Conserved Protein Domain Family
GPS2_interact
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pfam15784: GPS2_interact (this model, PSSM-Id:406267 is obsolete and has been replaced by 464868)
G-protein pathway suppressor 2-interacting domain
GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.
Links
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Statistics
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PSSM-Id: 406267
Aligned: 13 rows
Threshold Bit Score: 101.823
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015793204   11 YYPGVEAISPALPS-EESQPdysstfrTSKDELLQNIDKIDREISQTETQISELKERKKQ-LELKAVSRdsvKDVRENVD 88   two-spotted s...
EKC21189      241 YNPQVEAISPTLPP-DETSP-------SSKDQLLQAISKVDREISKVDKDIQKLKKKQEQ-LELEKCKP---PEEKQKVK 308  Pacific oyster
XP_028032656  156 TYNTVEVLSPNPPSeTSGEDqt---lrTTKDVLLKQISKVDREMALVETSLAKLKRKQEE-LQQSASKP---ARAEEPEE 228  wild silkworm
EFN66084      133 YTPQTEAISPTLPE-PNTQEda---lrSTKDELLQQIGKVDREIAKRENQLNMLRKRIKE-LEEAANKPleaTGLKRNIE 207  Florida carpe...
XP_016839513  337 YTPQTEAISPTLPE-PNTQEdtv--fkITKDDLLQQIAKVDREIAKRESQISKLRKKVKE-IEEVASKPleaPGTKRPVE 412  jewel wasp
XP_011678602  177 FMPKVENISPT----PCDQEtt---nkISKEGLISSMDKVDREIAKVESQISKLKKKQQE-LEQRAARP---IDTDKPLS 245  purple sea ur...
XP_027988036  149 FGGKHEAPSSPISGqPCGDDqnaspskLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQ-LEEEAAKP---PEPEKPVS 224  big brown bat
XP_027988036  149 FGGKHEAPSSPISGqPCGDDqnaspskLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQ-LEEEAAKP---PEPEKPVS 224  big brown bat
NP_001007033  140 SIGKIEPISPVSPV-PMEADldlvpsrLSKEELIQNMDRVDREITMVEQQISKLRKKQQQ-LEEEAAKP---QEPERTIS 214  zebrafish
Q9Y618        141 LTGKLEPVSPPSPP-HTDPElelvpprLSKEELIQNMDRVDREITMVEQQISKLKKKQQQ-LEEEAAKP---PEPEKPVS 215  human
PNJ81989       62 LTGKLEPVSPPSPP-HTDPElelvpprLSKEELIQNMDRVDREITMVEQQISKLKKKQQQ-LEEEAAKP---PEPEKPVS 136  Sumatran oran...
1_pfamImport    1 LAGKLEPVSPASPA-HAESEldllpprLSKEELIQNMDRVDREITMVEQQISKLKKKQKEkVQTEALRP---WGPSGRRS 76  
XP_014287577  191 YNPQVEAISPTLPS-EA--LqedanfrSTKDDLLHGIAKVDREITKTELQISKLKRKQQE-LEEAAKKPaikKEEEEVPQ 266  brown marmora...

XP_015793204   89 NS--SETRQLSIAQH 101  two-spotted spider mite
EKC21189      309 DIvvTETKHQSIAQI 323  Pacific oyster
XP_028032656  229 AP----SRHRSLAQC 239  wild silkworm
EFN66084      208 EQs-QQPKHQSLAQK 221  Florida carpenter ant
XP_016839513  413 EAs-SQPKHQSLVQK 426  jewel wasp
XP_011678602  246 PAfgSEPKQQNIIQI 260  purple sea urchin
XP_027988036  225 PPp-VEQKHRSIVQI 238  big brown bat
XP_027988036  225 PPp-VEQKHRSIVQI 238  big brown bat
NP_001007033  215 PPp-SEAKHRSLVQI 228  zebrafish
Q9Y618        216 PPp-IESKHRSLVQI 229  human
PNJ81989      137 PPp-IESKHRSLVQI 150  Sumatran orangutan
1_pfamImport   77 PGd-LPSGHSSVRRV 90  
XP_014287577  267 PK------HQSPAQK 275  brown marmorated stink bug
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