3ZMI,2NR9


Conserved Protein Domain Family
Rhomboid
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pfam01694: Rhomboid (this model, PSSM-Id:396315 is obsolete and has been replaced by 426384)
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Rhomboid family
This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
Links
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Statistics
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PSSM-Id: 396315
Aligned: 60 rows
Threshold Bit Score: 82.2586
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3ZMI_A    38 PTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRL-----GSGKLIVITLI-----SALLSGYVQQKFSGP--- 104 Escherichia coli
Q12270    47 SLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETH-----GTVYTGVFLNL-----SALFAGILYCLLGKLlyp 116 Saccharomyces cerev...
Q9M1B5    45 TAIEGHYWRMITSALSHISVLHLVFNMSALWSLGVV--EQLghvglGTAYYLHYTLVlv-vfSGVLVIGIYHLLIARfki 121 thale cress
O74926    50 LLQKRQLYEIITYVTLHLSMLHIVFNFVSLLPAMSQFEKKQ-----GTLACILVTVIpytlfPGIMHLIVYHFFLRKdy- 123 Schizosaccharomyces...
EHH17235  54 ALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTV-----GTVRHCFFTVI-----FAIFSAIIFLSFEAVssl 123 Rhesus monkey
Q8LB17    58 IISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIM-----GSVRLLYLTVL-----LATTNAVLHLLIASLagy 127 thale cress
Q9RSX7    86 PRQVGTFWHVFTAPFLHAGFPHLIANTVPLAVLAFMTAVR------SVSRFLVATFL-----IALIGGGLVWLLGRSg-- 152 Deinococcus radiodu...
P9WM21    71 PLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLGFLMTLA------GLSRFVWATAI-----IWILGGLGTWLIGNVgss 139 Mycobacterium tuber...
P53426    83 LLKTDVLWGISFAPVLHANWQHLVANTIPLLVLGFLIALA------GLSRFIWVTAM-----VWIFGGSATWLIGNMgss 151 Mycobacterium lepra...
P74553    49 PRSLEGLRGIVFAPFLHADFGHLIANSVPFVVLAWLVMLQ------EVSDFWIVTII-----TMVVGGLGVWLIAPPn-- 115 Synechocystis sp. P...

3ZMI_A   105 ------------WFGGLSGVVYALMGYVWLRGERDPQSGIYLQRG------LIIFALIWIVAGWFDLFgm--sMANGAHI 164 Escherichia coli
Q12270   117 ----------eaLVAGASGWCFTLFAYYSFKESQIRPRTRIFRTDysiptlYTPLVLLVAIAVVIPGS------SFWGHF 180 Saccharomyces cerev...
Q9M1B5   122 dy------frrvTAVGYSCVVFGWMTILSVKQPSSKLNLFGLLSLpi---sFAPFESLIFTSIIVPQA------SFLGHL 186 thale cress
O74926   124 -----------vSIAGLSGWAFAFISASCVHSPQRLISFFNLFSIpa---yCFPIIYLIMTTILVPKA------SFIGHA 183 Schizosaccharomyces...
EHH17235 124 sk-----lgeveDARGFTPVAFAMLGVTTVRSRMRRALVFGMVVPs----vLVPWLLLGASWLIp-------qTSFLSNV 187 Rhesus monkey
Q8LB17   128 npfyqydhlmneCAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVpa---kLYPWILLIVFQLLMTn------VSLLGHL 198 thale cress
Q9RSX7   153 -----------sVHLGASELVFGYLAYLLGVGWWERTPLSVVIAV------IAFALYGGVLWGVLPSNp---aISWEAHL 212 Deinococcus radiodu...
P9WM21   140 c--------gptDHIGASGLIFGWLAFLLVFGLFVRKGWDIVIGL------VVLFVYGGILLGAMPVLgqcggVSWQGHL 205 Mycobacterium tuber...
P53426   152 f--------gptDHIGVSGLIFGWLAFLLVFGLFVRRGWDIIGCM-------VLFAYGGVLLGVMPVLgrcggVSWQGHL 216 Mycobacterium lepra...
P74553   116 -----------tVTVGASILIFGYLGFLLFRGWFQKNLASIVLSI------VVLVLYGSALWGLLPGRa---gVSWQGHL 175 Synechocystis sp. P...

3ZMI_A   165 AGLAVGLAMAFVDSL 179 Escherichia coli
Q12270   181 FGLCVGYAIGYKESW 195 Saccharomyces cerevisiae S288C
Q9M1B5   187 SGILVGYAISWGLIG 201 thale cress
O74926   184 SGAVMGYCTPFMLGS 198 Schizosaccharomyces pombe 972h-
EHH17235 188 CGLSIGLAYgltycy 202 Rhesus monkey
Q8LB17   199 CGILSGFSYSYGLFN 213 thale cress
Q9RSX7   213 FGFIGGLVAAALLHR 227 Deinococcus radiodurans
P9WM21   206 SGAVAGVVAAYLLSA 220 Mycobacterium tuberculosis H37Rv
P53426   217 CGAISGVVAAYLLSA 231 Mycobacterium leprae TN
P74553   176 FGFIGGAIAAWLIAR 190 Synechocystis sp. PCC 6803
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