6Z3A,6S8F,5KC2,2CHX,6T9J,4JSV


Conserved Protein Domain Family
PI3_PI4_kinase

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pfam00454: PI3_PI4_kinase 
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Phosphatidylinositol 3- and 4-kinase
Some members of this family probably do not have lipid kinase activity and are protein kinases,.
Statistics
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PSSM-Id: 395364
Aligned: 41 rows
Threshold Bit Score: 135.535
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6Z3A_E             2074 IYGIMCK-KEDVRQdnqYMQFATTMDFLLSKDIASRKRslgINIYSVLSLREDCGI-LEMVPNVVTLRSILSTKYE---- 2147 Sacchar...
P42951              170 GSSGSYFvYGTRADesvPVGVFKPKDEEPYGPFSPKWTkwaHRTFFPCLFGRSCLI-PNLGYICESAASLLDRRLEth-- 246  Sacchar...
Q99M64              132 GSSGSYFvKDSQGR---IIAVFKPKNEEPYGNLNPKWTkwlQKLCCPCCFGRDCLV-LNQGYLSEAGASLVDQKLEl--- 204  Norway rat
Q9SXC6              369 dmlpqyerrNDMRQ-------------VLDRDRRQRCL---FKRFSDEDRARNEAI-AYLLDHPEDGHRSQSEQIYgf-- 429  thale c...
Q9SGW8              243 gTGGTYLmQDSSGLn--yVSVFKPMDEEPMAVNNPQ-----QLPVSSDGQGLKRGTrVGEGATREVAAYLLDHPKSglrs 315  thale c...
Q9FNF8              266 GSGGAYFmQDPSGHk--yVSVFKPIDEEPMAVNNPH-----GQPVSVDGEGLKKGTqVGEGAIREVAAYILDYPMTgprt 338  thale c...
Q9ZPY9              264 GTGGAYFmQGPSGNk--FVGVFKPIDEEPMAENNPQ-----GLPLSPNGEGLKKGTkVGEGALREVAAYILDHPKSgnks 336  thale c...
Q9C671              171 GLGGAYYfKNSRGEs---VAIVKPTDEEPYAPNNPKG----FVGKALGQPGLKRSVrVGETGYREVAAYLLDKEHFa--- 240  thale c...
O22199              130 GMGGAYLlQTGKGHn---IAVAKPVDEEPLAFNNPKK----SGNLMLGQPGMKHSIpVGETGIRELAAYLLDYQGFs--- 199  thale c...
WGS:AAAA:OsI_01341  124 GIGGALLlEDGRSVd--hVAVIKPL----------------LDDASSPSHGGGGGY-ASKAVLREVAAFLLDHDGFa--- 181 
6Z3A_E             2148 ---------SLKIKYSLKS-------------LHDRWQHTAVDgk------------leFYMEQVDKFPPILYQWFLENF 2193 Sacchar...
P42951              247 -------lvPYTDTASIESfnfydnrkkwvlgYNLQKKKQKKLgsfqlflkeyinadefFHKYPLPGMYSDVKHSFHRKS 319  Sacchar...
Q99M64              205 ---------NIVPRTKVVYlasetfnysaidrVKSRGKRLALEkvpk---------vgqRFNRIGLPPKVGSFQLFVEGY 266  Norway rat
Q9SXC6              430 --------sRVRRAVWVRC-------------------------------------------RIKNQMKMGVLIEFLESS 458  thale c...
Q9SGW8              316 vskevmgfaGVPPTAMVRSs-----------hKVYNYPNG-------------------FSSCATKDAKVGSLQMFMKNN 365  thale c...
Q9FNF8              339 fphdqtgfaGVPPTTMVKCl-----------hKDFNHPN--------------------GYSFSPENTKIGSLQMFVSNV 387  thale c...
Q9ZPY9              337 mfgeeigfaGVPPTAMIECl-----------hPGFNHPKGI-------------------------KTKIGSLQMFTEND 380  thale c...
Q9C671              241 ---------NVPPTALVKIt-----------hSIFNVNDGVKAs---------------KPMEKMLVSKIASLQQFIPHD 285  thale c...
O22199              200 ---------GVPPTALVSIs-----------hVPFHVSD--------------------AFSFSSMPYKVASLQRFVGHD 239  thale c...
WGS:AAAA:OsI_01341  182 ---------RVEPTALIKI------------------------------------------SRPAMPTTTASIQRFAAHE 210 
6Z3A_E             2194 PDP----I------------------------------------NWFNA----------RNTY-ARSYAVMAMVGHILGL 2222 Sacchar...
P42951              320 SGE----DinhkpettrnltdetepskqinsspisteseenskfEWTESs---------LSQF-RLELEKLIILDYIMRN 385  Sacchar...
Q99M64              267 KDA----D------------------------------------YWLRRfeaeplpentNRQL-LLQFERLVVLDYIIRN 305  Norway rat
Q9SXC6              459 VTVqslgT------------------------------------VYSEL----------PDDVgAEEIHKIVVLDIRFGN 492  thale c...
Q9SGW8              366 GSC----E------------------------------------DIG------------PGAFpVEEVHKICVFDIRMAN 393  thale c...
Q9FNF8              388 GSC----E------------------------------------DMG------------YRVFpVDQVHKISVLDIRLAN 415  thale c...
Q9ZPY9              381 GSC----E------------------------------------DMG------------PLSFpVEEVHKISVLDIRLAN 408  thale c...
Q9C671              286 YDA----S------------------------------------EHG------------TSNFpVSAVHRIGILDIRILN 313  thale c...
O22199              240 FDA----G------------------------------------ELG------------PGSFtATSVHRIGILDVRLLN 267  thale c...
WGS:AAAA:OsI_01341  211 CDA----G------------------------------------ELG------------PSRFsVASVHRIGSLDVRLLN 238 
6Z3A_E             2223 GDRHCENILL------D--IQTG-------------KVLHVDF-DCL----FEKGKRLPV------P-EIV--PF-RLTP 2266 Sacchar...
P42951              386 TDRGLDNWMV------KliKLSNnkw--------rlKLAAIDNgLSFpwkhPDEWRLYPYgwl-ylPlQLLakPFsEQMR 450  Sacchar...
Q99M64              306 TDRGNDNWLIkydypmD--NPNCrdtdwvmvrepviKVAAIDNgLAFplkhPDSWRAYPFywa-wlPqAKV--PFsQEIK 380  Norway rat
Q9SXC6              493 IDRNLGNLLV------QaePRNGsa----------aHLVPIDHeLSFfn-dAHPYITCGAcwikwlEqIDK--DFsSQLV 553  thale c...
Q9SGW8              394 ADRHAGNILTg-----K--SEEGk-----------tLLIPIDHgYCL----PENFEDCTFewl-ywPqAKL--PFsADTI 448  thale c...
Q9FNF8              416 ADRHAGNILV---------SRDGkdg--------qmVLTPIDHgYCF----PNKFEDCTFewl-ywPqAKE--PYsSETL 471  thale c...
Q9ZPY9              409 ADRHGGNILM---------TKDEsg---------klVLVPIDHgYCL----PESFEDCTFewl-ywPqARK--PYsAETQ 463  thale c...
Q9C671              314 TDRHSGNLLV------K--KLDGdgmf------gqvELVPIDHgLCL----PETLEDPYFewi-hwPqASI--PFsEDEL 372  thale c...
O22199              268 LDRHAGNMLVkrcdkkEayNRLGt-----------aELVPIDHgLCL----PECLDDPYFewl-nwPqALV--PFsDTEL 329  thale c...
WGS:AAAA:OsI_01341  239 IDRHAGNILVkk--spEseCASGgstl------tplDLVPIDHgLCL----PEQLDDPYFewl-hwPqSSL--PFsGAEL 303 
6Z3A_E             2267 NLLDALgiIGTEGTFKKSSEVTLALMRKNEVALMNVIET--IMYDRNMDHSI 2316 Saccharomyces cerevisiae S288C
P42951              451 SHFLPI--LTSTNWWEESYQEFLALFSRDQDFNVRMWKKqwAVLKGQAFNVV 500  Saccharomyces cerevisiae S288C
Q99M64              381 DLILPK--ISDPNFVKDLEEDLYELFKKDPGFDRGQFHKqiAVMRGQILNLT 430  Norway rat
Q9SXC6              554 NYVAALdpDRDLEFLRHCGWEPNQRYIENFTVFATFLKK--AVSQGLTALQI 603  thale cress
Q9SGW8              449 DYINSLdsEQDIALLQLHGWNVPEAVSRTLRISTMLLKK--GVERNLTPYQI 498  thale cress
Q9FNF8              472 EYIKSLdpEKDIELLRFHGWEIPPSCTRVLRISTMLLKK--GSAKGLTPFTI 521  thale cress
Q9ZPY9              464 EYIRSLdaEEDIDLLKFHGWKMPAETAQTLRISTMLLKK--GVERGLTAFEI 513  thale cress
Q9C671              373 KYIANLdpLGDCEMLRRELPMVREASLRVLVLCTIFLKE--AAANGLCLAEI 422  thale cress
O22199              330 DYISNLdpFKDAELLRTELHSLPESAIRVLVVCTVFLKQ--AAAAGLCLAEI 379  thale cress
WGS:AAAA:OsI_01341  304 EYVASLdpFRDAAMLRAELPSLTEAAIRILTLCTIFLQR--AAAAGLCLADI 353 
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