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Conserved domains on  [gi|119621031|gb|EAX00626|]
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prolactin regulatory element binding, isoform CRA_a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
88-281 1.14e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTQLHWQEN 164
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRlLASGSADGTVRLWdlATGELLRTLTGHSG 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 165 GPT---FSstpyryqacrfgqvPDqpaGLRLF------TVQIphkrlrqpppcyltaWDGSNFLPLRTKSCGHEVVSCLD 235
Cdd:COG2319  290 GVNsvaFS--------------PD---GKLLAsgsddgTVRL---------------WDLATGKLLRTLTGHTGAVRSVA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 119621031 236 VSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLP 281
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSP 382
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
88-281 1.14e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTQLHWQEN 164
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRlLASGSADGTVRLWdlATGELLRTLTGHSG 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 165 GPT---FSstpyryqacrfgqvPDqpaGLRLF------TVQIphkrlrqpppcyltaWDGSNFLPLRTKSCGHEVVSCLD 235
Cdd:COG2319  290 GVNsvaFS--------------PD---GKLLAsgsddgTVRL---------------WDLATGKLLRTLTGHTGAVRSVA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 119621031 236 VSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLP 281
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-325 3.80e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 3.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  87 VVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTQLHwQE 163
Cdd:cd00200   14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLWdlETGECVRTLT-GH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 164 NGPTFSstpyryqaCRFgqVPDQP---AGLRLFTVQIphkrlrqpppcyltaWDGSNFLPLRTKScGHE-VVSCLDVSES 239
Cdd:cd00200   93 TSYVSS--------VAF--SPDGRilsSSSRDKTIKV---------------WDVETGKCLTTLR-GHTdWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 240 GTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLPEKGRgpellgshetaLFSVAVDSRC---------QLHL 310
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCV-ATLTGHTGEVNSVAFSPDGEK-----------LLSSSSDGTIklwdlstgkCLGT 214

                        250
                 ....*....|....*
gi 119621031 311 LPSRREECSCVAPAP 325
Cdd:cd00200  215 LRGHENGVNSVAFSP 229
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 88-110 1.84e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.84e-04
                           10        20
                   ....*....|....*....|...
gi 119621031    88 VCFNHDNTLLATGGTDGYVRVWK 110
Cdd:smart00320  18 VAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
88-109 1.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|..
gi 119621031   88 VCFNHDNTLLATGGTDGYVRVW 109
Cdd:pfam00400  17 LAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
88-281 1.14e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTQLHWQEN 164
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRlLASGSADGTVRLWdlATGELLRTLTGHSG 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 165 GPT---FSstpyryqacrfgqvPDqpaGLRLF------TVQIphkrlrqpppcyltaWDGSNFLPLRTKSCGHEVVSCLD 235
Cdd:COG2319  290 GVNsvaFS--------------PD---GKLLAsgsddgTVRL---------------WDLATGKLLRTLTGHTGAVRSVA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 119621031 236 VSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLP 281
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
88-281 6.54e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 6.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTQLHWQEN 164
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWdlATGKLLRTLTGHSG 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 165 GPT---FSstpyryqacrfgqvPDqpaGLRLF------TVQIphkrlrqpppcyltaWDGSNFLPLRTKSCGHEVVSCLD 235
Cdd:COG2319  248 SVRsvaFS--------------PD---GRLLAsgsadgTVRL---------------WDLATGELLRTLTGHSGGVNSVA 295

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 119621031 236 VSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLP 281
Cdd:COG2319  296 FSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGAVRSVAFSP 340
WD40 COG2319
WD40 repeat [General function prediction only];
88-281 5.40e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTQLHWQEN 164
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKlLASGSDDGTVRLWdlATGKLLRTLTGHTG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 165 GPT---FSstpyryqacrfgqvPDqpaGLRLF------TVQIphkrlrqpppcyltaWDGSNFLPLRTKSCGHEVVSCLD 235
Cdd:COG2319  206 AVRsvaFS--------------PD---GKLLAsgsadgTVRL---------------WDLATGKLLRTLTGHSGSVRSVA 253

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 119621031 236 VSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLP 281
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELL-RTLTGHSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-325 3.80e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 3.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  87 VVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTQLHwQE 163
Cdd:cd00200   14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLWdlETGECVRTLT-GH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 164 NGPTFSstpyryqaCRFgqVPDQP---AGLRLFTVQIphkrlrqpppcyltaWDGSNFLPLRTKScGHE-VVSCLDVSES 239
Cdd:cd00200   93 TSYVSS--------VAF--SPDGRilsSSSRDKTIKV---------------WDVETGKCLTTLR-GHTdWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 240 GTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLPEKGRgpellgshetaLFSVAVDSRC---------QLHL 310
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCV-ATLTGHTGEVNSVAFSPDGEK-----------LLSSSSDGTIklwdlstgkCLGT 214

                        250
                 ....*....|....*
gi 119621031 311 LPSRREECSCVAPAP 325
Cdd:cd00200  215 LRGHENGVNSVAFSP 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 86-251 1.54e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  86 KVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDG-KLVTVGRDLKASVW--QKDQLVTQLHWQ 162
Cdd:cd00200  139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWdlSTGKCLGTLRGH 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 163 ENGPTfsstpyryqACRFGqvPDQpaglRLFTVQIPHKRLRQpppcyltaWDGSNFLPLRTKScGHEV-VSCLDVSESGT 241
Cdd:cd00200  219 ENGVN---------SVAFS--PDG----YLLASGSEDGTIRV--------WDLRTGECVQTLS-GHTNsVTSLAWSPDGK 274

                        170
                 ....*....|
gi 119621031 242 FLglgtVTGS 251
Cdd:cd00200  275 RL----ASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-303 2.49e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 2.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  81 SDPLQKVVCFnHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTV-GRDLKASVW--QKDQLVT 157
Cdd:cd00200   51 TGPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSsSRDKTIKVWdvETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 158 QLHWQENGPTfsstpyryqACRFGqvPDQP---AGLRLFTVQIphkrlrqpppcyltaWDGSNFLPLRTKScGHE-VVSC 233
Cdd:cd00200  130 TLRGHTDWVN---------SVAFS--PDGTfvaSSSQDGTIKL---------------WDLRTGKCVATLT-GHTgEVNS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 234 LDVSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLP-------------------EKGRGPELLGSHE 294
Cdd:cd00200  183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTLRGHENGVNSVAFSPdgyllasgsedgtirvwdlRTGECVQTLSGHT 261


                 ....*....
gi 119621031 295 TALFSVAVD 303
Cdd:cd00200  262 NSVTSLAWS 270
WD40 COG2319
WD40 repeat [General function prediction only];
88-151 2.83e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 2.83e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVWQ 151
Cdd:COG2319  336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRtLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
88-255 1.19e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW--QKDQLVTqlhwqen 164
Cdd:COG2319  252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWdlATGKLLR------- 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 165 gpTFSSTPYRYQACRFGqvpdqPAGLRLF------TVQIphkrlrqpppcyltaWDGSNFLPLRTKScGHE-VVSCLDVS 237
Cdd:COG2319  325 --TLTGHTGAVRSVAFS-----PDGKTLAsgsddgTVRL---------------WDLATGELLRTLT-GHTgAVTSVAFS 381

                        170
                 ....*....|....*...
gi 119621031 238 ESGTFLGLGTVTGSVAIY 255
Cdd:COG2319  382 PDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
67-301 2.88e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  67 LRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDL 145
Cdd:COG2319   63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKtLASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 146 KASVW--QKDQLVTQLHWQENGPT---FSstpyryqacrfgqvPDqpaGLRLF------TVQIphkrlrqpppcyltaWD 214
Cdd:COG2319  143 TVRLWdlATGKLLRTLTGHSGAVTsvaFS--------------PD---GKLLAsgsddgTVRL---------------WD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 215 GSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLP------------- 281
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL-RTLTGHSGSVRSVAFSPdgrllasgsadgt 269

                        250       260
                 ....*....|....*....|....*.
gi 119621031 282 ------EKGRGPELLGSHETALFSVA 301
Cdd:COG2319  270 vrlwdlATGELLRTLTGHSGGVNSVA 295
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-285 3.88e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVG-RDLKASVW--QKDQLVTQLHwQEN 164
Cdd:cd00200   99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSsQDGTIKLWdlRTGKCVATLT-GHT 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621031 165 GPTFSSTPYryqacrfgqvpdqPAGLRLFTV----QIphkRLrqpppcyltaWDgsnflpLRTKSC-----GHEV-VSCL 234
Cdd:cd00200  178 GEVNSVAFS-------------PDGEKLLSSssdgTI---KL----------WD------LSTGKClgtlrGHENgVNSV 225

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119621031 235 DVSESGTFLGLGTVTGSVAIYIAFSLQCLyYVREAHGIVVTDVAFLPEKGR 285
Cdd:cd00200  226 AFSPDGYLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWSPDGKR 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-151 4.67e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 4.67e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119621031  88 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVWQ 151
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKrLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 88-110 1.84e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.84e-04
                           10        20
                   ....*....|....*....|...
gi 119621031    88 VCFNHDNTLLATGGTDGYVRVWK 110
Cdd:smart00320  18 VAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
88-109 1.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|..
gi 119621031   88 VCFNHDNTLLATGGTDGYVRVW 109
Cdd:pfam00400  17 LAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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