Conserved Protein Domain Family
CLASP_N
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pfam12348: CLASP_N (this model, PSSM-Id:315101 is obsolete and has been replaced by 432496)
CLASP N terminal
This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.
Links
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Statistics
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PSSM-Id: 315101
Aligned: 52 rows
Threshold Bit Score: 172.388
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2UCC9        339 VEDLFRVLSPAFegRESEDNWRHREKYITSLRRLTYGN-APHDFPQPFFTGIKTNLDGIFKAVNSLRTTLSTNGCLLIQD 417  Aspergillus o...
Q1DS65          1 MDARATELLATL--RNGNVSVDVKTTSLAKLKSEIKQKhVPDAAISPLFESFR---LAIASQHYSLSSAGFSALGHLLKR 75   Coccidioides ...
Q2H0S9          6 TDDQVANLIALL---RADVSIDTKVQQVTVVKSSIKQHmVPESCIVPVFEALH---LASSSQHALLVNAGFTALNHLFTR 79   Chaetomium gl...
Q0D0S3         77 MDMKVDDLQAAL--TNPNLSIENKYDRLISVKSDIKQKnVPASLIPSLFDCLR---LAIAHNNIHIYTAGFATLSHLLKR 151  Aspergillus t...
Q17AR9        308 MDEHMKSINTIV--GDKNMDWEKRVDALKKIRSLLMIN---VQNSPTFTQQLKDLSIAFLDILKELRSQVIREACITLAY 382  yellow fever ...
Q55BD8        409 FEYKMNEIIEIL--SNSDTEWSIKLNNILKFQAIIKSGaCKLSNFIIVFNRIK---ELLALQILDKRSILMKEACLTLSL 483  Dictyostelium...
Q6K6B1         78 LSREIERVASTL---HPDNEWAIRITAMQRVEGLVLGG---AADYSAFPMLLKQLVTPLITQILDRRSSVVKQACHLLNF 151  Japanese rice
XP_015575957  221 LIREFEKVASTL---VPEKDWSIRIAAMQRIEGLVLGG---AADYPCFRGLLKQLVSPLSTQLSDRRSSIVKQACHLLCF 294  castor bean
XP_001776918  276 LAKEFEKAASML---APTQDWSIRMSAMRRIEGIVVGG---ATKYSGFLQLLKQLVNPLCDQLADRRSSIVKQACQLLKV 349  Physcomitrell...
XP_002848749    1 MDERATELLAAL--RNTSLSVDAKIASLTKLKSEIKQRnVPTSAVGDIFDAIR---LAIASQHASLSAGGFSALGHLLKR 75   Arthroderma o...

Q2UCC9        418 LAKIGGSR-IDPMVEVIMQNLIKLCGGMKKISAQNGNVSVNDVLANVTyTPRL-LQHVTSACQDKNAQLRLFAAGWLKTL 495  Aspergillus o...
Q1DS65         76 LTLQEQHEaIALQGRATYQLLLERLGDHKERIRSQAAQAFTDFWPAAS--ADVeHHVLGAALIGKNARAKETSMVWLAKM 153  Coccidioides ...
Q2H0S9         80 LVRQDPRS-LTKEGTRALPLIVEKLGDQKEKFRQLASQALATLYKVAP--VEVeRSVRNIAMVGKNARAKEASLHWLLQM 156  Chaetomium gl...
Q0D0S3        152 LFIEELHTeVAAHARSLYPTLLERLGDHKERVRALAAQAFADLWKAAP--MDAeKHVLGTALVGRNPKAKEASLTWILSM 229  Aspergillus t...
Q17AR9        383 MSKLLKNR-LDQFVIYILQELINLIQNSAKVISSAGIIALKYVIKHTH-APKIvPIITQNLMQSKSKDIRSTLCEIMILL 460  yellow fever ...
Q55BD8        484 IAKELEHH-FEPYLEKYFDVLLKCIVVTTKIVSESSDNCIKCIISSSK-SCKIiPRIYEAISSDKSVIIRSKCTEYLYIL 561  Dictyostelium...
Q6K6B1        152 LSKELLRD-FEPCAELLIPVLLKNVVITIHVIAESSDNCIKEMLRNCK-VARIlPKIIEFAKNDKSAVLRARCCEYAILM 229  Japanese rice
XP_015575957  295 LSKELLGD-FEGCAEMFIPVLFKLVVITVLVIAESADNCIKTMLRNCK-VGRVlLRIADCAKNDRSAILRARCCEYALLI 372  castor bean
XP_001776918  350 LTKELKSD-FDVFAETFLPVLFKLVVITVLVIAESADACIKSMLQHCK-VARLlPKMVDFAKHDRSAVLRARCCEYLLLV 427  Physcomitrell...
XP_002848749   76 LYLQEQTAlIASQGRHTYSLLLEKLGDHKERVRAQASQAFADFWQASP--TETeHHVLEVALVGKSPRAKETSMMWLVKM 153  Arthroderma o...

Q2UCC9        496 LNKQS-HHKSSLEHGGGLa----lLEKSLKRGLTDANPGIREAMRGAFWTFHQMWPARGNNIL--SDLDNKTRHLLE 565  Aspergillus oryz...
Q1DS65        154 TREYG----------LLFr----iYVPALVTCLEDADGVVRDTAKSTVIELFQSAPPRAISDLkkQLIQNNVRKSIA 216  Coccidioides imm...
Q2H0S9        157 HQEQG----------LQFr----aYVPTMMELLEDADGMVRDVAKSTVIELFRNAPGPAKSDLkkQLKNFKVRPAIE 219  Chaetomium globo...
Q0D0S3        230 HTSHD----------LLFr----pYVASLVACLEDADSAVRDTAKSTVVGLFNSAPAHAKADLqrEMAEQHVRKSIV 292  Aspergillus terr...
Q17AR9        461 FDEWP---TKTLEKNSs------lLRDALRKGISDADSEARRHSRCAFWSFRRHFPDLADNLY--SSLDPATQRMME 526  yellow fever mos...
Q55BD8        562 LRDLPsSSGNHHHHHHLFekhldsIEKSIRIGVVDANLTARSYSRKVFIQFSLNWPDRSNSLF--STLDPSAQKTIE 636  Dictyostelium di...
Q6K6B1        230 LELWV--DTPEIQRSVd------lYEEFIKCCIEDATSEVRSSARACYRMFSRIWPERSHQLF--SSFESSRQKMIN 296  Japanese rice
XP_015575957  373 LEHWP--DAPEIQRSAd------lYEDMIRCCVADAMSEVRSTARMCYRMFAKTWPERSRRLF--SSFDPVIQRIIN 439  castor bean
XP_001776918  428 LERWF--DAPEMQRSAe------lYEDLIKCCCADAMSEVRSLARQCYRVFARCWPDRARRLY--QAFDPVTQKVIN 494  Physcomitrella p...
XP_002848749  154 TKERG----------VLFr----aHVPSLVVGLEDADSAVRETAKAAVIELFQNAPSRAISDLkkQIQSHNVRRSIT 216  Arthroderma otae...
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