2KB4,2KB3


Conserved Protein Domain Family
FHA_OdhI-like
?
cd22721: FHA_OdhI-like 
Click on image for an interactive view with Cn3D
forkhead associated (FHA) domain found in Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI) and similar proteins
OdhI is an essential component of the PknG signaling pathway. It regulates glutamate production under biotin non-limiting conditions. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.
Links
?
Statistics
?
PSSM-Id: 438773
Aligned: 4 rows
Threshold Bit Score: 177.972
Created: 15-Sep-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.
  • Comment:based on structures of other FHA domains with bound phosphopeptide
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      ###            ## #                # ##        
2KB4_A     38 GAENLPAGSALLVVKRGPNAGARFLLDQPTTTAGRHPESDIFLDDVTVSRRHAEFRINeGEFEVVDVGSLNGTYVNREPR 117 Corynebacterium gl...
2KB3_A     38 GAENLPAGSALLVVKRGPNAGARFLLDQPTTTAGRHPESDIFLDDVTVSRRHAEFRINeGEFEVVDVGSLNGTYVNREPR 117 Corynebacterium gl...
Q8NQJ3     38 GAENLPAGSALLVVKRGPNAGARFLLDQPTTTAGRHPESDIFLDDVTVSRRHAEFRINeGEFEVVDVGSLNGTYVNREPR 117 Corynebacterium gl...
VDG63688   38 GVEGLPEGAALLVVKRGPNAGARFLLDQDTTTAGRHPEADIFLDDVTVSRRHAEFRRTsGEFEVVDVGSLNGTYVNREPR 117 Streptococcus ther...

Feature 1                    #      
2KB4_A    118 NAQVMQTGDEIQIGKFRLVFLA 139 Corynebacterium glutamicum
2KB3_A    118 NAQVMQTGDEIQIGKFRLVFLA 139 Corynebacterium glutamicum
Q8NQJ3    118 NAQVMQTGDEIQIGKFRLVFLA 139 Corynebacterium glutamicum ATCC 13032
VDG63688  118 NSQTLSTGDEIQIGKFRLVFIS 139 Streptococcus thermophilus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap