 570
Cdd:TIGR00422 425 AKE---------EPLPDDKTNTGPSVELEQDT----------------DVLDTWFSSSL-WPFSTLGwpdetkdlkkfYP 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 571 SDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPDTVLngkNALGIDTLRWWV-GS 649
Cdd:TIGR00422 479 TDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVI---EKYGADALRFTLaSL 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 650 HSHNSLVPVSDSILKSEFKTVQSIRLIFRYLLGALNNArsKDLLENDDLLTL-DKYLLNSCYNFYKSVMHSYNTYKtYSV 728
Cdd:TIGR00422 556 VTPGDDINFDWKRVESARNFLNKLWNASRFVLMNLSDD--LELSGGEEKLSLaDRWILSKLNRTIKEVRKALDKYR-FAE 632
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212511402 729 CSQILH-FVPNNVSSRYVSAIKDRLYCDSQEssRRKACLYTLNSILYTLSYSLAPILPHLVEEVFLHHPVSSEN 801
Cdd:TIGR00422 633 AAKALYeFIWNDFCDWYIELVKYRLYNGNEA--EKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADS 704
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
658-836 |
3.23e-50 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 175.02 E-value: 3.23e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 658 VSDSILKSEFKTVQSIRLIFRYLLGALNN-ARSKDLLENDDLLTLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFV 736
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDfDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 737 PNNVSSRYVSAIKDRLYCDSQESSRRKACLYTLNSILYTLSYSLAPILPHLVEEVFLHHPVSSENKRVFFRKEPWVPREw 816
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVFLEDWPELPEE- 159
|
170 180
....*....|....*....|
gi 212511402 817 WSNDTTDKTILLLDNFKKDI 836
Cdd:cd07960 160 WKDEELEEKWEKLLALRDEV 179
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
82-649 |
1.58e-39 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 149.11 E-value: 1.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 82 FVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLA--LKNVETKNLKPIDIRNKAKNIA 159
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerKGGRKKKTIWIEEFREDPKEFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 160 LSMSKLQKESFKSWGVIGNWeNDCYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSsktalaeaellyvdissta 239
Cdd:cd00668 82 EEMSGEHKEDFRRLGISYDW-SDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVRITEQ------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 240 ltvrfevvqnfssepvylliwtttpwtlplnkavYFsnsIKYSLVKisnfsgmyiiasdliESLQKKLKQeitihsnmsc 319
Cdd:cd00668 142 ----------------------------------WF---FDMPKFK---------------EKLLKALRR---------- 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 320 keleglsykhpwdknkvlkvfesssvtlsgtglLHSVPAHGHEDFvmglqnnltpecfvdesgcytsdlgpplanlnifg 399
Cdd:cd00668 160 ---------------------------------GKIVPEHVKNRM----------------------------------- 171
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 400 egkntviktlssdiilsenythsyphdwrtnkpvfiracEQWfidtnqlknkaLENLRDsdtpdkyfqslikerpyWCLS 479
Cdd:cd00668 172 ---------------------------------------EAW-----------LESLLD-----------------WAIS 184
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 480 RQRTWGVPIPvffhktsrrpliskslihhicqlfessgsdiwwtgtleelfpdkicnelfvkreniirgNDIMDIWFDSG 559
Cdd:cd00668 185 RQRYWGTPLP-----------------------------------------------------------EDVFDVWFDSG 205
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 560 ISWSFALNGRK----------SDVFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPD 629
Cdd:cd00668 206 IGPLGSLGYPEekewfkdsypADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPS 285
|
570 580
....*....|....*....|
gi 212511402 630 TVLNGKnalGIDTLRWWVGS 649
Cdd:cd00668 286 DVVEKY---GADALRYYLTS 302
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
88-652 |
2.63e-35 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 138.53 E-value: 2.63e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 88 PPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLalknVETKNLKPIDIRN---------KAKNI 158
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVV----VEKKLGIEGKTRHdlgreefleKCWEW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 159 ALSMSKLQKESFKSWGVIGNWENDcYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALAEAELlyvdisst 238
Cdd:cd00817 85 KEESGGKIREQLKRLGASVDWSRE-YFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV-------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 239 altvrfevvqnfssepvylliwtttpwtlplnkavyfsnsikyslvkisnfsgmyiiasdlieslqkklkqeitihsnms 318
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 319 ckeleglsykhpwdknkvlkvfesssvtlsgtgllhsvpahghedfvmglqnnltpecfvdesgCYTSDlgpplanlnif 398
Cdd:cd00817 156 ----------------------------------------------------------------CSRSG----------- 160
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 399 gegknTVIktlssDIILSenythsyphdwrtnkpvfiracEQWFIDTNQLKNKALENLRDSD---TPDK----YFQSLIK 471
Cdd:cd00817 161 -----DVI-----EPLLK----------------------PQWFVKVKDLAKKALEAVKEGDikfVPERmekrYENWLEN 208
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 472 ERPyWCLSRQRTWGVPIPVFFHKTSRRpliskslihhicqlfessgsdiWWTGTLEELFPDKICNELFVK--RENIIRGN 549
Cdd:cd00817 209 IRD-WCISRQLWWGHRIPAWYCKDGGH----------------------WVVAREEDEAIDKAAPEACVPcgGEELKQDE 265
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 550 DIMDIWFDSGIsWSF-ALNGRKSDVFLE----------GKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKM 618
Cdd:cd00817 266 DVLDTWFSSSL-WPFsTLGWPEETKDLKkfyptsllvtGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKM 344
|
570 580 590
....*....|....*....|....*....|....
gi 212511402 619 SKSVGNVVDPDTVLNGknaLGIDTLRWWVGSHSH 652
Cdd:cd00817 345 SKSLGNVIDPLDVIDG---YGADALRFTLASAAT 375
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
21-796 |
1.21e-34 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 143.22 E-value: 1.21e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 21 KIAVEEKKKSKKFQSTVFIPSTTFPTYLKPNEVIERDQKIQQEANFLNLYAWQRKNVKGKEFVLHDGPPYANGKPHIGHA 100
Cdd:PTZ00419 1 KMKKEEIKLSKDEKKNKKRNISSMAASYDPKEVESGWYEWWEKSGFFKPAEDAKSLNSGKKFVIVLPPPNVTGYLHIGHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 101 INKISKDIILRSQLIQGRKIHYVPGWDCHGLpiellALKNVETKNLkpidirnkAKNIALSMSKLQKESF--KSW----- 173
Cdd:PTZ00419 81 LTGAIQDSLIRYHRMKGDETLWVPGTDHAGI-----ATQVVVEKKL--------MKEENKTRHDLGREEFlkKVWewkdk 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 174 --GVIGN----------WENDcYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALAEAELLYVDISS-TAL 240
Cdd:PTZ00419 148 hgNNICNqlrrlgssldWSRE-VFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKpTKI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 241 T-------VRFEVVQNFS-----SEPVYLLIWTTTPWTLPLNKAVyfsnsikyslvkisnfsgmyiiasdlieslqkklk 308
Cdd:PTZ00419 227 TipgydkkVEVGVLWHFAypledSGQEEIVVATTRIETMLGDVAV----------------------------------- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 309 qeiTIHSN-MSCKELEGLSYKHPWDKNKVLKVFESSS-VTLS-GTGLLHSVPAHGHEDFVMGLQNNLTPECFVDESGCYT 385
Cdd:PTZ00419 272 ---AVHPKdERYKKLHGKELIHPFIPDRKIPIIADDElVDMEfGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKIN 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 386 SDlGPPLANLNIFgEGKNTVIKTLSSDIILSENYTHSY--PHDWRTNKPVFIRACEQWFIDTNQLKNKALENLRDSD--- 460
Cdd:PTZ00419 349 EN-GGEFAGMHRF-DCRRKIEEELKEMGLLRDKVPNPMrlPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNGElki 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 461 TPDKY----FQSLIKERPyWCLSRQRTWGVPIPVFfhktsrrpLISKSLIhhicqLFESSGSDIWWTG-TLEE------- 528
Cdd:PTZ00419 427 IPSSHenvwYHWLENIQD-WCISRQLWWGHRIPAY--------RVISKGP-----ETDPSDEEPWVVArSEEEalekakk 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 529 LFPDKICNELFVKREniirgnDIMDIWFDSGIsWSFALNG---RKSDV-------FLE-GKDQFGGWFQSSLLTSVAVGN 597
Cdd:PTZ00419 493 KFGLSEEDFELEQDE------DVLDTWFSSGL-FPFSTLGwpdQTDDLqrffptsLLEtGSDILFFWVARMVMMSLHLTD 565
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 598 GLPFDKILTHGFAVDENGKKMSKSVGNVVDP-------------DTVLNG-------KNAL--------------GIDTL 643
Cdd:PTZ00419 566 KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPleviegislqdlnQKLYEGnlpekeiKRAIelqkkefpngipecGTDAL 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 644 RWWVGS---HSHNSLVPVSDSILKSEF--KTVQSIRLIFRYLLGALNNARS--KDLLENDDLLTLDKYLLNSCYNFYKSV 716
Cdd:PTZ00419 646 RFGLLAytqQGRNINLDINRVVGYRHFcnKLWNAVKFALMKLLKDFNLPNStlFKPNNVESLPWEDKWILHRLNVAIKEV 725
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 717 MHSYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLycDSQESSRRKAClyTLNSILYTLSYSLA---PILPHLVEEVFL 793
Cdd:PTZ00419 726 TEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRL--SKQSDGERKQH--AQDVLHTVLDIGLRllhPMMPFITEELYQ 801
|
...
gi 212511402 794 HHP 796
Cdd:PTZ00419 802 RLP 804
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
79-811 |
9.80e-34 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 140.08 E-value: 9.80e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 79 GKEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNVETKNLKPIDIRNKAkni 158
Cdd:PLN02943 87 GDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKMLASEGIKRTDLGRDE--- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 159 alSMSKLQKESFKSWGVIGN----------WENDcYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALAEA 228
Cdd:PLN02943 164 --FTKRVWEWKEKYGGTITNqikrlgascdWSRE-RFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDL 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 229 ELLYVDISSTALTVRFEVVqnfSSEPVYLLIWTTTPWTLPLNKAVyfsnSIKYSLVKISNFSGMYIIASdlieslqkklk 308
Cdd:PLN02943 241 EVEYSEEPGTLYYIKYRVA---GGSEDFLTIATTRPETLFGDVAI----AVNPEDDRYSKYIGKMAIVP----------- 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 309 qeitihsnMSC-KELEGLSYKHpwdknkVLKVFesssvtlsGTGLLHSVPAHGHEDFVMGLQnnltpecfvdesgcytsd 387
Cdd:PLN02943 303 --------MTYgRHVPIIADRY------VDKDF--------GTGVLKISPGHDHNDYLLARK------------------ 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 388 LGPPLANL--------NIFGEGKNTVIKTLSSDI------ILSENYTHSYPHDWRTNKPVFIRACEQWFIDTNQLKNKAL 453
Cdd:PLN02943 343 LGLPILNVmnkdgtlnEVAGLYWFEAREKLWSDLeetglaVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKAL 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 454 ENLRDSD---TPDKY------FQSLIKErpyWCLSRQRTWGVPIPVFF---HKTSRRPLISKSLIHHICQLFESSGSDIw 521
Cdd:PLN02943 423 KAVENGEltiIPERFekiynhWLSNIKD---WCISRQLWWGHRIPVWYivgKDCEEDYIVARSAEEALEKAREKYGKDV- 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 522 wtgtleELFPDKicnelfvkreniirgnDIMDIWFDSGIsWSFALNG------------RKSDVFLEGKDQFGGWFQSSL 589
Cdd:PLN02943 499 ------EIYQDP----------------DVLDTWFSSAL-WPFSTLGwpdvsaedfkkfYPTTVLETGHDILFFWVARMV 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 590 LTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDP-DTVlngkNALGIDTLRWWVGSHSHNSLVPVSDSILKSEFK 668
Cdd:PLN02943 556 MMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPlDTI----KEFGTDALRFTLALGTAGQDLNLSTERLTSNKA 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 669 TVQSIRLIFRYLL---------GALNNARSKDLLENDDLLTL---DKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFV 736
Cdd:PLN02943 632 FTNKLWNAGKFVLqnlpsqsdtSAWEHILACKFDKEESLLSLplpECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFF 711
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212511402 737 PNNVSSRYVSAIKDRLYCDSQESSRRKA---CLYTLNSILYTLSyslaPILPHLVEEVFLHHPvsseNKRVFFRKEPW 811
Cdd:PLN02943 712 WSDFADWYIEASKTRLYHSGDNSALSRAqavLLYVFENILKLLH----PFMPFVTEELWQALP----YRKEALIVSPW 781
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
70-834 |
5.90e-30 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 128.48 E-value: 5.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 70 YAWQRK--------NVKGKEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLalknV 141
Cdd:PLN02381 110 YAWWEKsgyfgadaKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVV----V 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 142 ETKNLKPidiRNkakniaLSMSKLQKESFKS----W-----GVIGN----------WENDCYyTFDTNYIINQLQIFWKM 202
Cdd:PLN02381 186 EKKLMRE---RH------LTRHDIGREEFVSevwkWkdeygGTILNqlrrlgasldWSRECF-TMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 203 YERGLIYYGLKPVFWSPSSKTALAEAELLYVDISS-TALTVrfevvqnfssePVYlliwtttpwtlplNKAVYFS--NSI 279
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKErTLLKV-----------PGY-------------DKPVEFGvlTSF 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 280 KYSLvkiSNFSGMYIIASDLIESLQKKlkQEITIH-SNMSCKELEGLSYKHPWDKNKVLKVFESSSVTLS-GTGLLHSVP 357
Cdd:PLN02381 312 AYPL---EGGLGEIVVATTRIETMLGD--TAIAIHpDDERYKHLHGKFAVHPFNGRKLPIICDAILVDPNfGTGAVKITP 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 358 AHGHEDFVMGLQNNLTPECFVDESGCYTSDLGPPLANLNIFgEGKNTVIKTLSSDIIL--SENYTHSYPHDWRTNKPVFI 435
Cdd:PLN02381 387 AHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFAGMPRF-AAREAVIEALQKKGLYrgAKNNEMRLGLCSRTNDVVEP 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 436 RACEQWFIDTNQLKNKALENLRDSDTPDKYF---QSLIKERPY------WCLSRQRTWGVPIPVFFHKTSRRPLisKSLi 506
Cdd:PLN02381 466 MIKPQWFVNCSSMAKQALDAAIDGENKKLEFipkQYLAEWKRWlenirdWCISRQLWWGHRIPAWYVTLEDDQL--KEL- 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 507 hhicqlfeSSGSDIWWTGTLEELFPDKICNELFVKRENIIRGNDIMDIWFDSGIswsFALN--GRKSD-----------V 573
Cdd:PLN02381 543 --------GSYNDHWVVARNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGL---FPLSvlGWPDDtddlkafyptsV 611
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 574 FLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILTHGFAVDENGKKMSKSVGNVVDPDTVLNGKNALGIDTlRWWVGSHSHN 653
Cdd:PLN02381 612 LETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHK-RLEEGNLDPK 690
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 654 SLVPVSDSiLKSEFK------------------TVQSIRL---IFRY---------LLGALNNARSKdlLENDDL--LTL 701
Cdd:PLN02381 691 ELVVAKEG-QKKDFPngiaecgtdalrfalvsyTAQSDKInldILRVvgyrqwcnkLWNAVRFAMSK--LGDDYTppATL 767
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 702 DKYLLNSCYNFYKSVMH--------SYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLYCDSQE-SSRRKACLYTLNSI 772
Cdd:PLN02381 768 SVETMPFSCKWILSVLNkaisktvsSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPEfASERAAAQDTLWIC 847
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212511402 773 LYTLSYSLAPILPHLVEEVF--LHHPVSSENKRVFFRKEPWVPREWWSNDTTDKTI-LLLDNFKK 834
Cdd:PLN02381 848 LDTGLRLLHPFMPFVTEELWqrLPQPKDHTRKDSIMISEYPSAVEAWTNEKVEYEMdLVLSTVKC 912
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
88-792 |
6.88e-30 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 128.19 E-value: 6.88e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 88 PPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLalknVEtKNLKpidirnkaKNIALSMSKLQK 167
Cdd:PRK14900 56 PPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMI----VE-KELK--------KTEKKSRHDLGR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 168 ESF-------------------KSWGVIGNWENDcYYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALAEA 228
Cdd:PRK14900 123 EAFlervwawkeqygsrigeqhKALGASLDWQRE-RFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 229 ELLYVDISSTAL-TVRFEVVQNFSSepvyLLIWTTTPWTLPLNKAVyfsnsikyslvkisnfsgmyiiasdlieslqkkl 307
Cdd:PRK14900 202 EVEHEEAHQGELwSFAYPLADGSGE----IVVATTRPETMLGDTAV---------------------------------- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 308 kqeiTIH-SNMSCKELEGLSYKHPWDKNKVLKVFESSSVTLS-GTGLLHSVPAHGHEDFVMGLQNNLTPECFVDESGCYT 385
Cdd:PRK14900 244 ----AVHpLDPRYMALHGKKVRHPITGRTFPIVADAILVDPKfGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMT 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 386 SDLGpPLANLNIFgEGKNTVIKTLSSDIILSENYTHSYP--HDWRTNKPVFIRACEQWFIDTNQLKNKALENLRDSDT-- 461
Cdd:PRK14900 320 AEAG-PLAGLDRF-EARKEVKRLLAEQGLDRGAKPHVLPlgRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQGRTrf 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 462 -PDKY---FQSLIKERPYWCLSRQRTWGVPIPVFFHkTSRRPLISKslihhicqlfessgsdiwwtgtlEELFPDKICNe 537
Cdd:PRK14900 398 iPEQWtntYMAWMRNIHDWCISRQLWWGHQIPAWYC-PDGHVTVAR-----------------------ETPEACSTCG- 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 538 lfvKREnIIRGNDIMDIWFDSGIsWSFALNG--RKSD---------VFLEGKDQFGGWFQSSLLTSVAVGNGLPFDKILT 606
Cdd:PRK14900 453 ---KAE-LRQDEDVLDTWFSSGL-WPFSTMGwpEQTDtlrtfyptsVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYL 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 607 HGFAVDENGKKMSKSVGNVVDPDTVLngkNALGIDTLRWWVGSHSHNSlvpvsdSILKSEFKTVQSIRLIFRYLLG---- 682
Cdd:PRK14900 528 HPMVRDEKGQKMSKTKGNVIDPLVIT---EQYGADALRFTLAALTAQG------RDIKLAKERIEGYRAFANKLWNasrf 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 683 ALNNARSKDLLEND----DLLTLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLYCDSQE 758
Cdd:PRK14900 599 ALMNLSGYQERGEDparlARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALASEDPE 678
|
730 740 750
....*....|....*....|....*....|....*.
gi 212511402 759 SSR--RKACLYTLNSILYTLSyslaPILPHLVEEVF 792
Cdd:PRK14900 679 ARRsvQAVLVHCLQTSYRLLH----PFMPFITEELW 710
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
88-794 |
6.92e-29 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 124.45 E-value: 6.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 88 PPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDcH-GlpIellALKNVETKNLKpidirnkAKNIalsmSK-- 164
Cdd:PRK05729 44 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD-HaG--I---ATQMVVERQLA-------AEGK----SRhd 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 165 LQKESF--KSWgvigNWENDCYYTfdtnyIINQLQ-------------------------IFWKMYERGLIYYGLKPVFW 217
Cdd:PRK05729 107 LGREKFleKVW----EWKEESGGT-----ITNQLRrlgascdwsrerftmdeglskavreVFVRLYEKGLIYRGKRLVNW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 218 SPSSKTALAEAELLYVDISSTALTVRFEVVQnfSSEpvYLLIWTTTPWTLPLNKAV--------Yfsnsikyslvkisnf 289
Cdd:PRK05729 178 DPKLQTALSDLEVEYKEVKGKLWHIRYPLAD--GSD--YLVVATTRPETMLGDTAVavnpederY--------------- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 290 sgmyiiaSDLIEslqKKLKQEITihsnmsckeleglsykhpwdkNKVLKVFESSSVTLS-GTGLLHSVPAHGHEDFVMGL 368
Cdd:PRK05729 239 -------KHLIG---KTVILPLV---------------------GREIPIIADEYVDPEfGTGAVKITPAHDPNDFEVGK 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 369 QNNL-TPECFvDESGCYTsDLGPPLANLNIFgEGKNTVIKTLSSDIILS--ENYTHSYPHDWRTNKPVFIRACEQWFIDT 445
Cdd:PRK05729 288 RHNLpMINIM-DEDGTIN-ENPGEYQGLDRF-EARKAIVADLEELGLLVkiEPHTHSVGHSDRSGVVIEPYLSDQWFVKM 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 446 NQLKNKALENLRDSDT---PDK----YFQSLIKERPyWCLSRQRTWGVPIPVFFHKtsrrpliskslihhicqlfessgS 518
Cdd:PRK05729 365 KPLAKPALEAVENGEIkfvPERwektYFHWMENIQD-WCISRQLWWGHRIPAWYDE-----------------------D 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 519 DIWWTGTLEELFPDKicnelfvkrENIIRGNDIMDIWFDSGIsWSFAlngrksdvFLegkdqfgGW----------FQSS 588
Cdd:PRK05729 421 GEVYVGREEPEAREK---------ALLTQDEDVLDTWFSSAL-WPFS--------TL-------GWpektedlkrfYPTS 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 589 LLTS--------VA--VGNGL------PFDKILTHGFAVDENGKKMSKSVGNVVDP-DTVlngkNALGIDTLRWwvgshs 651
Cdd:PRK05729 476 VLVTgfdiiffwVArmIMMGLhftgqvPFKDVYIHGLVRDEQGRKMSKSKGNVIDPlDLI----DKYGADALRF------ 545
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 652 hnSLVPVS----DsiLKSEFKTVQSIR-----L--IFRYLLGALNNARSKDLLENDDLLTLDKYLLNSCYNFYKSVMHSY 720
Cdd:PRK05729 546 --TLAALAspgrD--IRFDEERVEGYRnfankLwnASRFVLMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEAL 621
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212511402 721 NTYKtYSVCSQIL-HFVPNNVSSRYVSAIKDRLYCDSQESSRRKAcLYTLNSILYTLSyslaPILPHLVEEVFLH 794
Cdd:PRK05729 622 DKYR-FDEAARALyEFIWNEFCDWYLELAKPVLQEAAKRATRATL-AYVLEQILRLLH----PFMPFITEELWQK 690
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
198-794 |
1.53e-18 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 91.27 E-value: 1.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 198 IFWKMYERGLIYYGLKPVFWSPSSKTALAEAELLYVDISSTALTVRFEVVqnfsSEPVYLLIWTTTPWTLPLNKAV---- 273
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLA----DGSGYIVVATTRPETMLGDTAVavhp 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 274 ----YfsnsikyslvkisnfsgmyiiaSDLIEslqKKLKQEITihsnmsckeleglsykhpwdkNKVLKVFESSSVTLS- 348
Cdd:COG0525 233 ederY----------------------KHLIG---KTVILPLV---------------------GREIPIIADEYVDPEf 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 349 GTGLLHSVPAHGHEDFVMGLQNNL-TPECFvDESGCYTsDLGPPLANLNIFgEGKNTVIKTLSSD--IILSENYTHSYPH 425
Cdd:COG0525 267 GTGAVKITPAHDPNDFEVGKRHNLpMINIL-DEDGTIN-ENAGKYRGLDRF-EARKAIVADLEELglLVKVEPHKHSVGH 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 426 DWRTNKPVFIRACEQWFIDTNQLKNKALENLRDSDT---PDK----YFQSLIKERPyWCLSRQRTWGVPIPVFFHKtsrr 498
Cdd:COG0525 344 SDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEIkfvPERwektYFHWMENIRD-WCISRQLWWGHRIPAWYCP---- 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 499 pliskslihhicqlfesSGsDIWWTGTLEELFPDkiCNElfvkrENIIRGNDIMDIWFDSGIsWSFAlngrksdVFlegk 578
Cdd:COG0525 419 -----------------DG-EVYVARTEPEACAK--AGS-----VNLTQDEDVLDTWFSSAL-WPFS-------TL---- 461
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 579 dqfgGW----------FQSSLLTS--------VA--VGNGL------PFDKILTHGFAVDENGKKMSKSVGNVVDP-DTV 631
Cdd:COG0525 462 ----GWpektedlkyfYPTSVLVTgfdiiffwVArmIMMGLhftgevPFKDVYIHGLVRDEQGRKMSKSKGNVIDPlDLI 537
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 632 lngkNALGIDTLRW-WVGSHSHNslvpvsdsilksefktvQSIRL-----------------IFRYLLGALNNARSKDLL 693
Cdd:COG0525 538 ----DKYGADALRFtLAALASPG-----------------RDIKFdeervegyrnfanklwnASRFVLMNLEGFDPGLDP 596
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 694 ENDDLLTLDKYLLNSCYNFYKSVMHSYNTYKtYSVCSQIL-HFVPNNVSSRYVSAIKDRLYCDSQESsrRKACLYTLnsi 772
Cdd:COG0525 597 DPEELSLADRWILSRLNKTIAEVTEALEKYR-FDEAAQALyDFVWNEFCDWYLELAKPRLYGGDEAA--KRETRATL--- 670
|
650 660
....*....|....*....|....*
gi 212511402 773 LYTLSYSLA---PILPHLVEEVFLH 794
Cdd:COG0525 671 VYVLEQILRllhPFMPFITEEIWQK 695
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
89-227 |
9.15e-18 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 85.28 E-value: 9.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 89 PYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNvetkNLKPIDIRNKaknialsMSKLQKE 168
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEE----GVTPQELCDK-------YHEIFKD 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212511402 169 SFKSWGVignwENDCYY--TFDTNYIINQlQIFWKMYERGLIYYGLKPVFWSPSSKTALAE 227
Cdd:cd00814 78 LFKWLNI----SFDYFIrtTSPRHKEIVQ-EFFKKLYENGYIYEGEYEGLYCVSCERFLPE 133
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
89-230 |
1.00e-17 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 86.19 E-value: 1.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 89 PYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNvetkNLKPIDIRNKaknialsMSKLQKE 168
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKE----GITPEELVDR-------YHEIHRE 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212511402 169 SFKSWGVignwENDCYY--TFDTNYIINQlQIFWKMYERGLIYYGLKPVFWSPSSKTALAEAEL 230
Cdd:pfam09334 77 DFKKFNI----SFDDYGrtTSERHHELVQ-EFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYV 135
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
89-234 |
1.62e-16 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 84.01 E-value: 1.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 89 PYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNvetkNLKPIDirnkaknIALSMSKLQKE 168
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKE----GITPQE-------LVDRIHAEFKE 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212511402 169 SFKSWGVignwENDCYY--TFDTNYIINQlQIFWKMYERGLIYYGLKPVFWSPSSKTALAEAellYVD 234
Cdd:COG0143 79 LFEKLGI----SFDNFIrtTSPEHKELVQ-EIFQRLYDNGDIYKGEYEGWYCPECERFLPDR---YVE 138
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
89-209 |
1.17e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 78.27 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 89 PYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNvetkNLKPIDIRNKaknialsMSKLQKE 168
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE----GITPEELIAR-------YHAEHKR 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 212511402 169 SFKSWGVignwENDCYY--TFDTNYIINQlQIFWKMYERGLIY 209
Cdd:PRK00133 80 DFAGFGI----SFDNYGstHSEENRELAQ-EIYLKLKENGYIY 117
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
89-227 |
1.44e-14 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 77.80 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 89 PYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNvetkNLKPIDIRNKAKNIalsmsklQKE 168
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQE----GLTPKELVDKYHEE-------FKD 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 169 SFKSWGVignwENDCYY-TFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALAE 227
Cdd:TIGR00398 77 DWKWLNI----SFDRFIrTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPD 132
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
702-794 |
3.64e-13 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 67.43 E-value: 3.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 702 DKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLYCDSQESsrrkACLYTLNSILYTLSYSLA 781
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS----RAQTTLYEVLETLLRLLA 76
|
90
....*....|...
gi 212511402 782 PILPHLVEEVFLH 794
Cdd:pfam08264 77 PFMPFITEELWQK 89
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
95-836 |
7.99e-13 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 72.59 E-value: 7.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 95 PHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPI----ELLALKNVET----KNL--KPIDIRNKAK---NIALS 161
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaERIARGDPETielyKSLygIPEEELEKFKdpeYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 162 MSKLQKESFKSWGVIGNWENDcYYTFDTNY---IINQlqiFWKMYERGLIYYGLKPVFWSPSSKTALAEAELLYvDISST 238
Cdd:PRK12300 81 FSEEAKEDMKRIGYSIDWRRE-FTTTDPEYskfIEWQ---FRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLD-GEEPE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 239 alTVRFEVVQNFSSEPVYLLIWTTTPWTLPLNKAVYFSNSIKYSLVKISNfsGMYIIASDLIESL--QKKlkqEITIHSN 316
Cdd:PRK12300 156 --IVEYTLIKFEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDG--EKWIVSKEAAEKLsfQDR---DVEIIEE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 317 MSCKELEGLSYKHPWDkNKVLKVFESSSV-TLSGTGLLHSVPAHGHEDFV--MGLQNN--------LTPECFVDESGCY- 384
Cdd:PRK12300 229 IKGSELIGKKVKNPVT-GKEVPILPADFVdPDNGTGVVMSVPAHAPYDYValRDLKKNkelldviePIPLIEVEGYGEFp 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 385 ----------TSDLGPPL------------------ANLNIFG-----EGKNTVIKTL----SSDIIlsenYTHSyphdw 427
Cdd:PRK12300 308 akevveklgiKSQEDPELeeatkevyraefhkgvlkENTGEYAgkpvrEAREKITKDLiekgIADIM----YEFS----- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 428 rtNKPVFIRaC----------EQWFIDTN-----QLKNKALENLRdsDTPDKY---FQSLI---KERPywClSRQRTWGV 486
Cdd:PRK12300 379 --NRPVYCR-CgtecvvkvvkDQWFIDYSdpewkELAHKALDNME--IIPEEYrkeFENTIdwlKDRA--C-ARRRGLGT 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 487 PIPVffhktSRRPLI---SKSLI--------HHICQLfessgsdiwwtgtleELFPDKICNELFvkrENIIRGN-DIMDI 554
Cdd:PRK12300 451 RLPW-----DEEWIIeslSDSTIymayytiaHKIREY---------------GIKPEQLTPEFF---DYVFLGKgDPEEV 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 555 WFDSGISwsfalngrkSDVFLEGKDQFGGWFQSSLLTSVA--VGNGLPFdKILTH-----------GFAVDE----NGKK 617
Cdd:PRK12300 508 SKKTGIP---------KEILEEMREEFLYWYPVDWRHSGKdlIPNHLTF-FIFNHvaifpeekwprGIVVNGfvllEGKK 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 618 MSKSVGNVVdpdTVLNGKNALGIDTLRWWV-GSHSHNSLVPVSDSILKSEFKTVQSIRLIFRYLlgalnnarsKDLLEND 696
Cdd:PRK12300 578 MSKSKGNVI---PLRKAIEEYGADVVRLYLtSSAELLQDADWREKEVESVRRQLERFYELAKEL---------IEIGGEE 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 697 DLLTLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVPNNVssryvsaikdRLYcdsqesSRR--KACLYTLNSILY 774
Cdd:PRK12300 646 ELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDL----------RWY------LRRvgEANNKVLREVLE 709
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212511402 775 TLSYSLAPILPHLVEEvfLHHPVSSENkrvFFRKEPW-VPREWWSNDTTDKTILLLDNFKKDI 836
Cdd:PRK12300 710 IWIRLLAPFTPHLAEE--LWHKLGGEG---FVSLEKWpEPDESKIDEEAELAEEYVKRLIEDI 767
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
73-492 |
2.35e-12 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 71.01 E-value: 2.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 73 QRKNVKGKEFVLhDGPPYANGKP-HIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALknvETKNlKPIDi 151
Cdd:PLN02563 104 DVDTSKPKFYVL-DMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQYAI---ETGT-HPKI- 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 152 rNKAKNIALSMSKLqkesfKSWGVIGNWENDCyYTFDTNYIINQLQIFWKMYERGLIYYGLKPVFWSPSSKTALAEAELL 231
Cdd:PLN02563 178 -TTLKNIARFRSQL-----KSLGFSYDWDREI-STTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVV 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 232 -------------------------YVD----------------------IS-STALTVRFEVVQNFSSEP-VYLLIWTT 262
Cdd:PLN02563 251 dglsergghpvirkpmrqwmlkitaYADrlledlddldwpesikemqrnwIGrSEGAELDFSVLDGEGKERdEKITVYTT 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 263 TPWTlpLNKAVYFSNSIKYSLVkisnfsgmyiiaSDLIESLQKKLKQE-ITIHSNMS-------CKELEGL---SY-KHP 330
Cdd:PLN02563 331 RPDT--LFGATYLVVAPEHPLL------------SSLTTAEQKEAVEEyVDAASRKSdlertelQKEKTGVftgSYaINP 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 331 --------WDKNKVLKVFesssvtlsGTGLLHSVPAHGHEDFVMGLQNNLtPECFV---DESGCYTSDLGPPLANLNIFG 399
Cdd:PLN02563 397 atgeaipiWVADYVLGSY--------GTGAIMAVPAHDTRDFEFAQKFDL-PIKWVvkpADGNEDDAEKAYTGEGVIVNS 467
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 400 EGKNTVIKTLSSDIILSenythsyphdwrtnkpvfirACEQWFIDTNQLKNKALENLRDsdtpdkyfqslikerpyWCLS 479
Cdd:PLN02563 468 SSSGLDINGLSSKEAAK--------------------KVIEWLEETGNGKKKVNYKLRD-----------------WLFA 510
|
490
....*....|...
gi 212511402 480 RQRTWGVPIPVFF 492
Cdd:PLN02563 511 RQRYWGEPIPVVF 523
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
89-217 |
5.38e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 68.04 E-value: 5.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 89 PYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKNVETKnlKPIDIRNKAKnialsmsklQKE 168
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDP--EDWTEYNIKK---------MKE 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 212511402 169 SFKSWGVIGNWENDCYYTFDTNYIINQLQiFWKMYERGLIYYGLKPVFW 217
Cdd:cd00812 78 QLKRMGFSYDWRREFTTCDPEYYKFTQWL-FLKLYEKGLAYKKEAPVNW 125
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
598-792 |
7.38e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 65.67 E-value: 7.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 598 GLP-FDKILTHGFAVDEnGKKMSKSVGNVVDPDTVLngkNALGIDTLRWWV---------GSHSHNSLVPVSDSILKSEF 667
Cdd:PRK11893 280 GLPlPKRVFAHGFLTLD-GEKMSKSLGNVIDPFDLV---DEYGVDAVRYFLlreipfgqdGDFSREAFINRINADLANDL 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 668 KTV--QSIRLIFRYLLGALNnarskdllENDDLLTLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVpnnvssryv 745
Cdd:PRK11893 356 GNLaqRTLSMIAKNFDGKVP--------EPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--------- 418
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 212511402 746 saIKDRLYCDSQE--------SSRRKACLYTLNSILYTLSYSLAPILPHLVEEVF 792
Cdd:PRK11893 419 --RAANKYIDEQApwslaktdPERLATVLYTLLEVLRGIAVLLQPVMPELAAKIL 471
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
690-794 |
1.36e-10 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 61.41 E-value: 1.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 690 KDLLENDDLLTLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVpNNVSSRYVSAIKDRLYcDSQESSRRKACLYTL 769
Cdd:cd07961 37 KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI-DELTNWYIRRNRKRFW-GEEGDDDKLAAYATL 114
|
90 100
....*....|....*....|....*
gi 212511402 770 NSILYTLSYSLAPILPHLVEEVFLH 794
Cdd:cd07961 115 YEVLLTLSRLMAPFTPFITEEIYQN 139
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
89-645 |
4.84e-10 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 63.53 E-value: 4.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 89 PYANGKPHIGHAINKISKDIILRSQLIQGrkiHYV--P-GWDCHGLPIELLALKN-----VETKnlkpidirnkaKNIAl 160
Cdd:COG0495 42 PYPSGRLHMGHVRNYTIGDVVARYKRMQG---YNVlhPmGWDAFGLPAENAAIKNgvhpaEWTY-----------ENIA- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 161 SMsklqKESFKSWGVIGNWE---NDC---YYTFdtnyiiNQlQIFWKMYERGLIYYGLKPVFWSPSSKTALA-E------ 227
Cdd:COG0495 107 NM----RRQLKRLGLSYDWSreiATCdpeYYKW------TQ-WIFLQLYEKGLAYRKEAPVNWCPVDQTVLAnEqvidgr 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 228 -----------------------AELLYVDIS-------------------STALTVRFEVVQNFSSEPVYlliwTTTPW 265
Cdd:COG0495 176 cwrcgapvekkelpqwflkitdyADELLDDLDkldgwpekvktmqrnwigrSEGAEVDFPVEGSDEKITVF----TTRPD 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 266 TL------------PLNKAvyfsnsikysLVKISNfsgmyiiaSDLIESLQKKLKQEITIHSNMSCKELEGL---SY-KH 329
Cdd:COG0495 252 TLfgatfmvlapehPLVKE----------LATPEQ--------NAAVAAFIEEAKKKSEIERTSETKEKTGVftgLYaIN 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 330 PWDKNKVlKVFESSSVTLS-GTGLLHSVPAHGHEDFVMGLQNNL----------------TPECFVDESGCYTSDlgpPL 392
Cdd:COG0495 314 PLTGEKI-PIWIADYVLMDyGTGAVMAVPAHDQRDFEFAKKYGLpikqviapedgddpdiLEEAYTGDGVLINSG---EF 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 393 ANLNiFGEGKNTVIKTLSSDIILSE--NYthsyphdwRtnkpvfiraceqwfidtnqlknkalenLRDsdtpdkyfqsli 470
Cdd:COG0495 390 DGLD-SEEAKEAIIEWLEEKGLGKRkvNY--------R---------------------------LRD------------ 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 471 kerpyWCLSRQRTWGVPIPVffhktsrrpliskslIHhiC-----------QL---------FESSGS-------DiwWT 523
Cdd:COG0495 422 -----WLISRQRYWGEPIPI---------------IH--CedcgvvpvpedQLpvelpedvdFDPTGGsplarapE--WV 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 524 GTleelfPDKICNELFvKREniirgNDIMDIWFDSgiSWSFA--LNGRKSDVFLEGK--------DQF-GGwfqssllts 592
Cdd:COG0495 478 NV-----TCPKCGGPA-RRE-----TDTMDTFVDS--SWYYLryTDPHNDEAPFDPEaanywlpvDQYiGG--------- 535
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 593 V--AVGN--------------GL-----PFDKILTHG--FAVDENGK------KMSKSVGNVVDPDTVLngkNALGIDTL 643
Cdd:COG0495 536 IehAILHllyarfftkvlrdlGLvsfdePFKRLLTQGmvLEVGKDGVviggieKMSKSKGNVVDPDEII---EKYGADTL 612
|
..
gi 212511402 644 RW 645
Cdd:COG0495 613 RL 614
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
676-792 |
3.12e-07 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 50.25 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 676 IFRYLLGALNNArSKDLLENDDLLTLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVPNNVSSRYVSAIKDRLYCD 755
Cdd:cd07962 19 AARFVLMNLEDD-DEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKPRLYGE 97
|
90 100 110
....*....|....*....|....*....|....*..
gi 212511402 756 SQEssRRKACLYTLNSILYTLSYSLAPILPHLVEEVF 792
Cdd:cd07962 98 DEE--EKKAARATLYYVLETILRLLHPFMPFITEELW 132
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
419-645 |
4.76e-07 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 52.64 E-value: 4.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 419 YTHSYPHDWRtnkpvfiRACEQWFIDTNQLKNKAlENLRDSDTPDKYFQSLIKERPYW--ClSRQRTWGVPIPvffhkts 496
Cdd:cd00812 117 YKKEAPVNWC-------KLLDQWFLKYSETEWKE-KLLKDLEKLDGWPEEVRAMQENWigC-SRQRYWGTPIP------- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 497 rrpliskslihhicqlfessgsdiwWTgtleelfpdkicnelfvkreniirgnDIMDIWFDSgiSWSFA-------LNGR 569
Cdd:cd00812 181 -------------------------WT--------------------------DTMESLSDS--TWYYArytdahnLEQP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 570 KSDVFLEGKDQFGGW---------------------FQSSLLTSVAVGNGLPFDKILTHGFaVDENGKKMSKSVGNVVDP 628
Cdd:cd00812 208 YEGDLEFDREEFEYWypvdiyiggkehapnhllysrFNHKALFDEGLVTDEPPKGLIVQGM-VLLEGEKMSKSKGNVVTP 286
|
250
....*....|....*..
gi 212511402 629 DTVLNGknaLGIDTLRW 645
Cdd:cd00812 287 DEAIKK---YGADAARL 300
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
88-211 |
9.07e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 52.58 E-value: 9.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 88 PPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLAlknvETKNLKPIDI--RNkAKNIALSMSKL 165
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKA----EEAGISPQELadRN-SAAFKRLWEAL 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 212511402 166 qkesfkswgvigNWENDCYY-TFDTNYiINQLQIFW-KMYERGLIYYG 211
Cdd:PRK11893 84 ------------NISYDDFIrTTDPRH-KEAVQEIFqRLLANGDIYLG 118
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
90-211 |
1.20e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.50 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 90 YANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLAlknvETKNLKPidirnkaKNIALSMSKLQKES 169
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAA----EKAGKTP-------QEYVDEISAGFKEL 82
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 212511402 170 FKSWGVignwENDCYY-TFDTNYIINQLQIFWKMYERGLIYYG 211
Cdd:PRK12267 83 WKKLDI----SYDKFIrTTDERHKKVVQKIFEKLYEQGDIYKG 121
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
598-644 |
1.45e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 49.03 E-value: 1.45e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 212511402 598 GLP-FDKILTHGFAVDENGKkMSKSVGNVVDPDTVLngkNALGIDTLR 644
Cdd:PRK12267 280 GLPlPKKVFAHGWWLMKDGK-MSKSKGNVVDPEELV---DRYGLDALR 323
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
78-140 |
2.45e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 44.70 E-value: 2.45e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212511402 78 KGKEFVLHDGPPYANGKPHIGHAINKISKDIILRSQLIQGRKIHYVPGWDCHGLPIELLALKN 140
Cdd:PLN02224 67 EADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAAN 129
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
660-784 |
6.30e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 37.49 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212511402 660 DSILKSEFKTVQSIRLIFRYLLGALNNARSKdlLENDDLLTLDKYLLNSCYNFYKSVMHSYNTYKTYSVCSQILHFVpnN 739
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGGTQPK--WDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFT--N 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 212511402 740 VSSRYVSAIKDRLYCDSQessrRKACLYTLNSILYTLSYSLAPIL 784
Cdd:cd07375 77 ELNWYLDELKPALQTEEL----REAVLAVLRAALVVLTKLLAPFT 117
|
|
| |
