5ZQV


Conserved Protein Domain Family
PBD_PPP1R3A
?
cd22255: PBD_PPP1R3A 
Click on image for an interactive view with Cn3D
PP1C binding domain found in protein phosphatase 1 regulatory subunit 3A (PPP1R3A) and similar proteins
PPP1R3A, also called protein phosphatase 1 glycogen-associated regulatory subunit (PP1G), protein phosphatase type-1 glycogen targeting subunit, or RG1, acts as a glycogen-targeting subunit for PP1 that is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility, and protein synthesis. PPP1R3A plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase. It interacts with the PPP1CC catalytic subunit of PP1 and associates with glycogen. This model corresponds to the protein phosphatase 1 catalytic subunit (PP1C) binding domain of PPP1R3A, which contains a RVxF PP1C-binding motif that mediates interactions with PP1C.
Links
?
Statistics
?
PSSM-Id: 439277
Aligned: 25 rows
Threshold Bit Score: 61.5778
Created: 13-Oct-2021
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
PP1C binding
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:PP1C binding site [polypeptide binding site]
Evidence:
  • Structure:5ZQV: Mus musculus PPP1R3A in complex with PPP1CA; contacts at 4A
    - View structure with Cn3D
  • Comment:RVxF is a PP1C-binding motif.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
5ZQV_E          9 QISKDNFLEVPNLSDSLCEDEEvt------------------------fqPGFSPQPSRRGSDSsed------------- 51   human
KPP71336       23 AALPDSLADSSMESAGELDHFEvsnpsgcpeiqsr---egdkdkagdgdePNSPSPRKRSGSVSsed------------- 86   Asian bonytongue
XP_023666206   22 CVPSTWVPHNPMDHKGEPPHADtsgrpdvvgvsq----pggedkpdhetaPKTPPLPWQGDSLYvsg------------- 84   Paramormyrops...
CDQ64483       64 SGSVLPSQCRQTASPLMSTDDPrplg---------------------psnFMESPDTRTRGSRDikeggvreeeergsly 122  rainbow trout
XP_028810870   18 PGTSCCVKYVTKDDEEEREEDQeifkwvd---------------gsnkqgFVSSLICYSNDSDDsg-------------- 68   denticle herring
XP_019720759   46 IRSPDEAQGHLADDDDDDDDDEgsed--------------------vrliPRCSPVPRRRGSSIhdeta----------- 94   tiger tail se...
XP_031438967   18 LDSSPWFQCPAKEDEIRREEEDseevds-----------------egkwrSKSPPTSDVSDESEp--------------- 65   Atlantic herring
XP_026778786   57 PAMASCYTEPSTLSAWIQDEDEe---------------------------EKEPKSPQRSSSDEsees------------ 97   striped catfish
XP_026875579   13 HRTKPPALGPQLWDEGEEEDEKev------------------------hgNQEPKTPSRSSSDEsees------------ 56   electric eel
XP_005159256   23 AGLFGSLATEQKLEDGEDDMEEdevkngdcealqinvvntkprgresflkPPHSPTQRRRCKSLptsaera--------- 93   zebrafish

Feature 1                                 ####### # # #######      
5ZQV_E         52 --------------iylDTPSSGTRRVSFADSFGFNLVSVKEFDSWELP 86   human
KPP71336       87 --------------sdpEPPPVITRKVSFADAFGLDLVSVKEFDSWNTP 121  Asian bonytongue
XP_023666206   85 --------------tdrECWPTQARRVSFADTFGLNLVSIKEFDTRGMS 119  Paramormyrops kingsleyae
CDQ64483      123 tqkgatdesdesdgsepEPLAVIRRKVSFADAFGLDLVYVKEFDSTDLT 171  rainbow trout
XP_028810870   69 ---------------peTPTPIVRRKVSFADAFGLNLVSVVEFDSLDKR 102  denticle herring
XP_019720759   95 ------------eylriQAFLSPGKRVSFADTTGGDLVDVREFVTFDSD 131  tiger tail seahorse
XP_031438967   66 ----------------eSPPPIVRRRVSFADALGLNLVSVKEFSCQDPE 98   Atlantic herring
XP_026778786   98 -------------epepSLASVVRRKVSFADAFGLDLVSVKEFDNRVES 133  striped catfish
XP_026875579   57 -------------eaelPPAYATRRKVSFADAFGLDLVSVKEFDTGADS 92   electric eel
XP_005159256   94 -----------kleiarSRSPSSQKKVRFADSLGLDLISVKHFDDTDMP 131  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap