Conserved Protein Domain Family
RING-HC_RNF166
?
cd16549: RING-HC_RNF166 (this model, PSSM-Id:319463 is obsolete and has been replaced by 438211)
RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins
RNF166 is encoded by gene RNF166 targeted by thyroid hormone receptor alpha1 (TRalpha1), which is important in brain development. It plays an important role in RNA virus-induced interferon-beta production by enhancing the ubiquitination of TRAF3 and TRAF6. RNF166, together with three closely related proteins: RNF114, RNF125 and RNF138, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM).
Links
?
Statistics
?
PSSM-Id: 319463
Aligned: 6 rows
Threshold Bit Score: 78.7165
Created: 3-May-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens BRCA1 (1JM7) binds two Zn2+ ions through its RING-HC finger.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #            # #  #  #           #  #    
Q96A37        30 QYTCPICLEVYHRPVaiGSCGHTFCGECLQPCLQVpSPLCPLCRLPF 76  human
CAF92401      41 QFSCPICLEVYHKPVsiASCAHTFCGECLQPCLQVtSPLCPLCRVPF 87  spotted green pufferfish
Q3KPU8        34 QFGCPICLEVYYKPVaiGSCGHTFCGECLQPCLQVsSPLCPLCRMPF 80  African clawed frog
Q5F3B2        37 QFSCPICLEVFHRAVgiAGCGHTFCGECLQPCLQVpSPLCPLCRMPF 83  chicken
XP_006008322  56 QYSCPICLEVYYKPVsiTSCGHTFCGECLQPCLQVpSPLCPLCRMPF 102 coelacanth
XP_002737160  19 NFICSICLEVYRKPVt-ITCGHTFCRECLKPCIATaAPQCPVCRAAF 64  Saccoglossus kowalevskii

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap