4M8N


Conserved Protein Domain Family
Plexin_cytopl
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pfam08337: Plexin_cytopl (this model, PSSM-Id:311994 is obsolete and has been replaced by 462434)
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Plexin cytoplasmic RasGAP domain
This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Links
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Statistics
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PSSM-Id: 311994
Aligned: 54 rows
Threshold Bit Score: 353.804
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4M8N_A         47 AIPFLDYKHFASRIFF-----------PE---------------AgtltavmirdigeDSEQTTVDE-KCLAFAELIRDK 99   zebrafish
O45657       1194 GPELINFPHFVENLLWsdnnlt----------------sapslaRtl----------pV---------TLAQFHALLSFK 1238 Caenorhabditi...
XP_011412156  384 GIPYHSYQSYTQYILF-----------PKeveaat----iasllEh-----------sGFSSKNAEK-AMDQFDKLMSNK 436  Pacific oyster
XP_011667763  897 GMPFVSGADYIRNMLFwglkvqpmtndPE------------------------------LPQESIKQ-AMSEFSKLLNRK 945  purple sea ur...
XP_011674296  421 GVPFVNALDYSKNMLFaglavlppttdPE------------------------------YMNSDLET-AMIMFSRQLSNP 469  purple sea ur...
EGT44270      956 qPEIVDFSRFMENLLWaentlt-----------------vpilaRtl----------pM---------ALAQFHALLSFK 999  Caenorhabditi...
XP_004998121 1444 eahprpfGEYARRVYF-----------TAldthpl---pvrprfPgt----------nD---------CIEQFTFFLQQD 1490 Salpingoeca r...
XP_009861867 1160 riiylppwEYITQVLF-----------NQrsghpv------------------ldenamVGQGTVKQdALKSLLSVIKNK 1210 vase tunicate
XP_002599826 1243 GIPFLDYRTYMMRVLF-----------PGqdmhp-----vlketNvr----------eS-RRVQWEQ-AMNQFSALLNNK 1294 Florida lancelet
XP_002112670 1252 GAPQHPFRVYIHKMLF-----------PNvkhgemhpvfapisvR-------------GSRKSRLED-SLSSFLDLLLRD 1306 Trichoplax ad...

4M8N_A        100 QFLSCFVHALEEQK-NFSIKDKCTVASLLTLAL--HGDLLYLTEIMEDLLQSLMDQSSnAN--PKLLLRRTESIVEKLLT 174  zebrafish
O45657       1239 GFIFTIVEAAESDV-SISTSEKSMLASLLISVL--LRNFSYCTEVVVDLLRAHIARSVqNKr-AELLFRNSDSVVEKMFS 1314 Caenorhabditi...
XP_011412156  437 YFVKSLIGTLEKQR-KITLSDKAQFAANFSVIM--MGKMRDFFEIVNCLLSTLVD-SAnKKq-HKTLFNRFESISLRLLS 511  Pacific oyster
XP_011667763  946 EFLMQYIQGLDEAK-NLKQKDRVNIASLLSTILttEGRFHYLTDVMLTLMAEKIEESD-ENr-LKQLFKSVGSILEKLIS 1022 purple sea ur...
XP_011674296  470 DFLTNFIKQLEEQR-KPKRRDRVNIASLITALLvtEGKFGYFTETLFKLLEESIEEGA-ESgrARSLFRRTETIVEKLLS 547  purple sea ur...
EGT44270     1000 EFIFTIVDVAESRN-SISTSEKSMLASLLISVL--IRNFSYCTEIVISLLKTHIAKAVeNKr-AELLFRNSDSLVEMMIS 1075 Caenorhabditi...
XP_004998121 1491 DFLRAFVGVMEGEGrAFSVRDRCQVASLLMCSA--NGDEAMGTHTLSTLLDQYFTAn--SRrdPRLMLRRTESVAEKLLT 1566 Salpingoeca r...
XP_009861867 1211 DVLLVLVRTLEEQR-KFTVQEKGNMASLLTICL--FDDLPYYTRVMLELLTGLIQKHV-SRn-PKLLLRRSESVVEKMVS 1285 vase tunicate
XP_002599826 1295 HFLLTFIRIMEESReSFSSRD----------------------NILKTLLLHMIEKSV-ERn-PKLMLRRTESVVDKMLT 1350 Florida lancelet
XP_002112670 1307 KFLITFIATLEKQP-DFKPKDKCNIASFLIVAL--HENMDYVTKVLMKLLIEMIRKLP-PKgqPQLFLKRNDSITEKLLS 1382 Trichoplax ad...

4M8N_A        175 NWMSICLYGFL-RESVGQPLFLLVSALTQQISKGPVDSVTEKALYTLSEDWLLCQAQDFEPLKLKVVFAVgtgeeISESL 253  zebrafish
O45657       1315 KWMSICLYSHL--TPQMNSYFYLYKALQYQTDKGPVDAVTGDARYTINEAKLLRESVDTKTLKIRVIPFEk----CDESI 1388 Caenorhabditi...
XP_011412156  512 HWLSVSLYPYL-KEGGGSSLFMLYKSTQTVVEKRPVDEVTGEAKNTLSEDNFLREKIDCLTMKLEIDLNGn---gN--LY 585  Pacific oyster
XP_011667763 1023 NWVALCMYKHL-QKQVAYPLYVLYQAIKGQVDKGPVDAITGQAHFSLNFDYLLDEDVEFEDVTLQIVD-------KEHKV 1094 purple sea ur...
XP_011674296  548 NWISICMYQYL-KRQVAESLYLLYQSIKMQVEKGPIDITTGQSVFSLNFECLLEEEVEFNELTLSVVGRD-----RHHKY 621  purple sea ur...
EGT44270     1076 KWWCICLYPSL--KPQMNSFYNLYKALQFQTDRGPVDAVTGDARYTINEANLLRECVETRTIIVNVIPLEn----CHDTV 1149 Caenorhabditi...
XP_004998121 1567 AWLTTGMHDAV-LRDAARPLYNLTQALKIYAWKGPVDAVTGAATYTLNADALLRERVEYEPLTLHVDM-------NRQVY 1638 Salpingoeca r...
XP_009861867 1286 HWLSINLYDECiNEQAGKPLFLLTKAVHYLVSSAPCDVIAKKAFNSLNEMTLLGTELQYETVVLHATIVEeg-gkVTTSV 1364 vase tunicate
XP_002599826 1351 NWLSISLYPFL-KETAGQPLFMLYKAIKYQVEKGPVDAILGFARYSITEDRLLREQVDHEVLTLNVVSLPg---gPSGHL 1426 Florida lancelet
XP_002112670 1383 NWLALCLYQYS-NKRFGQPLYLLYHAIKQQISKGPVDQKTGEARYCLSEEKLLREQVDETEISVMASIG------DGQQI 1455 Trichoplax ad...

4M8N_A        254 --EVIALTCDTIQQVKEKILQTFQRKFGFRYTQQIRDIEI-----EY-EKE-GK-FVMLQEVDDTSEIR-GH--VTMLNT 320  zebrafish
O45657       1389 --DLEVHACDAICQVKQKVASAVYRETPYSQRPRITQFEL-----KY-KCPkRG-DVKLTDVLPIETLS-QKklPVKLFT 1458 Caenorhabditi...
XP_011412156  586 --TCEVLDCDTINQVKSKCLYQIYKNKPASEMPSTDEVDL-----EW-MAGkSG-RLTLSNIDQTSERG-DG--MVRRNT 653  Pacific oyster
XP_011667763 1095 leQVKVLDVDTITQAKQKILDAVYCKRQTAQQLRSNEVDL-----VL-LNGcMG-RLVLKDRDPITETR-GH--WIKANT 1164 purple sea ur...
XP_011674296  622 --YVKVLDVDCMTQVKQKILDAAYRNSHIVQQNRAHEMDL-----LWyHPGgE--ERILKDRDELNKTV-GNtkDLFINT 691  purple sea ur...
EGT44270     1150 --RLELHSCDAIRQVKQKVAAAVYYKTPYSQRPRITQFDL-----RF-KCPrQG-EIRLVEF---RTLS-KKklPVKLLT 1216 Caenorhabditi...
XP_004998121 1639 --EVHVNSCDTIGQILEKL-----KLVVTTAGADVSDFDTrvlvlQR-EEG----LRVLKDIDDSSKMS-AG--WVQLNT 1703 Salpingoeca r...
XP_009861867 1365 --DVKVVNVDSIKQAKTKIIEAVYKDKPYSECPKPDDLDF-----ALmNSSeST-GITLSDVDGMSVVD-GK--YTKINT 1433 vase tunicate
XP_002599826 1427 pfTVKALSCDTITQVKDKILDMAYKNIPYSTRLHADECEL-----EW-RHGrAG-QLILRDTDVTSEMN-HR--WKKLNT 1496 Florida lancelet
XP_002112670 1456 --SLKLFDCDTITQAKEKILDAIYINQPYSARPSVAEFELeav---tvRHGqPPyRLPMFDEDSSNEVYeNG--WYKLNT 1528 Trichoplax ad...

4M8N_A        321 LKHYQVGDGACI----KVITP------------------------------------------KIhaplktqnsvkDDKN 354  zebrafish
O45657       1459 LADYGISDGCTLemspAVYTAesyrnsladsgqssw-----------------------------------ssldrcspi 1503 Caenorhabditi...
XP_011412156  654 LKHYHVLDNSRM----ALLYK----------------------------------------------------------- 670  Pacific oyster
XP_011667763 1165 IKAYKVSyqqqyiyfkidsqkfn--------------------------------------------------------- 1187 purple sea ur...
XP_011674296  692 VKTYGVSDGCQV----ALIVKasmnetgtyqpvtpgvqlfqqyqe----------------hagpddvrdrdyirirtme 751  purple sea ur...
EGT44270     1217 ISDYDVQDGSILemtpAFYALenhsqsiadsetlsc-----------------------------------tsvdinspa 1261 Caenorhabditi...
XP_004998121 1704 ASFYGMRDGDQL----AFVKSdtdggdarrrrnnn--------------ssssggggggggggSLfkvrtksks---rid 1762 Salpingoeca r...
XP_009861867 1434 LKHYNVPDNAVV----VLRPHdvenqapq---------------------------------------------dvsspl 1464 vase tunicate
XP_002599826 1497 LEHYKVPDSCSV----ALLRKpeqqmkldrtfe-------------------nlgvnqslsssSLapl------mqGDPE 1547 Florida lancelet
XP_002112670 1529 IGHYKITDNTTL----KLHRVynrnsdtfsisttyqytrpsrnqlharynnvsnqvtlggnkeNLsqplp--------nq 1596 Trichoplax ad...

4M8N_A        355 FSIK-Y-----------------------------------------------FHLVDp---DID-TDLs---------- 372  zebrafish
O45657       1504 yssskY-----------------------------------------------YHLTN----PSSgTMTf---------- 1522 Caenorhabditi...
XP_011412156  671 -----FspdvehddeddtyvnqrspsdvditippnvqliqsvsstgslenlrqWHLVK----NIE-EEDs---------- 730  Pacific oyster
XP_011667763      --------------------------------------------------------------------------------      purple sea ur...
XP_011674296  752 sggsrI-----------------------------------------------MHLVAenqmPTE-SSTs---------- 773  purple sea ur...
EGT44270     1262 ysfleH-----------------------------------------------YHLVK----STSgSLMc---------- 1280 Caenorhabditi...
XP_004998121 1763 pmaceP-----------------------------------------------WHLVK----PDT-DGTa---------- 1780 Salpingoeca r...
XP_009861867 1465 lpPKhM-----------------------------------------------YHLIN--------PSEeeqsngytdvq 1489 vase tunicate
XP_002599826 1548 EGCR-Y-----------------------------------------------WHLVK----ARD-ELErsns------- 1567 Florida lancelet
XP_002112670 1597 vrEK-A-----------------------------------------------FHLMK----HSDsNTTn---------- 1614 Trichoplax ad...

4M8N_A        373 ---------N-HPEK----KALKIKEMYLIKLLSTKVAVHSFVENLFKSIWGLp--NNKAPLAVKYFFDFLDEQAERKKI 436  zebrafish
O45657       1523 --------kK-KSSNdsnlLPKSIPEVYLTRLLTSKGTVETYVEDFLESVLYMh--DSSYPPILKFFFDILDREASVNGV 1591 Caenorhabditi...
XP_011412156  731 ---------HeKPSK----LKDIGKTSHITNLMHTKLVLQDNIKEVFDSVLN----HETVPLVVHYLFGVLENLANKNSV 793  Pacific oyster
XP_011667763      --------------------------------------------------------------------------------      purple sea ur...
XP_011674296  774 -------------------LTKLDREFLAPRLLVTKKTIQTRLDEFLACVFKK---PAETPLTIKYLFDFFDKMANKYCD 831  purple sea ur...
EGT44270     1281 --------rP-KSSTd---VPKSIPEVYLTRLLTSKGTVEAYIEDFFESVLYMh--AYKFPPILKYVFDTLDHEAEINEV 1346 Caenorhabditi...
XP_004998121 1781 --------aA-AAAA----ATRVPSEIFLTYLMTVKTALQPFVDDLVDAVFNI----DQPSPAVRFLFHFLDDQARKHNI 1843 Salpingoeca r...
XP_009861867 1490 sdagkkadeM-LDNL----MKRPFQEMFLTRMVKAKTTIQEYVDGVFNSILR----PKPISKTVRYFFQFLDREADRHKI 1560 vase tunicate
XP_002599826 1568 -----vkrdS-RFLK----EQRAIPEIYLTRLLATKGTLQKFVDDAFSAILC----TSPVPPSIKYFFDLLDHEAKKHGI 1633 Florida lancelet
XP_002112670 1615 --------------------ERILPEAFLMCLLLTKGTLQQYTQDLFESLFTLphhSNTFPLAIKYLFDFLNSQASQMQF 1674 Trichoplax ad...

4M8N_A        437 TDP-DVLHIWKTNSLPLRFWVNILKNPDFVFsDMEKSPHLDGCLSVIAQAFMDSFSLTDTHLDKHSPTNKLLYGKDIPQY 515  zebrafish
O45657       1592 SE--NICQQWKANGYVLRVWANFVRNPQLVF-DVPHSISMDANLSTVAQTMMDCFSFSEPVLGAHSPSSRLLFAKDVARL 1668 Caenorhabditi...
XP_011412156  794 -EP-DTLLCWKSESYAMRVWATLLVRPEFLF-DIQKARHVEPCLNVIKQVFIDCFHST--KISKDSSLQKLLFAQEVPHY 868  Pacific oyster
XP_011667763      --------------------------------------------------------------------------------      purple sea ur...
XP_011674296  832 EKSeEIAEAWKSNSLPLHYWMTTLTHPSYVF-DMRQSRSADQSVSVLANMLDNACKKIRSENTQESALNRVLFYRDLPGH 910  purple sea ur...
EGT44270     1347 ED--NISHQWKANGFVLRVWANFIKNPQLAL-DLPHSISMDANLSIIAQTMIDCFSFSEPVLSAQSPSSRLLFAKDVARL 1423 Caenorhabditi...
XP_004998121 1844 SDP-RTTHIWKSNAFPLRFWINLIKNPDFLL-HVQQTRTVSSGLSTVAQVIMDSCSVSDQQLGKHSPANKHLYRKEVAEY 1921 Salpingoeca r...
XP_009861867 1561 NDP-EVLHIWKTNSLLLRYWVNVLKNPEFVF-DLNKTDIVDSCLNVITQAFMDACTTTNRKLGHDSPSNKLLYAKDADNY 1638 vase tunicate
XP_002599826 1634 DDP-ETLHIWKTNSVPLRFWVNVLKNPEFVF-DIFKLGIVDACLSVIAQTFIDSCSAAEHKLGKDSPSNKLLYAREIPQY 1711 Florida lancelet
XP_002112670 1675 NDP-AVVKSWKNNTLPLRYYINIIRNPQFLF-DIDKSPIVDSCLSVISQAFGDACSVSDTKVSKDSPSNRLLYAREIPRY 1752 Trichoplax ad...

4M8N_A        516 KQEVKSYYKLVKDQTSISSQELKTFLQEESKKHQNE--FNESAALRELYKYMQRYFTEI 572  zebrafish
O45657       1669 RPLSVDLFKRVKNSPPLGMDELRTELVNMANDVSTC--KGSSLALSELLSWVRGNGIRI 1725 Caenorhabditis elegans
XP_011412156  869 QKKTEQFYKALGNKAAITDADFWSEMSRLSLLQQEHlkFSKSAALVKLYRFVNQYVEEI 927  Pacific oyster
XP_011667763      -----------------------------------------------------------      purple sea urchin
XP_011674296  911 IRTIGEYYENIKGLPPPTTEELQEDFNRITQDFSGL--FSRVATLNKLYDFTShdtgpl 967  purple sea urchin
EGT44270     1424 RPFSADLLKRIKNFPSLSINELEIEL-----DLSTY--KGSSLALSELLSWVRGNAIRI 1475 Caenorhabditis brenneri
XP_004998121 1922 KQKIANFYTAISRLPPPTDAELQASFASAQSGEQAC---DRPDAVCGLMEYALRFREQL 1977 Salpingoeca rosetta
XP_009861867 1639 KVMVKEFFINISNTPTVTQEEVTQILQKQSASYASR--FNQMVALNGIYEHLVKYREQV 1695 vase tunicate
XP_002599826 1712 RQKVQTYYKEVQQMTAVSDQEMITLLVEETKDHTHE--FNTLAAVNELYDYAMKYQDQL 1768 Florida lancelet
XP_002112670 1753 RDKVAEFYKSIQNLPTVSEKEMMKEMKLLSETLKDD--LDKSSALLQLYDYAYSnikaf 1809 Trichoplax adhaerens
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