Conserved Protein Domain Family
CYCLIN_CCNA1_rpt1
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cd20560: CYCLIN_CCNA1_rpt1 
first cyclin box found in cyclin-A1 (CCNA1)
CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410263
Aligned: 6 rows
Threshold Bit Score: 305.998
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative CDKA-type cyclin
Feature 1:putative CDK interface [polypeptide binding site]
Evidence:
  • Comment:CDK = cyclin-dependent kinase
  • Comment:Based on the structure evidence that Homo sapiens CCNA2 (1QMZ) binds CDK2.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         # ### ##  #                                    
8134359      176 LLDFNTVSPMLVDSSllsqsed-isslgtDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEV 254 human
116172       129 LLDISEASPMVVDTSpqtsped-dsvtdpDAVAVSEYIHEIHQYLREAELKHRPKAYYMRKQPDITSAMRTILVDWLVEV 207 African clawed ...
OWK61553     120 LLDLSSGSPMVVDTSfqsqpe--dhmedvVTLAVGEYAEDIHQYLREAELRFRPKPFYMKKQPDITTGMRAILVDWLVEV 197 Bengalese finch
XP_007889443  48 YLDLSEASPMLVDSSvnsqshhgystdsvDYLAAEEYTEDIYRYLREAEVKLRPRFGYMRKQPDITTGMRSILVDWLVEV 127 elephant shark
Q92161       106 VQDLGSGSCMDSSMQslpee-----aayeDILCVPEYAEDIHRYLRECEVKYRPKPGYMRKQPDITNCMRVILVDWLVEV 180 goldfish
XP_006010273 144 YLDASTASPMMMDTSlqspaed-qlkfpvDVLSVAEYADDIYWYLREAELRNRPKYAYMRKQSDITPGMRAILVDWLVEV 222 coelacanth

Feature 1              #                                  #  #####   ##            ##  #  ##  ## 
8134359      255 GEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKV 334 human
116172       208 GEEYKLHTETLYLAMNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVYITDDTYSKKQLLRMEHVLLKV 287 African clawed ...
OWK61553     198 GEEYKLRTETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLAAKYEEIYPPDVDEFVYITDDTYTKKQLLRMEHLLLKV 277 Bengalese finch
XP_007889443 128 SEEYSLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAMLIASKYEEIYPPEIDEFIYVTDDTYTKKQLLRMEHLLLKV 207 elephant shark
Q92161       181 GEEYKLCSETLFLAVNYLDRFLSCMSVLRGKLQLVGTAAVLLAAKYEEVYPPEVDEFVYITDDTYTKKQLLRMEQHLLRV 260 goldfish
XP_006010273 223 GEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKV 302 coelacanth

Feature 1         ###
8134359      335 LAFD 338 human
116172       288 LAFD 291 African clawed frog
OWK61553     278 LGFD 281 Bengalese finch
XP_007889443 208 LTFD 211 elephant shark
Q92161       261 LAFD 264 goldfish
XP_006010273 303 LAFD 306 coelacanth

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