Conserved Protein Domain Family
KH-I_HNRNPK_rpt2
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cd22433: KH-I_HNRNPK_rpt2 
second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
hnRNP K, also called transformation up-regulated nuclear protein (TUNP), is a pre-mRNA binding protein that binds tenaciously to poly(C) sequences. It may be involved in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. It can also bind poly(C) single-stranded DNA. hnRNP K plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. hnRNP K contains three K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Links
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Statistics
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PSSM-Id: 411861
Aligned: 21 rows
Threshold Bit Score: 104.643
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ### #####  ##  ##     ####                                 
P61978       144 DCELRLLIHQSLAGGIIGVKGAKIKELREnt-qTTIKLFQECCPhSTDRVVLIGGkpDRVVECIKIILDLI 213 human
AAF78762      94 DFDVRLLIHQSLAGCVIGKGGQKIKEIRDrigcRFLKVFSNVAPqSTDRVVQTVGkqSQVIEAVREVITLT 164 fruit fly
XP_027228670 107 ETDARILVHQSQAGCIIGKAGTKIKELREec-gGQIKVYTNCCPqSTDRVIQITGdrERAILTITRILELI 176 Penaeus vannamei
EFX66209     114 DSDARLLVHQSQIGCIIGRGGAKVKELREst-gTRITVYSVCCPrSTDRIVQILGkpSDCGECIKQIIALV 183 common water flea
WP_155383874 116 LLDLRILIHHSQVGSVIGKSGDKIKELREkhrmQIIKIYQEFAPrSTDRVLQLIGepXNVFACVEDIMETL 186 Nitriliruptoraceae bacte...
CBY41924      60 DIDMRMLVHQSKAGAVIGFKGETIKGLRDkt-gCKINVYQDPAPhSSDRLIKVAGqpDKIATCFGEILLIL 129 Oikopleura dioica
P91277       124 PCEVRMLVHQSHAGALIGRNGSKIKELREkc-sARLKIFTGCAPgSTDRVLITSGeqKNVLGIIEEVMKEL 193 Caenorhabditis elegans
XP_018649338  81 GVDLRLLVHQSQAGCVIGRAGYKIKELREqsglHTLKVYQMLCPcSTDRVIQLVGdvGKVLDCLRSIAELL 151 Schistosoma mansoni
XP_002602052 124 NCELRMLVHQSQAGCIIGRAGFKIKELREqt-eANIKVYSECMPgSTERVVALTGkpEKCVGAIKKIIELL 193 Florida lancelet
OWF47732     113 DCEMRLLVHQSQAGCIIGRAGFKIKELREkt-gAQIKVYSQCCPqSTERVVAIGGkpKVVINCVDTIHQLL 182 Yesso scallop

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