Conserved Protein Domain Family
Tmemb_185A
?
pfam10269: Tmemb_185A (this model, PSSM-Id:370938 is obsolete and has been replaced by 402059)
Transmembrane Fragile-X-F protein
This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.
Links
?
Statistics
?
PSSM-Id: 370938
Aligned: 26 rows
Threshold Bit Score: 133.333
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
CBI27072      28 LKLDHAVSYSWWIIFAPLWLFHA---VVARGRF-------SLPApSMPHDRHWAPFHAVTAT----PLLVAFELLLCIYL 93  wine grape
2_pfamImport   1 LRLDDVINWNYWVIFLPIWFWKS---AAILGALmgsyvwwRHPQ-YRVEGEGYVHYKAMLIClalhLLLLMFELLVCDKL 76 
EDS32129      30 LRLDDYIDWPYWVIFIPLWVWKS---IATLGAIvgaivwcRYPH-YRVEGDSYAHFKAMLISlslhLILLMFELLACDRL 105 southern house ...
XP_782890     30 LRLDETIQCSFWLVFLPLWFWKG---VVIVGAIvagvvwwKHPE-YRVEGEGYIDMKAIIIClalnSLLLIFEILACDQL 105 purple sea urchin
XP_004065037  30 LRLDGIIQWSYWAVFAPIWLWKL---MVIVGASvgtgvwaRNPQ-YRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRI 105 western lowland...
Q05AZ1        30 LRLDNIIQWSYWAVFAPIWLWKL---MVIVGASvgtgvwaRNPQ-YRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRI 105 tropical clawed...
Q4D9L8       117 VRLDYNKGWPWAAVFAPVWVALVpllLIGGLLVfhgvtrrEIAS-----------------------TLLGLMCFLVTFA 173 Trypanosoma cruzi
Q38EE7       117 VRLDYELSWKWPVVFIPLWIALAppiLLALGLLaagikqlDFLC-----------------------VCVGVEILLFVGS 173 Trypanosoma brucei
EGG19771     121 VKINHRVDWSWAKVFSPFWIIWG---LVVLAMIivaavsrRMRS---------------TVLmsksVAILVFGALIVANL 182 Cavenderia fasc...
Q86KX9       120 VKTKGAVDWSWAKVFSPAWIIMS---LVIVFTAflailskKLTF---------------FIWaahnLFIMTFMGLLVSKL 181 Dictyostelium d...

CBI27072      94 QHSYViKCIaAVNLKIVFLPLLALEAAILIDNIRMCKAL------MPGDDESIS--------------DEAIWETLPHFW 153 wine grape
2_pfamImport  77 ENN-------RHFWILVFIPLIFISIISIAICIWSVKHD------RSFELELFC-------------------------- 117
EDS32129     106 TSG-------RHLWVLVFIPLIFGSVASVGACVWAVKHD------RSFELELFC-------------------------- 146 southern house ...
XP_782890    106 ESSNAaKPW-RHPWLIVFMPLFLTSPVSIAACVWGFKHD------RGLELEAMC-------------------------- 152 purple sea urchin
XP_004065037 106 ERG-------SHFWLLVFMPLFFVSPVSVAACVWGFRHD------RSLELEILC-------------------------- 146 western lowland...
Q05AZ1       106 ERGN------HYFWLLVFMPLFFVSPVSVAACVWGFRHD------RSLELEILC-------------------------- 147 tropical clawed...
Q4D9L8       174 VAMFVvGLSgALTWTIALAPSAAIYVFQSCFILRYLLPFq----fRNGFAEFIP--------------PGSSVCLSRMYW 235 Trypanosoma cruzi
Q38EE7       174 IATFVaGLCgALSWPVALSPAIAFYAVRVLHIIPHLFPSrfvqnsEDGSGEVTF--------------SRKKYCL----- 234 Trypanosoma brucei
EGG19771     183 DHAIH------IDWTVVFIPVYFLLAVNICSIIPNTIYS------R--YLKRLQgekeyfnaatdyglGYAGWLYRRYIF 248 Cavenderia fasc...
Q86KX9       182 DATTY--TAsSMLWSEVFIPIYALIVTSILQ--KYEIFS------REHYEKRFSspehldt-ctnfglGHPGFILRKLLR 250 Dictyostelium d...

CBI27072     154 VAISMVFFIAATTFTLLKL----------CGDVAALGWWDLFINF------------GIAECFASIVCTRWYNPAIHRNS 211 wine grape
2_pfamImport 118 -SVNILQFI----FLALRL----------DEFII----WSWVVVFvplwivmclaliGVLYAIIFATILLRSNDVNPEH- 177
EDS32129     147 -AVNALQFV----FLPLKL----------DGFVS----WSWEVVFvplwivlclslvAVLYSIIFCGILLRTPEVSHQQ- 206 southern house ...
XP_782890    153 -SINILQFI----FIALKL----------DEIIT----WRWGVVFiplwiltclmclIVLYYVIWSLLILRATELMAEQ- 212 purple sea urchin
XP_004065037 147 -SVNILQFI----FIALRL----------DKIIH----WPWLVVCvplwilmsflclVVLYYIVWSVLFLRSMDVIAEQ- 206 western lowland...
Q05AZ1       148 -SVNILQFI----FIALRL----------DRIIT----WPWLVVCvplwilmsflclVVLYYIVWSVLFLRSMDVIAEQ- 207 tropical clawed...
Q4D9L8       236 GFLLETVFEKLCCFSFISLallraaqtggEDTSKLISFW---IVFtplily-fgcmtLVSAARRFFAGTVEGQSCLLSR- 310 Trypanosoma cruzi
Q38EE7       235 -FVVMVLFEEGCAIAFFTLlmlramqkseESKDEPLSFW---IVFspliac-lglkaLLHLCFCMICSKVEQPNQQASQ- 308 Trypanosoma brucei
EGG19771     249 EAMEVWFIV----FLVIRL----------DRIVT----WSWWINAipil----------vsmLIRLITIVADSKYLAKHT 300 Cavenderia fasc...
Q86KX9       251 DLVASWFFV----FLMLKL----------DHVVE----WNWWINSipvf----------fyiIFYLVLMALDNS--SKMN 300 Dictyostelium d...

CBI27072     212 HIrq-----tgSSSMIIRYLDWNSglvvssdedqhqsrlcdlqdigghIMKIPLVGFQILLFMRLE------GTP----S 276 wine grape
2_pfamImport 178 ------------RRTSVNSAVAYS------------------------FLVVPMLVAEVLVANKLD------GDP----- 210
EDS32129     207 ------------KKSAINSAIGNC------------------------ATVLPILVFQVLLADKLD------NEN----- 239 southern house ...
XP_782890    213 ------------RRANFMTAVTAV------------------------SLVAPLLTFEILLVNRLD------GIN----- 245 purple sea urchin
XP_004065037 207 ------------RRTHITMALSWM------------------------TIVVPLLTFEILLVHKLD------GHN----- 239 western lowland...
Q05AZ1       208 ------------RRTHITMAVSWM------------------------AIVVPLLTFEILLVHRLD------GHN----- 240 tropical clawed...
Q4D9L8       311 ------------LCRALAAAMGYA----------------------------SLLFMACMLAAKCEaeqnhkAVSlhpsA 350 Trypanosoma cruzi
Q38EE7       309 ------------KSTSAFLFVVYS----------------------------SMIYVACMIAAKANveinkwTDGfnpsA 348 Trypanosoma brucei
EGG19771     301 QGses----eeESSFNTFLICCYI------------------------ILIIPIVIFLGLLVSYLN------GKG----- 341 Cavenderia fasc...
Q86KX9       301 NLsmdederasNESVNSFLYCIFI------------------------FLMIPVILFISLLAAHIS------ADR----- 345 Dictyostelium d...

CBI27072     277 SARHIPIPLLFAPLFLL 293 wine grape
2_pfamImport 211 --KALSFVASISPMFLS 225
EDS32129     240 --LDWPFIGVAGPLLLS 254 southern house mosquito
XP_782890    246 ---DYPVSAVFCPLYIS 259 purple sea urchin
XP_004065037 240 ---AFSCIPIFVPLWLS 253 western lowland gorilla
Q05AZ1       241 ---YFAYIPIFVPLWLS 254 tropical clawed frog
Q4D9L8       351 AVALLPLEVTLA--LAV 365 Trypanosoma cruzi
Q38EE7       349 AVAVIPIQVIFISLFLA 365 Trypanosoma brucei
EGG19771     342 ----FAIASVFIPIFIi 354 Cavenderia fasciculata
Q86KX9       346 ----FAIANVFIPIFIV 358 Dictyostelium discoideum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap