Conserved Protein Domain Family
SR-25
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pfam10500: SR-25 (this model, PSSM-Id:431320 is obsolete and has been replaced by 463119)
Nuclear RNA-splicing-associated protein
SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localization signals strongly implies that this is a nuclear protein that may contribute to RNA splicing. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway.
Links
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Statistics
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PSSM-Id: 431320
Aligned: 11 rows
Threshold Bit Score: 188.951
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007239762   5 RSRSRSRERKStsrq--greRRTEKKRRKYSSSSS-SSSSASPSSQKKHGrVSNKSms------kDRKTERKKQKRRRSS 75  Mexican tetra
Q66PJ3       191 RKRSRSRSRSR---------GRGSEKRKKKSRKDTsRNCSASTSQGRKAS-TAPGAeaspspcitERSKQKARRRTRSSS 260 human
EGW14956       7 RKRSRSRSRSRg--------RRGSEKRSKKSSKDAsKNCSASKSPGHKACsTSE-----------ERSKHKARRTAR--- 64  Chinese hamster
Q4V8I5         7 RKRSRSRSRSRg--------RRGSEKRSKRSSKDSsRNCSTSKSQGHKASsTSGVE---------ERSKHKAQRTSR--S 67  Norway rat
XP_604454      7 RKRSRSRSRSR---------GRGSEKKRKKSSKDVrRSCSASRSQSRKASsTSSGAe--------ERSKHKARRRPR-SS 68  cattle
1_pfamImport   1 RKGSRSRSGTR---------ERGSEKRRKKSSKDApRSCSASRSQASPSPcIT------------ERSKHKARRRPR--S 57 
Q502P0         3 GSDSDSRSRSR---------NREENKSRSLSSSSA---RRPSPNHEKKH----------------EHSSEKKKMKRRRSS 54  zebrafish
XP_005989016   3 RSRSRERSRSRtktsscgkgLKRDGKKRSRSSSSSrRSTSLSKKCHHSTSpSK------------ERKPEKKKAKRKPSA 70  coelacanth
Q5F4A9         7 RKRSRSSSRSPs--------GSGREKGGARSS-------AASPGPRHRLSsAAAREg--------RKKEGRKKKKRKAKA 63  chicken
XP_001521084   9 RSRSRSGSRGRp--------ERSKEMRRKRGSKERrRSRSASGSRSRRPRaASHKP---------ERSKDRGRKRRRPSS 71  platypus
XP_003761099  39 RSRSRSRSGSHgp------pEHGERRRRRRSSKDMgRSPSASGSQGQRISlGSNGE---------ERSRDKARKRRRPRS 103 Tasmanian devil

XP_007239762  76 SSSSSSSSSSSSSSISSSSSTSSSde----eAKKKKKHRMTKKRLKKMka---kkKKKEKKEKKr-lKkiKKLA-AKAEK 146 Mexican tetra
Q66PJ3       261 SSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKYKDKRRKKKKK-------RKKLKKKGK---E--KAEA-QQVEA 320 human
EGW14956      65 --SSSSSSSSSSSSSASSSSSSDG-------RKKRGKNKDKKRKKKKKr------KKKLKRKGK---E--KAVVlHPAEA 124 Chinese hamster
Q4V8I5        68 SSSSSSSSSSSSSSSTSSSSSSDG-------RKKRGKHKDKKKRKKKKk-----rKKKMKRKGK---E--KAVVvHQAEA 130 Norway rat
XP_604454     69 SSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKHKDKKRKKKKKk-----rKKKLKKRGK---E--KARM-QQTEA 130 cattle
1_pfamImport  58 SSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKHKDKKRKKKKKr------KKRLKKKGK---E--KAKV-QQAEA 118
Q502P0        55 SSSSSSSSPSPS-------------------REKKAKKKKKRREAKKLkre-kkkEKKEKKRQKklaLkaERAA-ALTAS 113 zebrafish
XP_005989016  71 STSSDSSSPASSTSTCSSSLSDSDtes-kesKQQKGKNKTKKSKKKSKkmn-rksKKMKKKKAK---EapTAAK-PKLSK 144 coelacanth
Q5F4A9        64 SSSDRSSSSRSSSSSSSTSSSDSDtrakqhsRRKRGKHKDKKKKKKMK--------KKLKKKSK---ErvKEER-GVSEA 131 chicken
XP_001521084  72 SSSSTSSSSSSSSSSSSSSRSSSGg------RKKRSKRKDKKRRKKKKkk----aKKKVKKKCR---EkgEAGT-QSPQG 137 platypus
XP_003761099 104 SSSSSSSSSSSSSSSSTSSSSSSGass--ggRKKRGKRKDKKSTKKKAkkklrkkKKKKKKKEE---KaaKAKA-KAVEE 177 Tasmanian devil

XP_007239762 147 VATKApliipvpgsvqvektqsyLETWQNDDAAE-HGPVMTDEQKASFSTKRPMTKEEYEARQSVIRRVTDPETGRTRLI 225 Mexican tetra
Q66PJ3       321 LPGPS------------------LDQWHRSAGEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTRLI 382 human
EGW14956     125 LPGPS------------------LDQWHKSAGED-DGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLI 185 Chinese hamster
Q4V8I5       131 LPGPS------------------LDQWHRSAGEDnDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLI 192 Norway rat
XP_604454    131 LPGPS------------------LDQWHRAAKEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLI 192 cattle
1_pfamImport 119 LPGPS------------------LDQWHRAAEEEeHGPVLTDEQKTRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLI 180
Q502P0       114 VPAPVpeek----------pqtyLKTWQSEETKE-HGPAMTDEQKAKLSTRRPLTKEEYEARQSVIRRVLDPETGRTRLI 182 zebrafish
XP_005989016 145 MAGPS------------------VEQWQRETWVE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETRRTRLV 205 coelacanth
Q5F4A9       132 LPGPS------------------LELWQKEPLAD-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTRLI 192 chicken
XP_001521084 138 MPGPS------------------LDQWQKEPLEE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVVRKVVDPETGRTRLI 198 platypus
XP_003761099 178 MPGPS------------------LDQWRKEPPVE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTRLI 238 Tasmanian devil

XP_007239762 226 RGDGEVLEEIVSKERHKDINK----------------------------QSTKADGTTFQKRLGI 262 Mexican tetra
Q66PJ3       383 KGDGEVLEEIVTKERHREINK----------------------------QATRGDCLAFQMRAGL 419 human
EGW14956     186 KGDGEVLEEIVTKERHREINKvgvtalamlcprcvytqylmlltcflpqQATRGDGLAFQMRAGL 250 Chinese hamster
Q4V8I5       193 KGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQMRAGL 229 Norway rat
XP_604454    193 KGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQMRAGL 229 cattle
1_pfamImport 181 KGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQLRAGL 217
Q502P0       183 RGDGEILEEIVSKERHKDINK----------------------------QSTRGDGDAFQKRLGI 219 zebrafish
XP_005989016 206 KGDGEILEEIVSRERHKEINR----------------------------QATVGDGVSFQTRMGL 242 coelacanth
Q5F4A9       193 KGDGEVLEEIVSKERHKEINK----------------------------QATRGDGLAFQVRTGM 229 chicken
XP_001521084 199 KGDGEILEEIVTKERHKEINK----------------------------QATRGDGLAFQLRAGL 235 platypus
XP_003761099 239 KGDGEVLEEIVTKERHKEINK----------------------------QATRGDGLTFQLRAGL 275 Tasmanian devil
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