Conserved Protein Domain Family
CTNNB1_binding
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pfam08347: CTNNB1_binding (this model, PSSM-Id:429937 is obsolete and has been replaced by 462440)
N-terminal CTNNB1 binding
This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.
Links
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Statistics
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PSSM-Id: 429937
Aligned: 18 rows
Threshold Bit Score: 184.279
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003224258   19 GGGSGD-DLGAPDELIPFQDEGdEQDKGA-GG--RGSAHGDLDELKSSLVHESESRGAgggggSSSESEAErppppprpR 94  green anole
10_pfamImport   1 NGGGGD-DLGANDEMISFKDEG-EQEEKI-SE--NVSAERDLDDVKSSLVNESENNSS-----SSDSEQAErrpqtrpdS 70 
EEN52158       30 NGSGGD-DLGASDETISFKDEG-EQEEKS-----AENVSNDLSDIKSSLVNESESSQSgavpsEGSKPPLQs-------- 94  Florida lancelet
Q9W7C0          7 GGGGGDpELCATDEMIPFKDEGdPHKEQIfAEisHSEEEGDLAEIKSSLVNETEISPN-----SNS-------------H 68  zebrafish
8_pfamImport    1 SGGGGDpELCATDEMIPFKDEGdPHKEQIfAElsHSEEEGDLADIKSSLVNESESSPN-----SNS-------------- 61 
7_pfamImport    1 SGGGGDpELCATDEMIPFKDEGdPHKEQIfAElsHSEEEGDLADIKSSLVNESESSPN-----SNS-------------H 62 
6_pfamImport    1 GGGGGDpELCANDEMIPFKDEGdPQKEKIfAEisHPEEEGDLADIKSSLVNESEINPS-----TIS-------------H 62 
XP_003410438    9 GGGGGDpELCATDEMIPFKDEGdPQKEKIfAEisHPEEEGDLADIKSSLVNESEIIPA-----SNG-------------H 70  African savann...
3_pfamImport    1 NSAGED-DLGASDEMISFKDEG-DQEEKI-RE--SAFTERDLADLKSSLVNESEVSSHprvpeSH--------------P 61 
Q8JHX2          5 GSGGGD-DLGATDEMLAFKDEG-EQEEKI-PE--NAFTERDLADLKSSLVNESEGSGSpaaaaD---------------P 64  chicken

XP_003224258   95 ESF-QKPRDspaSVAEVLRRQQD-G-------GFFKG-TPYPSYP-FLMIPELG---SPYLQSGALSPgGARTylqvkwP 160 green anole
10_pfamImport  71 ESY-EKTRD---YFSEALRRQQD-G-------GFFKS-PHYPGYP-FLMIPDLT---NPYLSNGSLSP-SARTylqmkwP 132
EEN52158       95 ------------YPREDSRRGDE-GskaesvpVVSRG-PAYLTPG-GVIVSNMGvypHP---NGSLA------------- 143 Florida lancelet
Q9W7C0         69 DAArQSQITpdsYHEKHRDHPDD-Gkl---qdLYSKG-HPYPSYPgYIMMTNMNn--EPYMNNGSLS------------- 128 zebrafish
8_pfamImport   62 HGVrQSQIPd-sYHEKHRDHQEDgSkihnnv-tnccghAPYTVTPvPVLP-------EPYLRQEPISi------------ 120
7_pfamImport   63 EIVkQH------FSSTYKGHRES---------VYHKHfPPHPSGPcYTAPRSFYpfsFPCLPFSSLSv------------ 115
6_pfamImport   63 EAArRSQVPqdsY-DKAREHPDEaGkhp-dgvLYNKG--PYQGYPgYIMMPNMN---DPYMSNGSLS------------- 122
XP_003410438   71 EVArQAQTSqesYHDKAREHPDE-Gkhp-dggLYNKG-PSYSGYSgYIMMPNMNn--DPYMSNGSLS------------- 132 African savann...
3_pfamImport   62 EAMrRTQDAqlvYQDKLTDHMED-Gvkh-qdeGMYKG-SGYPSYP-FLMLSD------PYLSNGSVS------------A 119
Q8JHX2         65 EAIrRVQDPqrvYQEKLPDHMDDaGmkh-qdpGMYKG-SAYSGYP-FLMLSD------PYLPNGSMS------------P 123 chicken

XP_003224258  161 LldvpagatlkdtrspSPAHL-SNKVPVVQHAHHMHPLTPLITYSNDHFSPG-SPPSHL-----SPEI-DPKT--GIPRP 230 green anole
10_pfamImport 133 LldvpgsaglkdsrspTPGHL-SNKVPVVQHAHHVHPLTPLITYSNEHFSPG-TPPSHL-----SPEIlDPKT--GIPRT 203
EEN52158      144 ------------------ASAtSNKVSVVHGPPHPGPLTQLMMYSNEHFAPG--TPPHIgvppnSIEV-DPKT--GIPRP 200 Florida lancelet
Q9W7C0        129 ----------------PPIPRtSNKVPVVQPSHAVHPLTPLITYSDEHFAPG-PHSGHH-----PQDV-NPKQa-GMPRH 184 zebrafish
8_pfamImport  121 ---------------sLPQ---SNKVPVVQPSHAVHPLTPLITYSDEHFAPG-SHSGHH-----PHDG-SSKQgrGMPRQ 175
7_pfamImport  116 ---------------sPP----SNKVPVVQPSHAVHPLTPLITYSDEHFAPG-SHSGHH-----PHDG-SSKQgrGMPRQ 169
6_pfamImport  123 ----------------PPIARtSCQLSVVQPAHVLHALGEFFTYTEQGFKPGvSHPSFL-----PSRK-NVRQ--GMPRH 178
XP_003410438  133 ----------------PPIPRtSNKVPVVQPSHAVHPLTPLITYSDEHFSPG-SHPSHI-----PSDV-NSKQ--GMPRH 187 African savann...
3_pfamImport  120 L---------------------SSKVPVVQPSHGVH---PLIPYNNESFSHG-SHSTHL-----PADL-NQKQ--GVHRP 166
Q8JHX2        124 L---------------------SNKVPVVQPSHGVHPLTPLIPYSNDHFSHG-SHSPHL-----PADI-SQKQ--AVHRP 173 chicken

XP_003224258  231 PHPSELSPYYPLSPGAIGQIPHPLGW 256 green anole
10_pfamImport 204 PHPSELSPYYPLSPGAVGSIAHPLSW 229
EEN52158      201 RHPADLPPMYAIPPNQLPQLGPSYPk 226 Florida lancelet
Q9W7C0        185 HPGPDIPNFYPLSPGGVGQMTPPLGW 210 zebrafish
8_pfamImport  176 HPGPDMPNFYSLSPGGVGQITPPLGW 201
7_pfamImport  170 HPGPDMPNFYSLSPGGVGQITPPLGW 195
6_pfamImport  179 PPGPDIPTFYPLSPGGVGQITPPLGW 204
XP_003410438  188 PPAPDIPTFYPLSPGGVGQITPPLGW 213 African savanna elephant
3_pfamImport  167 AQTADIPTFYPLPSGGVGQISPSVGW 192
Q8JHX2        174 SQTSDIPGFYPLPPAGVGQITPSMGW 199 chicken
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