4A4A


Conserved Protein Domain Family
NAGLU_C

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pfam12972: NAGLU_C (this model, PSSM-Id:315618 is obsolete and has been replaced by 463763)
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Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold.
Statistics
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PSSM-Id: 315618
Aligned: 176 rows
Threshold Bit Score: 194.349
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4A4A_A        626 WTEDYIERRY-----GK------TNK------EILEAWNIILDTAYkKRN-DYYQGAAESIINARPGFG---------IK 678 Clostridium pe...
72_pfamImport   2 YFHDWVSARY-----GTenv-----------ksLYTGWELLRPTVFnNTN-LTVNAVPKSILELTPNIN---------GL 55 
71_pfamImport   2 YFHDWVSTRY-----GTknv-----------ksLYTGWELLRPTVFnNTN-LTMNAVQKSILELVPSTT---------GL 55 
47_pfamImport   1 YFASWVTKRY-----AGis---siPS------ELYRAWEILRTDVYsNTR-TDIPQVPVATYQLRPALS---------GI 56 
81_pfamImport   2 YFRAWARNRY-----SAag---iiPE------DVFTAWEQLRQHAYdVQD-NAIPSVGVSVYQLFPSLK---------GL 57 
67_pfamImport   1 YFHDWTTRRY-----Sgv---rqLPA------SLYQAWELLRVTVYdYRA-SDLIGVPVSVYQLEPNLTglyntttgkPT 65 
Q4X1M8        474 YFHNWAKTRY-----SSgvrgsaVPE------ELYQAWDILRITAYnNTN-LTSTAVSKSIFELQPSIS---------GL 532 Aspergillus fu...
XP_007589168  395 YFRSWVARRYnsgngST------LPT------DLFTAWGILRTTVYn-SN-FTSIGALKSLFELRPSLT---------GL 451 Neofusicoccum ...
CCE28450      471 YFHDWTTRRYsm--tGA------TPPr-----ELYEAWQVLRSSVYsNSR-SDIPQVPVATYQLRPALS---------GI 527 Claviceps purp...
XP_016757438  481 YFDDWVTSRY-----HC------DDAvaglpqDLYIAWDMMRQTIYnNTDiDTAEAVTKSIFELQPNTT---------GL 540 Sphaerulina mu...
4A4A_A        679 SASTwg-hSK----IVYDKSEFEKAIEIFAKNYD---E---FKDSDAFLYDFADILKQLLANSAQEYYEVMCNAYNNG-- 745 Clostridium pe...
72_pfamImport  56 LGRVg--rHGt--tINYDPAVMVDAWTELFKAGL---EdvkLFGNPAYQYDLVDWTRQVLVNSFDGLYKDLVTAYNSSa- 127
71_pfamImport  56 LGRVg--hHGt--tITYNPAVMVEAWTELFKAGL---QdikLFTNPAYQYDLVDWTRQVLVNSFEGLYKDLVAAYNSAa- 127
47_pfamImport  57 ANRTg--hFPhptaLHYDPLVLQGVWKLMLEALT---RqgsLWKVPAFQLDFVDVSRQMLSNQFDVLYADLVNAYKCStg 131
81_pfamImport  58 VNRTg--hYPpptaLQYDPKVMKNIWHLFYNSTI---DspgLLQIPAFHLDFVDVTRQVLGNAFIDIYTDLVNQFQATa- 131
67_pfamImport  66 ALH-------------YDPAALPPIWRLFVAAAA---AqprLWAEPGFRLDLVDVMRQVLSNAFGRLYADLVAAFTGGa- 128
Q4X1M8        533 LNRTs--hHPt--tVSYDPAALVQAWRLMDSAAS---KapsLWSQPAFLYDMVDITRQVMSNAFIPVYTNLVSTYQAGg- 604 Aspergillus fu...
XP_007589168  452 TGRAgf-yLTd---pPYDPSDLLSAWKYFLSAALaslE---LWSNPAFMFDAVDFTRQVLANTFATQYADLVATFNAS-- 522 Neofusicoccum ...
CCE28450      528 TNRTghfpHPt--aLHYDPRVLQKAWQLMFKSSL---RqthLWSSPAFQFDFLDLSRQMLSNAFDLRYSGLVRSYHCKis 602 Claviceps purp...
XP_016757438  541 LD-Rtg-hHSt--rILYDPEILVSAWKHFYSASQ---EtpqLWELESYRFDLVDITRQVLANAFYPLYGEFVNMTANS-- 611 Sphaerulina mu...
4A4A_A        746 ---------------N------------GE--Kf-----KfvSGKFL----------ELIKLQERVLSTRPEFLIGNWIE 781 Clostridium pe...
72_pfamImport 128 ---------------N------------AA--Ei-----RsrGSKLT----------ALLKTLDAVLATNENFQLATWIA 163
71_pfamImport 128 ---------------S------------SS--Vi-----KsrGAKLI----------ALLRTLDAVLATNEHFQLTPWIN 163
47_pfamImport 132 aggs------relrsN------------TPncDv-----KaaGARLL----------FLLSTLDLTLLTSRHFALQSWVD 178
81_pfamImport 132 ---------------N------------AT--Vi-----QdlGNSML----------SFIEDLDMALNTNEHFTFKKWLN 167
67_pfamImport 129 ---------------P------------PS--Ei-----AqrGQRMR----------AVLGDVDALLATQPHFSLRRWLN 164
Q4X1M8        605 ---------------S------------VS--T------D--GSNLI----------QLLRDLDSVLSTNDNFRLSTWIQ 637 Aspergillus fu...
XP_007589168  523 ---------------VsnfttgtngtagAE--Tv-----AekGKKLT----------DLLAMLDRVLSASRHFSLGPWIE 570 Neofusicoccum ...
CCE28450      603 kpskshelravsppkD------------AKc-Dv-----RaaGGSLL----------GLLWMLDYVLSTNAHFTLQRWTA 654 Claviceps purp...
XP_016757438  612 ---------------S------------LP--SsstasaEqtGARMLsllldldsvlE--------ASGNAHFSLESWIH 654 Sphaerulina mu...
4A4A_A        782 DARTMLK-Ds------------dDw-------------------tKD--LFEFNARALVTTWGSRnnadgGG-LKDYSNR 826 Clostridium pe...
72_pfamImport 164 AARASNP-S--------------Nt-----------------------sFLEYNARNQVTLWGPT-----GQ-IEDYASK 199
71_pfamImport 164 EARASSP-S--------------Ta-----------------------dFLEYNARNQITLWGPQ-----GN-IEDYASK 199
47_pfamImport 179 AASAWGK-A--------------A---------------------GNedLFTFNARSQVTVWQVNa----TN-LNDYAAK 217
81_pfamImport 168 SAESWGQ-S--------------I---------------------GApdAVAFNARSQVTVWSTEs----RA-LDDYAAK 206
67_pfamImport 165 AARAWGE-St------------gE---------------------NA--AIAYEARSQVTIWa-Pg----TL-LNDYAAK 202
Q4X1M8        638 SARSWVR-N--------------D---------------------TEadFYEYNARNQVTLWGPK-----GE-INDYASK 675 Aspergillus fu...
XP_007589168  571 AARVWAQ-Tp------------sSvgsdtiiagdgyggegnfssvAD--FFEYNARNQVTLWGPQ-----GE-ISGYASK 629 Neofusicoccum ...
CCE28450      655 GARKWGTlSg------------gH---------------------EE--LFALNARSQVTVWQVN-----ARdLNDYAAK 694 Claviceps purp...
XP_016757438  655 SARLWAP-TetnaadgdnmtaaaI---------------------AD--FYEYNARNQITLWGPG-----GE-ISDYASK 704 Sphaerulina mu...
4A4A_A        827 QWSGLTEDYYYARWEKWINGLQAEl-dGG-------AKAPNIDWFKMEYDWVNKKsdtdKlyptEASnENLGELAK 894 Clostridium perfri...
72_pfamImport 200 QWAGLVGDYYLGRWQQFIDYLATT---KHss---ynQTAFYHKLQAWEIQWGNQI----SgktsKAA-STGANEVQ 264
71_pfamImport 200 QWAGLVGTYYVERWQQFIDYLATT---KPsn---ynQTAFHQKLLAWETQWGQQK----St--kKTA-STGSTDIR 262
47_pfamImport 218 AWGGLVGSYYKGRWSIFVDALVAAs-sSGsl----dEGALARKLQVFEAEW--------------QA-G-KQTVEQ 272
81_pfamImport 207 AWSGIVKSYYGERWRIFINSLV-SareQGta---ldETALNDKIRHFELSWQYRG----YnpeaSDK-AQDIGGVA 273
67_pfamImport 203 AWSGLIATYYDERWRIFVDRLVDAaenHGgr---ldFAALHKEMSEFQTAWQTKG----YgvegEAA-ADSAADVQ 270
Q4X1M8        676 QWGGLVSSYYIPRWQKFLNYLENT---QAsk---ynATQIEAKLFDFELKWQEET----S----KPT-RAKTHDLR 736 Aspergillus fumigatus
XP_007589168  630 AWEGLVRSYYAERWRIFVDYLVSAl-eTGdgaseynASVLAERLFAFELAWQVAR----WeddrSTD-EDTnqkiq 699 Neofusicoccum parv...
CCE28450      695 AWSGLVASYYGERWRIFVNELVRAs-sRRqk---vdERALAKALGRFEADWQggkggeegarkvkmkrfvrelmqg 766 Claviceps purpurea...
XP_016757438  705 QWAGLIKTYYVPRWERFVHFTLNSs--TSad---gqNEALKKSLTEFELGWQMEK----SdsvsTPP-Gsqdleqt 770 Sphaerulina musiva...
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