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Conserved domains on  [gi|466393|gb|AAA28942|]
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Toll protein [Drosophila pseudoobscura]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
860-998 3.29e-38

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 3.29e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393       860 KFDAFISYSHKDqsFIEQYLVPQLEHGPQKFQLCVHERDWLVGGFIPENIVRSVADSRRTIIVLSQNFIESEWARMEFRA 939
Cdd:smart00255    1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 466393       940 AHRSALNEGRARIIVVIY-SDIGDVEKLDEELKAYLKMNtYLKWGDP---WFWDKLRFGVPHR 998
Cdd:smart00255   79 ALENALEEGGLRVIPIFYeVIPSDVRKQPGKFRKVFKKN-YLKWPEDekeQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-520 5.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 5.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    146 LDRLQNLKRLRFTSRRFTYIPADFLADLRNLSWLDLRANIvelpahLFDNLENLESLELGSNGLKHLPHGvFSRMPKLRH 225
Cdd:COG4886   68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    226 LNLWSNQLHNLTKhDFEGASSVVDVDLHANGIEQLPrDVFSLLTNLTEINLSANHFRSLPEGLFEhNKQLRQVRLLNNRv 305
Cdd:COG4886  141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQ- 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    306 plstlpdrlfanqpelrvlllrcdLETLPSDLlEQSTEITNISLRDNYLSTLPAklLEHQTNLLSLDLSNNKLTYLPDAL 385
Cdd:COG4886  217 ------------------------LTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    386 feHTTKLVDLNLAENMLTDISsdiFSKLEKLETLNMNNNLVKNIASNAFASNTALLHISMEHNLIDLQQPLLGSILQEQL 465
Cdd:COG4886  270 --NLTNLKTLDLSNNQLTDLK---LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 466393    466 NSPFSYLASLQSLNLRNNSIMFIYRDWNFNLINLQELDLSYNNISSLIYEDLQFL 520
Cdd:COG4886  345 SLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-621 1.01e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 1.01e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393       563 NPLVCDCTLLWFVQLVRGA-HVPdyakqfkfDTDRLTCSQPHNLQDlPVRLVPPKELYCS 621
Cdd:smart00082    1 NPFICDCELRWLLRWLQANeHLQ--------DPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
753-802 1.27e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 1.27e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 466393       753 NPWICNCEAKPLLLFTQSNyERIGDRGEMLCMDAEMP-TRMAELST-NDICP 802
Cdd:smart00082    1 NPFICDCELRWLLRWLQAN-EHLQDPVDLRCASPSSLrGPLLELLHsEFKCP 51
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
653-731 2.42e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 2.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 466393     653 HEGNLTKVPElpTLYDNLHIMELHMDNNTLLgprAAHSPAyaNVTSLHLAGNNVTHIDvDRLPPNLKHLDVRRNHLQAL 731
Cdd:PRK15370  228 NSNQLTSIPA--TLPDTIQEMELSINRITEL---PERLPS--ALQSLDLFHNKISCLP-ENLPEELRYLSVYDNSIRTL 298
LRRNT smart00013
Leucine rich repeat N-terminal domain;
632-669 1.22e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 466393       632 QCTRGCRCWvrtfdkALVIKCHEGNLTKVP-ELPTLYDN 669
Cdd:smart00013    1 ACPAPCNCS------GTAVDCSGRGLTEVPlDLPPDTTL 33
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
860-998 3.29e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 3.29e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393       860 KFDAFISYSHKDqsFIEQYLVPQLEHGPQKFQLCVHERDWLVGGFIPENIVRSVADSRRTIIVLSQNFIESEWARMEFRA 939
Cdd:smart00255    1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 466393       940 AHRSALNEGRARIIVVIY-SDIGDVEKLDEELKAYLKMNtYLKWGDP---WFWDKLRFGVPHR 998
Cdd:smart00255   79 ALENALEEGGLRVIPIFYeVIPSDVRKQPGKFRKVFKKN-YLKWPEDekeQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-520 5.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 5.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    146 LDRLQNLKRLRFTSRRFTYIPADFLADLRNLSWLDLRANIvelpahLFDNLENLESLELGSNGLKHLPHGvFSRMPKLRH 225
Cdd:COG4886   68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    226 LNLWSNQLHNLTKhDFEGASSVVDVDLHANGIEQLPrDVFSLLTNLTEINLSANHFRSLPEGLFEhNKQLRQVRLLNNRv 305
Cdd:COG4886  141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQ- 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    306 plstlpdrlfanqpelrvlllrcdLETLPSDLlEQSTEITNISLRDNYLSTLPAklLEHQTNLLSLDLSNNKLTYLPDAL 385
Cdd:COG4886  217 ------------------------LTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    386 feHTTKLVDLNLAENMLTDISsdiFSKLEKLETLNMNNNLVKNIASNAFASNTALLHISMEHNLIDLQQPLLGSILQEQL 465
Cdd:COG4886  270 --NLTNLKTLDLSNNQLTDLK---LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 466393    466 NSPFSYLASLQSLNLRNNSIMFIYRDWNFNLINLQELDLSYNNISSLIYEDLQFL 520
Cdd:COG4886  345 SLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 864-959 9.90e-18

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 80.05  E-value: 9.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393      864 FISYSHKDQSFIEQyLVPQLEHgpQKFQLCVHERDWLVGGFIPENIVRSVADSRRTIIVLSQNFIESEWARMEFRAAHRs 943
Cdd:pfam13676    2 FISYAGEDRAWAEW-LADALEA--AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77

                           90
                   ....*....|....*.
gi 466393      944 aLNEGRARIIVVIYSD 959
Cdd:pfam13676   78 -DPEGRKRLIPVRLEC 92
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 149-448 5.20e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 5.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     149 LQNLKRLRFTsrrFTY-------IPADFLaDLRNLSWLDLRANIV--ELPaHLFDNLENLESLELGSNGLK-HLPHGVFS 218
Cdd:PLN00113  256 LGNLKNLQYL---FLYqnklsgpIPPSIF-SLQKLISLDLSDNSLsgEIP-ELVIQLQNLEILHLFSNNFTgKIPVALTS 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     219 rMPKLRHLNLWSNQL-----HNLTKHDfegasSVVDVDLHANGIE-QLPRDVFSLlTNLTEINLSANHFRS-LPEGLfEH 291
Cdd:PLN00113  331 -LPRLQVLQLWSNKFsgeipKNLGKHN-----NLTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEGeIPKSL-GA 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     292 NKQLRQVRLLNN-----------RVPLSTLPDrLFANQPELRVLLLRCDLETLpsdlleqstEITNISlRDNYLSTLPAk 360
Cdd:PLN00113  403 CRSLRRVRLQDNsfsgelpseftKLPLVYFLD-ISNNNLQGRINSRKWDMPSL---------QMLSLA-RNKFFGGLPD- 470

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     361 lLEHQTNLLSLDLSNNKLTYLPDALFEHTTKLVDLNLAENMLTDISSDIFSKLEKLETLNMNNNLVKNIASNAFASNTAL 440
Cdd:PLN00113  471 -SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVL 549


                  ....*...
gi 466393     441 LHISMEHN 448
Cdd:PLN00113  550 SQLDLSQN 557
LRR_8 pfam13855
Leucine rich repeat;
174-233 4.20e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 4.20e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 466393      174 RNLSWLDLRAN-IVELPAHLFDNLENLESLELGSNGLKHLPHGVFSRMPKLRHLNLWSNQL 233
Cdd:pfam13855    1 PNLRSLDLSNNrLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 247-510 1.17e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    247 VVDVDLHANGIEQLpRDVFSLLT---NLTEINLSANHFRSLPEGL------FEHNKQLRQVRLLNNrvPLStlpdrlFAN 317
Cdd:cd00116   27 VLRLEGNTLGEEAA-KALASALRpqpSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDN--ALG------PDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    318 QPELRVLLLRCDLETLPsdlleqsteITNISLRDNYLSTLPAKLLEHQTNLLSLDLSNNKLTYLP-DAL---FEHTTKLV 393
Cdd:cd00116   98 CGVLESLLRSSSLQELK---------LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGAScEALakaLRANRDLK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    394 DLNLAENMLTD--ISS--DIFSKLEKLETLNMNNNLV--KNIA--SNAFASNTALLHISMEHNLIDLQqpllgsILQEQL 465
Cdd:cd00116  169 ELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLtdEGASalAETLASLKSLEVLNLGDNNLTDA------GAAALA 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 466393    466 NSPFSYLASLQSLNLRNNSI------MFiyRDWNFNLINLQELDLSYNNIS 510
Cdd:cd00116  243 SALLSPNISLLTLSLSCNDItddgakDL--AEVLAEKESLLELDLRGNKFG 291
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-621 1.01e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 1.01e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393       563 NPLVCDCTLLWFVQLVRGA-HVPdyakqfkfDTDRLTCSQPHNLQDlPVRLVPPKELYCS 621
Cdd:smart00082    1 NPFICDCELRWLLRWLQANeHLQ--------DPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRCT smart00082
Leucine rich repeat C-terminal domain;
753-802 1.27e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 1.27e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 466393       753 NPWICNCEAKPLLLFTQSNyERIGDRGEMLCMDAEMP-TRMAELST-NDICP 802
Cdd:smart00082    1 NPFICDCELRWLLRWLQAN-EHLQDPVDLRCASPSSLrGPLLELLHsEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
653-731 2.42e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 2.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 466393     653 HEGNLTKVPElpTLYDNLHIMELHMDNNTLLgprAAHSPAyaNVTSLHLAGNNVTHIDvDRLPPNLKHLDVRRNHLQAL 731
Cdd:PRK15370  228 NSNQLTSIPA--TLPDTIQEMELSINRITEL---PERLPS--ALQSLDLFHNKISCLP-ENLPEELRYLSVYDNSIRTL 298
LRRNT smart00013
Leucine rich repeat N-terminal domain;
632-669 1.22e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 466393       632 QCTRGCRCWvrtfdkALVIKCHEGNLTKVP-ELPTLYDN 669
Cdd:smart00013    1 ACPAPCNCS------GTAVDCSGRGLTEVPlDLPPDTTL 33
LRR smart00370
Leucine-rich repeats, outliers;
268-291 4.02e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 4.02e-03
                            10        20
                    ....*....|....*....|....
gi 466393       268 LTNLTEINLSANHFRSLPEGLFEH 291
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
695-754 6.94e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 466393      695 NVTSLHLAGNNVTHIDVD--RLPPNLKHLDVRRNHLQALNTTVLGFLNRTmprRSLMLSGNP 754
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPGAFSGLPSL---RYLDLSGNR 60
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
860-998 3.29e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 3.29e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393       860 KFDAFISYSHKDqsFIEQYLVPQLEHGPQKFQLCVHERDWLVGGFIPENIVRSVADSRRTIIVLSQNFIESEWARMEFRA 939
Cdd:smart00255    1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 466393       940 AHRSALNEGRARIIVVIY-SDIGDVEKLDEELKAYLKMNtYLKWGDP---WFWDKLRFGVPHR 998
Cdd:smart00255   79 ALENALEEGGLRVIPIFYeVIPSDVRKQPGKFRKVFKKN-YLKWPEDekeQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-520 5.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 5.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    146 LDRLQNLKRLRFTSRRFTYIPADFLADLRNLSWLDLRANIvelpahLFDNLENLESLELGSNGLKHLPHGvFSRMPKLRH 225
Cdd:COG4886   68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    226 LNLWSNQLHNLTKhDFEGASSVVDVDLHANGIEQLPrDVFSLLTNLTEINLSANHFRSLPEGLFEhNKQLRQVRLLNNRv 305
Cdd:COG4886  141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQ- 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    306 plstlpdrlfanqpelrvlllrcdLETLPSDLlEQSTEITNISLRDNYLSTLPAklLEHQTNLLSLDLSNNKLTYLPDAL 385
Cdd:COG4886  217 ------------------------LTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    386 feHTTKLVDLNLAENMLTDISsdiFSKLEKLETLNMNNNLVKNIASNAFASNTALLHISMEHNLIDLQQPLLGSILQEQL 465
Cdd:COG4886  270 --NLTNLKTLDLSNNQLTDLK---LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 466393    466 NSPFSYLASLQSLNLRNNSIMFIYRDWNFNLINLQELDLSYNNISSLIYEDLQFL 520
Cdd:COG4886  345 SLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
144-484 2.03e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 2.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    144 RHLDRLQNLKRLRFTSRRFTYIPADfLADLRNLSWLDLRAN-IVELPAHLFdNLENLESLELGSNGLKHLPHgVFSRMPK 222
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNqLTDLPEPLG-NLTNLKSLDLSNNQLTDLPE-ELGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    223 LRHLNLWSNQLHNLTkhdfegassvvdvdlhangieqlprDVFSLLTNLTEINLSANHFRSLPEGLfEHNKQLRQVRLLN 302
Cdd:COG4886  184 LKELDLSNNQITDLP-------------------------EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSN 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    303 NRvpLSTLPDrlFANQPELRVLLLR-CDLETLPSdlLEQSTEITNISLRDNYLSTLPAKLLEHQTNLLSLDLSNNKLTYL 381
Cdd:COG4886  238 NQ--LTDLPE--LGNLTNLEELDLSnNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    382 PDALFEHTTKLVDLNLAENMLTDISSDIFSKLEKLETLNMNNNLVKNIASNAFASNTALLHISMEHNLIDLQQPLLGSIL 461
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                        330       340
                 ....*....|....*....|...
gi 466393    462 QEQLNSPFSYLASLQSLNLRNNS 484
Cdd:COG4886  392 LLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
226-539 7.39e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 7.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    226 LNLWSNQLHNLTKHDFEGASSVVDVDLHANGIEQLPRDVFSLLTNLTEINLSANhfrslpeGLFEHNKQLRQVRLLNNRv 305
Cdd:COG4886   53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQ- 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    306 pLSTLPDRLfANQPELRVLLLR-CDLETLPSDLlEQSTEITNISLRDNYLSTLPAKLlEHQTNLLSLDLSNNKLTYLPDA 384
Cdd:COG4886  125 -LTDLPEEL-ANLTNLKELDLSnNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLPEP 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    385 LFEhTTKLVDLNLAENMLTDISSDIfSKLEKLETLNMNNNLVKNIASnafasntallhismehnlidlqqpllgsilqeq 464
Cdd:COG4886  201 LGN-LTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--------------------------------- 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 466393    465 lnspFSYLASLQSLNLRNNSIMFIyrDWNFNLINLQELDLSYNNISSLIYEDLQFLSKANLFVNITHNQISRINF 539
Cdd:COG4886  246 ----LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
266-565 1.76e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 1.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    266 SLLTNLTEINLSANHFRSLPEGLFEHNKQLRQVRLLNNRVPLSTLPDRLFANQPELRVLLLRCDLETLPSDLLEQSTEIT 345
Cdd:COG4886   20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    346 NISLRDNylstlpaKLLEHQTNLLSLDLSNNKLTYLPDALfEHTTKLVDLNLAENMLTDISSDIfSKLEKLETLNMNNNL 425
Cdd:COG4886  100 ELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    426 VKNIaSNAFASNTALLHISMEHNLIdlqqpllgsilqEQLNSPFSYLASLQSLNLRNNSIMFIYRDWNfNLINLQELDLS 505
Cdd:COG4886  171 LTDL-PEELGNLTNLKELDLSNNQI------------TDLPEPLGNLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLS 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    506 YNNISSLiyEDLQFLSKANlFVNITHNQISRINFYPQLpvmpdgevsTSVLRMDLNDNPL 565
Cdd:COG4886  237 NNQLTDL--PELGNLTNLE-ELDLSNNQLTDLPPLANL---------TNLKTLDLSNNQL 284
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 864-959 9.90e-18

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 80.05  E-value: 9.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393      864 FISYSHKDQSFIEQyLVPQLEHgpQKFQLCVHERDWLVGGFIPENIVRSVADSRRTIIVLSQNFIESEWARMEFRAAHRs 943
Cdd:pfam13676    2 FISYAGEDRAWAEW-LADALEA--AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77

                           90
                   ....*....|....*.
gi 466393      944 aLNEGRARIIVVIYSD 959
Cdd:pfam13676   78 -DPEGRKRLIPVRLEC 92
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 861-992 4.53e-13

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 68.16  E-value: 4.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393      861 FDAFISYSHKD--QSFIeQYLVPQLEHGPqkFQLCVHERDWLVGGFIPENIVRSVADSRRTIIVLSQNFIESEWARMEFR 938
Cdd:pfam01582    1 YDVFLSFRGSDtrEWFV-SHLLKELKQKG--IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 466393      939 AAHRSALnEGRARIIVVIY--------SDIGDVEKLDEELKAYLKMNTYLKW-----------------GDPWFWDKLR 992
Cdd:pfam01582   78 KILECAL-DLGQKVIPIFYevdpsdvrKQTGSFGKAFKKHKKVLTEEKVLKWrgalnevaniwhsksvsDESKFWKKIA 155
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 149-448 5.20e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 5.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     149 LQNLKRLRFTsrrFTY-------IPADFLaDLRNLSWLDLRANIV--ELPaHLFDNLENLESLELGSNGLK-HLPHGVFS 218
Cdd:PLN00113  256 LGNLKNLQYL---FLYqnklsgpIPPSIF-SLQKLISLDLSDNSLsgEIP-ELVIQLQNLEILHLFSNNFTgKIPVALTS 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     219 rMPKLRHLNLWSNQL-----HNLTKHDfegasSVVDVDLHANGIE-QLPRDVFSLlTNLTEINLSANHFRS-LPEGLfEH 291
Cdd:PLN00113  331 -LPRLQVLQLWSNKFsgeipKNLGKHN-----NLTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEGeIPKSL-GA 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     292 NKQLRQVRLLNN-----------RVPLSTLPDrLFANQPELRVLLLRCDLETLpsdlleqstEITNISlRDNYLSTLPAk 360
Cdd:PLN00113  403 CRSLRRVRLQDNsfsgelpseftKLPLVYFLD-ISNNNLQGRINSRKWDMPSL---------QMLSLA-RNKFFGGLPD- 470

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     361 lLEHQTNLLSLDLSNNKLTYLPDALFEHTTKLVDLNLAENMLTDISSDIFSKLEKLETLNMNNNLVKNIASNAFASNTAL 440
Cdd:PLN00113  471 -SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVL 549


                  ....*...
gi 466393     441 LHISMEHN 448
Cdd:PLN00113  550 SQLDLSQN 557
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
151-385 5.20e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.03  E-value: 5.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     151 NLKRLRFTSRRFTYIPADfLADLRNLSWLDlRANIVELPAHLfdnLENLESLELGSNGLKHLPhgvfSRMPK-LRHLNLW 229
Cdd:PRK15370  221 NIKTLYANSNQLTSIPAT-LPDTIQEMELS-INRITELPERL---PSALQSLDLFHNKISCLP----ENLPEeLRYLSVY 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     230 SNQLHNLTKHDfegASSVVDVDLHANGIEQLPRdvfSLLTNLTEINLSANHFRSLPEGLfehNKQLRQVRLLNNRVplST 309
Cdd:PRK15370  292 DNSIRTLPAHL---PSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQI--TV 360

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 466393     310 LPdrlfanqpelrvlllrcdlETLPSdlleqstEITNISLRDNYLSTLPAKLlehQTNLLSLDLSNNKLTYLPDAL 385
Cdd:PRK15370  361 LP-------------------ETLPP-------TITTLDVSRNALTNLPENL---PAALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
174-233 4.20e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 4.20e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 466393      174 RNLSWLDLRAN-IVELPAHLFDNLENLESLELGSNGLKHLPHGVFSRMPKLRHLNLWSNQL 233
Cdd:pfam13855    1 PNLRSLDLSNNrLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 148-425 6.95e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 6.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     148 RLQNLKRLRFTSRRFT-YIPADfLADLRNLSWLDLRANIV--ELPAHLFDNlENLESLELGSNGLK-HLPHGVFSRmPKL 223
Cdd:PLN00113  306 QLQNLEILHLFSNNFTgKIPVA-LTSLPRLQVLQLWSNKFsgEIPKNLGKH-NNLTVLDLSTNNLTgEIPEGLCSS-GNL 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     224 RHLNLWSNQLHNLTKHDFEGASSVVDVDLHANGIE-QLPRDvFSLLTNLTEINLSANHFRSLPEGLFEHNKQLRQVRLLN 302
Cdd:PLN00113  383 FKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSE-FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLAR 461

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     303 NRVpLSTLPDRLFANQPELRVLLLRCDLETLPSDLLEQStEITNISLRDNYLSTLPAKLLEHQTNLLSLDLSNNKLTYLP 382
Cdd:PLN00113  462 NKF-FGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLS-ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 466393     383 DALFEHTTKLVDLNLAENMLtdiSSDIFSKLEKLETL---NMNNNL 425
Cdd:PLN00113  540 PASFSEMPVLSQLDLSQNQL---SGEIPKNLGNVESLvqvNISHNH 582
LRR_8 pfam13855
Leucine rich repeat;
366-426 4.76e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 4.76e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 466393      366 TNLLSLDLSNNKLTYLPDALFEHTTKLVDLNLAENMLTDISSDIFSKLEKLETLNMNNNLV 426
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 247-510 1.17e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    247 VVDVDLHANGIEQLpRDVFSLLT---NLTEINLSANHFRSLPEGL------FEHNKQLRQVRLLNNrvPLStlpdrlFAN 317
Cdd:cd00116   27 VLRLEGNTLGEEAA-KALASALRpqpSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDN--ALG------PDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    318 QPELRVLLLRCDLETLPsdlleqsteITNISLRDNYLSTLPAKLLEHQTNLLSLDLSNNKLTYLP-DAL---FEHTTKLV 393
Cdd:cd00116   98 CGVLESLLRSSSLQELK---------LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGAScEALakaLRANRDLK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    394 DLNLAENMLTD--ISS--DIFSKLEKLETLNMNNNLV--KNIA--SNAFASNTALLHISMEHNLIDLQqpllgsILQEQL 465
Cdd:cd00116  169 ELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLtdEGASalAETLASLKSLEVLNLGDNNLTDA------GAAALA 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 466393    466 NSPFSYLASLQSLNLRNNSI------MFiyRDWNFNLINLQELDLSYNNIS 510
Cdd:cd00116  243 SALLSPNISLLTLSLSCNDItddgakDL--AEVLAEKESLLELDLRGNKFG 291
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 149-565 2.70e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     149 LQNLKRLRFTSRRFT-YIPADfLADLRNLSWLDLRANIV--ELPAHLfDNLENLESLELGSNGL-KHLPHGVfSRMPKLR 224
Cdd:PLN00113  139 IPNLETLDLSNNMLSgEIPND-IGSFSSLKVLDLGGNVLvgKIPNSL-TNLTSLEFLTLASNQLvGQIPREL-GQMKSLK 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     225 HLNLWSNQLHNLTKHDFEGASSVVDVDLHANGIE-------------------------QLPRDVFSLlTNLTEINLSAN 279
Cdd:PLN00113  216 WIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgpipsslgnlknlqylflyqnklsgPIPPSIFSL-QKLISLDLSDN 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     280 HFR-SLPEgLFEHNKQLRQVRLLNNRVPlSTLPDRLfANQPELRVLllrcdletlpsdlleqsteitniSLRDNYLSTLP 358
Cdd:PLN00113  295 SLSgEIPE-LVIQLQNLEILHLFSNNFT-GKIPVAL-TSLPRLQVL-----------------------QLWSNKFSGEI 348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     359 AKLLEHQTNLLSLDLSNNKLT-YLPDALFE--HTTKLVdlnLAENMLTDISSDIFSKLEKLETLNMNNNLVKNIASNAFa 435
Cdd:PLN00113  349 PKNLGKHNNLTVLDLSTNNLTgEIPEGLCSsgNLFKLI---LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEF- 424

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     436 snTALLHIsmehNLIDLQQpllgSILQEQLNSPFSYLASLQSLNLRNNSIMFIYRDwNFNLINLQELDLSYNNISSLIYE 515
Cdd:PLN00113  425 --TKLPLV----YFLDISN----NNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD-SFGSKRLENLDLSRNQFSGAVPR 493

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 466393     516 DLQFLSKAnLFVNITHNQISrinfypqlPVMPDgEVST--SVLRMDLNDNPL 565
Cdd:PLN00113  494 KLGSLSEL-MQLKLSENKLS--------GEIPD-ELSSckKLVSLDLSHNQL 535
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 366-454 1.04e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 51.78  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393      366 TNLLSLDLSNNkLTYLPDALFEHTTKLVDLNLAENmLTDISSDIFSKLeKLETLNMNNNLvKNIASNAFASNTALLHISM 445
Cdd:pfam13306   11 CSLTSITIPSS-LTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSSL-TSIGEYAFSNCSNLKSITL 86


                   ....*....
gi 466393      446 EHNLIDLQQ 454
Cdd:pfam13306   87 PSNLTSIGS 95
LRR_8 pfam13855
Leucine rich repeat;
198-257 3.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.79e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393      198 NLESLELGSNGLKHLPHGVFSRMPKLRHLNLWSNQLHNLTKHDFEGASSVVDVDLHANGI 257
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 154-420 5.46e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.74  E-value: 5.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    154 RLRFTSR--RFTYIPADFLADLRNLSWLDLRAN-IVELPAHLFDNLENLESLE--------LGSNGLKHLPHGVFSRMPK 222
Cdd:cd00116   59 SLNETGRipRGLQSLLQGLTKGCGLQELDLSDNaLGPDGCGVLESLLRSSSLQelklnnngLGDRGLRLLAKGLKDLPPA 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    223 LRHLNLWSNQLhnltkhdfEGASSvvdvdlhangiEQLPrDVFSLLTNLTEINLSANH-----FRSLPEGLfEHNKQLRQ 297
Cdd:cd00116  139 LEKLVLGRNRL--------EGASC-----------EALA-KALRANRDLKELNLANNGigdagIRALAEGL-KANCNLEV 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    298 VRLLNNRvpLSTLPDRLFANqpelrVLLLRCDLETLpsdlleqstEITNISLRDNYLSTLPAKLLEHQTNLLSLDLSNNK 377
Cdd:cd00116  198 LDLNNNG--LTDEGASALAE-----TLASLKSLEVL---------NLGDNNLTDAGAAALASALLSPNISLLTLSLSCND 261

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 466393    378 LTY-----LPDALFEHTTkLVDLNLAENMLTD-----ISSDIFSKLEKLETLN 420
Cdd:cd00116  262 ITDdgakdLAEVLAEKES-LLELDLRGNKFGEegaqlLAESLLEPGNELESLW 313
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
259-537 7.54e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 7.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     259 QLPRDVfsLLTNLTEINLSANHFRSLPEGLFEhnkQLRQVRLLNNRvpLSTLPDRLFANQPELRVLllRCDLETLPSDLL 338
Cdd:PRK15370  170 QRMRDC--LKNNKTELRLKILGLTTIPACIPE---QITTLILDNNE--LKSLPENLQGNIKTLYAN--SNQLTSIPATLP 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     339 EQsteITNISLRDNYLSTLPAKLlehQTNLLSLDLSNNKLTYLPDALFEhttKLVDLNLAENMLTDISSDIFSKLEKLet 418
Cdd:PRK15370  241 DT---IQEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHLPSGITHL-- 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     419 lnmnnnlvkNIASNAFASNTALLHISMEhnLIDLQQPLLGSIlqeqlnsPFSYLASLQSLNLRNNSIMFIYRDWNfnlIN 498
Cdd:PRK15370  310 ---------NVQSNSLTALPETLPPGLK--TLEAGENALTSL-------PASLPPELQVLDVSKNQITVLPETLP---PT 368

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 466393     499 LQELDLSYNNISSLIyedlQFLSKANLFVNITHNQISRI 537
Cdd:PRK15370  369 ITTLDVSRNALTNLP----ENLPAALQIMQASRNNLVRL 403
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-621 1.01e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 1.01e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393       563 NPLVCDCTLLWFVQLVRGA-HVPdyakqfkfDTDRLTCSQPHNLQDlPVRLVPPKELYCS 621
Cdd:smart00082    1 NPFICDCELRWLLRWLQANeHLQ--------DPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
390-450 1.08e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 1.08e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 466393      390 TKLVDLNLAENMLTDISSDIFSKLEKLETLNMNNNLVKNIASNAFASNTALLHISMEHNLI 450
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
342-402 3.87e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.87e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 466393      342 TEITNISLRDNYLSTLPAKLLEHQTNLLSLDLSNNKLTYLPDALFEHTTKLVDLNLAENML 402
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
474-534 4.15e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 4.15e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 466393      474 SLQSLNLRNNSIMFIYRDWNFNLINLQELDLSYNNISSLIYEDLQFLskANL-FVNITHNQI 534
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL--PSLrYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 336-520 5.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 5.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    336 DLLEQSTEITNISLRDNYLSTLPAklLEHQTNLLSLDLSNNKLTYLPDalFEHTTKLVDLNLAENMLtdissdifSKLEK 415
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI--------SVVEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    416 LETLNmnnnlvkniasnafasntallhiSMEHNLIDLQQPLLGSILQEQLNSPFSYLASLQSLNLRNNSIMFIyrDWNFN 495
Cdd:cd21340   86 LENLT-----------------------NLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAP 140

                        170       180
                 ....*....|....*....|....*
gi 466393    496 LINLQELDLSYNNISSLiyEDLQFL 520
Cdd:cd21340  141 LRNLEQLDASNNQISDL--EELLDL 163
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
184-404 6.35e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.55  E-value: 6.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     184 NIVELPAHLfdnlENLESLELGSNGLKHLPhgvfSRMPKLRHLNLWSNQLHNLTKHdfegASSVVDVDLHANGIEQLPrd 263
Cdd:PRK15387  233 NLTSLPALP----PELRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPAL----PSGLCKLWIFGNQLTSLP-- 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     264 vfSLLTNLTEINLSANHFRSLPE------GLFEHNKQLRQVRLLNNRVPLSTLPDRLFANQPELRVLLLR--------CD 329
Cdd:PRK15387  299 --VLPPGLQELSVSDNQLASLPAlpselcKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKlwaynnrlTS 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     330 LETLPSDLLEQ-------------STEITNISLRDNYLSTLPAKllehQTNLLSLDLSNNKLTYLPDALFeHTTKLVDLN 396
Cdd:PRK15387  377 LPALPSGLKELivsgnrltslpvlPSELKELMVSGNRLTSLPML----PSGLLSLSVYRNQLTRLPESLI-HLSSETTVN 451


                  ....*...
gi 466393     397 LAENMLTD 404
Cdd:PRK15387  452 LEGNPLSE 459
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 341-565 4.31e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 4.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     341 STEITNISLRDNYLSTLPAKLLEHQTNLLSLDLSNNKLTY-LPDALFEHTTKLVDLNLAENMLTDISSDIFskLEKLETL 419
Cdd:PLN00113   68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     420 NMNNNLVKNIASNAFASNTALlhismehNLIDLQqpllGSILQEQLNSPFSYLASLQSLNLRNN--------------SI 485
Cdd:PLN00113  146 DLSNNMLSGEIPNDIGSFSSL-------KVLDLG----GNVLVGKIPNSLTNLTSLEFLTLASNqlvgqiprelgqmkSL 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     486 MFIYRDWNF----------NLINLQELDLSYNNISSLIYEDLQFLSKANlFVNITHNQISRinfypqlPVMPDGEVSTSV 555
Cdd:PLN00113  215 KWIYLGYNNlsgeipyeigGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQ-YLFLYQNKLSG-------PIPPSIFSLQKL 286

                         250
                  ....*....|
gi 466393     556 LRMDLNDNPL 565
Cdd:PLN00113  287 ISLDLSDNSL 296
LRRCT smart00082
Leucine rich repeat C-terminal domain;
753-802 1.27e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 1.27e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 466393       753 NPWICNCEAKPLLLFTQSNyERIGDRGEMLCMDAEMP-TRMAELST-NDICP 802
Cdd:smart00082    1 NPFICDCELRWLLRWLQAN-EHLQDPVDLRCASPSSLrGPLLELLHsEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 252-503 1.39e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    252 LHANGIEQLprDVFSLLTNLTEINLSANHFRSLpEGLfEHNKQLRQVRLLNNRvpLSTLpdrlfanqpelrvlllrCDLE 331
Cdd:cd21340    9 LNDKNITKI--DNLSLCKNLKVLYLYDNKITKI-ENL-EFLTNLTHLYLQNNQ--IEKI-----------------ENLE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    332 TLPSdlleqsteITNISLRDNYLSTLpaKLLEHQTNLLSLDLSN------NKLTYLPDALFEHTTKLVDLNLAENMLTDI 405
Cdd:cd21340   66 NLVN--------LKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    406 SSdiFSKLEKLETLNMNNNLVKNIasnafasntallhismehnlidlqqpllgsilqEQLNSPFSYLASLQSLNLRNNSI 485
Cdd:cd21340  136 EP--LAPLRNLEQLDASNNQISDL---------------------------------EELLDLLSSWPSLRELDLTGNPV 180

                        250       260
                 ....*....|....*....|....
gi 466393    486 MFI--YRDwnfNLI----NLQELD 503
Cdd:cd21340  181 CKKpkYRD---KIIlaskSLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
469-509 1.59e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.59e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 466393      469 FSYLASLQSLNLRNNSIMFIYRDWNFNLINLQELDLSYNNI 509
Cdd:pfam13855   21 FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
250-305 2.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 2.42e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 466393      250 VDLHANGIEQLPRDVFSLLTNLTEINLSANHFRSLPEGLFEHNKQLRQVRLLNNRV 305
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
653-731 2.42e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 2.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 466393     653 HEGNLTKVPElpTLYDNLHIMELHMDNNTLLgprAAHSPAyaNVTSLHLAGNNVTHIDvDRLPPNLKHLDVRRNHLQAL 731
Cdd:PRK15370  228 NSNQLTSIPA--TLPDTIQEMELSINRITEL---PERLPS--ALQSLDLFHNKISCLP-ENLPEELRYLSVYDNSIRTL 298
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 335-568 4.27e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 4.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    335 SDLLEQSTEITNISLRDNYLSTLPAKL----LEHQTNLLSLDLSNNKLTYLPDAL------FEHTTKLVDLNLAENMLTD 404
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTLGEEAAKAlasaLRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    405 ISSDIFSKLEK---LETLNMNNNLVKNIASNAFAsnTALLHISMEHNLIDLQQPLLGSILQEQLNSPFSYLASLQSLNLR 481
Cdd:cd00116   96 DGCGVLESLLRsssLQELKLNNNGLGDRGLRLLA--KGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    482 NNSImfiyRDWNFNLI--------NLQELDLSYNNISSLIYEDLQ--FLSKANLFV-NITHNQISRINFYPQLPVMPdgE 550
Cdd:cd00116  174 NNGI----GDAGIRALaeglkancNLEVLDLNNNGLTDEGASALAetLASLKSLEVlNLGDNNLTDAGAAALASALL--S 247

                        250
                 ....*....|....*...
gi 466393    551 VSTSVLRMDLNDNPLVCD 568
Cdd:cd00116  248 PNISLLTLSLSCNDITDD 265
LRR_8 pfam13855
Leucine rich repeat;
150-209 4.77e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 4.77e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 466393      150 QNLKRLRFTSRRFTYIPADFLADLRNLSWLDLRAN-IVELPAHLFDNLENLESLELGSNGL 209
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNlLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 175-296 9.06e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 40.22  E-value: 9.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393      175 NLSWLDLRANIVELPAHLFDNLENLESLELGSNgLKHLPHGVFSRMpKLRHLNLwSNQLHNLTKHDFEGASSVVDVDLhA 254
Cdd:pfam13306   12 SLTSITIPSSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITI-PSSLTSIGEYAFSNCSNLKSITL-P 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 466393      255 NGIEQLPRDVFSlLTNLTEINLSANhFRSLPEGLFEHNKQLR 296
Cdd:pfam13306   88 SNLTSIGSYAFS-NCSLKSITIPSS-VTTIGSYAFSNCSNLK 127
LRRNT smart00013
Leucine rich repeat N-terminal domain;
632-669 1.22e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 466393       632 QCTRGCRCWvrtfdkALVIKCHEGNLTKVP-ELPTLYDN 669
Cdd:smart00013    1 ACPAPCNCS------GTAVDCSGRGLTEVPlDLPPDTTL 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 195-534 1.58e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     195 NLENLESLELGSNGLKHLPHGVFSRMPKLRHLNLWSNQLHNLTKHD-FEGASSVVDVDLHANGIE-QLPRDVFSLLTNLt 272
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETL- 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     273 eiNLSANHFR-SLPE--GLFEHNKQLR-QVRLLNNRVPLStlpdrlFANQPELRVLLLRCDLET--LPSDlLEQSTEITN 346
Cdd:PLN00113  146 --DLSNNMLSgEIPNdiGSFSSLKVLDlGGNVLVGKIPNS------LTNLTSLEFLTLASNQLVgqIPRE-LGQMKSLKW 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     347 ISLRDNYLSTLPAKLLEHQTNLLSLDLSNNKLTYLPDALFEHTTKLVDLNLAENMLTD-ISSDIFSkLEKLETLNMNNNL 425
Cdd:PLN00113  217 IYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFS-LQKLISLDLSDNS 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     426 VKNIASNAFAS--NTALLHISMEHnlidlqqpLLGSIlQEQLNSpfsyLASLQSLNLRNNSIMF-IYRDWNfNLINLQEL 502
Cdd:PLN00113  296 LSGEIPELVIQlqNLEILHLFSNN--------FTGKI-PVALTS----LPRLQVLQLWSNKFSGeIPKNLG-KHNNLTVL 361

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 466393     503 DLSYNNISSLIYEDL---QFLSKANLFVNITHNQI 534
Cdd:PLN00113  362 DLSTNNLTGEIPEGLcssGNLFKLILFSNSLEGEI 396
LRR_8 pfam13855
Leucine rich repeat;
415-485 2.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 2.11e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 466393      415 KLETLNMNNNLVKNIASNAFASNTALLHISMEHNLIdlqqpllgSILQEQLnspFSYLASLQSLNLRNNSI 485
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--------TTLSPGA---FSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 461-567 3.33e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393     461 LQEQLNSPFSYLASLQSLNLRNNSIMFIYRDWNFNLINLQELDLSYNNISSLIYEDLQFLSKANLfVNITHNQISrinfy 540
Cdd:PLN03150  430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRI-LNLNGNSLS----- 503

                          90       100       110
                  ....*....|....*....|....*....|....
gi 466393     541 pqlpvmpdGEVSTSV-------LRMDLNDNPLVC 567
Cdd:PLN03150  504 --------GRVPAALggrllhrASFNFTDNAGLC 529
LRR smart00370
Leucine-rich repeats, outliers;
268-291 4.02e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 4.02e-03
                            10        20
                    ....*....|....*....|....
gi 466393       268 LTNLTEINLSANHFRSLPEGLFEH 291
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
268-291 4.02e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 4.02e-03
                            10        20
                    ....*....|....*....|....
gi 466393       268 LTNLTEINLSANHFRSLPEGLFEH 291
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
269-327 4.77e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 466393      269 TNLTEINLSANHFRSLPEGLFEHNKQLRQVRLLNNRvpLSTLPDRLFANQPELRVLLLR 327
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL--LTTLSPGAFSGLPSLRYLDLS 57
LRR_8 pfam13855
Leucine rich repeat;
695-754 6.94e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 466393      695 NVTSLHLAGNNVTHIDVD--RLPPNLKHLDVRRNHLQALNTTVLGFLNRTmprRSLMLSGNP 754
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPGAFSGLPSL---RYLDLSGNR 60
LRR smart00370
Leucine-rich repeats, outliers;
366-388 7.11e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 7.11e-03
                            10        20
                    ....*....|....*....|...
gi 466393       366 TNLLSLDLSNNKLTYLPDALFEH 388
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
366-388 7.11e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 7.11e-03
                            10        20
                    ....*....|....*....|...
gi 466393       366 TNLLSLDLSNNKLTYLPDALFEH 388
Cdd:smart00369    2 PNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 152-324 9.30e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 9.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    152 LKR---LRFTSRRFTYIPAdfLADLRNLSWLDLRAN-IVELPAhlFDNLENLESLELGSNGLKHLPHgvFSRMPKLRHLN 227
Cdd:cd21340    1 LKRithLYLNDKNITKIDN--LSLCKNLKVLYLYDNkITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 466393    228 LWSNQ------LHNLTK----H------------DFEGAS------SVVDVDLHANGIEQLprDVFSLLTNLTEINLSAN 279
Cdd:cd21340   75 LGGNRisvvegLENLTNleelHienqrlppgeklTFDPRSlaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 466393    280 HFRSLPE--GLFEHNKQLRQVRLLNNrvPLSTLP---DRLFANQPELRVL 324
Cdd:cd21340  153 QISDLEEllDLLSSWPSLRELDLTGN--PVCKKPkyrDKIILASKSLEVL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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