microtubule associated monoxygenase, calponin and LIM domain containing 1, isoform CRA_a [Homo sapiens]
bMERB family protein( domain architecture ID 10572780)
bMERB (bivalent Mical/EHBP Rab binding) family protein is a DUF3585 domain-containing protein; similar to Mus musculus MICAL C-terminal-like protein, which may cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa
List of domain hits
Name | Accession | Description | Interval | E-value | |||
bMERB_dom | pfam12130 | Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact ... |
157-283 | 3.25e-41 | |||
Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact specifically with GTP-bound Rab proteins and mediate their versatile roles in membrane trafficking, including budding of vesicles from a donor membrane, directed transport through the cell and finally tethering and fusion with a target membrane. The 'bivalent Mical/EHBP Rab binding' (bMERB) domain is a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in endosomal trafficking. The bMERB domain displays a preference for Rab8 family proteins (Rab8, 10, 13 and 15) and at least some of the bMERB domains contain two separate binding sites for Rab-proteins, allowing Micals and EHBPs to bind two Rabs simultaneously. The strong similarity between the two binding sites within one bMRB domain strongly suggests an evolutionarily development via duplication of a common ancestor supersecondary structure element. The bMERB domain has a completely alpha-helical fold consisting of a central helix and N- and C-terminal helices folding back on this central helix. : Pssm-ID: 463467 [Multi-domain] Cd Length: 131 Bit Score: 138.80 E-value: 3.25e-41
|
|||||||
Name | Accession | Description | Interval | E-value | |||
bMERB_dom | pfam12130 | Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact ... |
157-283 | 3.25e-41 | |||
Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact specifically with GTP-bound Rab proteins and mediate their versatile roles in membrane trafficking, including budding of vesicles from a donor membrane, directed transport through the cell and finally tethering and fusion with a target membrane. The 'bivalent Mical/EHBP Rab binding' (bMERB) domain is a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in endosomal trafficking. The bMERB domain displays a preference for Rab8 family proteins (Rab8, 10, 13 and 15) and at least some of the bMERB domains contain two separate binding sites for Rab-proteins, allowing Micals and EHBPs to bind two Rabs simultaneously. The strong similarity between the two binding sites within one bMRB domain strongly suggests an evolutionarily development via duplication of a common ancestor supersecondary structure element. The bMERB domain has a completely alpha-helical fold consisting of a central helix and N- and C-terminal helices folding back on this central helix. Pssm-ID: 463467 [Multi-domain] Cd Length: 131 Bit Score: 138.80 E-value: 3.25e-41
|
|||||||
Name | Accession | Description | Interval | E-value | |||
bMERB_dom | pfam12130 | Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact ... |
157-283 | 3.25e-41 | |||
Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact specifically with GTP-bound Rab proteins and mediate their versatile roles in membrane trafficking, including budding of vesicles from a donor membrane, directed transport through the cell and finally tethering and fusion with a target membrane. The 'bivalent Mical/EHBP Rab binding' (bMERB) domain is a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in endosomal trafficking. The bMERB domain displays a preference for Rab8 family proteins (Rab8, 10, 13 and 15) and at least some of the bMERB domains contain two separate binding sites for Rab-proteins, allowing Micals and EHBPs to bind two Rabs simultaneously. The strong similarity between the two binding sites within one bMRB domain strongly suggests an evolutionarily development via duplication of a common ancestor supersecondary structure element. The bMERB domain has a completely alpha-helical fold consisting of a central helix and N- and C-terminal helices folding back on this central helix. Pssm-ID: 463467 [Multi-domain] Cd Length: 131 Bit Score: 138.80 E-value: 3.25e-41
|
|||||||
Blast search parameters | ||||
|