3TJ3


Conserved Protein Domain Family
NUP50
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pfam08911: NUP50 (this model, PSSM-Id:312461 is obsolete and has been replaced by 462629)
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NUP50 (Nucleoporin 50 kDa)
Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localization signals from importin-alpha.
Links
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Statistics
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PSSM-Id: 312461
Aligned: 81 rows
Threshold Bit Score: 34.5821
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3TJ3_C         8 KRNAEKELTDRNWd--------Qe--dEa-EE-VGtFSmASEEVLKNRA--IKKAKRRN------VGfesd--------- 58  human
XP_016271056   3 KRGAEKQLTQDNVd--------Dd--eRqeEGgSGdFRkASDQALSGRK--IRGLPKRR------GGgapgaapaa---- 60  Rhodosporidium ...
CEL57699       3 KRTSEHQITRDDGs--------Dd--eDheVK-VGm-SkADTTVLATRQ--IKGLPKRK------GAtplatsagss--- 59  Rhizoctonia sol...
XP_009267498   2 KRGAEKQLTQDDPeae----gdDn--sNyeEG-AKpFArANDSSLSQRK--IRGMPKRM------QSaapptqpgktqea 66  Wallemia ichthy...
XP_001830289   2 KRVADKQLIREEAdv-----eeTn--dTgePG-TG-FRkADEAVLATRKqvIRALPKRAaggsfnAAatpsaaa------ 66  Coprinopsis cin...
XP_003030483   2 KRGAERQATRDDAd-------nDg--dDnePG-QG-LKkADEATLAGRK--IRGLPKRS------RSstpaattd----- 57  Schizophyllum c...
XP_007328287   2 KRGAEKQISKDSFe-------eEe--eQeeTP-QTgFArANESVLKTRP--MRGLPKRAs-----VAslpppatq----- 59  Agaricus bispor...
XP_001877756   2 KRGAEKQLVKDAFd--------DdsneDesPS-QG-FKkADEAVLAARP--MRGLPKRV------TTstptpanp----- 58  Laccaria bicolo...
XP_007396926   2 KRGAEKQLTKDVed------idDd--eVveSG-QG-LKkADDNMLANRK--IRGLPKRAtag-laSGsaptla------- 61  Phanerochaete c...
EPT04488       2 KRGATRQLTKDEDvdddrdddgRd--dDeePQ-QG-LQlADAATLAKRP--MKSLPKRRga--gaSGsdkpqiqvpknga 73  Fomitopsis pini...

3TJ3_C        59 ----------------------tggaFKGFKGLVV 71  human
XP_016271056  61 ------------------aptgdvpkPSPFGGVAS 77  Rhodosporidium toruloides NP11
CEL57699      60 ----------------nssstdpsprMASFTGFGA 78  Rhizoctonia solani AG-1 IB
XP_009267498  67 akin------pfafnpptksedsapkSNPFSAFSA 95  Wallemia ichthyophaga EXF-994
XP_001830289  67 -------------------atnappkFGGFAGFGA 82  Coprinopsis cinerea okayama7#130
XP_003030483  58 -------------------apssapkFAGFSGFGG 73  Schizophyllum commune H4-8
XP_007328287  60 ------------------tgvadtprFNGFSGFGS 76  Agaricus bisporus var. burnettii JB137-S8
XP_001877756  59 ------------------sapastpkFGGFNGFGI 75  Laccaria bicolor S238N-H82
XP_007396926  62 ---------------------avpskFAGFAGFGT 75  Phanerochaete carnosa HHB-10118-sp
EPT04488      74 vyfgrtrdpseaaaatatsepepapkFGGFGGFGT 108 Fomitopsis pinicola FP-58527 SS1
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