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Conserved domains on  [gi|8133102|gb|AAF73471|]
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Ran binding protein 13 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Importin_rep_3 pfam18806
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 826-900 5.68e-26

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


:

Pssm-ID: 465873  Cd Length: 75  Bit Score: 101.80  E-value: 5.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8133102    826 LKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL 900
Cdd:pfam18806   1 LTLPERPTVKAACSFLTEFISQSREHPALKQVVQAYGELLVRTILLGIGGGSPRSLVENLADVLLALNKKYPEEL 75
Importin_rep pfam18773
Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally ...
 402-441 1.60e-22

Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally similar to HEAT repeats. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, mediating docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


:

Pssm-ID: 436727  Cd Length: 40  Bit Score: 90.89  E-value: 1.60e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 8133102    402 QFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAE 441
Cdd:pfam18773   1 QYPSDEEYNSWSADEKEQFRCYRQDISDTLMYSYNILHEE 40
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 116-263 8.36e-22

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


:

Pssm-ID: 462459  Cd Length: 147  Bit Score: 92.67  E-value: 8.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102    116 SKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAedspvdGQGRCLALLELLTVLPEE---FQTSRLPQYRKGLVRT 192
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSS------NPTGCELFLRILKVLPEEifdFSRTSLTQDRNNRLKD 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8133102    193 SLAVECGAVFPLLEQLLQQP-SSPSCVRQKVLKCFSSWVQlEVPLQDC--EALIQAAFAALQDSELFDSSVEAI 263
Cdd:pfam08389  75 LLRSNMEQILELLLQILEASqNANSELVEAVLKCLGSWLS-WIPIGLIvnNPLLNLLFSLLNDPDLREAAVECL 147
Importin_rep_2 pfam18786
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 584-627 8.28e-16

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


:

Pssm-ID: 408557  Cd Length: 44  Bit Score: 71.87  E-value: 8.28e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 8133102    584 TSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEE 627
Cdd:pfam18786   1 PSQCLWLMQALGFLLSALTTEDILHHLHSLISPEIQQLPKLVQQ 44
Importin_rep_2 pfam18786
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 631-669 1.56e-14

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


:

Pssm-ID: 408557  Cd Length: 44  Bit Score: 68.40  E-value: 1.56e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 8133102    631 PSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLP 669
Cdd:pfam18786   1 PSQCLWLMQALGFLLSALTTEDILHHLHSLISPEIQQLP 39
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 45-109 2.19e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.19e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8133102      45 AQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQI 109
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELL 65
 
Name Accession Description Interval E-value
Importin_rep_3 pfam18806
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 826-900 5.68e-26

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 465873  Cd Length: 75  Bit Score: 101.80  E-value: 5.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8133102    826 LKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL 900
Cdd:pfam18806   1 LTLPERPTVKAACSFLTEFISQSREHPALKQVVQAYGELLVRTILLGIGGGSPRSLVENLADVLLALNKKYPEEL 75
Importin_rep pfam18773
Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally ...
 402-441 1.60e-22

Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally similar to HEAT repeats. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, mediating docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 436727  Cd Length: 40  Bit Score: 90.89  E-value: 1.60e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 8133102    402 QFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAE 441
Cdd:pfam18773   1 QYPSDEEYNSWSADEKEQFRCYRQDISDTLMYSYNILHEE 40
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 116-263 8.36e-22

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 92.67  E-value: 8.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102    116 SKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAedspvdGQGRCLALLELLTVLPEE---FQTSRLPQYRKGLVRT 192
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSS------NPTGCELFLRILKVLPEEifdFSRTSLTQDRNNRLKD 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8133102    193 SLAVECGAVFPLLEQLLQQP-SSPSCVRQKVLKCFSSWVQlEVPLQDC--EALIQAAFAALQDSELFDSSVEAI 263
Cdd:pfam08389  75 LLRSNMEQILELLLQILEASqNANSELVEAVLKCLGSWLS-WIPIGLIvnNPLLNLLFSLLNDPDLREAAVECL 147
Importin_rep_2 pfam18786
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 584-627 8.28e-16

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 408557  Cd Length: 44  Bit Score: 71.87  E-value: 8.28e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 8133102    584 TSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEE 627
Cdd:pfam18786   1 PSQCLWLMQALGFLLSALTTEDILHHLHSLISPEIQQLPKLVQQ 44
Importin_rep_2 pfam18786
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 631-669 1.56e-14

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 408557  Cd Length: 44  Bit Score: 68.40  E-value: 1.56e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 8133102    631 PSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLP 669
Cdd:pfam18786   1 PSQCLWLMQALGFLLSALTTEDILHHLHSLISPEIQQLP 39
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 45-109 2.19e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.19e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8133102      45 AQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQI 109
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELL 65
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 20-650 3.32e-13

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 74.20  E-value: 3.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102    20 DFTVENVEKALHQLYYDPNIENKNlAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYE 99
Cdd:COG5101   10 DLDIALLDKVVTTFYQGDGRKQEQ-AQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQ 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   100 SLKAQLFTQITRFASGSKI------VLTRLCVALASLALSMMPDAWPCAVADMVrlfQAEDSPVDgqgRCLALLELLTVL 173
Cdd:COG5101   89 GIRNYVVQLVIEKSQDDKVrdkqkyVLNKLDLTLVQILKQEWPRNWPTFIPELI---NVSQISME---VCENNMIVLKLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   174 PEE---FQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKV--LKCFSSWVQLE-VPLQDCEALIQAAF 247
Cdd:COG5101  163 SEEvfdFSAEQMTQVKKRLLKNQMKIEFPQIFGLCKQILEYSRDESLIEATLesLLRFLEWIPLDyIFETNIIELVLEHF 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   248 AALQDSELFD-SSVEAIVNAISQPDAQRYV---------NTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGE 317
Cdd:COG5101  243 NSMPDTRVATlSCLTEIVDLGRHPQENAEKerilvihfqCIEFLKMYSNKPQEEDIYEVYGGMDKNEQIFVQKLAQFLSS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   318 NHSR--ALLDQ-----------------------------VEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYT 366
Cdd:COG5101  323 LYEVyiSLLEAremaenllnahgyliqisrinereifktaLEYWNKLVADLYSEFQRLPATEMSPLIQLSVGSQAISTNP 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   367 LQDDILSFEaekqavyQQVYRPVYFQLVDVLLHKaqFPSDEEYGFWSSDEKEQFRIYRVDiSDT----------LMYVYE 436
Cdd:COG5101  403 NQDSTKPLR-------KHIYIGILSQLRLVLIEN--MVRPEEVLIVENDEGEIVREFVKE-TDTielyksmrevLVYLTH 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   437 MLGAELLSNLYDKLGRLLTSSEepYSWQHTEALLYGFQSIAETI-DVN----YSDVVPGLIGL--IPRISISNVQLADTV 509
Cdd:COG5101  473 LIVDDTEKYMIGKLARQLDGKE--WSWNNLNTLCWAIGSISGAMsEVNekrfFVNVIKDLLALceMKRGKDNKAVVASNI 550

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   510 MFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVS--TLKKICRECKY--------DLPPYAA----NIVAVSQD 575
Cdd:COG5101  551 MYVVGQYPRFLKAHWSFLKTVVKKLFEFMHEDHEGVQDMAcdTFIKIVQKCPVhfvtqqegESEPFIVyiirNLPKTTGD 630

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8133102   576 VLMKQIHKtsqcmwLMQALGFLLSAL-QVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTT 650
Cdd:COG5101  631 LEPQQKHT------FYEACGMVISEVpKTRDYKRLVLDLMDLPNSAWLNIVIQADENINRLSDTMTVKIDANKMKT 700
IBN_N pfam03810
Importin-beta N-terminal domain;
45-107 1.45e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.07  E-value: 1.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8133102     45 AQKWLMQAQVSPQAWHFSWQLLQ-PDKVPEIQYFGASALHIKISRYWSD----IPTDQYESLKAQLFT 107
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSnSENPLEVRQLAALYLKNLITRHWEEeknsLPPEEKEQIKNNLLN 68
 
Name Accession Description Interval E-value
Importin_rep_3 pfam18806
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 826-900 5.68e-26

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 465873  Cd Length: 75  Bit Score: 101.80  E-value: 5.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8133102    826 LKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL 900
Cdd:pfam18806   1 LTLPERPTVKAACSFLTEFISQSREHPALKQVVQAYGELLVRTILLGIGGGSPRSLVENLADVLLALNKKYPEEL 75
Importin_rep pfam18773
Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally ...
 402-441 1.60e-22

Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally similar to HEAT repeats. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, mediating docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 436727  Cd Length: 40  Bit Score: 90.89  E-value: 1.60e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 8133102    402 QFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAE 441
Cdd:pfam18773   1 QYPSDEEYNSWSADEKEQFRCYRQDISDTLMYSYNILHEE 40
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 116-263 8.36e-22

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 92.67  E-value: 8.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102    116 SKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAedspvdGQGRCLALLELLTVLPEE---FQTSRLPQYRKGLVRT 192
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSS------NPTGCELFLRILKVLPEEifdFSRTSLTQDRNNRLKD 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8133102    193 SLAVECGAVFPLLEQLLQQP-SSPSCVRQKVLKCFSSWVQlEVPLQDC--EALIQAAFAALQDSELFDSSVEAI 263
Cdd:pfam08389  75 LLRSNMEQILELLLQILEASqNANSELVEAVLKCLGSWLS-WIPIGLIvnNPLLNLLFSLLNDPDLREAAVECL 147
Importin_rep_2 pfam18786
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 584-627 8.28e-16

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 408557  Cd Length: 44  Bit Score: 71.87  E-value: 8.28e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 8133102    584 TSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEE 627
Cdd:pfam18786   1 PSQCLWLMQALGFLLSALTTEDILHHLHSLISPEIQQLPKLVQQ 44
Importin_rep_2 pfam18786
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 631-669 1.56e-14

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 408557  Cd Length: 44  Bit Score: 68.40  E-value: 1.56e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 8133102    631 PSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLP 669
Cdd:pfam18786   1 PSQCLWLMQALGFLLSALTTEDILHHLHSLISPEIQQLP 39
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 45-109 2.19e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.19e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8133102      45 AQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQI 109
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELL 65
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 20-650 3.32e-13

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 74.20  E-value: 3.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102    20 DFTVENVEKALHQLYYDPNIENKNlAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYE 99
Cdd:COG5101   10 DLDIALLDKVVTTFYQGDGRKQEQ-AQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQ 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   100 SLKAQLFTQITRFASGSKI------VLTRLCVALASLALSMMPDAWPCAVADMVrlfQAEDSPVDgqgRCLALLELLTVL 173
Cdd:COG5101   89 GIRNYVVQLVIEKSQDDKVrdkqkyVLNKLDLTLVQILKQEWPRNWPTFIPELI---NVSQISME---VCENNMIVLKLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   174 PEE---FQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKV--LKCFSSWVQLE-VPLQDCEALIQAAF 247
Cdd:COG5101  163 SEEvfdFSAEQMTQVKKRLLKNQMKIEFPQIFGLCKQILEYSRDESLIEATLesLLRFLEWIPLDyIFETNIIELVLEHF 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   248 AALQDSELFD-SSVEAIVNAISQPDAQRYV---------NTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGE 317
Cdd:COG5101  243 NSMPDTRVATlSCLTEIVDLGRHPQENAEKerilvihfqCIEFLKMYSNKPQEEDIYEVYGGMDKNEQIFVQKLAQFLSS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   318 NHSR--ALLDQ-----------------------------VEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYT 366
Cdd:COG5101  323 LYEVyiSLLEAremaenllnahgyliqisrinereifktaLEYWNKLVADLYSEFQRLPATEMSPLIQLSVGSQAISTNP 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   367 LQDDILSFEaekqavyQQVYRPVYFQLVDVLLHKaqFPSDEEYGFWSSDEKEQFRIYRVDiSDT----------LMYVYE 436
Cdd:COG5101  403 NQDSTKPLR-------KHIYIGILSQLRLVLIEN--MVRPEEVLIVENDEGEIVREFVKE-TDTielyksmrevLVYLTH 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   437 MLGAELLSNLYDKLGRLLTSSEepYSWQHTEALLYGFQSIAETI-DVN----YSDVVPGLIGL--IPRISISNVQLADTV 509
Cdd:COG5101  473 LIVDDTEKYMIGKLARQLDGKE--WSWNNLNTLCWAIGSISGAMsEVNekrfFVNVIKDLLALceMKRGKDNKAVVASNI 550

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8133102   510 MFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVS--TLKKICRECKY--------DLPPYAA----NIVAVSQD 575
Cdd:COG5101  551 MYVVGQYPRFLKAHWSFLKTVVKKLFEFMHEDHEGVQDMAcdTFIKIVQKCPVhfvtqqegESEPFIVyiirNLPKTTGD 630

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8133102   576 VLMKQIHKtsqcmwLMQALGFLLSAL-QVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTT 650
Cdd:COG5101  631 LEPQQKHT------FYEACGMVISEVpKTRDYKRLVLDLMDLPNSAWLNIVIQADENINRLSDTMTVKIDANKMKT 700
IBN_N pfam03810
Importin-beta N-terminal domain;
45-107 1.45e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.07  E-value: 1.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8133102     45 AQKWLMQAQVSPQAWHFSWQLLQ-PDKVPEIQYFGASALHIKISRYWSD----IPTDQYESLKAQLFT 107
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSnSENPLEVRQLAALYLKNLITRHWEEeknsLPPEEKEQIKNNLLN 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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