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Conserved domains on  [gi|300116332|emb|CBL95002|]
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leucine-rich repeat-containing G protein-coupled receptor 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 486-759 3.40e-173

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320485  Cd Length: 274  Bit Score: 500.53  E-value: 3.40e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 565
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 566 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 645
Cdd:cd15363   81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 646 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 725
Cdd:cd15363  161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 300116332 726 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-405 6.50e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 6.50e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  47 LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNql 126
Cdd:COG4886   29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 127 rhvptEALQNLRSLQSLHLHNNRIHSLGKkCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEkAFV 206
Cdd:COG4886  107 -----EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 207 GNPSLITIHFYDNPIQFVGrSAFQHLPELRTLTLNGaSQITEFPD-LTGTANLESLTLTGAQISSLPQTvcNQLPNLQVL 285
Cdd:COG4886  180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG-NQLTDLPEpLANLTNLETLDLSNNQLTDLPEL--GNLTNLEEL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 286 DLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF 365
Cdd:COG4886  256 DLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 300116332 366 PITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 405
Cdd:COG4886  336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
 
Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 486-759 3.40e-173

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 500.53  E-value: 3.40e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 565
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 566 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 645
Cdd:cd15363   81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 646 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 725
Cdd:cd15363  161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 300116332 726 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-405 6.50e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 6.50e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  47 LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNql 126
Cdd:COG4886   29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 127 rhvptEALQNLRSLQSLHLHNNRIHSLGKkCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEkAFV 206
Cdd:COG4886  107 -----EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 207 GNPSLITIHFYDNPIQFVGrSAFQHLPELRTLTLNGaSQITEFPD-LTGTANLESLTLTGAQISSLPQTvcNQLPNLQVL 285
Cdd:COG4886  180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG-NQLTDLPEpLANLTNLETLDLSNNQLTDLPEL--GNLTNLEEL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 286 DLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF 365
Cdd:COG4886  256 DLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 300116332 366 PITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 405
Cdd:COG4886  336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-312 2.99e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.74  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR-HVPTEaLQNLRSLQSLHLHNNR 149
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRE-LGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 150 IHSLGKKCFDGLHSLETLDLNYNNLD-EFPTAIRTLSNLKELGFHSNNIR-SIPEKAFvGNPSLITIHFYDNPI------ 221
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLsgeipe 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 222 ----------------QFVGR--SAFQHLPELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISS-LPQTVCNQlPN 281
Cdd:PLN00113 303 lviqlqnleilhlfsnNFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLSTNNLTGeIPEGLCSS-GN 381

                        250       260       270
                 ....*....|....*....|....*....|...
gi 300116332 282 LQVLDLSYNLLEDL--PSFSVCQKLQKIDLRHN 312
Cdd:PLN00113 382 LFKLILFSNSLEGEipKSLGACRSLRRVRLQDN 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-314 3.40e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.59  E-value: 3.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  95 LRLAGNALTYIpkGAFTGLYSLKVLMLQNNQLRHVptEALQNLRSLQSLHLHNNRIHSLGKkcFDGLHSLETLDLNYNNl 174
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 175 defptaIRTLSNLKELgfhsnnirsipekafvgnPSLITIHFyDNpiqfvgrsafQHLPELRTLTLNGASqitefpdLTG 254
Cdd:cd21340   80 ------ISVVEGLENL------------------TNLEELHI-EN----------QRLPPGEKLTFDPRS-------LAA 117

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300116332 255 TAN-LESLTLTGAQISSLPQTVCnqLPNLQVLDLSYNLLEDL----PSFSVCQKLQKIDLRHNEI 314
Cdd:cd21340  118 LSNsLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
115-174 3.94e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 3.94e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 174
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 503-748 2.57e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  503 NALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSfarhgawWENG-VGCHVIGFLSIFASESSVF 581
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  582 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA----SPLCLP-LPFGEPSTMGYMVA 656
Cdd:pfam00001  75 LLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKPVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  657 LILLNSLC-FLMMTIAYTKLYC------NLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 729
Cdd:pfam00001 155 ISVLGFLLpLLVILVCYTLIIRtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234

                         250       260
                  ....*....|....*....|..
gi 300116332  730 KFILLVVVPLP---ACLNPLLY 748
Cdd:pfam00001 235 DKALSVTLWLAyvnSCLNPIIY 256
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-70 5.85e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 5.85e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 300116332    33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLSVFTSY 70
Cdd:smart00013   1 ACPAPCNCSG-----TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 486-759 3.40e-173

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 500.53  E-value: 3.40e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 565
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 566 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 645
Cdd:cd15363   81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 646 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 725
Cdd:cd15363  161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 300116332 726 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 486-759 5.33e-156

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 456.24  E-value: 5.33e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 565
Cdd:cd15138    1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSLPPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 566 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 645
Cdd:cd15138   81 KVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFPT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 646 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 725
Cdd:cd15138  161 GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLISIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 300116332 726 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15138  241 PEIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 486-759 1.18e-116

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 354.87  E-value: 1.18e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 565
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 566 HVIGFLSIFASESSVFLLTLAALERGFSVKySAKFETKAP-FSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLP-- 642
Cdd:cd15362   81 RATGFLSVFASEASILLLTLAAVQCSVSVS-CVRAYGKSPsLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPsp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 643 LPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLT 722
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 300116332 723 FISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 276
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 486-758 9.01e-86

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 274.05  E-value: 9.01e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 565
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 566 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 645
Cdd:cd15361   81 KVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 646 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 725
Cdd:cd15361  161 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 300116332 726 PEVIKFILLVVVPLPACLNPLLYILFNPHFKED 758
Cdd:cd15361  241 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 273
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 486-759 2.22e-82

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 265.64  E-value: 2.22e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPI-KLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 564
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKKVpKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 565 CHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFEtKAPFSSLKVIILLCALLALTMAAVPLLGGSK-------YGAS 637
Cdd:cd14980   81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILYSINqpgdnrlYGYS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 638 PLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKG-----DLENIWDCSMVKHIALLLFTNCILNCPVAF 712
Cdd:cd14980  160 SICMPSNVSNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSrksarRSSSKRDKRIAIRLALILITDLICWLPYYI 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 300116332 713 LSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd14980  240 VIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 486-759 3.74e-50

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 177.79  E-value: 3.74e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 486 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 565
Cdd:cd15136    1 WWLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 566 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 645
Cdd:cd15136   81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFET 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 646 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLdkGDLENIW---DCSMVKHIALLLFTNCILNCPVAFLSFSSLINLT 722
Cdd:cd15136  161 ETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSV--RGSGRAAnsnDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGLP 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 300116332 723 FISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15136  239 LISVSNAKILLVFFYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 487-759 1.86e-36

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 138.88  E-value: 1.86e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 487 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 566
Cdd:cd15964    2 FLRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 567 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 646
Cdd:cd15964   82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 647 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNL-----DKGDLeniwDCSMVKHIALLLFTNCILNCPVAFLSFSSLINL 721
Cdd:cd15964  162 TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVrnpqyKSGDK----DTKIAKRMAVLIFTDFICMAPISFYALSAILNK 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 300116332 722 TFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15964  238 PLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRRDV 275
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 487-759 2.08e-34

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 133.06  E-value: 2.08e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 487 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 566
Cdd:cd15360    2 ILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 567 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 646
Cdd:cd15360   82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 647 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGD-LENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 725
Cdd:cd15360  162 SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNfVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLIT 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 300116332 726 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15360  242 VSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-405 6.50e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 6.50e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  47 LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNql 126
Cdd:COG4886   29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 127 rhvptEALQNLRSLQSLHLHNNRIHSLGKkCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEkAFV 206
Cdd:COG4886  107 -----EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 207 GNPSLITIHFYDNPIQFVGrSAFQHLPELRTLTLNGaSQITEFPD-LTGTANLESLTLTGAQISSLPQTvcNQLPNLQVL 285
Cdd:COG4886  180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG-NQLTDLPEpLANLTNLETLDLSNNQLTDLPEL--GNLTNLEEL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 286 DLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF 365
Cdd:COG4886  256 DLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 300116332 366 PITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 405
Cdd:COG4886  336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 487-759 1.19e-33

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 130.75  E-value: 1.19e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 487 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 566
Cdd:cd15359    2 FLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 567 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 646
Cdd:cd15359   82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 647 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENI-WDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 725
Cdd:cd15359  162 TLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLIT 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 300116332 726 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15359  242 VTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-393 1.36e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.13  E-value: 1.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  55 LGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEAL 134
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 135 QNLRSLQSLHLHNNRIhslgkkcFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEkAFVGNPSLITI 214
Cdd:COG4886   93 GDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 215 HFYDNPIQFVGrSAFQHLPELRTLTLNGaSQITEFPD-LTGTANLESLTLTGAQISSLPQTVCNqLPNLQVLDLSYNLLE 293
Cdd:COG4886  165 DLSNNQLTDLP-EELGNLTNLKELDLSN-NQITDLPEpLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 294 DLPSFSVCQKLQKIDLRHNEIYEIkvDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGL 373
Cdd:COG4886  242 DLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                        330       340
                 ....*....|....*....|
gi 300116332 374 THLKLTGNHALQSLISSENF 393
Cdd:COG4886  320 LTTLLLLLLLLKGLLVTLTT 339
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 487-757 7.26e-31

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 122.69  E-value: 7.26e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 487 LIRIGVWTIAVLALTCNALVTstVFRSPLYISPI--KLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 564
Cdd:cd15137    2 VLRVFIWVVGIIALLGNLFVL--IWRLKYKEENKvhSFLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 565 CHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFeTKAPFSSLKVIILLCALLALTMAAVPLLG----GSKYGASPLC 640
Cdd:cd15137   80 CTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSG-RRLGLRRAIIVLACIWLIGLLLAVLPLLPwdyfGNFYGRSGVC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 641 LPLPFGEPSTMG--YMVALIL-LNSLCFLMMTIAYTKLYCNLDK-----GDLENIWDCSMVKHIALLLFTNCILNCPVAF 712
Cdd:cd15137  159 LPLHITDERPAGweYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPIIV 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 300116332 713 LSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKE 757
Cdd:cd15137  239 IGILALSGVP-IPGEVYAWVAVFVLPINSALNPILYTLSTPKFRK 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-399 1.17e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 1.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 136 NLRSLQSLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIh 215
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSL- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 216 fYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFpdltgtANLESLTLTGAQISSLPQTVCNqLPNLQVLDLSYNLLEDL 295
Cdd:COG4886   80 -LLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL------TNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 296 PS-FSVCQKLQKIDLRHNEIYEIKvDTFQQLLSLRSLNLAWNKIAIIhPNAFSTLPSLIKLDLSSNLLSSFP--ITGLHG 372
Cdd:COG4886  152 PEpLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPepLANLTN 229

                        250       260
                 ....*....|....*....|....*..
gi 300116332 373 LTHLKLTGNHaLQSLISSENFPELKVI 399
Cdd:COG4886  230 LETLDLSNNQ-LTDLPELGNLTNLEEL 255
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 495-752 1.70e-16

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 80.41  E-value: 1.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 495 IAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTfgsfarhGAWWENGVGCHVIGFLSIF 574
Cdd:cd00637    8 IFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLL-------GRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 575 ASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKY--GASPLCLPLPFGEPSTMG 652
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYdyGGYCCCCLCWPDLTLSKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 653 YMVALILLN-SLCFLMMTIAYTKLYCNL-------------DKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSF-SS 717
Cdd:cd00637  161 YTIFLFVLLfLLPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLlDV 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 300116332 718 LINLTFISPEVIKFILLVVVPLPACLNPLLYILFN 752
Cdd:cd00637  241 FGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-312 2.99e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.74  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR-HVPTEaLQNLRSLQSLHLHNNR 149
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRE-LGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 150 IHSLGKKCFDGLHSLETLDLNYNNLD-EFPTAIRTLSNLKELGFHSNNIR-SIPEKAFvGNPSLITIHFYDNPI------ 221
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLsgeipe 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 222 ----------------QFVGR--SAFQHLPELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISS-LPQTVCNQlPN 281
Cdd:PLN00113 303 lviqlqnleilhlfsnNFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLSTNNLTGeIPEGLCSS-GN 381

                        250       260       270
                 ....*....|....*....|....*....|...
gi 300116332 282 LQVLDLSYNLLEDL--PSFSVCQKLQKIDLRHN 312
Cdd:PLN00113 382 LFKLILFSNSLEGEipKSLGACRSLRRVRLQDN 414
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 487-759 1.12e-15

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 78.29  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 487 LIRIGVWTIAVLALTCNALVTS--TVFRSPLYISpiKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 564
Cdd:cd15966    2 ILRVFVWVMAFITCFGNLFVIGmrSFIRAENKTH--AMCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 565 CHVIGFLSIFASESSVFLLTLAALERGFSVKYsakfetkaPFSSLK-------VIILLCALLALTMAAVPLLG----GSK 633
Cdd:cd15966   80 CRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVF--------PFSNIRpgkcqtlIILISIWLVGFIIAVIPFWNedffGNY 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 634 YGASPLCLPLPFG---EPSTMGYMVALIL-LNSLCFLMMTIAYTKLYCNLDKGDLENI-------WDCSMVKHIALLLFT 702
Cdd:cd15966  152 YGKNGVCFPLHSDqteKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQKTGLQTTevrshihRDVAVANRFFFIVFS 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 300116332 703 NCILNCPVAFLSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 759
Cdd:cd15966  232 DAICWIPIFLLKILSLFQVE-IPGTITSWIVIFILPINSALNPILYTLTTSFFKEKL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-354 1.38e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.43  E-value: 1.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLHLHNNri 150
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTN-- 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 151 hSLGKKCFDGLHS---LETLDLNYNNLD-EFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGR 226
Cdd:PLN00113 367 -NLTGEIPEGLCSsgnLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRIN 445

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 227 SAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQIS-SLPQTVCNqLPNLQVLDLSYNLLE-DLPS-FSVCQK 303
Cdd:PLN00113 446 SRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGS-LSELMQLKLSENKLSgEIPDeLSSCKK 524

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 300116332 304 LQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIK 354
Cdd:PLN00113 525 LVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQ 575
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-314 3.40e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.59  E-value: 3.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  95 LRLAGNALTYIpkGAFTGLYSLKVLMLQNNQLRHVptEALQNLRSLQSLHLHNNRIHSLGKkcFDGLHSLETLDLNYNNl 174
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 175 defptaIRTLSNLKELgfhsnnirsipekafvgnPSLITIHFyDNpiqfvgrsafQHLPELRTLTLNGASqitefpdLTG 254
Cdd:cd21340   80 ------ISVVEGLENL------------------TNLEELHI-EN----------QRLPPGEKLTFDPRS-------LAA 117

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300116332 255 TAN-LESLTLTGAQISSLPQTVCnqLPNLQVLDLSYNLLEDL----PSFSVCQKLQKIDLRHNEI 314
Cdd:cd21340  118 LSNsLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-263 3.90e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  51 DCSDLGLSELPSNLSVFTS--YLDLSMNNISQLlPNPLPSLRFLEELRLAGNALTYIPkgAFTGLYSLKVLMLQNNQLRH 128
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNleELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 129 VPTEAlqNLRSLQSLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGN 208
Cdd:COG4886  265 LPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 300116332 209 PSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTL 263
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR_8 pfam13855
Leucine rich repeat;
115-174 3.94e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 3.94e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 174
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 487-757 1.66e-12

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 68.74  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 487 LIRIGVWtiAVLALTCNALVTSTVFRSplYISPIKLL----IGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENG 562
Cdd:cd15965    2 VQRVFVW--VVSAVTCFGNIFVICMRP--YIRSENKLhamsIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 563 VGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIIlLCALLALTMAAVPLLGG----SKYGASP 638
Cdd:cd15965   78 TQCQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTITILI-LIWIIGFIIAFIPLSNKeffrNYYGTNG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 639 LCLPLPFGEPSTMG---YMVALIL-LNSLCFLMMTIAYTKLYCNLDKGDLENIW-------DCSMVKHIALLLFTNCILN 707
Cdd:cd15965  157 VCFPLHSEQPESTGaqiYSVVIFLgLNLAAFIIIVFSYGSMFYSIHQTAIMATEisnhikkEMTLAKRFFFIVFTDALCW 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 300116332 708 CPVAFLSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKE 757
Cdd:cd15965  237 IPIFILKLLSLLQVE-IPGTISSWVVIFILPINSALNPILYTLTTRPFKE 285
LRR_8 pfam13855
Leucine rich repeat;
92-150 1.67e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 1.67e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 300116332   92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLHLHNNRI 150
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
94-327 6.95e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 6.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  94 ELRLAGNALT----YIPKGAFTglyslkvLMLQNNQLRHVPtEALQNlrSLQSLHLHNNRIHSLGKKCFDglhSLETLDL 169
Cdd:PRK15370 182 ELRLKILGLTtipaCIPEQITT-------LILDNNELKSLP-ENLQG--NIKTLYANSNQLTSIPATLPD---TIQEMEL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 170 NYNNLDEFP----TAIRTL---------------SNLKELGFHSNNIRSIPEKAfvgnPSLIT-IHFYDNPIQFVGRSAf 229
Cdd:PRK15370 249 SINRITELPerlpSALQSLdlfhnkisclpenlpEELRYLSVYDNSIRTLPAHL----PSGIThLNVQSNSLTALPETL- 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 230 qhLPELRTLTLnGASQITEFPDLTGTAnLESLTLTGAQISSLPQTVCnqlPNLQVLDLSYNLL----------------- 292
Cdd:PRK15370 324 --PPGLKTLEA-GENALTSLPASLPPE-LQVLDVSKNQITVLPETLP---PTITTLDVSRNALtnlpenlpaalqimqas 396

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 300116332 293 --------EDLPSF-SVCQKLQKIDLRHNEIYEIKVDTFQQLLS 327
Cdd:PRK15370 397 rnnlvrlpESLPHFrGEGPQPTRIIVEYNPFSERTIQNMQRLMS 440
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 71-314 8.62e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.91  E-value: 8.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  71 LDLSMNNISQL----LPNPLPSLRFLEELRLAGNALTYIPKG------AFTGLYSLKVLMLQNNQLRHVPTEALQNLR-- 138
Cdd:cd00116   28 LRLEGNTLGEEaakaLASALRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLLrs 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 139 -SLQSLHLHNNRIHSLG-KKCFDGL----HSLETLDLNYNNLdefptairTLSNLKELGfhsnnirsipeKAFVGNPSLI 212
Cdd:cd00116  108 sSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRL--------EGASCEALA-----------KALRANRDLK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 213 TIHFYDNPIQFVG----RSAFQHLPELRTLTLN-------GASQITE-FPDLtgtANLESLTLTGAQISSLP-QTVCNQL 279
Cdd:cd00116  169 ELNLANNGIGDAGiralAEGLKANCNLEVLDLNnngltdeGASALAEtLASL---KSLEVLNLGDNNLTDAGaAALASAL 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 300116332 280 PN----LQVLDLSYNLLEDLPSFSVCQ------KLQKIDLRHNEI 314
Cdd:cd00116  246 LSpnisLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
138-197 6.68e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 6.68e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300116332  138 RSLQSLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNI 197
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
280-338 2.65e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.65e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300116332  280 PNLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 338
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 132-338 2.69e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.11  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 132 EALQNLRSLQSLHLHNNRI-----HSLGKKCFDGlHSLETLDLNYNNLDEfPTAIRTLSNLKelgfhsnnirsipekafv 206
Cdd:COG5238  230 EALKGNKSLTTLDLSNNQIgdegvIALAEALKNN-TTVETLYLSGNQIGA-EGAIALAKALQ------------------ 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 207 GNPSLITIHFYDNPIQFVGRSAFQhlpelrtltlngasqitefPDLTGTANLESLTLTGAQIS-----SLPQTVcNQLPN 281
Cdd:COG5238  290 GNTTLTSLDLSVNRIGDEGAIALA-------------------EGLQGNKTLHTLNLAYNGIGaqgaiALAKAL-QENTT 349

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300116332 282 LQVLDLSYNLLEDLPSFSVCQKLQ------KIDLRHNEIYEIKVDTFQQLL---SLRSLNLAWNKI 338
Cdd:COG5238  350 LHSLDLSDNQIGDEGAIALAKYLEgnttlrELNLGKNNIGKQGAEALIDALqtnRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
185-242 3.16e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.16e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 300116332  185 SNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG 242
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
302-382 1.03e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  302 QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFStlpslikldlssnllssfpitGLHGLTHLKLTGN 381
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS---------------------GLPSLRYLDLSGN 59


                  .
gi 300116332  382 H 382
Cdd:pfam13855  60 R 60
LRR_8 pfam13855
Leucine rich repeat;
257-314 1.00e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  257 NLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEI 314
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-221 2.76e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 2.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  57 LSELPSNLSVFTSYLDLSMNNISqLLPNPLP-SLRFLEELRlagNALTYIPKGAFTGLYSLKVlmlQNNQLRHVPTEALQ 135
Cdd:PRK15370 253 ITELPERLPSALQSLDLFHNKIS-CLPENLPeELRYLSVYD---NSIRTLPAHLPSGITHLNV---QSNSLTALPETLPP 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 136 NLR------------------SLQSLHLHNNRIHSLGKKCfdgLHSLETLDLNYNNLDEFPTAIRtlSNLKELGFHSNNI 197
Cdd:PRK15370 326 GLKtleagenaltslpaslppELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400

                        170       180
                 ....*....|....*....|....*....
gi 300116332 198 RSIPEK--AFVG---NPSLITIHFydNPI 221
Cdd:PRK15370 401 VRLPESlpHFRGegpQPTRIIVEY--NPF 427
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 494-756 3.39e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 49.74  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 494 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMltgvssavlaGVDAFTF---GSFARHGAWWENGVGCHVIGF 570
Cdd:cd15073    9 VAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDL----------GVSIIGYpfsAASDLHGSWKFGYAGCQWYAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 571 LSIFASESSVFLLTLAALERgFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASP---LC-LPLPFG 646
Cdd:cd15073   79 LNIFFGMASIGLLTVVAVDR-YLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPtgaTCtINWRKN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 647 EPSTMGYMVALILLN-SLCFLMMTIAYTKLYCNLDKGDLENIW-----DCSMVKHIALLLFTnCILNCPVAFLSFSSLIN 720
Cdd:cd15073  158 DSSFVSYTMSVIVVNfIVPLAVMFYCYYNVSRFVKKVLASDCLesvniDWTDQNDVTKMSVI-MIVMFLVAWSPYSIVCL 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 300116332 721 LT-FISPEVIKFILLVVVPLPA----CLNPLLYILFNPHFK 756
Cdd:cd15073  237 WAsFGEPKKIPPWMAIIPPLFAksstFYNPCIYVIANKKFR 277
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 494-757 3.64e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 49.51  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 494 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLtgvsSAVLAGVdaFTFGSFARHgaWWENG-VGCHVIGFLS 572
Cdd:cd14969    9 LIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLL----MSVVGYP--LSFYSNLSG--RWSFGdPGCVIYGFAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 573 IFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIIlLCALLALTMAAVPLLGGSKYGASPL---CLP-LPFGEP 648
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIA-FIWLYGLFWALPPLFGWSSYVPEGGgtsCSVdWYSKDP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 649 STMGYMVALILlnsLCFLM----MTIAYTKLYC-----------NLDKGDLENIWDCSM--VKHIALLLFTNCILNCPVA 711
Cdd:cd14969  160 NSLSYIVSLFV---FCFFLplaiIIFCYYKIYRtlrkmskraarRKNSAITKRTKKAEKkvAKMVLVMIVAFLIAWTPYA 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 300116332 712 FLSFSSLIN-LTFISPevikfiLLVVVP-----LPACLNPLLYILFNPHFKE 757
Cdd:cd14969  237 VVSLYVSFGgESTIPP------LLATIPalfakSSTIYNPIIYVFMNKQFRR 282
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-304 7.57e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 7.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  69 SYLDLSMNNISQLLPNPLPSLR---FLEELRLAGNALTyIPKGAF--TGLYS----LKVLMLQNNQLRHVPTEALQNL-- 137
Cdd:cd00116   84 QELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLG-DRGLRLlaKGLKDlppaLEKLVLGRNRLEGASCEALAKAlr 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 138 --RSLQSLHLHNNRIHSLG--KKCFDGLHS--LETLDLNYNNLDE-----FPTAIRTLSNLKELGFHSNNIRSIPEKAFV 206
Cdd:cd00116  163 anRDLKELNLANNGIGDAGirALAEGLKANcnLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALA 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 207 -----GNPSLITIHFYDNPIqfvGRSAFQHLPElrtltlngasqitefpdltgtanlesltltgaqisslpqtVCNQLPN 281
Cdd:cd00116  243 sallsPNISLLTLSLSCNDI---TDDGAKDLAE----------------------------------------VLAEKES 279

                        250       260
                 ....*....|....*....|...
gi 300116332 282 LQVLDLSYNLLEDLPSFSVCQKL 304
Cdd:cd00116  280 LLELDLRGNKFGEEGAQLLAESL 302
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 503-748 2.57e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  503 NALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSfarhgawWENG-VGCHVIGFLSIFASESSVF 581
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  582 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA----SPLCLP-LPFGEPSTMGYMVA 656
Cdd:pfam00001  75 LLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKPVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  657 LILLNSLC-FLMMTIAYTKLYC------NLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 729
Cdd:pfam00001 155 ISVLGFLLpLLVILVCYTLIIRtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234

                         250       260
                  ....*....|....*....|..
gi 300116332  730 KFILLVVVPLP---ACLNPLLY 748
Cdd:pfam00001 235 DKALSVTLWLAyvnSCLNPIIY 256
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 57-354 3.96e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 47.56  E-value: 3.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332   57 LSELPsNLSVFTSYLDLSMNNISQL--LPNPLPSLRFLEELRLAG-NALTYIPKGAftglyslkvlmlqnnqlrhvptea 133
Cdd:PLN03210  647 LKEIP-DLSMATNLETLKLSDCSSLveLPSSIQYLNKLEDLDMSRcENLEILPTGI------------------------ 701

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  134 lqNLRSLQSLHLHN-NRIHSLgkkcFDGLHSLETLDLNYNNLDEFPTAIRtLSNLKELGFHSNNIRSIPEKA-------F 205
Cdd:PLN03210  702 --NLKSLYRLNLSGcSRLKSF----PDISTNISWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVqpltplmT 774

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  206 VGNPSLITIHFYDNPIQFVGRSAFQHL-----------------------PELRTLTLNGASQITEFPDLtgTANLESLT 262
Cdd:PLN03210  775 MLSPSLTRLFLSDIPSLVELPSSIQNLhklehleiencinletlptginlESLESLDLSGCSRLRTFPDI--STNISDLN 852

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  263 LTGAQISSLPQTVcNQLPNLQVLDLSYnlledlpsfsvCQKLQKIDLRHNEIYEIKVDTFQQLLSLR--SLNLAWNKIAI 340
Cdd:PLN03210  853 LSRTGIEEVPWWI-EKFSNLSFLDMNG-----------CNNLQRVSLNISKLKHLETVDFSDCGALTeaSWNGSPSEVAM 920

                         330
                  ....*....|....
gi 300116332  341 IHPNAFSTLPSLIK 354
Cdd:PLN03210  921 ATDNIHSKLPSTVC 934
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 280-312 6.18e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 6.18e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 300116332  280 PNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHN 312
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 492-757 8.35e-05

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 45.25  E-value: 8.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 492 VWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFtfgsfarHGAWWENGVGCHVIGFL 571
Cdd:cd14967    6 LSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTL-------LGYWPFGPVLCRFWIAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 572 SIFASESSVFLLTLAALERGFSV----KYSAKFETKapfsSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGE 647
Cdd:cd14967   79 DVLCCTASILNLCAISLDRYLAItrplRYRQLMTKK----RALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 648 PSTmGYMVALILLNSLC-FLMMTIAYTKLYCNLDKgdleniwDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTF-IS 725
Cdd:cd14967  155 PNK-IYVLVSSVISFFIpLLIMIVLYARIFRVARR-------ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDcVP 226

                        250       260       270
                 ....*....|....*....|....*....|..
gi 300116332 726 PEVIKFILLVVVpLPACLNPLLYILFNPHFKE 757
Cdd:cd14967  227 PILYAVFFWLGY-LNSALNPIIYALFNRDFRR 257
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 51-338 9.25e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  51 DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRlagnALTYIPKGaftglysLKVLMLQNNQLRHVP 130
Cdd:COG5238   99 EVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLI----QVLKDPLG-------GNAVHLLGLAARLGL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 131 TEALQNLRSLQSlhlhnnrihslgkkcfdglHSLETLDLNYNNLDEfptairtlSNLKELGfhsnnirsipeKAFVGNPS 210
Cdd:COG5238  168 LAAISMAKALQN-------------------NSVETVYLGCNQIGD--------EGIEELA-----------EALTQNTT 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 211 LITIHFYDNPIQFVGRSAF----QHLPELRTLTLN-------GASQITEFpdLTGTANLESLTLTGAQIS-----SLPQT 274
Cdd:COG5238  210 VTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSnnqigdeGVIALAEA--LKNNTTVETLYLSGNQIGaegaiALAKA 287

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300116332 275 VCNQlPNLQVLDLSYNLLED------LPSFSVCQKLQKIDLRHNEI----YEIKVDTFQQLLSLRSLNLAWNKI 338
Cdd:COG5238  288 LQGN-TTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIgaqgAIALAKALQENTTLHSLDLSDNQI 360
PLN03150 PLN03150
hypothetical protein; Provisional
 119-220 1.29e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 119 LMLQNNQLRHVPTEALQNLRSLQSLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLD-EFPTAIRTLSNLKELGFHSNNI 197
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502

                         90       100
                 ....*....|....*....|....
gi 300116332 198 RSIPEKAFVGNPSLITI-HFYDNP 220
Cdd:PLN03150 503 SGRVPAALGGRLLHRASfNFTDNA 526
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 139-189 1.79e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 300116332  139 SLQSLHLHNNRIHSLGKkcFDGLHSLETLDLNYNNLdefptaIRTLSNLKE 189
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK------ITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
70-126 4.47e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 300116332   70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-65 5.08e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 5.08e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 300116332   33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLS 65
Cdd:pfam01462   1 ACPVPCHCSA-----TVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-70 5.85e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 5.85e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 300116332    33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLSVFTSY 70
Cdd:smart00013   1 ACPAPCNCSG-----TAVDCSGRGLTEVPLDLPPDTTL 33
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 100-236 1.03e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  100 NALTYIPKGAFTGLYSLKVLMLQNNqLRHVPTEALQNLrSLQSLHLHNNrIHSLGKKCFDGLHSLETLDLnynnldefpt 179
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITL---------- 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 300116332  180 airtlsnlkelgfhSNNIRSIPEKAFVGNpSLITIHFYDNpIQFVGRSAFQHLPELR 236
Cdd:pfam13306  87 --------------PSNLTSIGSYAFSNC-SLKSITIPSS-VTTIGSYAFSNCSNLK 127
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 495-759 2.09e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 41.11  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 495 IAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFgsfarhgAWWENGVGCHVIGFLSIF 574
Cdd:cd15074   10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAH-------RWLFGDIGCVFYGFCGFL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 575 ASESSVFLLTLAALER---GFSVKYSAKFETKAPFSSLKVIillcALLALTMAAVPLLGGSKYGasplclPLPFG----- 646
Cdd:cd15074   83 FGCCSINTLTAISIYRylkICHPPYGPKLSRRHVCIVIVAI----WLYALFWAVAPLVGWGSYG------PEPFGtscsi 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 647 -------EPSTMGYMVALILlnsLCFLM----MTIAYTKLYCNLDKGDLENIWDCSMVKHIALL---LFTNCILNC---- 708
Cdd:cd15074  153 dwtgasaSVGGMSYIISIFI---FCYLLpvliIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIerkVTKVAVLICagfl 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 300116332 709 ----PVAFLSFSSlinlTFISPEVIKFILLVVVPLPA---CL-NPLLYILFNPHFKEDL 759
Cdd:cd15074  230 iawtPYAVVSMWS----AFGSPDSVPILASILPALFAkssCMyNPIIYLLFSSKFRQDL 284
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-168 2.37e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  87 PSLRFLEelrLAGNALTYIpkGAFTGLYSLKVLMLQNNQLRHVP--TEALQNLRSLQSLHLHNNRIhSLGKKCFDGL--- 161
Cdd:cd21340  120 NSLRVLN---ISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV-CKKPKYRDKIila 193


                 ....*...
gi 300116332 162 -HSLETLD 168
Cdd:cd21340  194 sKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 67-150 3.65e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLHLH 146
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498


                 ....
gi 300116332 147 NNRI 150
Cdd:PLN03150 499 GNSL 502
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 158-392 4.19e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 158 FDGLHSLETLDLNYNNLDE-----FPTAIRTLSNLKELGFHSNNIRSIPEkafvgnpslitihfydnpiqFVGR--SAFQ 230
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLNETGRIPR--------------------GLQSllQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 231 HLPELRTLTLN----GASQITEFPDLTGTANLESLTLTGAQISSLP-QTVCNQL----PNLQVLDLSYNLLEDLPS---- 297
Cdd:cd00116   79 KGCGLQELDLSdnalGPDGCGVLESLLRSSSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRLEGASCeala 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332 298 --FSVCQKLQKIDLRHNEIYEIKVDTFQQLL----SLRSLNLAWNKI----AIIHPNAFSTLPSLIKLDLSSNllssfPI 367
Cdd:cd00116  159 kaLRANRDLKELNLANNGIGDAGIRALAEGLkancNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDN-----NL 233

                        250       260
                 ....*....|....*....|....*...
gi 300116332 368 TgLHGLTHLK---LTGNHALQSLISSEN 392
Cdd:cd00116  234 T-DAGAAALAsalLSPNISLLTLSLSCN 260
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 185-347 5.91e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.52  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  185 SNLKELGFhSNNIRSIPEKAFVGNPSLITIHFYDNpIQFVGRSAFQHlpelrtltlngasqitefpdltgtANLESLTLt 264
Cdd:pfam13306  11 CSLTSITI-PSSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYN------------------------CSLTSITI- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300116332  265 GAQISSLPqtvcnqlpnlqvldlSYnlledlpSFSVCQKLQKIDLRHNeIYEIKVDTFQQlLSLRSLNLaWNKIAIIHPN 344
Cdd:pfam13306  64 PSSLTSIG---------------EY-------AFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSITI-PSSVTTIGSY 118


                  ...
gi 300116332  345 AFS 347
Cdd:pfam13306 119 AFS 121
LRR_8 pfam13855
Leucine rich repeat;
233-292 6.38e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300116332  233 PELRTLTLNGaSQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 292
Cdd:pfam13855   1 PNLRSLDLSN-NRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 257-299 9.37e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 9.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 300116332  257 NLESLTLTGAQISSLPqtVCNQLPNLQVLDLSYN-LLEDLPSFS 299
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNnKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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