6MM1


Conserved Protein Domain Family
EHMT_ZBD
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cd20905: EHMT_ZBD 
Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
EHMT1 (also known as GLP) and EHMT2 (also known as NG36 and G9a) are histone methyltransferases that methylate the K9 position of histone H3, marking genomic regions for transcriptional repression. They may play a role in the G0/G1 cell cycle transition and are associated with promoting various types of cancer. Mutations in EHMT1 are associated with the genetic disorder Kleefstra syndrome. A functional role for the zinc-binding domain has not been established.
Links
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Statistics
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PSSM-Id: 411018
Aligned: 96 rows
Threshold Bit Score: 96.6913
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:6MM1: human histone-lysine N-methyltransferase EHMT2 binds zinc
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # #                                                                       
6MM1_A          4 FEELPLCSCRMEAPKIDrise-----ragHKCMATESVdgELSGCNa------AILKRETMRPSSRVALMVLCETHRARM 72   human
GBM34563     1471 DLQLKVCRCSAVEVPCLcnge-----elqSICEAEDTVdeKIVPCTk------SISQQYLLTPSSEIKHRAFCDIHLWRL 1539 Araneus ventr...
XP_015905682 1551 IHSKSFCTCIKDDVPCLfdge-----slqQTCEGEDTVdgNIVPCSr------QIYTHSLLSPSQKVKFRIFCDIHLWRL 1619 common house ...
KFM73886      289 MISHPVCCCSEKEKPCIctdg-----nlqEVCEGEDTVddNIIPCSn------KVSKQYLLTPSSEIRHRAFCDIHLWRL 357  Stegodyphus m...
GAV05619       51 ETTSATCSCLNLLSLKDapaall-hlltgSVCGALCQRgkSLIKCSqp----lTNAECIIRFSPSRGALVPLCSAHQRQL 125  Ramazzottius ...
TRY63080      652 PLQPCVCFCAKSSKELAlslhpskssgqtVICQAVEVVgsNRVGCKn------PVKNMKYRQVLENGKKFLCCDAHIQRM 725  Tigriopus cal...
XP_023331604  500 LMLKTLCTCEAESIPIAgk--------dgLNCQAVEVVggYRVGCKn------KITRSEIVKTSPELDPISLCDMHRDRL 565  Eurytemora af...
XP_016344564   53 QTSLKLPAENIISGNHGsihed---eqdaPETQSSESGnaAKSITTls----lPAARQEGDAQRGPEEFKAVNPAPPRLA 125  Sinocyclochei...
XP_011569137  114 PAVLGACLCEAPSNVYAapse----leepVFCRAIETSpsGRVGCShpa-rrlGASHAPLLRAGPRTPYALLCELHTSLL 188  diamondback moth
GBP08239      555 ARVLGTCYCDLPSNVYItsse----itepMFCRAVEMIdgVRVGCShkaarlpDGSLAPLRRAGPRTPYIVMCSLHTAQM 630  Eumeta japonica

Feature 1           #                                                      #                      
6MM1_A         73 VKHHCCPGCGYFCTAGTFLECHPdf-----rvAHRFHKACVsql------ngMVFCPHCGEDAs---------------- 125  human
GBM34563     1540 KKHHCCPKCGIFCTQGSFLCCSYdhpvkgakeTHFFHPSCFlvpd----tglPPGCPHCCTFSnfknvhfslteevpeet 1615 Araneus ventr...
XP_015905682 1620 KHHHCCPCCGIFCTQGKFLMCQCenvekhneeIHLFHTDCYlvpr----aglPPGCPHCCRFTn---------------- 1679 common house ...
KFM73886      358 QRHHCCPKCGVFCTQGSFMLCSSddtgktddqLHLFHQGCFllpv----pglPPRCPHCCKYSi---------------- 417  Stegodyphus m...
GAV05619      126 QAHMICPICGIFIEGGTVAACVQegld-gqreTHLFHRKCLqstmqnkvlfsSSSCPHCGCSVe---------------- 188  Ramazzottius ...
TRY63080      726 KSHHCCGFCGEFCAHGLFYMCRPnkr----slPHFFHKQCYmkq-----eagNRKCPHCNLGDip--------------- 781  Tigriopus cal...
XP_023331604  566 LTHSCCPLCGEFCSHGLVFMCRVsat----spPHLFHRFCYqnk-----pkeERCCPHCSSKKpp--------------- 621  Eurytemora af...
XP_016344564  126 WKTMVRPAPAPSALKGTFMECQPdg-----niSHRFHRSCAsli------rgQVYCPHCGEEAs---------------- 178  Sinocyclochei...
XP_011569137  189 RKHMCCTTCGLFCTQGIFYRCSL---------GHFFHLDCGltap----akaAPGCPHCGLLSyqwqg------------ 243  diamondback moth
GBP08239      631 RRHMCCAACGIFCTHGIYYKCSK---------GHLFHSECGlpyg---etrqPSGCPHCGFYNnghiahnkkc-----cw 693  Eumeta japonica

Feature 1                         
6MM1_A        126 -------eAQEVTIPR 134  human
GBM34563     1616 ltqspnkcTEELNITE 1631 Araneus ventricosus
XP_015905682 1680 --------FDEVQLAL 1687 common house spider
KFM73886      418 --------FKTINLFL 425  Stegodyphus mimosarum
GAV05619      189 -------kAVSVTVQT 197  Ramazzottius varieornatus
TRY63080      782 -------iTVQLKLSM 790  Tigriopus californicus
XP_023331604  622 -------lAVQLKMTM 630  Eurytemora affinis
XP_016344564  179 -------hAKEVTIPK 187  Sinocyclocheilus anshuiensis
XP_011569137  244 ---panceCRRVRLRM 256  diamondback moth
GBP08239      694 vklemhcsNRRILLPE 709  Eumeta japonica

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