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Conserved domains on  [gi|119609402|gb|EAW88996|]
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guanine nucleotide binding protein (G protein), alpha 13, isoform CRA_c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G_alpha super family cl29918
G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding ...
 59-184 9.33e-60

G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding site


The actual alignment was detected with superfamily member smart00275:

Pssm-ID: 214595 [Multi-domain]  Cd Length: 342  Bit Score: 189.33  E-value: 9.33e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609402    59 SEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGdPHCLRDVQKFLVEC 138
Cdd:smart00275 218 SEYDQVLEEDESTNRMQESLNLFESICNSRWFANTSIILFLNKIDLFEEKIKKVPLVDYFPDYKG-PNDYEAAAKFIKQK 296

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 119609402   139 FRNKRRDQQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLM 184
Cdd:smart00275 297 FLRLNRNSSRKSIYHHFTCATDTRNIRVVFDAVKDIILQRNLKDAG 342
 
Name Accession Description Interval E-value
G_alpha smart00275
G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding ...
 59-184 9.33e-60

G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding site


Pssm-ID: 214595 [Multi-domain]  Cd Length: 342  Bit Score: 189.33  E-value: 9.33e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609402    59 SEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGdPHCLRDVQKFLVEC 138
Cdd:smart00275 218 SEYDQVLEEDESTNRMQESLNLFESICNSRWFANTSIILFLNKIDLFEEKIKKVPLVDYFPDYKG-PNDYEAAAKFIKQK 296

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 119609402   139 FRNKRRDQQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLM 184
Cdd:smart00275 297 FLRLNRNSSRKSIYHHFTCATDTRNIRVVFDAVKDIILQRNLKDAG 342
G-alpha cd00066
Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins ...
 59-180 4.72e-58

Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins contains the guanine nucleotide binding site. The heterotrimeric GNP-binding proteins are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. Extracellular signals are received by receptors, which activate the G proteins, which in turn route the signals to several distinct intracellular signaling pathways. The alpha subunit of G proteins is a weak GTPase. In the resting state, heterotrimeric G proteins are associated at the cytosolic face of the plasma membrane and the alpha subunit binds to GDP. Upon activation by a receptor GDP is replaced with GTP, and the G-alpha/GTP complex dissociates from the beta and gamma subunits. This results in activation of downstream signaling pathways, such as cAMP synthesis by adenylyl cyclase, which is terminated when GTP is hydrolized and the heterotrimers reconstitute.


Pssm-ID: 206639 [Multi-domain]  Cd Length: 315  Bit Score: 184.27  E-value: 4.72e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609402  59 SEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGDPHCLRDVQKFLVEC 138
Cdd:cd00066  195 SEYDQVLVEDESVNRMQESLKLFDSICNSRWFANTSIILFLNKKDLFEEKIKKSPLTDYFPDYTGPPNDYEEAAKYIKKK 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 119609402 139 FRNKRRDqQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNL 180
Cdd:cd00066  275 FLDLNRN-PNKEIYPHFTCATDTENIRFVFDAVKDIILQNNL 315
G-alpha pfam00503
G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular ...
 59-175 9.58e-49

G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.


Pssm-ID: 459835 [Multi-domain]  Cd Length: 316  Bit Score: 160.45  E-value: 9.58e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609402   59 SEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGDPHCLRDVQKFLVEC 138
Cdd:pfam00503 201 SEYDQVLYEDDSTNRMEESLKLFEEICNSPWFKNTPIILFLNKKDLFEEKLKKSPLSDYFPDYTGNPNDYEEALKYIRNK 280

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 119609402  139 FRNKRRDqQQKPLYHHFTTAINTENIRLVFRDVKDTI 175
Cdd:pfam00503 281 FLDLNKN-PNRKIYTHFTCATDTENIRFVFDAVKDII 316
 
Name Accession Description Interval E-value
G_alpha smart00275
G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding ...
 59-184 9.33e-60

G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding site


Pssm-ID: 214595 [Multi-domain]  Cd Length: 342  Bit Score: 189.33  E-value: 9.33e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609402    59 SEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGdPHCLRDVQKFLVEC 138
Cdd:smart00275 218 SEYDQVLEEDESTNRMQESLNLFESICNSRWFANTSIILFLNKIDLFEEKIKKVPLVDYFPDYKG-PNDYEAAAKFIKQK 296

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 119609402   139 FRNKRRDQQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLM 184
Cdd:smart00275 297 FLRLNRNSSRKSIYHHFTCATDTRNIRVVFDAVKDIILQRNLKDAG 342
G-alpha cd00066
Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins ...
 59-180 4.72e-58

Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins contains the guanine nucleotide binding site. The heterotrimeric GNP-binding proteins are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. Extracellular signals are received by receptors, which activate the G proteins, which in turn route the signals to several distinct intracellular signaling pathways. The alpha subunit of G proteins is a weak GTPase. In the resting state, heterotrimeric G proteins are associated at the cytosolic face of the plasma membrane and the alpha subunit binds to GDP. Upon activation by a receptor GDP is replaced with GTP, and the G-alpha/GTP complex dissociates from the beta and gamma subunits. This results in activation of downstream signaling pathways, such as cAMP synthesis by adenylyl cyclase, which is terminated when GTP is hydrolized and the heterotrimers reconstitute.


Pssm-ID: 206639 [Multi-domain]  Cd Length: 315  Bit Score: 184.27  E-value: 4.72e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609402  59 SEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGDPHCLRDVQKFLVEC 138
Cdd:cd00066  195 SEYDQVLVEDESVNRMQESLKLFDSICNSRWFANTSIILFLNKKDLFEEKIKKSPLTDYFPDYTGPPNDYEEAAKYIKKK 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 119609402 139 FRNKRRDqQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNL 180
Cdd:cd00066  275 FLDLNRN-PNKEIYPHFTCATDTENIRFVFDAVKDIILQNNL 315
G-alpha pfam00503
G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular ...
 59-175 9.58e-49

G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.


Pssm-ID: 459835 [Multi-domain]  Cd Length: 316  Bit Score: 160.45  E-value: 9.58e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609402   59 SEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGDPHCLRDVQKFLVEC 138
Cdd:pfam00503 201 SEYDQVLYEDDSTNRMEESLKLFEEICNSPWFKNTPIILFLNKKDLFEEKLKKSPLSDYFPDYTGNPNDYEEALKYIRNK 280

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 119609402  139 FRNKRRDqQQKPLYHHFTTAINTENIRLVFRDVKDTI 175
Cdd:pfam00503 281 FLDLNKN-PNRKIYTHFTCATDTENIRFVFDAVKDII 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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