Conserved Protein Domain Family
eIF3_p135

?
pfam12807: eIF3_p135 (this model, PSSM-Id:315476 is obsolete and has been replaced by 463717)
Translation initiation factor eIF3 subunit 135
Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.
Statistics
?
PSSM-Id: 315476
Aligned: 160 rows
Threshold Bit Score: 96.8698
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q2H9U9          679 ISFPMDGRSLTSLLHRRGINLRYLGKLAslseNT---------RLECFR------DVCVREMIARSFKHVAAKYLKTLPL 743  Chaetomium ...
49_pfamImport     1 NSRLADSLSVSDCFHLNGVNIRYLGKVI-----NslnqndyphIL----------MILQKTLLVKCLKHVLREIMRLSVQ 65  
10_pfamImport     1 SAMPVDGIALARMMHKRGINMRYLGKVA----ELaasqygndhPLVYLA------EL---EMLARAVKHVFSNNIAKHSF 67  
121_pfamImport    1 SFMPIDGIALSRALHRNGINIRYLGDMLy-------------vILDKYPentamiRLFTSEIFARSAKHLIRAYISKTPR 67  
O59742          704 SFLPIDGVALCRAMHRSGINIRYLGEIAn-------------iILQKSPnnvillKLVTSEIFIRSIKHVFRNFLAVVPQ 770  Schizosacch...
P34466          744 VVQPIDGDNLADIMHINGINIRYLGEIG-----KrlensvsfaR-----------PLVLSDIVARSAKHVIRKINVQITA 807  Caenorhabdi...
32_pfamImport     1 -VQPIDGDNLADVMHSKGINIRYLGEIG-----KriedsnlfaR-----------PLVLSDIVARSAKHIIRKINVETLA 63  
48_pfamImport     1 TLQPIDGENLADVMHAKGINIRYLGEIG-----KrlqdtnsfaR-----------PLVLSDIVARSAKHVIRKINVQTSA 64  
A8XAA9          745 TVQPIDGNNLADILHSKGINIRYLGEIG-----KrvqdtnsfaR-----------PLVLSDIVARSAKHVIRKINVQTPV 808  Caenorhabdi...
3_pfamImport      1 TSFPVDGDALTQLMHSNGLNMRYLGAAL-----NhimtmhqkaSASHFAk-----KLIASEMIARVAKRMLRHRLSNSQN 70  
Q2H9U9          744 PLTSSCFSHLFNCLLGTELNPK------------------PVAEIDesYRSLFD----EADL------------------ 783  Chaetomium ...
49_pfamImport    66 NEIPYSISNALNCIFSVSDIRDrlekg--------eicqqKNNTNNenMGGGEKnkqgKKNKkqhsnkqqkiqvlnksnc 137 
10_pfamImport    68 YNRASSVAYLLCCIFSE-----------------------DEAFKDspVYKEYLqkipSESFq----------------- 107 
121_pfamImport   68 CLISHVVSHFFNCLLAESEDDQs-----------------FPFLPEesISQFYPet------------------------ 106 
O59742          771 VLRSHLLSHLLNNLFTVYGYVEp-----------------TKPLINenIANLFFqa------------------------ 809  Schizosacch...
P34466          808 DQLSASTSHILNCLF-------------------------SVVLDPspIAANVAkkanKKNGkkr--------------- 847  Caenorhabdi...
32_pfamImport    64 DQLSASTSHILNCLF-------------------------SVVTDPspVATNATkksnKKNGkkk--------------- 103 
48_pfamImport    65 DQLSSSTSHILNCLF-------------------------SVVSEPspVGTTATkkanKKNGkkk--------------- 104 
A8XAA9          809 DQLVVSTSHILNCLF-------------------------STVSEPspVASHAHkkssKKNGkkk--------------- 848  Caenorhabdi...
3_pfamImport     71 HAVADAVASFFNALFDAPVATAasscvfpdatalilqgeaAQQQDGkaNAGKKKskpnKANKaalvvsl----------- 139 
Q2H9U9          784 ------AFEKVTPEGLREEVQSEAARRFRFVL---------------PDSWWS------QVR--HLQLLREISLKLGLQI 834  Chaetomium ...
49_pfamImport   138 ivlpqwEVSKLKPSQIWEKVLNLAKKRYGYDGfp-----------enMSNLNLl-----NLKfnKLSILRDLLRTIGVQI 201 
10_pfamImport   108 -----------TPTQVKESVAQNVASRFRYRIh-------------nSAKFVK-----------SPPLLRNICLKLGIQL 152 
121_pfamImport  107 ----cqMLVSMSPKLVSEALMKESQSRFGYKI---------------PREFVK------EVN--QISLIRLICLKLGIQL 159 
O59742          810 ----tqVIYSINSTSLYSSIKKEASSRFRFNL---------------TDDLLH------SLN--PICILRGTCLRLGIQI 862  Schizosacch...
P34466          848 ---vtsAWSSLTTSALWNSIREDSASYYGYPI---------------EADSLEkftelhDIQ--KTALFRRICKVMGVQL 907  Caenorhabdi...
32_pfamImport   104 ---stgVWSTLTTASLWKSICEEASYYYGYPI---------------DAESLDkfteqhDIQ--KTALFRRICRIMGVQL 163 
48_pfamImport   105 ---tagIWSALTTASLWKSICEESAYYYGFSI---------------ESESLDkfiethDIQ--KTAIFRRICKVMGVQL 164 
A8XAA9          849 ---nsgVWATLTTASLWKSICEESAYYYGYHI---------------DTETLDkfleqhEIQ--KTALFRRVVKIMGVQI 908  Caenorhabdi...
3_pfamImport    140 pvataeLQAPSALSNLWAAIFDEVKQHFRFDFaahlaknaapsfaavSAAF--------GIE--LVPLLRAVCVKTGIQL 209 
Q2H9U9          835 QIKKFRF 841  Chaetomium globosum CBS 148.51
49_pfamImport   202 LYKDYYF 208 
10_pfamImport   153 LCRDYFC 159 
121_pfamImport  160 ACKDYV- 165 
O59742          863 SCKDYFs 869  Schizosaccharomyces pombe 972h-
P34466          908 VARDYQL 914  Caenorhabditis elegans
32_pfamImport   164 VARDYQL 170 
48_pfamImport   165 VAKDYQL 171 
A8XAA9          909 VARDYQL 915  Caenorhabditis briggsae
3_pfamImport    210 SARDYLI 216 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap