Conserved Protein Domain Family
Milton
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pfam12448: Milton (this model, PSSM-Id:372115 is obsolete and has been replaced by 463588)
Kinesin associated protein
This domain family is found in eukaryotes, and is typically between 143 and 173 amino acids in length. The family is found in association with pfam04849. This family is a region of the protein milton. Milton recruits the heavy chain of kinesin to mitochondria to allow the motor movement function of kinesin.
Links
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Statistics
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PSSM-Id: 372115
Aligned: 13 rows
Threshold Bit Score: 152.024
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDW36967             496 GN--------YMDSGNVSMTTLGAMSMSSSSGPRmasm------------------aypaG-SYYRG---G---GNQSLG 542  Drosop...
WGS:AANI:GJ18018-PA  471 GN--------YLDSGNVSMTQLGAMSMSSASGPRmasm------------------aypaG-SYYRGasgG---SSNSLG 520  Drosop...
EDS34260             421 RA--------NTTGFSDGYSQLGSMTMSSSSQPRmapyvfpgatggtttthsyksgssiyS-TMY----------ESSLG 481  southe...
5_pfamImport           1 -Rsrc--hspGLPG-----SSPLSAHSSSSSTPR--------------------------T-SCYGSg--N---TSITLE 40  
XP_021322520         387 QRsmgp-spmNIPGSNQT-SSMNSRRSSCMSTPR--------------------------S-SMYGG---Dg----VEID 430  zebrafish
XP_015212332         386 QRsllp-spmNIPGSNQS-----SALSSCRSTPR--------------------------S-SFYGS---Dv--SNIVID 427  spotte...
XP_025767584         411 QRsslapsplNIPGSNQT-SCFTSGRSSRVGTPR--------------------------SnSIYGS---Et-gSGIILD 459  Nile t...
XP_011479193         347 QRset---ptGIPGSNQSLSARTSPQSSGHSTPH--------------------------S-SVYGG---DisgDGVTLD 393  Japane...
XP_014195076         521 QRsltp-tnsNIPGSNQSLSARTSPQSSGLSTPH--------------------------S-SIFGG---DlsgESVALD 569  Burton...
XP_314926            312 fetvrsasraNPNGFSDSFSQLGSMTMSSSSQPRmapg------------------ssvyS-TMYGG---Gg--GSSL-G 366  Anophe...
CAF99478             461 RRsvtp-tssNIPGSNQSLSSRTSPQSSGLSSPH--------------------------S-SNYGG---DvsgDGVALD 509  spotte...
XP_017213872         468 LRsqn--pspQLPG-----SSPTSLRSSRISTPR--------------------------T-SYNEPd--N---ISIIME 508  zebrafish
PNI81228             133 QRsltp-spmNIPGSNQS-SAMNSLLSSCVSTPR--------------------------S-SFYGSd--I---GNVVLD 178  chimpa...

EDW36967             543 VKTLSNESLNSQSDD------G-Y---PAQpS-GVPGAPGARELEAALKRLTPG-----------EVLARRAMLSYApig 600  Drosop...
WGS:AANI:GJ18018-PA  521 LKTLSSESLNSQSDD------G-Y---PAQpS-GVPGAPGAKELEAALKRLTPA-----------EVLARRAMLSYApag 578  Drosop...
EDS34260             482 GRSFSRESLVSESED------G-Yp-gPAQ-A-GIPGAPGAKDLEAALKRLTPA-----------EVLARRAMLQHApag 540  southe...
5_pfamImport          41 DKPGC---SHAQKEDsscvchSg----PKR-L-GQPGTPGGQDLEAALRSLSRRqqnhsserpffDVERERKLHALA--- 108 
XP_021322520         431 NRTNSLLLETQSPQDg-----S-Nd-sNRK-P-GTPGTPGSHDLQAALRRLSLRrdnylserrffEEERERKLNALAedk 501  zebrafish
XP_015212332         428 NRTNSIILETESPEGs-----S-DgdaNKK-P-GTPGTPGSRDLEVALRRLSLRrenylserrffEEERERKLRDLA--- 496  spotte...
XP_025767584         460 NRTSSIL---ETPDDg-----S-Ed-sNKR-PpGTPGTPGSRDLEAALRRLSLRrdnylsekrffEEERERKLAYLA--- 525  Nile t...
XP_011479193         394 NRTQSILMETASNQDs-----A-Kn-lDKK-------TSGAEDLRVALRRLSLRrqnnlserrffE-------EERE--- 449  Japane...
XP_014195076         570 NRTQSILMETASNQDs-----T-Eg-qEKK-------ASGAEDLRLALRRLSLRrqnnlserrffEEERERRRGGHP--- 632  Burton...
XP_314926            367 GRTYSRESLTADSED------G-Yp-gPAQ-T-GIPGAPGAKDLEAALKRLTPA-----------EVLARRAMLQHAplg 425  Anophe...
CAF99478             510 NRVQSILME--SNQDs-----GtDg-rEKK-------ASGAEDLRLALRRLSLRrqnnlserrffEEERDRRQGGHG--- 571  spotte...
XP_017213872         509 DKNSP----PTHSQDh-----G-Ll-eSKR-L-GQPGTPGGQDLEEALRSLSERqeshtserpffEVERERKLRALLsg- 574  zebrafish
PNI81228             179 NKTNSIILETEAADLg-----N-De-rSKK-P-GTPGTPGSHDLETALRRLSLRrenylserrffEEEQERKLQELA--- 246  chimpa...

EDW36967             601 tYNYDEPTmHGGAGas------nsNLplgvrTP-DSI-----MSTGSSRmsassnnmSA--SMTHQWRLPEKLQIIKPME 666  Drosop...
WGS:AANI:GJ18018-PA  579 tYNYDEPA-HGRSGvaaggqaaglTLpmgvrTP-DSI-----MSTGSGS--------SG--LTTHQWRLPEKLQIVKPME 641  Drosop...
EDS34260             541 tYSYDDQPs---------------GIplgcrTP-DSI-----MSTGSSGlsgm---------sstQWRLPEKLQIVKPIE 590  southe...
5_pfamImport         109 -SKCDEAEcSSGF------------L-----TPnDSLvsspaASTGTNYsngssrhsCGssGGSRS-YLPDRLQIVKPLE 169 
XP_021322520         502 sQFYEDSE-DGG-G----------PL-----TPaDSI-----MSLGLNSv------fSI--YSSRS-YLPEKLQIVKPLE 550  zebrafish
XP_015212332         497 ----DGGElHSGS------------L-----TPaESI-----MSLGTHHsgls-----vfsFGSRS-YLPEKLQIVKPLE 544  spotte...
XP_025767584         526 -K---EEE-KGGP------------G-----TPtESL-----FSL-SSHtsvg-siwSGysFTPRS-YLPEKLQIVKPLE 575  Nile t...
XP_011479193         450 -RRQGGQV-GLQES----------VL-----TPsDSI-----MSLGNLHl-----------WASRGPYLPDKLQIVKPLE 496  Japane...
XP_014195076         633 -GLHD--A-LSQES----------LL-----TPsESI-----MSLGNLHl-----------WASRGPYLPDKLQIVKPLE 677  Burton...
XP_314926            426 tYSYDEQP-AGIPL----------GC-----RTpDSI-----MSTGSSGlsgl-sssSA--AGNGQWRLPEKLQIVKPIE 481  Anophe...
CAF99478             572 -ALGVALE-H--QS----------AM-----TPsESI-----MSLGNIHv-----------WASRGPYLPDKLQIVKPLE 616  spotte...
XP_017213872         575 sSGSDGG--SSGF------------L-----TPnSST-----ASTGTNYsgts-thsSGt-GSSRS-HLPERLQIVKPLE 627  zebrafish
PNI81228             247 ----EKGElRSGS------------L-----TPtESI-----MSLGTHSrfseftgfSGmsFSSRS-YLPEKLQIVKPLE 299  chimpa...

EDW36967             667 GS 668  Drosophila persimilis
WGS:AANI:GJ18018-PA  642 GS 643  Drosophila virilis
EDS34260             591 GS 592  southern house mosquito
5_pfamImport         170 GS 171 
XP_021322520         551 GS 552  zebrafish
XP_015212332         545 GS 546  spotted gar
XP_025767584         576 GS 577  Nile tilapia
XP_011479193         497 GS 498  Japanese medaka
XP_014195076         678 GS 679  Burton's mouthbrooder
XP_314926            482 GS 483  Anopheles gambiae str. PEST
CAF99478             617 ap 618  spotted green pufferfish
XP_017213872         628 GS 629  zebrafish
PNI81228             300 G- 300  chimpanzee
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