Conserved Protein Domain Family
PPARgamma_N
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pfam12577: PPARgamma_N (this model, PSSM-Id:372202 is obsolete and has been replaced by 463633)
PPAR gamma N-terminal region
Peroxisome proliferator-activated receptors (PPAR) are nuclear hormone receptors that control the expression of genes involved in lipid homeostasis in mammals. This sequence region is found at the N-terminus of these proteins. The family is found in association with pfam00104, pfam00105. It is not clear if this region is a separate protein domain.
Links
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Statistics
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PSSM-Id: 372202
Aligned: 11 rows
Threshold Bit Score: 110.243
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003462784   1 MVDT-EMPFWP-TNFGLSSMDLSVMDDHSHSFDIKPFTTVDF----------------------SSIS------------ 44  Domestic guinea...
XP_026949696 138 MVDT-EMPFWP-TNFGISSVDLSVMDDHSHSFDIKPFTTVDF----------------------SSIS------------ 181 Pacific white-s...
XP_006004475   1 MVDT-QMPLWS-MNFGLSSVDLTDLDDHSHSFDIKPFTTVDF----------------------SSIS------------ 44  coelacanth
XP_006631094  23 MVDT-QMPVWP-MNFGLNAVDLADLDDSSQSFDMKPFTTVDY----------------------SSIS------------ 66  spotted gar
XP_012810576   1 MVDT-EMPFWSsLSFGMNAME--ALEEHCQPYDIKPFATVDF----------------------SSIN------------ 43  tropical clawed...
POI35150       1 MVDT-EMPFWP-VNFGISPVDLSAMDDHMHSFDIKPFTTVDF----------------------SSIS------------ 44  Chinese bamboo-...
AKG51674       1 MVDTqQLLAWP-VGFSLSTVDLPEFNDSSHCLDMKHLSTSDY----------------------ASISsssipsslsppl 57  Chinese medaka
XP_028432308  20 MVDTqQLLAWP-VGFSLSAVDLSELDDSSHFLDMKHLSTLDYasissssipsslspplvssissA--------------- 83  yellow perch
XP_007229696   1 MVDT-QMFSWP-MGFGLSTLDLEELDDSSHSLDMKPYSTLDY----------------------PTIS------------ 44  Mexican tetra
NP_571542     17 MVDT-QTFGWP-VGFGLSALELEELEDDTHSLDIKPFSTLDY----------------------SSIS------------ 60  zebrafish
CAG07050      46 MVDTqQLLAWP-VGFSLNSMDLPELYDHPHSLDMKHLTTLDY----------------------TSISssstqssmspsf 102 spotted green p...

XP_003462784  45 -------TPHYEDIP-----FPRVDPMVADY--KYDLKLQEY---------------------------QNAIKV 78  Domestic guinea pig
XP_026949696 182 -------APHYEDIP-----FPRADPMVADY--KYDLKLQEY---------------------------QSAIKV 215 Pacific white-sided ...
XP_006004475  45 -------SMHYEHSP-----LSGIDQTTTDY--EYDLRIPEY---------------------------QYAVKt 78  coelacanth
XP_006631094  67 -------SLAYETSP-----LPSEDLAQFDY--MYDFKMNEN---------------------------PNTIKM 100 spotted gar
XP_012810576  44 -------S-HYEDILdektfLCRGEQSPIDY--KYDLKLQEC---------------------------QSSIKL 81  tropical clawed frog
POI35150      45 -------SPHYEDIP-----LGRADQTSIDY--KYDIKLQd---------------------------cQSAIKL 78  Chinese bamboo-partr...
AKG51674      58 vssmsstGMAYDPSPp----QSEDHLTNMDYtnLHSYRTEld--------------------------thSSVKL 102 Chinese medaka
XP_028432308  84 -------GVAYDPSPp----QNDEQLTNMDFtnMHSYRMEpd--------------------------thNLIKL 121 yellow perch
XP_007229696  45 -------GAEYEPSPp----QSE-MTHMMDLthMYSYRAQea-------------------------syRTldan 82  Mexican tetra
NP_571542     61 -------GIDYENNPt----QNDPTPHMMDLthMYSYRTQenyrthepiyrpehssyspeentyraqqiQNSIKL 124 zebrafish
CAG07050     103 vacisptDMGYDPSPp----LSEEHMTGMDYlnMHGC---------------------------------NSIKL 140 spotted green puffer...
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