Conserved Protein Domain Family
zf-FCS
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pfam06467: zf-FCS (this model, PSSM-Id:399461 is obsolete and has been replaced by 428958)
MYM-type Zinc finger with FCS sequence motif
MYM-type zinc fingers were identified in MYM family proteins. Human protein ZMYM3 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. ZMYM2 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.
Links
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Statistics
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PSSM-Id: 399461
Aligned: 39 rows
Threshold Bit Score: 34.6557
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q65174         56 HSSFKCWTCHLYFKTVPKfvptymRENErgeiemGVLGNFCSFSCAASY 104  African swine fever virus BA71V
Q14202        446 LKTNCCDQCGAYIYTKTGspgpelLFHE------GQQKRFCNTTCLGAY 488  human
A6QPH9        376 LVMNCCEQCGEYLPGKGAgn--nvLVIE------GQQMRFCCQSCVNEY 416  cattle
NP_001171456  717 CKAARCHACKRQGKLLET------IHWR------GQIRHFCNQQCLLRF 753  house mouse
Q5RDJ2        763 YKAARCDCCKSQGTLKEr------VQWR------GEMKHFCDQHCLLRF 799  Sumatran orangutan
Q14202        628 GVVSQCEHCRQEKLLHEK------LRFS------GVEKSFCSEGCVLLY 664  human
ERE81644      675 NVMAMCEYCKIEKIIKET------VRFS------GADKSFCSEGCKLLY 711  Chinese hamster
Q9VHA0         58 AKRATCTWCGEGKLPLQYv-----LPTQ------TGKKEFCSETCIAEF 95   fruit fly
OXB57379      357 LIMNCCEHCGEYLPSKGAgn--ntLTID------GQQKRFCCQNCVGEY 397  scaled quail
CAG02316      143 LSMACCANCGNYCHNKPMl-----LQMD------GSGQVLCNAECLAKY 180  spotted green pufferfish
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