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Conserved domains on  [gi|10435947|dbj|BAB14710|]
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unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 361-535 3.93e-80

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


:

Pssm-ID: 464780  Cd Length: 174  Bit Score: 254.63  E-value: 3.93e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947   361 PWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESL 440
Cdd:pfam15625   1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947   441 TLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAP-TEEVEFSSNQHVTLDHEGVGSGVPfsFEADGSNQLTLMTSGKVSH 519
Cdd:pfam15625  81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGVP--LEADGSNSLGLLTSGTVSY 158

                         170
                  ....*....|....*.
gi 10435947   520 SVAWAIGENGIPLIPP 535
Cdd:pfam15625 159 SVSWAVDENGVPLAPP 174
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 1-99 2.40e-59

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


:

Pssm-ID: 465443  Cd Length: 255  Bit Score: 202.12  E-value: 2.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947     1 MLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRP 80
Cdd:pfam17661 157 ILFVPSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRP 236

                          90
                  ....*....|....*....
gi 10435947    81 PVLTQEQSIKAELETLYKK 99
Cdd:pfam17661 237 PIFSLEESLKPELETLYKK 255
 
Name Accession Description Interval E-value
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 361-535 3.93e-80

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


Pssm-ID: 464780  Cd Length: 174  Bit Score: 254.63  E-value: 3.93e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947   361 PWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESL 440
Cdd:pfam15625   1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947   441 TLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAP-TEEVEFSSNQHVTLDHEGVGSGVPfsFEADGSNQLTLMTSGKVSH 519
Cdd:pfam15625  81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGVP--LEADGSNSLGLLTSGTVSY 158

                         170
                  ....*....|....*.
gi 10435947   520 SVAWAIGENGIPLIPP 535
Cdd:pfam15625 159 SVSWAVDENGVPLAPP 174
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 1-99 2.40e-59

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


Pssm-ID: 465443  Cd Length: 255  Bit Score: 202.12  E-value: 2.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947     1 MLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRP 80
Cdd:pfam17661 157 ILFVPSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRP 236

                          90
                  ....*....|....*....
gi 10435947    81 PVLTQEQSIKAELETLYKK 99
Cdd:pfam17661 237 PIFSLEESLKPELETLYKK 255
 
Name Accession Description Interval E-value
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 361-535 3.93e-80

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


Pssm-ID: 464780  Cd Length: 174  Bit Score: 254.63  E-value: 3.93e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947   361 PWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESL 440
Cdd:pfam15625   1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947   441 TLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAP-TEEVEFSSNQHVTLDHEGVGSGVPfsFEADGSNQLTLMTSGKVSH 519
Cdd:pfam15625  81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGVP--LEADGSNSLGLLTSGTVSY 158

                         170
                  ....*....|....*.
gi 10435947   520 SVAWAIGENGIPLIPP 535
Cdd:pfam15625 159 SVSWAVDENGVPLAPP 174
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 1-99 2.40e-59

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


Pssm-ID: 465443  Cd Length: 255  Bit Score: 202.12  E-value: 2.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435947     1 MLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRP 80
Cdd:pfam17661 157 ILFVPSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRP 236

                          90
                  ....*....|....*....
gi 10435947    81 PVLTQEQSIKAELETLYKK 99
Cdd:pfam17661 237 PIFSLEESLKPELETLYKK 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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