Conserved Protein Domain Family
TMEM131_like

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pfam19532: TMEM131_like 
Transmembrane protein 131-like
Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localization. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. This family is related to pfam12371.
Statistics
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PSSM-Id: 437364
Aligned: 11 rows
Threshold Bit Score: 1922.6
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007496276  185 FGTGMPRFSPEGSTKQLPNAHL-LLPHVQSIQISQTQ--AETTNTSLLQVHLECSLHNKVCQHLKSCYLESDDPLLLQMS 261 
Q3U3D7        185 SGVGTRRVSTEGSAEQLPNAYF-LLPQVQSIQLSQTQ--AETTNTSLLRVQLECSLHNKVCQQLKSCSLGSDDALHLEMN 261  house mouse
XP_002933525  181 FGVGIPAAGSDDYKNALQNTNV-IFPHIANIHLSQSQ--AEAINSSVWQVRLKCSVPFKKHQLGKNC-LPSGHSLLLQIY 256 
2_pfamImport    1 TGVGVPI-----PELSVDDKLL-FFPRIQNIQEKKSN-------CTLSELSFELTLPLQSYKDFQKHCLLRNEKLILYVD 67  
1_pfamImport    1 FGVGVSSTQVVMGDQHYSDDKLvFFPRIQNIQEKSSN-------CTLSELSFELALPLQSYRDFQKYCFLRNNLL-LYTH 72  
XP_004940935  286 FGVGTLTSSPEEPRIQLANAYL-LLPHIQNIQASRRLvqAETMNTSLLRVHLECSLPSEAYQQVKSCCSMSNDPMLLEMS 364 
XP_006004924  193 FGVGVPRVSLNTAKKQQPSTHL-LFGNIKNIQLKQIE-----VDTSIAEVSLQCDFTTEKHIQ-SSCL--TDNQILLQIS 263  coelacanth
XP_007669999  185 YGNGISRASTETSTKQISNAYL-LLPHMQSIQIFQTQ--AETTNANLLQVRLECSLHN-VCQQLKSCCFTSEDALLLQMS 260  platypus
XP_027812028  185 SGIGTRRISAKGSAEQLPNAYF-LLPQVQSVQLSQTQ--AETTNSSLLQVQLECSLHNKVCQQLKSCYVESDDVLRLQMS 261  sheep
XP_030866212  185 SGIGTRRISTEGSAKQLPNAYF-LLPKVQSIQLSQMQ--AETTNTSLLQVQLECSLHNKACQQLKGCYLESDDVLRLQMS 261  western lowla...
XP_014429943  185 FGMGSMGTPSEDSNKQLVKTCL-LLPRIQNIQISQTL--AETTNTSLLKVHLECSLHNNVCQQLKSCCFISDDPMLLEMS 261  Chinese soft-...
XP_007496276  262 IILTMETSPEEYEESRQDLLDNLSIVYVAI--DKTETSDDSAVNMYVLHSGNSLLWIQDVHHFSRRDSLSLQFEPVLLPS 339 
Q3U3D7        262 IIVAVENSSKQPEENTQALLDHLSIVYVAT--DESDTSDESAVNMYVLHSGNSLIWIQDIHHFSQKNVLSLQFEPVLLST 339  house mouse
XP_002933525  257 FAVRLDGGQHDLETLRNYVLENIFMIFVTS--NHIGNIDDPIIGVYVLNSGNGLVHMQDVHHFLGDIL-IVNFEPVMLLS 333 
2_pfamImport   68 ISLHMGECYKEFEIVKSYLLENMFVLYLPV--HKEGTSGEQINLVYFLHSGNNILYIKDVHFLPRASTITVEFEPILLET 145 
1_pfamImport   73 ISLNTEECYHKFEKIKSYLLENIFVLYMPVi--KESTSGEQIHIVYFLHSGNKSMYIKNVHFLSSGGTITVEFEPIQLET 150 
XP_004940935  365 LTVRMENAQEDFVKQRQYLLENLFVVYVAV--EKTKTSGDFVVDMYVLHSGNSRVHIQEIRQLSQKNRKLVEFEPVLMSS 442 
XP_006004924  264 MHGRPKEVSEEFEELKLYMLENLLVTYTLTfgDDGF--DTSRVTMYVLNSGAKDLNIKNIQLLSHTDTATVEFVPVLLTT 341  coelacanth
XP_007669999  261 I---MENSPKEFEEYQEDLLDNLSVVYVAT--DRTEASDESTIDVYILHSGNSVLWIQDVYHLPQRDILSLQFESVLLPT 335  platypus
XP_027812028  262 IIVTMENTSKEFEENTQDLLDHLSIIYVAT--DKSESSDDSAVNMYILHSGNSLIWIQDVRHFSQRDVLSLQFEPVLLPT 339  sheep
XP_030866212  262 IMVTMENFSKEFEENTQDLLDHLSIVYVAT--DESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVRLPT 339  western lowla...
XP_014429943  262 LVLRMEHSHQEFVDHRQYLLENLFVVYVTM--DKTETSNDSTVNMYVLHSGNSILRIQDIQRFSQKDTSSVRFEPILLPS 339  Chinese soft-...
XP_007496276  340 STTNFTKIASFICKA-SSCL--SETdy--rGEERSQKGMASLQACLSRPVVQGYFAI------DPSAIQFHLEPHWNASG 408 
Q3U3D7        340 STTNFTKIASFTCKAgTSCD--SGI-----MGLRKKKASPAMQACLSSPVVQGYFRT------DASTAQFHIESHETATG 406  house mouse
XP_002933525  334 ASINFTRAASISCSA-ESRE--SEYnfsedEEMNVPEAAAAPYPCISHNVTEGYLGL------DLSNISFFMQPLQEPAG 404 
2_pfamImport  146 SVTNLTRVASIICKAaMPDD--MGN--------CSGEGTHVIDNSLITKTFPALQLI------ERNMGHDSSSSFQVRAG 209 
1_pfamImport  151 SVTNLTRVASIICEA-TAVP--DDVenclgEVMYVVKGSLALKASPTLQLTEGNLQR------DSSSSFQVMSRHG--SE 219 
XP_004940935  443 SSTNFTKVASISCEA-AFCD--NAEpysadKRNSLVEGTTALQACLSCPVMEGYFDV------NPSAAMFHIEPHHNISG 513 
XP_006004924  342 SATNFIKLASFVCKA--AAFerTCSr---------aVQLDRLESSATLKIHPALYFVkgdfgfDPT-TLIRLKQKHSGSS 409  coelacanth
XP_007669999  336 STTNFTKVASFVCKA-SSCD--SETsysgeVNRNFLEGTATLKACFSHPVVKGYFGI------DPSEAQFHIETLQSTFG 406  platypus
XP_027812028  340 SKTNFTKIASFTCKA-PSCE--SGV-----REDRKKKDSPTLKACLSSPVVQGYFRM------DPSATQFHIENHENTSG 405  sheep
XP_030866212  340 STTNFTKIASFTCRA-TSCD--SGIi----EDVKKTTHTPTLKACLFSSVAQGYFRM------DSSATQFHIETHENTSG 406  western lowla...
XP_014429943  340 STTNFTKVASIVCKV-ASCD--NEIhyagdVKMNALEGTTTLKACLSHPVMEG---L------DPSAALFHIEPHHNASG 407  Chinese soft-...
XP_007496276  409 --VWSIWYTNRFSPSVVVKDVLVSKETKHILKVQNFTGPLFLPPGCWNIFSLRLDVKDTAVNMFTHVSLTTNLGATFVIP 486 
Q3U3D7        407 --VWSIWYRSHFDQSIVLKDVFVSKETKHILKVLSFRGPLFLPPGCWNIFSLKLAVKGIVLNLFTNVFLTTNTGAIFAIP 484  house mouse
XP_002933525  405 --LWSIWLENNLSFHISLSEVSVAQGKEGLLKILNFTRLLALPSGCWTVFTFKIHAKDTPLNYLTYILIGTSLGVTFKIP 482 
2_pfamImport  210 heFWTVWFTNYFKFKILIRNVSIPEEVSHLLTILNFTGPVTLIPGCWHILSLQFKAGKTPRTLNTHLTIVIGSGLVLKLP 289 
1_pfamImport  220 --FWTVWFTNYFEFKVSISSVYVPEEAAHLLTILNFTGPVILVPGCWHILSLQFNDGKTPITLNTHLVIVTGSGLTLELP 297 
XP_004940935  514 --FWSVWFTNNFEFSIELNEVYVSRETKNILKILNFAEPLTLSPGCWNVFSLKLDVKNNVTNVLSSICLATSVGVMIEIP 591 
XP_006004924  410 --VWEMWFTNPFEFSITVNEVSLAKESTDLLKILNFSGPVTLSPGCWNFFSLQYEPKRTPRTL-TNLLLATNLGITFEIP 486  coelacanth
XP_007669999  407 --FWSVWLTNHFNHSVILNDVFVPKEAKHILKIVNFTGPLFLPPGCWNIFSLKFGVKNTAVNIFTHVFLTTDMGVIFAIP 484  platypus
XP_027812028  406 --LWSMWYLNHFDRGVVLNDVFVSKETKHIIKILNFTGPLFLPPGCWKIFSLKLAVKDSALNVFTHVFLTTNIGAAFAIP 483  sheep
XP_030866212  407 --LWSIWYRNNFDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIP 484  western lowla...
XP_014429943  408 --FWSIWFTNNFEFSIELNDVFVARETKNLLKILNFTEPLTLPPGCWNVFSLKLSIKDTVINIFSSVFLATNVGVTFAIP 485  Chinese soft-...
XP_007496276  487 LQIYSPPAKMGNLGSEVIAHCGMHYYMAKLNRG-SPHWQGGFPLDHPTWKVDSQLANKFYQRWQNIKSGHVC-RRSFSGM 564 
Q3U3D7        485 LQIFSAPTKEGSLGFEVLAHCGMHYFMGKSKTE-NPNWERSLSLDRSTWDMDSELANKLYERWKKYKSGDAC-RRNVLGM 562  house mouse
XP_002933525  483 VHIQSAFSKLGNMQEKIHVQCGEHPLIRILDAGgALRWQQSLSLSMSAWGIDYELGTELYEKYQKMLSGENVgKEYLEGS 562 
2_pfamImport  290 LHL-CLLHMQGNMYSDSILQCGVYCYLGTEAAV---HWHNSLSLGFLSWKVDSELGLDLRHKWQQMTEKRAK-RKILIDE 364 
1_pfamImport  298 LHL-CSIHVQGNAYSDAVLQCGIYCYLGAKAAV---HWHDSLSLESSSWKVDSELGLDLRHKWQQMKEKGTS-RQRMIDE 372 
XP_004940935  592 LQIYSTVSKQADLHFEVIAHCDVHCYLGKSDSA-NLLWQRSLSLDRSAWDVDSELARELYERWQKIRRGEACsRRSILGS 670 
XP_006004924  487 LLIHLVSSKQGDLHFEATTDCGVHRSSGTSKAV-GVLWHESLSLGDSAVDIDSTYGTELYESLQKIKCRELC-REHSLHQ 564  coelacanth
XP_007669999  485 LQIYSALSKEGPLGFEVVAHCGLHYYLEKSNTT-SRHWQESLSLDHSTWNVDSELANRLFRRWQKIKSGEVC-RRNVLGM 562  platypus
XP_027812028  484 LQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAE-NPNWEGSLSLDRSTWDVDSELANTLYERWKKLKHRDVC-KRTVLGV 561  sheep
XP_030866212  485 LQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAG-NPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVC-KRNVLGT 562  western lowla...
XP_014429943  486 LRIYSTLSKQGDLQFEAVAHCDIHCYLGKSDTA-NLLWERSLSLDHSTWNVDSELASELYERWLKIKHGEAC-RRNFLGM 563  Chinese soft-...
XP_007496276  565 TPFVYPKNSEESrSFASSLPRLITEPGLTLNFSASALRNSMVKYFVLKNPSSFPVTLHLVPLSSYSKPEWALNLLHKWFD 644 
Q3U3D7        563 SQFAFTKKSKETePFVSFLPRVVPEPNLVLNFSATALRNSAVKYFVVRNPTPQPVSLQLLPLSLYPRPEAAVRLLHKWFG 642  house mouse
XP_002933525  563 GSAQQKSNGKKH--SVSFLPQLITKPGAVVNFTATALSNNSVMHVTLKNPSPFPVTVQLLPLSHYPNPQAALSMLSKWYG 640 
2_pfamImport  365 NHLMHEKIQQSF-SSDFIWPRLSQD--FIISFSATASHNTTIKHFILKNPSDLPVTVQLLPVAYYPNPEDVLVLLKKWYE 441 
1_pfamImport  373 DPGLWETMLQSF-SSDFIWPRL--SPDFLMSFSATASHNTTVKHFILKNPSDLPVTVQLMPVAHYPNPEAVLGLLKNWYK 449 
XP_004940935  671 TCLIHQKQPEEEvSFAFFLPRLTAEPSLTLSFNATAVKSSMVKYFKLRNPSSFPVALQLLPLSYYPDPQASLSLLSKWFG 750 
XP_006004924  565 N--DFQQNGPEGvSSNFNWPHLISESSSDLSFSATAIYNSTVNYFTLKNTAAFPVTAQLMPLSHYPDPHIALNLLSKWYN 642  coelacanth
XP_007669999  563 TQFAQPQKSEELeSFSFFLPRLITEPGLTLNFSATALRNSMVKYFVLKNPSSLPVMLQLLPLSFYPEPEAALSLLHKWFG 642  platypus
XP_027812028  562 TRFAHSKKPKESePFAVFLPCLVPEPGLVLNFSATALRNSMVKYFVVKNPSSWPVSLQLLPVSLYPKPEAAARLLHKWFG 641  sheep
XP_030866212  563 TRFAHLKKSKESeSFVFFLPRLIAEPGLVLNFSATALRSRMVKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFG 642  western lowla...
XP_014429943  564 TRIARPKKPEEE-SFAFFLPRLITEPGLTLNFSATALKNSMVKYFILRNPSSFPVMLQLLPLSYYPDPQASLSLLSKWFD 642  Chinese soft-...
XP_007496276  645 IDVQLINFTTSEFQ---------LTEMCPHL-DA---HAHDdlsvtSQSEEVHLHLQPLERRRVGVVFTPIDYKKVTSII 711 
Q3U3D7        643 TDMQMVNLSTGEFQ---------LTQACPYQ-GE---PSEE-----SSLGALHVHLQALETRRVGVVFTPADYGKVTSLI 704  house mouse
XP_002933525  641 VNEQAFDVTTAEFR---------LQKECSNM-HE---EPHE-----CTTEVLELQLLPWESQQIGVIFTPLDYRKVTSLI 702 
2_pfamImport  442 LT-QDINVTTNEFM---------LVKTLDEK-GSk--HVEPds--kQSDGILQFTLQPREMRKVGVEFTPVTHGLVTSLI 506 
1_pfamImport  450 LRRQGISVTANEFR---------LVKLSDNK-HTesyKQMEld-nrPSAGILLLTLQPREVRKIGVEFAPVSHSLVTSLI 518 
XP_004940935  751 INVEAINFTTTEFR---------LMDEYSHR-NA---HQEDllskkCSSELLRLNLQPLETREVGVIFTPVDYKRVASII 817 
XP_006004924  643 FKTQAINVTTTEFKlmresakedLYQDNPGR-AK---LNDE---------VLQFQLLPGETRRIGVVFTPVDYKKVASLI 709  coelacanth
XP_007669999  643 TDVQAINFTTGEFQ---------LTETCSHR-NI---YEENlapvkSRFEVLHFHLRPLESRRIGVIFTPVDYRKVTSLI 709  platypus
XP_027812028  642 TDMQMINFTTSEFQ---------LTKACPDL-GV---PSEE-----SRFGILHLHLQPLERKRVGVVFTPADYGKVSSLI 703  sheep
XP_030866212  643 TDMQMINFTTGEFQ---------LTETCPHL-GM---HSEE-----SRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLI 704  western lowla...
XP_014429943  643 TKVQAINFTTTEFR---------LMEEYAHRqDA---QQEGltnmkSSLEVLQLHLQPLETRRIGVVFTPVDYKRVTSLI 710  Chinese soft-...
XP_007496276  712 LIRNNLTIFDMVTVEGFGARELLKVGGRLPGMGGSLRFKVPESTLMDCRRQLKESKQILSITKNFKVENVGLLTTTVSSM 791 
Q3U3D7        705 LIRNNLTVVDMVGVEGFGAQELLKVGGRLPGAGGSLRFKVPESTLMDCHRQLKDSKQILSITKNFKVENIGPLPITVTSL 784  house mouse
XP_002933525  703 LIRNNLTILDMITVEGVGAREMLRMGGRLPGIGGSLRFKVPESTLMDCRQQLKESKQILSITKVFKVENIGSLPITIQSM 782 
2_pfamImport  507 LIRNNLTVLDVVTVEGFGAIEVLKVGGKLPGAPGSLRFKVPESTLMECRGKSKGNELNLTIRRSFKVENVGPLTVSVISM 586 
1_pfamImport  519 LMRNNLTILDVLTVEGFGANEVLKVGGKLPGATGSLRFKMPESTLMECRGKSKGSELNLTIRKNFRIENVGPLKVTVISM 598 
XP_004940935  818 LIRNNLTVLDVVNVEGYGARELLKVGGRLPGAGGSLRFKVPEATLMDCRRQLKDSKQIVSITKNFKVENIGPLPITISSM 897 
XP_006004924  710 LIRNNWTVLDMVTVEGVGARELLKVGGKLPGLGGVLRFKMPESTLMECRNKSKASKPFLSIRKNFKVENAGLLPIIVTSM 789  coelacanth
XP_007669999  710 LIRNNLTILDMVIVEGFGARELLKVGGRLPGTGGSLRFKVPESTLMDCRQQLKDSKQILSITKNFKVENIGPLPITVSSM 789  platypus
XP_027812028  704 LIRNNLTVIDMIGVEGFGARELLKVGGRLPGTGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVTSL 783  sheep
XP_030866212  705 LIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSL 784  western lowla...
XP_014429943  711 LIRNNLTVLDVVNVEGFGARELLKIGGRLPGTGASLRFKVPEATLMDCRRQLKDSKKTVSITKNFKVENIGHLPITVSSM 790  Chinese soft-...
XP_007496276  792 KINGYNCQGYGFEVLGCREFSLDPNSSREISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHLLPLCADVVPGP 871 
Q3U3D7        785 KINGYNCQGYGFEVLDCHPFSLSPNTSRDISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHMLPLCAEVVPGP 864  house mouse
XP_002933525  783 KINGYSCQGFGFEVLDCHAFSLNQNSSREISIVFIPDFTSSWVIRELTLVSASNLEFRFTLNVTLPHHLLPLCADGVPGP 862 
2_pfamImport  587 SINGYRCQGFGFQILNCESFVLDVNSSHEISILFTPDFTTSWVIRELQLLTARGLQFQFTLNMSLPHHLLPLCADLVPAL 666 
1_pfamImport  599 SINGYKCQGFGFHILKCDSFVLEANSSHEISIVFTPDFTTSWVIRELQLLTARGLQFQFTLNVTLPHHMLPLCADLVPAL 678 
XP_004940935  898 KINGYSCQGYGFEVLDCQEFFLAQNSSREISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHLLPLCADVVPGP 977 
XP_006004924  790 SINGYECQGFGFEVLECQSFVLGHNGSHEISIMFTPDFSSSWVIRELALETATGSEFYFILNVTLPHHMLPLCADIVPGP 869  coelacanth
XP_007669999  790 KINGYNCQGYGFEVLDCQEFSLDPNSSREISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHLLPLCADVVPGP 869  platypus
XP_027812028  784 KINGYNCQGYGFEVLDCHQFSLGPNMSRDISIVFTPDFTSSWVIRELTLVTAAGLEFRFTLNVTLPHHLLPLCADVVPGP 863  sheep
XP_030866212  785 KINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGP 864  western lowla...
XP_014429943  791 KINGYSCQGYGFEVLDCQEFFLAQNSSREISIVFTPDFTSSWVIRELTLVTSADVEFRFTLNVTLPHHLLPLCADVVPGP 870  Chinese soft-...
XP_007496276  872 SWEESFWKLTVLFVSLSLLGVILIAFHQAQYILMEFMKSRQRHNPISSS-QQNSSPVDVISPDSYK---SSCKTFLDSYS 947 
Q3U3D7        865 SWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNGSSSS-QQNGDPVAMISSHPHK---STCKNFLDTYS 940  house mouse
XP_002933525  863 SWENSFWKVTVMCVSFSLLAVILIATQHAHCILIDFLKSRHRNCSISAS-HQISSQVDTITSESFR---GSCKNYTDSFS 938 
2_pfamImport  667 SWEQPFWIVVCLFSCLLLVCVIIMAYQRAQYILTEFSQSRQRTCQTSLLlQQDRTSINTLGATTCKlsrTGCKTCIEGKN 746 
1_pfamImport  679 SWEQPFWMIVCLFSCLLLFCVIIMAYQRAHYILTEFSQSRSRPCHTSLLlQQDRTSINTLGSTTYKlsrTGCKAYSEGNN 758 
XP_004940935  978 SWEESFWRLTVLFVSLSLLGVILIAFQQAQYILAEFMKSRQRPNPSSSL-QQNSNSVDVISSDSYK---GSCKTFMDSYS 1053
XP_006004924  870 SWEGAFWGIMVLFASLLLVGVIFLAHQQAQCILTEFTKSRPRPNQNSSL-LQDGNSVDTVGSSTYKp-rGSCKTFTDSCS 947  coelacanth
XP_007669999  870 SWEESFWRLTVLFVSSSLLGVIVIAFQQAQYILTEFMKSRQRQNPNSCS-QQNSNSVDVISSDSYK---SSCKSFVDSYS 945  platypus
XP_027812028  864 SWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSS-QQSASPVDVISPHSHK---SNCKNFLDTYA 939  sheep
XP_030866212  865 SWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSS-QQNNGPMDVISPHSYK---SNCKNFLDTYG 940  western lowla...
XP_014429943  871 SWEESFWKLTVLFVSFSLLGVILIAFQQAQYILAEFMKSRQRPNPSSSL-QQNSNPLDIINSDSYK---GSCKTFMDSCN 946  Chinese soft-...
XP_007496276  948 PSDKGRGKGFLSVSSaPPNR-IQNATKRSPATCTHTQKKHKCSVYYSKQKASPSGAShTSANPDNKQs-LMPGSSASSPK 1025
Q3U3D7        941 PSDKGRGKSCLPVGP-SLSR-LQNAAKRSPATYGHSQKKHKCSFYYSKQKPSASAASsANVTTEEKQt-VTLASSLSVAK 1017 house mouse
XP_002933525  939 SPDKGKGRGCLTVTA-PQNR-SQNASKRGPATYSHSQKKHKCSVYYSVKQKSSSSTAsSVATLCDASeqQTSDMPSANPK 1016
2_pfamImport  747 SPDRGKGRGTVQING-TSVR-TLNISKRSPGNAGHCSKKLK---YYNKNKLNTSSIScGTSEGYQLT---NGGPFYCSKE 818 
1_pfamImport  759 VSDRGKGRGTIALNG-SSVR-TQSTSKRSPINSNHCPRKLK---YYSKSKLNTSTNItNGTSEEYRQ---TSGVPFYSPK 830 
XP_004940935 1054 SSDKGKGKGFLSVGT--SSR-SQNAAKRSPATYSHSQKKHKCSVYYSKQKPNAVAGSaIATTDEKQN--QIVENQISAPK 1128
XP_006004924  948 SLDKGKGKGSLLVGS-PSSRgSQNLSKRNPGAYNNIQKKHKCSVYYNKPKISNGHCFtPPTDELYQP---TSDGQTPAFQ 1023 coelacanth
XP_007669999  946 PSDKGKGKGFLSVAT-PPSR-IQNATKRSPATYSHSQKKHKCSVYYSKQKASTVVASnANTTTDEKQt-LAAETHASAPK 1022 platypus
XP_027812028  940 PSDKGRGKSCLPVSS-PQSR-IQNATKRSPATYGHSQKKHKCSAYYGRHRGSAAVASsAGAAS---------EDKPAPAK 1008 sheep
XP_030866212  941 PSDKGRGKNCLPVNT-PQSR-IQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASsTSTTTEEKQt-SPLGSSLPAAK 1017 western lowla...
XP_014429943  947 TSDKGKGKGFLSVAT-PSSR-SQNAAKRSPATYSHSQKKHKCSVYYSKQKPNTITGN-VITTTDEKQn-QTLENQTSAPK 1022 Chinese soft-...
XP_007496276 1026 EDHGTDATNESWIn---lKYANGLNVNlQKNLTLPGNFLNK-----EENALKNNLIv----KNPSSESDLKEEVQRCMFP 1093
Q3U3D7       1018 EDICTNVLSENWVs---lRYASGINGSlQKNLTLPKNVLHK-----EESSLKNTVV-----TNTPSECSMKEGVHTYMFP 1084 house mouse
XP_002933525 1017 DSDCNEILNLNST--------ESRDTDnERHLSSPDNNLGK-----EEPAKQDPHLq----QRTANESPLKEKPVLCMFP 1079
2_pfamImport  819 QQSCTESPPYMKPcd--eRYAPFVGQD----LEKVEEIVQE-------CEIKPFCL-----ETEPTTEHADHEPVTCVLS 880 
1_pfamImport  831 EQQ-PHMESLPYMklhdeNYGPFAGENlEKVEEMVQECEGKpffleTEPTTDHELVtcvlsEEQSSVLPIPDIKELNHYG 909 
XP_004940935 1129 EDICANVVSENWVt---lKYANGISVN--KNLTLRENFLGK-----EESALKNTVLi----KSSSSECSLKEDLQTCMFP 1194
XP_006004924 1024 EGLCADPIHCENLtg--lRYLDGISKRvENVYLHPENVLDKk----EETALPNKYAt---gRVSPESAAAKEERQANVFP 1094 coelacanth
XP_007669999 1023 EDLCVDTGGENWIn---fKYANGISVNvQKNLTLPGNFLGK-----EENTLKNTNVv----KNTSSECDVKEVTQTCMFP 1090 platypus
XP_027812028 1009 GDGCPAGPGEAWVg---lRCAGGLSANlQKSLALPRSFLGK-----EENTLKSAVA-----ASSPSEGHVKEGAQTCMFP 1075 sheep
XP_030866212 1018 EDICTDAMGENWIs---lKYASGINVNlQKNLTLPKNLLNK-----EENTLKNTIVf----NNPSSECNMKEGIQTCMFP 1085 western lowla...
XP_014429943 1023 EDICTDIVSENWL-----KYANGINENmQKNLTLPENFLDK-----EESALKNTVLm----KSSSSVCDLKEDLQTCMFP 1088 Chinese soft-...
XP_007496276 1094 KETELKTSETVSELKQRE-LCPLKTSKKLPENHFPKNSPHH-PSDLQEI-SRKNNgNNQQMAI-KNEVENCETLKKQv-- 1167
Q3U3D7       1085 KETDSKISENVAELKEQE-PCPQKTSKKPPESTLPKTPPQYlQSDLPEV-SRKHG-NKQQAPV-RSEVDSFEPVRAA--- 1157 house mouse
XP_002933525 1080 VETNLKTSESLSEPKLQPdFCDLPVPSKMSVSHLSKNLSNP-QMESQTV-SKKNEgNRQQTPP-TLHREVLESTRKQa-- 1154
2_pfamImport  881 EERSSEIP--IAALDNKE----LSHYGSFHAHSLDDHHDHL----VPEE-SFRTD--ETQVSLtTIDDLQQGTMEKI--- 944 
1_pfamImport  910 SFQAHTLDENHDHLVSAE---SFRTDETQFASSIIKDKPQQ--GTMEKI-SENLK-VEEQVSLeLQEKAHVPVLQNVl-- 980 
XP_004940935 1195 RETNLKASENVAEVKEQE-FCPVKMSKKLPESHLSRSSPQQ-QLELQEI-SRKNSgNNQQALL-RNETEDCESLKKQi-- 1268
XP_006004924 1095 KETNLNLTENAVEHREPE-FCFVTSLGKHADNPMPGNQLNS-EKEQSDAlDHHEg-STHQMTI-LGRKENCEKVKQAi-- 1168 coelacanth
XP_007669999 1091 KETDIKTSENLTELKERE-LCSLKTPKKLPESPLPRNSPPP-QAELQET-SRKNNgSNPQVPN-KNEVENCEALKKQvvi 1166 platypus
XP_027812028 1076 KETDFQISESVAELKERE-VCQMKTPKKLPENHLPRSSPQC-QSDLPDI-SRKNNgNNQQVPV-KNEVDNCETLKKV--- 1148 sheep
XP_030866212 1086 KETDIKTSENTAEFKERE-LCPLKTSKKLPENHLPRNSPQYhQPDLPEI-SRKNNgNNQQVPV-KNEVDHCETLKKV--- 1159 western lowla...
XP_014429943 1089 KETNLKTLENITELKEQE-FYPLQTSKKLPESHLSRNSPQQ-QPELQDI-SRKTNgNNQQVPL-RIETENCEILKKQv-- 1162 Chinese soft-...
XP_007496276 1168 DVKPSSEKKIHKTSKED-TCCGKQDIPSs-VEQ-------EEKKKRPQEKKDGNLPNLN-WNKTRTSRKNKKKGVTASA- 1236
Q3U3D7       1158 DAEPSSVRKTQGASPED-TCSEKQDTPS--AEQe-----dPSRKRKLQERREGSTQALN-WNKTRPCRRNKKRASAQASs 1228 house mouse
XP_002933525 1155 AKDASNEKISRSTSREE-KLCGRNDALAa-IKHe-----ePLRKKSPIDKRDGIFQNVN-WNKNRSSARKNKKKNTVFPa 1226
2_pfamImport  945 SENVKTEAQVPDKPQEKnCVPELQNAQPpfVTHklstsetPLDKVKQKRQVKGEVTTHNkWKGRKSCGKNKNISLRSTDq 1024
1_pfamImport  981 ---PSFIVQILPTAEQK---------TS--IDN--------VKQKRQQEKSEVTIRN-K-WKGRKSCGKNRNISAQSIE- 1035
XP_004940935 1269 NIKPSTEKKINKGRKEEtLCCTKEEITS--SEQe-----dAFRKKKPQEKKEGNVPNMN-WNRNRTSRKNKKKNVNIST- 1339
XP_006004924 1169 -SELSLDRKGLKGPKPV-ASCVKSEVSV--VEn-------AVEDKKKMENNSANIPGKA----NRTSRKHRRR------- 1226 coelacanth
XP_007669999 1167 STKPSSEKKVHKAPKEE-PCCGKAELPS--LEQe-----dPYRKKRPQEKREGNLPNVN-WNRNRTTRKNKKKGIAVSA- 1236 platypus
XP_027812028 1149 DTKSSSEKKIHKAAKDD-GCSEKQDIPS--IEQe-----dPYRKKALQEKKEGNGQNLN-WNKNRLCRKNKKRGAAQVL- 1218 sheep
XP_030866212 1160 DTKPSSEKKIHKTSRED-MFSEKQDIPF--VEQe-----dPYRKKKLQEKREGNLQNLN-WSKNRTCRKNKKRGVVPVS- 1229 western lowla...
XP_014429943 1163 NMKPSTEKKISKGPKEDiPCCGKQEVVS--VEVfx---xxXXRKKRSQEKREGNLLNTS-WNRNRTSRKNKKKNVNASP- 1235 Chinese soft-...
XP_007496276 1237 --RAPEQNELKHACSEferpelrgnppLRNWCTPSGAvDVCKTESKMT-SVAP--GEt-----EGHYQRPKkKC--GDKF 1304
Q3U3D7       1229 spRPSEQSEQRLVCSD-----------VRSWCAQDGAgEKCKAGTEVSgSSPErrEE------DSYYQKSEkKC--ADKF 1289 house mouse
XP_002933525 1227 --RGAEQNDVKHKWQEversdlrgpnrIKHWNSLPNG-DLFKGEPKNG-RFPLr-GDa------ECYQILKkKP--ADKF 1293
2_pfamImport 1025 --AGGVHSQRNYNCRQkealy--qdrsRKVWQCAKKEkSNIHTKPDIY--LKEaeGDc--------CSNWKmLI--RKVR 1088
1_pfamImport 1036 ---QAGGVHSERTYNRrqkedrvqdrsRKVWQYGKKE----NANIYTKpDFYLkeAEn-----GHCCPNWRvLL--GKVR 1101
XP_004940935 1340 --RVSEQSELKYLCNEyerldlrenigIRAWRPQGDG-ENCKADQKPG-SLSIq-GEt-----ESFYQWSKkNC--LEKF 1407
XP_006004924 1227 ------VPEQTGLTRTeerteprtqnsLRSWCPNGNR-ETCTMGTRADcSFTSteKSrpalynSRLCHPSSrKKavEKRL 1299 coelacanth
XP_007669999 1237 --RVPEQSEPKHMCSDferpdlrsnigLRNWCGQGSTvEICKPEPQTA-SLSAsqGEt-----ENFYQRPKkKC--VEKF 1306 platypus
XP_027812028 1219 --RPSDQSELKLMCSEferselsgdinVRNWRIQENPgEACGAAASTGsSLRAtqGEa-----EGCFQKPGkKS------ 1285 sheep
XP_030866212 1230 --RPPEQSDLKLVCSDferselssdinVRSWCIQESTrEVCKADAEIAsSLPAaqREa-----EGYYQKPEkKC--VDKF 1300 western lowla...
XP_014429943 1236 --RVPEQNELKRICSEferpelrtnigIRNCCAQSNG-EICKTDQKVV-SLSTq-GEt-----ESLYQRSK-NC--LEKF 1302 Chinese soft-...
XP_007496276 1305 CSDSSSDCSSSSGSVRASRGSWGSWSSTSSsDGDKKPSLPSR-HFLP--SRENVSQNDFPSETPI--------------T 1367
Q3U3D7       1290 CSDSSSDCGSSSGSVRASRGSWGSWSSSSS-DCDRRPVVDIQ-HFLP--PGDGVSPQNFPSEASV--------------P 1351 house mouse
XP_002933525 1294 SSDSSSDCSSSRGSVRASRGSWGSWSSASSsEGDKKNGLPTR-HFLP--SRESMPQSGFPAEAPI--------------A 1356
2_pfamImport 1089 SGESSSDSGSSSDSVRASLDSWGSWSSSSS-EGEKDQSINPQlHFVP---SATQKERIFQQASPIyspslqehhssgnrS 1164
1_pfamImport 1102 SGESSSDSGSSSDSVRASRDSWGSWSSSSS-EGEKDQSINAK-LHFV--SSAAQRERIFQQASPF--------------Y 1163
XP_004940935 1408 CSDSSSDCGSSSGSVRASRGSWGSWSSTSSsDGDKKPMITAR-HFLP--SRENISQNDFPSETPI--------------T 1470
XP_006004924 1300 SSDSCSDYGSSSSSVRASRGSWGSWSSTSSsEGEKDSGRPKM-HFIPieQRENNSENRLPIEIKH--------------L 1364 coelacanth
XP_007669999 1307 CSDSSSDCGSSSGSVRASRGSWGSWSSTSSsDGDKKPAVPPR-HFFP--SRETISQNDFPTETPI--------------T 1369 platypus
XP_027812028 1286 CSDSGSDCGsssggvRASRGSWGSWSSGSSsDGDRKPAAGAP-RCLP--PGDSALQNDFSSEAPI--------------S 1348 sheep
XP_030866212 1301 CSDSSSDCGSSSGSVRASRGSWGSWSSTSSsDGDKKPMVDAQ-HFLL--AGDSVSQNDFPSEAPI--------------S 1363 western lowla...
XP_014429943 1303 CSDSSSDCGSSSGSVRASRGSWGSWSSTSSsDGDKKPMITSR-HFLP--SRENISQTDFPTETPI--------------T 1365 Chinese soft-...
XP_007496276 1368 LNLSHNICNPSr----------DMNTIPQY--------------AEPLCSDFPDVTSDPDKNKGLYPPG--DLWPGQPVC 1421
Q3U3D7       1352 LSLPQHVCSST-----------DVSVLPEF--------------TESPCPGLPATPAGAGEEKGLYPPG--GLWPSQPVC 1404 house mouse
XP_002933525 1357 LNLSHSICNTSt----------DINAMPRY--------------PEILSPSYTSVTDTEKSK-GRYSHE--DIWSTQPVC 1409
2_pfamImport 1165 HSTNNNVCLRGa----------AEPSTPPD---------------KNHCPTFAAVAAGLKKSPGLYTTVngQCLKS--IP 1217
1_pfamImport 1164 SPTLQEHHSPGsrr------laHFSQLPSNnvhlrgdpqpsslqDKSHCPSFAAVAAGLKKSPGLYTSVngQCLKS--IP 1235
XP_004940935 1471 LNLSHNICNTSr----------DMNSIPQY--------------PDTLCPNFTDIAADPEKNKGLYPAG--DLWPPQPVC 1524
XP_006004924 1365 QHQNYNLCGMStnnsyqtraeqATTALPSS----------------YTCPSFAEIAAGLGKNAGPYPEE--EVWSPQPFP 1426 coelacanth
XP_007669999 1370 LNLSHNICNPSr----------DMNTVPQY--------------PETLCPGFPDMSAEPDKNKGLYPTG--DLWPAQPVC 1423 platypus
XP_027812028 1349 LNLSRNICNPT-----------DVSGLPAP--------------ADAPCPSLPAGPAAAEDQ-GLCAPG--DLWPAQPLC 1400 sheep
XP_030866212 1364 LNLSHNICNPM-----------TVNSLPQY--------------AEPSCPSLPAGPTGVEEDKGLYSPG--DLWPTPPVC 1416 western lowla...
XP_014429943 1366 LSLSHNICNTSr----------DINTVSQY--------------PETLCPNFSDITADPDKNKGFYPTG--DLWPAQPVC 1419 Chinese soft-...
XP_007496276 1422 PTNSLNYNLENSMP-CMIQEPPPVQN----SFIDWNTT-CEGQFPNVYCPLEVNDYNGFPEENMNYHNGFPCPTEVPSTA 1495
Q3U3D7       1405 LTSSFNCPVENGAP-GVSQEPTSIPDs---SFIDWSAS-CEGQFPSVYCPLELNDYNAFPEENMNYTNGFPCSSKVQTDF 1479 house mouse
XP_002933525 1410 LPNDVNYNVEGTVS-CVMRDPAPAQN----SFINWNST-CDGQFSGIYGPLELNDLAPYNEENMNYHSGFSCPEVQNPAF 1483
2_pfamImport 1218 PVHGLAYLSGNGM----QVEPQSGDA----A--GYSDH-CSNALSTFHE----NYFSNVSEANVNLHNPFIDTEGENSSL 1282
1_pfamImport 1236 PANGMAYHSGNGM--QFNPQPNAAADyshlSrTTYNGDhCSNIFNTYHE----NDFSNVSEGNLNSLHPFIYTEGQNASF 1309
XP_004940935 1525 LTNSLNYNLENNLP-CMIQETPPIHN----SFIDWNAT-CDSQFSNVYCPFEMNEYGAIPEENMNYSNGFPGTAAMQNTA 1598
XP_006004924 1427 VTNGFEYRIENNLA-FFPPKIPSVHN----GFHGWDDV-CEDQYSGVYYPFNQNNFGSLPDDHMNYQHSFPCSEVQNTDF 1500 coelacanth
XP_007669999 1424 LTNGLNYNLENNMP-CMIQEPPPVHN----SFIDWNAT-CEGQFPNMYCPVEVNDYTAFPEENMNYHNGFPCPAEVQSTA 1497 platypus
XP_027812028 1401 VTGGFGCALESGGpaTLPPPAAVPSS----SFIDWNAT-CEGQFPSVYCPLELNDFNAFPEDSMSYPSGFPCPAEVQTDF 1475 sheep
XP_030866212 1417 VTSSLNCTLENGMP-CVIQESAPVHN----SFIDWSAT-CEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADAQTDF 1490 western lowla...
XP_014429943 1420 LTNSLNYNLENNVP-CMIQETPAIHN----SFIGWNTT-CDSQFPNIYCPLEMNEYGAFPEENMNYPNGFPCTAEVQNTA 1493 Chinese soft-...
XP_007496276 1496 fISHSSQSSWS----------TPSTVPPAWEPANYvspsVSDPeftPYLASTRSLSPMSGLFGSIWAPQNDVYESCC-SI 1564
Q3U3D7       1480 -IGHSTPSTWN----------TPASMPAAWGHASL----VNSP---SYLTSTRSLSPMSGLFGSIWAPQSEVYETCC-PI 1540 house mouse
XP_002933525 1484 -IEHQCQPTWNmsapvppappQDPPMPSTWEPASY-----------PYLSSTRSLSPMSGLFGSIWAPQNDGFDGCC-PV 1550
2_pfamImport 1283 ---ADSASSWT-----------NLEAPCSWNHSNY----VRTP---SYLSGTRSLSPMSGLFGSIWTPQCDPYHSYF-TS 1340
1_pfamImport 1310 -ADSSCADTWT-----------TQDAPSSWKLPNY----VSTP---SYLSGTRSLSPMSGLFGSIWTPQCEPYQSYF-TS 1369
XP_004940935 1599 fIDQSCTSTWN----------APHNMPPTWEPASY----VNST---PYLSNTRSLSPMSGLFGSIWAPQSDVYESCC-PV 1660
XP_006004924 1501 -IGHNCLPTWNa--------dPVQDTPNTWDPTNV----INSP---PYFSGTRSLSPMSGLFGSIWTPQNNLYESCH-PV 1563 coelacanth
XP_007669999 1498 fIDHTCQSTWS----------TPPNLPPAWEPASY----INST---PYFSSTRSLSPMSGLFGSIWAPQSDMYENCCpAV 1560 platypus
XP_027812028 1476 -VDHSSPSAWG----------SPPSVPTAWGHAGL----ISSP---PYLTSTRSLSPMSGLFGSIWAPQSDMYESCC-AI 1536 sheep
XP_030866212 1491 -IDHNSQSTWN----------TPPNMPAAWGHASF----ISSP---PYLTSTRSLSPMSGLFGSIWAPQSDVYENCC-PI 1551 western lowla...
XP_014429943 1494 fIDHNCQSTWS----------APPSMTPTWEPASY----VNSS---PYLSSARSLSPMSGLFGSIWAPQSDVYENCC-PV 1555 Chinese soft-...
XP_007496276 1565 SPTTQHSTHMENPaVMCKqEYYPRFNPFRAYMNLDIWTTTANRNTNFPLSRDSG-YCGNV 1623
Q3U3D7       1541 SPATEHATHMENQ-VMCK-EYYLGFNPFRAYMNLDIWTSTANRNANFPLSRDSS-YCGNM 1597 house mouse
XP_002933525 1551 NGSPPHSEHVGNHsVMCKqEYSPRFNPFHAYMNLDIWTATANRNAAFPISRDSGsYCGNL 1610
2_pfamImport 1341 GSAVSYTSVNENLeTACSqEQTASFDPFGTYMNLHIWNSSCSRVCSSQLSSDSG-YYGDI 1399
1_pfamImport 1370 DNSVSHTLVNENLeSTCTqGQTSSFDPFGTYVNLHIWNSSSSRVCNSQFSSDSG-YYGDI 1428
XP_004940935 1661 SATTQHSTHVENQaVMCKqEYYPRFNPFRAYMNLDIWTTAANRNPNFPLSRDSG-YCGNV 1719
XP_006004924 1564 QSAAQCLAANESQaVMYKpDGYSGFDPFHTYMNFDIWTSSSNRSSNSQLSSDSG-FCVMS 1622 coelacanth
XP_007669999 1561 SATSQHSAHVESQaVMCKqE----FNPFRAYMNLDIWTTAANRNANFPLSRDSG-YCGNV 1615 platypus
XP_027812028 1537 NPTAEHSAHMENQaAMCK-EYYPGFNPFRAYMDLDIWTSTASRSANFPLSRGSG-YCGDV 1594 sheep
XP_030866212 1552 NPTTEHSTHMENQaVVCK-EYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSS-YCGNV 1609 western lowland gorilla
XP_014429943 1556 SATGQHSAHVENQaVMCKpEYYPRFNPFRAYMNLDIWTTAANRNANFPLSRDSG-YCGNV 1614 Chinese soft-shelled turtle
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