Conserved Protein Domain Family
Spy

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COG3914: Spy 
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]
Statistics
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PSSM-Id: 443119
Aligned: 291 rows
Threshold Bit Score: 300.371
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_070393851    2 TNWQQQAEQYLIQGDYSKAATLYEQAIEAEPDVIAYYWHLGLLFLLQGQETEAQTTWLLVMAEAESEQLESWSEELLQVL 81  
WP_010994734  185 PSTVLIRKEVFDKVGLFNNELCQLVDLEMWLRIMSQYKIGFIDQVLSHFRIHPQQQTRRNIDLKDAILLDYQKLFQYIAD 264 
WP_011613136 1434 ARKAIEITQTYLPRNMAAELSNQAREHYGIEAMKMAASMLKIGNNNGAIAQMREGLKCSNSSSVINLLVSILINAETEAE 1513
WP_012161820  286 GDKTFSGLPLDDILKAKDASPRCGLMVINLNTGAIEHWLRFEGIITELYDVQILPQVQRPMALGFQSEEIAQLITLGPQV 365 
WP_012161820  286 GDKTFSGLPLDDILKAKDASPRCGLMVINLNTGAIEHWLRFEGIITELYDVQILPQVQRPMALGFQSEEIAQLITLGPQV 365 
WP_104009922  186 TTVLIKKEAFEKVGLFNPELCQIVDLEMWLRIMSRYKIGFIDQYLSQFRIHHQQQTHRNASLKDVIFLDYQKLFYFIAND 265 
WP_015131465  538 LIRKEVFEKVGLFNSEFCQLVDLEMWLRIMSQYKVGFVNQVLSHFRIHPQQQTRRNANLKDAILLDYQKLFQTIYSDTRY 617 
WP_015174074  595 IGLFDSGLSQYVDLDMWWRIMGNYHIGFVDEKLSSLRIHPEQQTWKNFAAGENHKDVVRFYKKLLNSPDYSFLDRQIKQT 674 
WP_083888239  338 RLLKSGGLIADVRRSIEISQSYLPSAIADKLSNQAREHYALYALNTAKKLLTDGDSEAAIAQIREGLKCSQSAQLKEALV 417 
WP_006670383   97 FWNINSFFYYCVEFPAYLDLCHRYGFKGAFKIINIEHQKSANEVVHVKALLSVIKPAPNLQQHQKEKLIAKDNAEEATKP 176 
WP_070393851   82 QREAER------------------------------------RQ---GLGDDAVAWA---IRQHMREI---Cp-T--NLT 113 
WP_010994734  265 DSRYPDitr------------------------------qmaAVryaILSNDHTEl---nRLRNQIAQqwlNipDe-KLA 310 
WP_011613136 1514 TSLIQAtsqhllslepqlieskktphkvetnllpslaeinkeIElykQNQLDKSALVklqEIRKKIAYfwlSidTleNLK 1593
WP_012161820  366 PDPPQPnptvs--------------------------pappkPPttlTQPEDQPELAdlrQHRQHLVQqwlNlpLe-QLE 418 
WP_012161820  366 PDPPQPnptvs--------------------------pappkPPttlTQPEDQPELAdlrQHRQHLVQqwlNlpLe-QLE 418 
WP_104009922  266 SRYPGFtrq-------------------------------maACkyaILSRDNAEl---nRLQKQTAEqwlSlpDe-KLA 310 
WP_015131465  618 PLATRQq----------------------------------aLYkyaTLSQQNDEl---rHSRRQIAEewlNisDe-QIK 659 
WP_015174074  675 IRQKLAlrtqpsl-----------------------selsalLEqynKLPSKQPLLAl-rLYRQQLAEywlNlpAk-KLE 729 
WP_083888239  418 SLLLLGeshqps------------------------tgfsssINqqqKESSNESATAnsqPTRKQIADiwlNlpAe-QVA 472 
WP_006670383  177 KIQIEGknqhtl------------------------aqlsncLQqykNDPDNHSALVylkQLRIQIAEqwlSsnNe-DLE 231 
WP_070393851  114 NLLEiialsiklesfrgddltelgvislLQTHpspecnqqllkevlEQILdaeplhpaslafteaclaYLpnpevwfwpl 193 
WP_010994734  311 EIYAg----------------------lLGKT--------------HKVL------------------LAnsi------- 329 
WP_011613136 1594 IAYLg----------------------dFCQI--------------HKAL------------------LTssi------- 1612
WP_012161820  419 AAYGg----------------------eLGQA--------------HRTL------------------VNhdl------- 437 
WP_012161820  419 AAYGg----------------------eLGQA--------------HRTL------------------VNhdl------- 437 
WP_104009922  311 EMYAg----------------------lFGKI--------------HKIL------------------LRnsi------- 329 
WP_015131465  660 DIYVg----------------------lLGKT--------------HKML------------------LNssi------- 678 
WP_015174074  730 TAYSk----------------------dMGKA--------------HKLL------------------LDsal------- 748 
WP_083888239  473 SAFAg----------------------dAGKQ--------------HQAL------------------LAsdi------- 491 
WP_006670383  232 NEYSg----------------------fLGQA--------------YKAI------------------IDsri------- 250 
WP_070393851  194 lsasmKIG-HTLKQP-TIAAGFLECYRCLDPEhiEIVRHLATFYqdagnydqgietAKLCYSL----------SEslpDQ 261 
WP_010994734  330 ---ndKNFaSKDSILvKDIV--ISQEFT-NCK--SIQNLLAAMM------------LGDFNRVlllsd-fsqiPEwllYD 388 
WP_011613136 1613 ---tdESLtETEKKIvTQIKANIVKGFK-EPL--DIKYLLAGML------------YQRADQLevkye-kapiPKwfaID 1673
WP_012161820  438 ---ryEPLtAAEQAFiEPLMTALTT------H--PVQSLLALMP------------YRAAYQLperwfepitiPSwlvND 494 
WP_012161820  438 ---ryEPLtAAEQAFiEPLMTALTT------H--PVQSLLALMP------------YRAAYQLperwfepitiPSwlvND 494 
WP_104009922  330 ---ndKSLtKKDGILfNEIF--ISQELN-RPK--AIQNLLAAML------------FGDFNQLllssn-fsqvPEwllYD 388 
WP_015131465  679 ---kyECLtSEEQTFvNDLFKNVAQGLQ-QPK--AIQHLLAAML------------YYRADQLplqhd-lssiPHwllKD 739 
WP_015174074  749 ---knETLtEEEQSFvQQLSSKLAEGGEI-AE--KMQYLLAAML------------YGDAYQLpleyn-naaiPQwffDD 809 
WP_083888239  492 ---ryEPLtDTEETFvSELVANVAKGFN-EPK--AINYLLAAML------------YRRADQLplkyd-ratvPNwfaNE 552 
WP_006670383  251 ---kqEPLnTSEESLiNEIKKQLYANVQ-TDT--YLRTLLVLML------------YCYPEELqikye-fskiPTwfiNE 311 
WP_070393851  262 IsgIQLVLRGIMNAGGyWQEVsAACQTL-ESLlVSli-keQPANLsdvetlrlltPFFSLAHVHDKpsHFRPILNQIAEL 339 
WP_010994734  389 YiqFLFPVQDYFKLLGnTVEYyQYIEKSvYLLhKYifqelDSYSSykatnyftqiANFIHIYFNEi--NLKDVYVKRADI 466 
WP_011613136 1674 YlnFMFASPQVFQEIGeTDNYyHFMTGWlSYVhNNisinsESELWqaiarifvenANWIPLYFTTRp-NLKNLYIKRAEI 1752
WP_012161820  495 YlaYMQAVPLFFQAVGeSEQYaQYLNHWfTFIhRKihqnlNSASWqsvaa-vaaeAVFAPIYFNDl--NLKDTFIKWAAI 571 
WP_012161820  495 YlaYMQAVPLFFQAVGeSEQYaQYLNHWfTFIhRKihqnlNSASWqsvaa-vaaeAVFAPIYFNDl--NLKDTFIKWAAI 571 
WP_104009922  389 YlqFLLSPQGYFKALGdSKKYhEYLEKCtYSLhEYifkelGSSSSyqitnyftqiANFTHIYFNDn--NLKDIYVKRAEI 466 
WP_015131465  740 YlqFLFSSPVYFQEPGeADNYyHYMQGWiDYLhTClfknsDSPLWheivnnfaliANFISIYFNEn--NLKSIYVKRAEI 817 
WP_015174074  810 FlkFIFQSPGYFKQNWeVERYsEYFQQLiKYVaANiasfpDSEVWrylaafiaknVSFQALYLSEg--NPIEILSQRADI 887 
WP_083888239  553 YlkFMFTCPNVFQTRGeADSYyQFIQGWiDYLhTNlfknaDSPLWqniallfaqvANFIPLYFTTa--NLRDIYTKRAEI 630 
WP_006670383  312 YlkFILDPQRIFSKPGeAETYyDHIHNFmNELhHFicenkTASLAndiarkfldlCNFIPLYFTDr--NLKDVYVKRADI 389 
WP_070393851  340 FQRni--rGYTEEKAewyvefisgeqgvgsreqgagsrevgnlnkreieEGGKTTRPLKVGYLSGCLKQHSVGWLARWLF 417 
WP_010994734  467 IEQclkinGHKIDYEf--------------------------------qDRDRNRKKIRLGILSAHFTPSAETFAYLPVY 514 
WP_011613136 1753 IEFalkklGLELNYTm--------------------------------pPYQFNRSKIRLGIIKDHYTPQTETYSLLPVF 1800
WP_012161820  572 TEFslehrGMTVHQHg--------------------------------sPRPSHRSKIRLGVLNQAYSPHSETFSTLPFY 619 
WP_012161820  572 TEFslehrGMTVHQHg--------------------------------sPRPSHRSKIRLGVLNQAYSPHSETFSTLPFY 619 
WP_104009922  467 IECylklnGNKIDYKf--------------------------------vERPVNIKRIRLGILASHFRPSAETFACLPVY 514 
WP_015131465  818 LDFflkinGYQVDYEf--------------------------------aERPVNRKKIRLGILASHFSPAAETFAYLPIY 865 
WP_015174074  888 LEFylkniGCQIEWSf--------------------------------sQRQAERNKIRVGFLLDKISDESETRAAIPSF 935 
WP_083888239  631 IEFslknrGSSIDCIf--------------------------------pARSPNRTKIRVGIINDHFAPQTETFATIPVF 678 
WP_006670383  390 VEFilkqnNHQLDYDf--------------------------------sDRKRNNPKIRIGILASHFSPAAETFASLPIY 437 
WP_070393851  418 EHHDRKRFQLYGYFVDYklVNDNLQKWYLNHVDHPRKLGIYFLEAAKKIYQDQLDILIDLDSIT--LDITCAVMALKLAP 495 
WP_010994734  515 EYLSRD-FEVILYSLTE--TSHRLEQYCRISANLFKVLPKGLSDQVNAIRTDDLDILFVATNVTvvTSQICQLAIHRLAR 591 
WP_011613136 1801 EHLDRSKFEIFLYAIKS--NGHPLEQYCQSRADKFLQLPNELKNQVQTIRDDNLDILFFGSNITatIKNSTLLATHRLAR 1878
WP_012161820  620 EHLDRQQFEIILYAESS--QDHPLEAYCRSRCDQFVLLPQDLPESVQRIRNDDLDILLFGINIAvgNKSTARLAMYRLAR 697 
WP_012161820  620 EHLDRQQFEIILYAESS--QDHPLEAYCRSRCDQFVLLPQDLPESVQRIRNDDLDILLFGINIAvgNKSTARLAMYRLAR 697 
WP_104009922  515 EHISRD-FEVILYSLTE--TSHRLEQYCQRSANSFKLLPQELSAQVSTIRADDLDILFIATNVTavTNQICLLAIHRLAR 591 
WP_015131465  866 EYISRD-FEVILYSLNQ--TGHPLEQYCQSCANFFKLLPQDLAGQVNTIRADDLDVLFIATNVTvvTNQICLLSMHRLAR 942 
WP_015174074  936 EYLDRSKFEIIVYHFQV--QDERLGKYCENCADKLVQLSEDLPNQVREMRSHDLDILLICTNTTdtSQPSALLCLHRLAR 1013
WP_083888239  679 EHLNRNQFEIYLYALNT--SGHQLEQYCQSRADKLVALPKDFTSQVQTIRADDLDILFFGTNLTaiNKPLTSLAMHRLAR 756 
WP_006670383  438 EYLSR-EFEVILYSLSK--TNTPLEQYCKLCANSFKQLPNKLEEQVQVIRSDDLDILWVGTNVTayVNQIFLLSLHRMAR 514 
WP_070393851  496 VQVTWLGW--DASGLPAIDYVIADPYVLPDS-AQQYYSEKIWRLPQTYIAVD--G----FevGVpSLRRDHLDIPNDATV 566 
WP_010994734  592 IQITSGASv-ATTGMRNMDYYISGTLTDPSPtAQEQYQEKLIKLEGTAHCFSy-GteegK--LTtPVERNSLGIPGNAVV 667 
WP_011613136 1879 VQVTSINSp-TTTGMASIDYYISGKLTAPTEmTKEHYTEKLVNLEGSGLCFQd-PiaetL--PVvQPLRSSWGATNETTI 1954
WP_012161820  698 VQVSANSSp-VTSGINNIDYYLSGELTTPAEtFQSQYSEKLVTWAGPSCCYRfpPsaqqP--TAaSYYRRDLNIADDAVV 774 
WP_012161820  698 VQVSANSSp-VTSGINNIDYYLSGELTTPAEtFQSQYSEKLVTWAGPSCCYRfpPsaqqP--TAaSYYRRDLNIADDAVV 774 
WP_104009922  592 IQVTSGASv-VTTGMRNIDYYISGTLTDPSPiAQDHYQEKLIKLEGTAHCFSy-GteegK--LTiLVKRNSLGIPENAVV 667 
WP_015131465  943 IQATSGGSv-VTTGMRNIDYYISGTLTDPSVtAEQQYQEKLVRIAGSAHCFSy-GterdN--ATvKVNRESLGISEETII 1018
WP_015174074 1014 VQIATGAStpATTGTRNIDYFIAGDLTLPAG-AAADYREKLISLEGSGVCLSy-TvgsaP--AKvEPTRSSWGATDESVV 1089
WP_083888239  757 VQTTSFCSp-TTTGIRHMDYYIAGQFTAPDAsYQEQYREQLAVLQGSGFCFTy-AteseV--ATvKPTRQSLGISDNTTV 832 
WP_006670383  515 IQMTSVASv-VTTGIRNIDYYISGELTDHLEtAQEHYKEKLIKLEGTAHCFSy-GpelpQ--VRtTVDRQSLGIGSDRVI 590 
WP_070393851  567 YLSSQRGYKRNPDTTRLQMKIIKAVPHSYFLIKGESD----QDSiT---RFFNQIAEEEGVECDRLRFL--PEVpTEAVH 637 
WP_010994734  668 FISGANYFKTVPELMDTWAKIISIVPNSVLVLLPFGPnwssNYPkAefiNHLNSIFSRHGLGTERLRVLdpQPVpDREDM 747 
WP_011613136 1955 FISGANFYKIIPEIRETWAKILRAVPNSILVLYPFNPnwtnSYPvGsfiQQMRGTLERHGIHSKRLVVI--KPLpSKSDI 2032
WP_012161820  775 FVSGANFFKLIPELRITWTQILAAVPNSVLLLYPFSAws-hHYPvSafrNHMAALFAGDGIDPSRLIIQ--DPIpNREQV 851 
WP_012161820  775 FVSGANFFKLIPELRITWTQILAAVPNSVLLLYPFSAws-hHYPvSafrNHMAALFAGDGIDPSRLIIQ--DPIpNREQV 851 
WP_104009922  668 FISGANYFKIVPELVATWANIISRVPNSVLVLLPFGPnwsnAYPkAnfiDHLNSIFSQHGLATERLIVLdiQPIpDREDM 747 
WP_015131465 1019 FSSGANFFKIIPELVETWAKIIAKVPNSVLILLPFGPnwsnAYPkKyfeNKLKQVFSKYEILAERLIVLdpQPVpNREDV 1098
WP_015174074 1090 FVSGAQALTITPELRETWAKIIAAVPNSILVLYPFSSrs-eNYPtVpfyNQIRALFAEYGIDKKRLVVI--KALpSRADC 1166
WP_083888239  833 FISGANFYKILPELRESWVKILAAVPDSILILYPFGPawtrTYPaTpfvNNLNAVCAKYGVNNNRLRFV--KQLpSRADV 910 
WP_006670383  591 FISGANFFKIIPDLIETWAKIIAGVPNSVLVLMPFGPnwsnTYPkKsfiKQLNHHFTQHGIQTERLVVLdpNPTpNRDDV 670 
WP_070393851  638 RANLGIADVVLDTYPYNGATTTLETLWMGIPLVTRVGEQFVARNSYTMMMNAGITEGIA-WTDDEYIEWGIRLGKDPALR 716 
WP_010994734  748 KEYYKIADVYLDSYPFAGTTSLIEPLQVNLPVIARQGSCFRSAMGAAIIQTLNIPDLVA-DSEDSYIELAVALGNNSALR 826 
WP_011613136 2033 KKCLELADIYLDSFPYGGATSLLDPLMLGLPPVVVEGNALRFRQGPALLREINIEDLIA-DGEESYINLAVKLATNSEWR 2111
WP_012161820  852 KQLLQIADVYLDAYPFTGVTSLLDPLEVGLPVVTQAGHSLRSRQGPALLESIDLTDLIA-TDEQGYVELAIQLGQDSTRR 930 
WP_012161820  852 KQLLQIADVYLDAYPFTGVTSLLDPLEVGLPVVTQAGHSLRSRQGPALLESIDLTDLIA-TDEQGYVELAIQLGQDSTRR 930 
WP_104009922  748 KEYYKIADVYLDSYPFAGTTSLIEPLQVNLPVIARQGNCFRSAMGAAIIQTLNIPDLVA-DSEESYIELAVALGTNSELR 826 
WP_015131465 1099 KEYFKSADIYLDSYPFSGTTSLVEPLQINLPVVSRQGTSFRSAMGAAMVQALEIADLVA-DSEESYIQLAIALGNNPILR 1177
WP_015174074 1167 IKCLELADIYLDSYPYSSACSLAEPLLVGLPVVARKGQTTRSRQSAAVLEELLLPEMVA-DSENSYLDLSTALGTNPELR 1245
WP_083888239  911 KEFLQLADVYLDSYPYAGATSLIDPLQVGLPAVVVEGNALRFRQGSAMLRELQMPDLIA-YDEASYIQLAVTLGTNPQLR 989 
WP_006670383  671 KEYFKIADIYLDSYPFSGTTSLMEPLQVGLPIVSRRGSSFRSSMGVAILQSLNIPDLVTlTSEKSYIDLAVALGTNSELR 750 
WP_070393851  717 QQISWKLRQSRQTAP-LWNGKEFTREMEKAYEAMWRSRE 754 
WP_010994734  827 QQKSAEIKEKMQSNPsFLDSRSYSAKMGSLFQELFSDYI 865 
WP_011613136 2112 QQKRQEIKEKMQQNPaFLDSRSYSAEIGKLFQELFQKWQ 2150
WP_012161820  931 QQYRTLIQQKMAANPaFMDSPAYGAQVGTLLQQLLPSSF 969 
WP_012161820  931 QQYRTLIQQKMAANPaFMDSPAYGAQVGTLLQQLLPSSF 969 
WP_104009922  827 RQKSDQIREKMQDNPsFLDSRSYASKIESLFKELFNNYL 865 
WP_015131465 1178 QQKSAQIKEKMQGNPsFLDSRAYSAKIGNLFQELFSKYL 1216
WP_015174074 1246 QHYRDRILQKMAANPkYLDSRACSTQLGTLFERLFRESR 1284
WP_083888239  990 QQKRQEIQQKMQANPaCFDSVAYSGAIGKLFQELFGKWQ 1028
WP_006670383  751 QQISNQIQKKMQAHPrFLDTRAYSLQMGLVFKQLFQNHL 789 
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