2N8Y,1H8B


Conserved Protein Domain Family
EFhand_Ca_insen
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pfam08726: EFhand_Ca_insen (this model, PSSM-Id:400872 is obsolete and has been replaced by 430177)
Ca2+ insensitive EF hand
EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes. EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets. This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties. The calcium insensitive EF hand is still able to mediate protein-protein recognition.
Links
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Statistics
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PSSM-Id: 400872
Aligned: 19 rows
Threshold Bit Score: 88.5264
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2N8Y_A         83 DTDTADQVMASFKIL-AGDK-NYITMDELRRELPPDQA-EYCIARMAPYTGP----DSVPGA-LDYMSFSTALYG 149 
Q29EZ8       2344 NVQSYEEIENAFRAItAADR-PYVTKEELYCNLTKDMA-DYCVQRMKPFSEPrs-gQPIKDA-LDYIDFTRTLFQ 2414 Drosophila pseudoo...
P02549       2350 NIKSSDEIENAFQAL-AEGK-SYITKEDMKQALTPEQV-SFCATHMQQYMDPr--gRSHLSG-YDYVGFTNSYFG 2418 human
Q5AVH3        605 DQNTAEQVFQSFREV-ADGK-PYVTELDLRHSLIPDEIiEHLVKTMPQHEGPdlleDRDLPK-YDYISFMERMMN 676  Aspergillus nidulans
Q0UG56        635 DQNTAEQVFESFKEV-ADGK-PYVTELDLRHSLVPDEViDDLLSTMPEHKGPdmqeDRDIPK-FDYITYMERYMG 706  Parastagonospora n...
Q2U7P8        559 DQNTAEQVLQSFREV-ADGK-PYVTELDLRHSLIPDEViDHLVQTMPRHEVFdrgeDQNEPK-YDYYSFMQKMME 630  Aspergillus oryzae
Q0CDG2        559 DQNTAEQVLQSFHEV-ADGK-PYVTEMDLRLSLIPEELiEHLTQTMPKHQGPvksqDRDVPQ-YDYISFMGKMMA 630  Aspergillus terreu...
XP_011391034  566 DTTSPDQLLEAFQGL-AGDK-PYVTELDLRLALLPQGSiDYLKAAMPQVRv-----DGVEDAvYDYEGYLTGLFG 633  Ustilago maydis 521
XP_001618830  329 NVGSSQEVENAFKALtEGGKrKFVTESDLYQSLTKEQA-EYCIDRMQPYVDDk--gREIPGA-YDYKSFCKALFA 399  starlet sea anemone
XP_004023005  169 NVKSSEEIESAFRALsSEGK-PYVTKEELYQNLTREQA-DYCVSHMKPYVDGk--gRELPTA-FDYVEFTRSLFv 238  sheep
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