Conserved Protein Domain Family
7tmA_OXGR1
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cd15375: 7tmA_OXGR1 
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.
Links
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Statistics
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PSSM-Id: 320497
Aligned: 8 rows
Threshold Bit Score: 411.39
Created: 25-Nov-2008
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:partly based on the structure of human P2Y1 receptor with bound nucleotide antagonist MRS2500
  • Comment:also based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #  ##            ###### #
Q96P68        34 HYLPVIYGIIFLVGFPGNAVVISTYIFKMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASgeNWIFGDFMCKFIRFSF 113 human
CAG04953      12 YYLPVTYAIIFIVGLLGNLTSIFIYLTKLRPWRSSSIIMVNLALTDLLYVLSMPFLVYYYSNreLWALGDFMCRFVRFSF 91  spotted green p...
NP_001035473  27 YYLPAMYGAIFIVGVIGNITALLVYLLKVRPWKSSTIIMVNLVLTDLLFMISLPFLVYYYVLndSWTLGITVCRFARFIF 106 zebrafish
XP_425594     34 LYLPVMYSLIFLVGFPGNVIAICVYSFKMRPWKSSTIIMLNLALTDLLYLTSLPFLIHYYASgeHWVFGGFLCKFIRFGF 113 chicken
XP_007889005  35 YYLPVMYSFIFFIGLIGNIIAITVYIFKIRPWKSNTVINCNLILTDLLYVSSLPFIIYSYINsnSWKLGEFMCKFTRLIF 114 elephant shark
XP_006639074  26 YYLPVMYSIIFIVGLVGNIISIMIYVFKMRPWKSSSIIMLNLAISDLLYVLSLPSFIYYYINqdSWTMGEFMCKLSRFVF 105 spotted gar
XP_003218718  37 TYLSFIYIALFVVCFPGNIFVISVYVFKMRPWRSSTIIMFNLAVTDLLYVCCLPFLVHYAINgeDWIFGNFMCKFIRFNF 116 green anole
XP_006259054  34 YYISAFYGIIFVLCFPVNIVVIFMYFFKMRPWKSSTIIMLNLAITDLFYLTTLPFLIHYFANgnNWIFGNVMCKFIMFNF 113 American alligator

Feature 1        #  #                                            # #####             # ###       
Q96P68       114 HFNLYSSILFLTCFSIFRYCVIIHPMsCFSIHKtRCAVVACAVVWIISLVAVIPMTFLItstnrtNRSACLDLtssdeln 193 human
CAG04953      92 HFHLYGSILFLTCFAVFRYVVVIKPLlAAQVQQrIWGIIACLVVWVLAATEVAPMWTMIssmevnNQTRCLDFastipad 171 spotted green p...
NP_001035473 107 HFNLYGSILFLTCFSIFRYVAIVHPQhSHKIRRkRWGVVSCALVWVVTVAELSPIFNLFatmeidNKTYCLDFasnd-aq 185 zebrafish
XP_425594    114 HFNLYSSILFLTCFSAFRYMVIVHPMkFFHVQRrRWTAVACAAIWVISLAAVSPINFLIsskeeqNRSLCLDFtssenlg 193 chicken
XP_007889005 115 YLNLYGSIMFLMCLSIFRFLVIIYPLrAYEVQKkPWAFLACCLVWLITIAEVLPMITFItlesksNTFTCLDFgsspnpe 194 elephant shark
XP_006639074 106 HFNLYGSILFLTCLSIFRFIVVVHPLrVAQVQKrKWGILACVIVWVITAAELTPTLLMVnlidvnHTMQCLDFasnh-re 184 spotted gar
XP_003218718 117 YFNTYSSIYFLTCFSLFRFVVIVYPMsCFSIQKrRWAIAACTAVWVLSLLAVSPMTFLVttkqsfNRLICTDLtnsepln 196 green anole
XP_006259054 114 YFNMYSSILFLCCFSIFRYIVVLYPInWIFVHKkKWAMMACIVVWVISLGAVSPLGFLIttkkkqNRTICMDLtnvtnln 193 American alligator

Feature 1         #  ### ### ##                                              #  ## ##  #         
Q96P68       194 tIKWYNLILTATTFCLPLVIVTLCYTTIIHTLTHGLqtdsCLKQKARRLTILLLLAFYVCFLPFHILRVIRIEsrllsis 273 human
CAG04953     172 vVRWYSWILAALGFLLPLVVVYMCYISVAKQLARGPktssPSRSRARRATMLILLVFGLCFLPYHVLRVVRIEtrdeysp 251 spotted green p...
NP_001035473 186 kIWPYSWVLTVLGYLVPLVVVCVCYWRIIEKLKEGPhmgcKKRVRARRFIVLILTCFAVCFLPFHVLRAFRIYtrltpet 265 zebrafish
XP_425594    194 aIRWYNWLLTSLAFFLPLVTVTLCYTLIICALATGPqtraSYKQKARRLAIVLLVVFYVCFLPFHLFRVARIElqlcpis 273 chicken
XP_007889005 195 qLLVYSWILTVLGYLIPLLIIFICSLKIVYTLKKGPyvnlASKLRARRLIIVILIVFTICFLPLHLFRLLRLYfrlpnvt 274 elephant shark
XP_006639074 185 tVWWYGLFLTILGYLIPLVIVCACYCRIVQALGKGPhvqsACRVKARKLIVVILLVFILCYLPFHILRILRVDtrrpgvd 264 spotted gar
XP_003218718 197 sARWFNWILTIFGFFLPLIAVTLCYAVIIYTLAQGPhtgtNHKQKARMLAIVLLAVFYVCFLPFHIFRGVRIElklhpvd 276 green anole
XP_006259054 194 aSWWYNLLLTVFAFLLPLLIVTLCYSAIIYTLDKGPnnrtSYKQKARKLAILILAVFYVCFLPFHIFRGVRIElqlypvs 273 American alligator

Feature 1                 ## ###  #  ##                     
Q96P68       274 ---csienqIHEAYIVSRPLAALNTFGNLLLYVVVSdNFQQAV 313 human
CAG04953     252 elmpcmkniVHAVYIFSRPLAGLNTFFNLALYTLSGdKFRVAF 294 spotted green pufferfish
NP_001035473 266 --ncmldhgVHAAYIISRPIAVLNIIFNLPLYTLSGdSFKQAF 306 zebrafish
XP_425594    274 ---chvekqIHTIYIISRPLAALNTCGNLLLYVVMGdNFQQAI 313 chicken
XP_007889005 275 --etclthtVNAIYIITRPIAALHTFCNLALYIIDD-NFKQAL 314 elephant shark
XP_006639074 265 ---cvtmrrVHAAYIITRPITGLNTFFNLGLYTLAGdQFQQAF 304 spotted gar
XP_003218718 277 ---cstmklVRDMFIVTTSLASLNTFGNLLLYVVLGdNFQQAI 316 green anole
XP_006259054 274 ---cpiktqILGIFTATKPLAALNVVGNLLLYVVMGgNFQRAV 313 American alligator

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