1W98,5L2W


Conserved Protein Domain Family
CYCLIN_CCNE1_rpt1
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cd20579: CYCLIN_CCNE1_rpt1 
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first cyclin box found in G1/S-specific cyclin-E1 (CCNE1)
CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410282
Aligned: 10 rows
Threshold Bit Score: 288.701
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interface
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ## #  ##  ##  #   #                                  #                    
1W98_B         8 SPLPVLSWANREEVWKIMLNKEKTYLRDqhfleqHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEN 87  human
5L2W_B        32 SPLPVLSWANREEVWKIMLNKEKTYLRDqhfleqHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEN 111 human
3023468      102 SPLPRLGWANQDDVWRNMLNKDRIYLRDknffekHPQLQPNMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQKN 181 African clawed ...
Q91780       102 SPLPRLGWANQDDVWRNMLNKDRIYLRDknffqkHPQLQPNMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQKN 181 African clawed ...
P50756       102 SPLPRLGWANQDDVWRNMLNKDRIYLRDknffqkHPQLQPNMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQKN 181 African clawed ...
P47794       105 TPLPALCWASKDEVWNNLLGKDKLYLRDtrvmerHPNLQPKMRAILLDWLMEVCEVYKLHRETFYLGQDYFDRFMATQEN 184 zebrafish
P49707       100 SPLPILGWANRDDVWKNMINKEETYVRDklymqrHPLLQPKMRTILLDWLMEVCEVYKLYRETFYLAQDFFDRFMATQQN 179 chicken
P24864       103 SPLPVLSWANREEVWKIMLNKEKTYLRDqhfleqHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQEN 182 human
XP_007887579 104 SPLPILGWANRDEVWNNLVKKDQTYLRDkdvlqkHPLLQPKMRAILLDWLMEVCEVYKLHRETLYLAQDFFDRFMATQQN 183 elephant shark
XP_005997071 106 SPLPVLSWASQNDVWKNMIRKEEMYVKDkrfmqrHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMGTQQN 185 coelacanth

Feature 1                      #   #####   ##                #  ##  ##  ##
1W98_B        88 VvKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACsGDEILTMELMIMKALKW 144 human
5L2W_B       112 VvKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACsGDEILTMELMIMKALKW 168 human
3023468      182 ViKSRLQLIGITSLFIAAKMEEIYPPKLHQFAFITDCACtEDEITSMELIIMKDLDW 238 African clawed frog
Q91780       182 ViKSRLQLIGITSLFIAAKLEEIYPPKLHQFSFITDGACtEDEITRMELIIMKDLGW 238 African clawed frog
P50756       182 ViKSRLQLIGITSLFIAAKLEEIYPPKLHQFSFITDGACtEDEITRMELIIMKDLGW 238 African clawed frog
P47794       185 VlKTTLQLIGISCLFIAAKMEEIYPPKVHQFAYVTDGACtEDDILSMEIIIMKELNW 241 zebrafish
P49707       180 VvKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACtEDEILSMELIIMKALNW 236 chicken
P24864       183 VvKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACsGDEILTMELMIMKALKW 239 human
XP_007887579 184 VvKTRLQLIGISALFIAAKLEEIYPPKLHQFAYVTDGACtEDEILDTELIILKALKW 240 elephant shark
XP_005997071 186 VvKTRLQLIGISALFIAAKLEEIYPPKLHQFAHVTDGACtEEEINDMELVIMKALKW 242 coelacanth

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