2E5J


Conserved Protein Domain Family
RRM_MTHFSD
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cd12270: RRM_MTHFSD 
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RNA recognition motif (RRM) found in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
This subfamily corresponds to methenyltetrahydrofolate synthetase domain (MTHFSD), a putative RNA-binding protein found in various vertebrate species. It contains an N-terminal 5-formyltetrahydrofolate cyclo-ligase domain and a C-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The biological role of MTHFSD remains unclear.
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Statistics
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PSSM-Id: 409713
Aligned: 9 rows
Threshold Bit Score: 103.94
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E5J_A        21 DVYVGNLPrDARVSDLKRALRElGSVPLRLTWQGpRRRAFLHYPD----------SAAAQQAVSCLQGLRLGTDTLRVAL 90  human
Q52L34       312 TVYIGDIPsTTRVSELKSMLRErGAAPLRLTWQGaQHRAFLDYRD----------VAQAKQALSSLEGISINGISLLVEL 381 African clawed ...
NP_001038564 307 TVYLSDIPpALRVSELKGLLREqEVVPLQIRWQGaKRKAFLLYAD----------FTGAERATAILQKLFINGHTIQAKC 376 zebrafish
BAH72686      47 VLKVGNIAnNVRVRDLKAALMErGVKPLHITWRGpRGFAYLRYSNs--------sDLDKDDVMGSLQNVRIKPNGIETAQ 118 pea aphid
EFN60600     338 SLKLSNISsGVRVRDLKNALLErGIKPSEITWQGyRGICYLHFSKlrnenalpdqPIQVDSIVANLQQLRIGEFMNNEEG 417 Camponotus flor...
NP_649466    384 CIKLTNLSrDIRVKDLKSELRKrECTPMSISWKGhFGKCFLHFGNrkgv---pstQDDMDKVLKSLNDLSLTITTGGETA 460 fruit fly
XP_001846943 346 CIRVSNINrSMRIKELKQVLRVrDLNPMFIKWNGfHGKCYLHFPKkp-------dMNDDDAGAELLKQLENLTVTVTPRE 418 southern house ...
XP_002610203 341 TLWVGKLSgSLRVSDFKSHLHEsNINPSRVIWKGnRGFAFLLFKE----------AGAVDEAAKKLQDLDFSGKKVTVER 410 Florida lancelet
KFP92994     242 TVYVGNIPpSVRVSELKSALREfHATPLRLNWQGaQHRAFLDYKD----------KATAESAVSSLKGLSLGGNTLRVEL 311 white-tailed eagle

2E5J_A        91 AR 92  human
Q52L34       382 AR 383 African clawed frog
NP_001038564 377 VS 378 zebrafish
BAH72686     119 TQ 120 pea aphid
EFN60600     418 FI 419 Camponotus floridanus
NP_649466    461 PA 462 fruit fly
XP_001846943 419 KD 420 southern house mosquito
XP_002610203 411 AK 412 Florida lancelet
KFP92994     312 AK 313 white-tailed eagle
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