2CQV


Conserved Protein Domain Family
IgI_8_hMLCK_like
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cd05762: IgI_8_hMLCK_like 
Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar protein; member of the I-set of IgSF domains
The members here are composed of the eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar proteins. Myosin light-chain kinase (MLCK) is a key regulator of different forms of cell motility involving actin and myosin II. Agonist stimulation of smooth muscle cells increases cytosolic Ca2+ which binds calmodulin. This Ca2+-calmodulin complex in turn binds to and activates MLCK. Activated MLCK leads to the phosphorylation of the 20 kDa myosin regulatory light chain (RLC) of myosin II and the stimulation of actin-activated myosin MgATPase activity. MLCK is widely present in vertebrate tissues; it phosphorylates the 20 kDa RLC of both smooth and nonmuscle myosin II. Phosphorylation leads to the activation of the myosin motor domain and altered structural properties of myosin II. In smooth muscle MLCK it is involved in initiating contraction. In nonmuscle cells, MLCK may participate in cell division and cell motility; it has been suggested MLCK plays a role in cardiomyocyte differentiation and contraction through regulation of nonmuscle myosin II.
Links
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Statistics
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PSSM-Id: 409419
Aligned: 4 rows
Threshold Bit Score: 193.247
Created: 17-Aug-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #####                                                                           
2CQV_A          7 GPQIIQFPEDQKVRageSVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKL 86   human
2851396      1224 PPQITQFPEDRKVRageSVELFAKVVGTAPITCTWMKFRKQIQENEYIKIENAENSSKLTISSTKQEHCGCYTLVVENKL 1303 chicken
NP_001099152  241 PPQIQQFPDDMKIMagqEVILQCKFTGELPISCTWLKFRKPIQEGQGISIVSTDSSSQLTITEGQQEHCGCYTIEIKNSF 320  zebrafish
AAB41402      244 PPQILQFPDDMKIWr-vRRSVCCRFTGAQPISCTWLKFRKPIQEGQGISIVSTDSSSQLTITEGQQEHCGCYTIELKNSC 322  goldfish

Feature 1                            
2CQV_A         87 GSRQAQVNLTVVDKPDPPA 105  human
2851396      1304 GSRQAQVNLTVVDKPDPPA 1322 chicken
NP_001099152  321 GVRQAALNLTIVDKPDPPA 339  zebrafish
AAB41402      323 GVRQAALNLTIVDKPDPPA 341  goldfish

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