Q7Z1Z1 236 HLESCLQHMLTS--HEDVELGRCIRKHVG--VACTWNYEMQKLFHNNqSAIKEsy----aKNM-----KELKDAITLHPI 302 Caenorhabditis ... NP_001135630 242 HLDSCRSDILSS--RSDEWLGRCLQDSLG--LACVSKYQNLHFTSLElP---Rnl---niENLa---eESLRGALSVYPM 308 western clawed ... XP_002942593 255 HLENCRNDILSA--RPDEWLGRCIIDYTH--VNCVQEHEGVRYRYFElG---Kna---dpEKEn---dPRFTNAFTAHPV 321 western clawed ... XP_003215028 262 HLESCRNDILSA--RPDEWLGRCIIDYTG--VDCVAEHEGLRYQYFElG---Knt---dpEREs---dPRFNAAFTVHPV 328 green anole XP_007234628 266 FLEQCRNDIVSV--RPDEWLGRCIIDYAG--TSCVEEHEGLHYNYFEiE---Kdm---ewKTMsveenHHFQDALSVHPV 335 Mexican tetra XP_001923418 255 FLEHCRTDIISV--RPDEWLGRCIIDYAG--VNCVEEYEGVNYNYFRmE---Nnm---dfLRMe---nDRFQKALTVHPV 321 zebrafish XP_002588920 240 clfVTMETILDL--QPDEWLGRCLHDVMG--ISCVGEAEGVDYHTYEfS---Stt---dpDNEd---sQEFQKAHTVHPV 306 Florida lancelet XP_002122339 284 QLDACSEDGSQAslSPDKWLGRCIKRATSgaVECVDEEEAIFYHTFNmE---NsnlnfevEt-----tPEFEEAVTVSGV 355 vase tunicate CBY14086 255 EMNKCLSGIQAD--SPDEWLGRCLLTLTKgeVGCVNTEEVQTYESINlENDQQfd----vETAs---sKLFEKAVSAFPV 325 Oikopleura dioica XP_784212 251 YWEECMQKAWSS--LPDLEVARCIKEHSG--AHCVDNYEGTTFKALNfQ---Dkv---ltAKDik--dKKLKEVLTVFHV 318 purple sea urchin
Q7Z1Z1 303 KDPAVMRKVHLRNREIKLREARAKRSLLS----SELSTAKA----------------QTLVrmtPNRTNDLTPWEYINnN 362 Caenorhabditis ... NP_001135630 309 RDPVVMYQLQRRLSHIRLHRTYSRIRQLQ----AEIQNLSLwtqstev--swpvginPPFS---PTSRFDLLTWEYFTeT 379 western clawed ... XP_002942593 322 LDPVQMYRLHKRFAHLELERTYQEMEQLQ----REIQNTSSlsvegehsatwplginSPFQ---PRTRFEVLRWDYFTeD 394 western clawed ... XP_003215028 329 LDPIQMYRLHRYFARVELEHTYQEIQQLQ----REIQNTSSlsadgalsatwpigiaSPFQ---PKTRFEVLRWDYFTeE 401 green anole XP_007234628 336 SSPEQMYHLHRYFTKRELQKTYEEIKKLQ----AEIKNISHvavdgnrsaawpigipPPFQ---PKSRFEVLRWDYFTeE 408 Mexican tetra XP_001923418 322 SSADLMYRLHKHFTEIELQRTYEEIEKLQ----SEIKNVSEvaadgnksalwpigitPPFE---PKNRFEVLRWDYFTeE 394 zebrafish XP_002588920 307 VEPTDLYRLHRRFAHIELDLLYPPIQTLNpcfpAQIKNLSHktpegeagltwpiginPPFK---PQSRFDVLSWDYFTeT 383 Florida lancelet XP_002122339 356 NSPQMMFQLHKKYSQLEIDKAYKEIGEIQ----DEIKSLVPklpegerelswpiginPSFK---PTNRWDIIVWDYFTeD 428 vase tunicate CBY14086 326 ATTTEVYKLHKRFSEVEIDMTYRKIEFLQ----EEIKNLSAktpqgedglswpigvnPPFQ---PSNRWEVINWDYFDsT 398 Oikopleura dioica XP_784212 319 MDQRIIYKLHKYFTEVSVNRSYAEIARLQ----RDIQVTSQyapggkasitwpigrqPPFK---AQSRFDVFGWEYFTmT 391 purple sea urchin
Q7Z1Z1 363 KiLFCADRVNcPRHTVDLSIRTEMADTITQLFDEFNTNarqrGRVLQFQSLQYGYMRVEPTKGVDYVLDMLLWFK-KFRp 441 Caenorhabditis ... NP_001135630 380 H-AYSCHDGA-PKCPLQGVGLLDVQQILEEAVEQLNGHyy-piLQFHLRRLLNGYRRFDPTRGMEYTLDLLLQVTtE-Rg 455 western clawed ... XP_002942593 395 Q-TFSCTDGS-PKCELIGADLADVTDVISTAVDELNRKyq-pvLHVRKQQLLNGYRRFDPTRGMEYTLDLQLELVtQ-Rg 470 western clawed ... XP_003215028 402 S-AFSCVDGA-PKCELRGADAADVADVVTEAVEELNRRyq-pvLHVRKQQLLNGYRRFDPTRGMEYTLDLQLEVVtQ-Kg 477 green anole XP_007234628 409 Q-MFSCADGA-PKCQINGADHEDVNSVIQMALAELNKKys-pvLQLSAPRLINGYRRFDPTRGMEYTLDLQLQATtE-Sg 484 Mexican tetra XP_001923418 395 N-LFSCLDDA-PKCTINGADRVDVIDVIKVAAEELNKKyn-pfVQLSEPHLVNGYRRLDHTRGMEYTLDLQFQATtE-Sg 470 zebrafish XP_002588920 384 H-LYTCPDGA-PKCELQGVDRQDVDDIITTSVQRLNDKyqkqGLTFEHVRLLNGYRRFDPTRGMEYELDLLVGETgP-Dn 460 Florida lancelet XP_002122339 429 Y-TLTCP-GEvPKCDLTGVDKLDIQNILQIALDRLNEKynpqGLILEKRKLINGYRRFDPQRGMEYILDLLLTVImENEn 506 vase tunicate CBY14086 399 H-TLTCPGEI-PKCELSDMEKKDVHDIVATAVSRLQEKykpqNMEIDLIKLENGYKRFDPQRGMEYMLDLKLRVTvDSG- 475 Oikopleura dioica XP_784212 392 H-IYAITDIE-SKVPLTGAHKQDIDEIVTTAMGQLNDKye---kaFTLGRLVNGYRRFDPTRGMEYTLDLELKMTaQk-- 464 purple sea urchin
Q7Z1Z1 442 pnrttISV-RRHAYVQQTFGKLRSLsegvfrsnmranstlieDPTLHMIMPLRGR-AAIFARFAQHLKSICA--RGgDDl 517 Caenorhabditis ... NP_001135630 456 h---vGVL-SKRLSLLRPLGRVEILpmpy----------vteATRAQLVLPLEPTdTAYVAGFLDAFATNLL--DT-QD- 517 western clawed ... XP_002942593 471 h---sRSI-TKRVHLVRPLSEVEIIpmpy----------vteASRINIILPLTAQdREHAARFLQAFTD--I--QG-NE- 530 western clawed ... XP_003215028 478 h---sRSL-AKRVHLLRPLSEVEIIpmpy----------vteASRVNVILPLTAAeRDYATRFLEVYATAAF--EN-AE- 539 green anole XP_007234628 485 h---gQAI-EHRVHLVRPLSQVEIIpmpy----------vteATRVHVVLPLTSPnRPIALRFLDLCASNLF--EL-GE- 546 Mexican tetra XP_001923418 471 h---qKSI-TRRVHLVRPLSQVEIIpmpy----------vteATRINILLPISSYeSHAALRFLDHCSTNLF--ET-SE- 532 zebrafish XP_002588920 461 i---rDVV-TKRVKLLRPLSQVEIIpmpy----------vteTTRLYVILPVTVHdREQVAKFLDSYAQVVL--DI-HE- 522 Florida lancelet XP_002122339 507 q---eIEL-SHRVNMLRPLSQVEIIpmpy----------vteSAKVHIILPLTKQeRVYFEAFMDKYAKVCL--NN-DE- 568 vase tunicate CBY14086 476 -----QTElSHRVDLLRPLSQVEIIpmpy----------vteTTKINMILPVSVDeAEALKVFLDKFEKKVLisKD-KD- 538 Oikopleura dioica XP_784212 465 -----KTI-QKRVHLLRPLNKVEILpmpy----------vteYTQVTIIIPVVASkQEQVKTFLDIYTKVCL--ES-KE- 524 purple sea urchin
Q7Z1Z1 518 AV-SLTIVLYSS----------EDEMENRETIEMLRASFIP-------VTViemgdvsfsRGVALMRGAETL--PANALL 577 Caenorhabditis ... NP_001135630 518 NVaLTVVLLYDLasag---rttDAFEEVRTVISQLERRFSHf-----hVEQvrvrtespsQVGIMEVVSKKH--PMDTLF 587 western clawed ... XP_002942593 531 NSlLTLLFIYDPfqaqq-vsqnDIFGQVKSIIAEYERKYRDl-----kIPWisvktdapsQIRLMDIISKKH--PVDTLF 602 western clawed ... XP_003215028 540 NAvLTFLFIYDPfeaqq-vaqnDVFGAVKARITEYERRYTQv-----kIPWisvktdapsQIKVMDIISKKH--PVDTLF 611 green anole XP_007234628 547 NVvLTFLFLYEPaeaqk-vgssDVFAEVKAKVAAVEHHYPNv-----kIPWisvktenpgFLRVMDIVSRKH--PVDTLF 618 Mexican tetra XP_001923418 533 NAvLNFLFTYEPaeaqk-vstnDVFKEVKAKITAVESRYPNv-----kVSWisiktespgVLRILDIVSRKH--PVETLF 604 zebrafish XP_002588920 523 NSaLTVVFIYDPldaqn-iqeeDVFGMLKSMITYYERKYPNa-----kIPWisiktdvptQLKIMDIISKKH--PVDALF 594 Florida lancelet XP_002122339 569 NVaLNIVFVYDPetaqr-ihqdDIFAEQKQLLQSYEARYKKdgkegklIPWvsiktevpsQLKTMDIVAKKY--PTESLF 645 vase tunicate CBY14086 539 SIlLTIIFIYGAaeaekvhqkdDPFTVQKERLGALEVKYGSqenrpkvIPWmsiktdipsQLRILDVIVRTKkfTADSLF 618 Oikopleura dioica XP_784212 525 KVaLMLIFIYNPvqars-matdDIFGVVKGHVSYLERKYTGa-----hISWlsvkttmpsLIALMDVISTKF--ASDTLF 596 purple sea urchin
Q7Z1Z1 578 FFTDVDMLFTCDALKRIKSNTILNAQIYFPIVFSEFSHESWS----ENDkllaDAFHYGRGRGYFRHFGYGLAAMYKADL 653 Caenorhabditis ... NP_001135630 588 FLVSGRSQVTTEAVNRCRMNTIKAWQVFSPIHYQEYSADIVRhglhPPPsqhpMQN------GRFDRFSFSEFCFYNSDF 661 western clawed ... XP_002942593 603 FLAGVGSHLNTEFLNRCRMNTINNWQVFFPIHFQGYNPEVSEhgqqPHS----ATLELLRDAGRFDRDVFEESCFYNADY 678 western clawed ... XP_003215028 612 FVAGVSTEVTTEFLNRCRMNTINSWQVFFPIHFQGYNPTIAFhnqpLPL----SGLDLVRDAGHFDRDAFNEACFYNADY 687 green anole XP_007234628 619 LVATADTVINSEFLNRCRMNAISGWQVFFPIHFQDFDPRIAYpdgsAP-----ATPDLLREAGHFDRYAFEEACFYNADY 693 Mexican tetra XP_001923418 605 LLATVDTVFNSEFLNRCRMNAINGWQVFFPIHFQEFDPIVAYpdqtPP-----SSPDLLREAGHFDRYTFEEACFYNSDY 679 zebrafish XP_002588920 595 LLVTVTDELTIEFLNRCRMNTIAGWQAFFPIHFAQYSPELIYdtkpYP-----ATVEFGKEFGHFDVHAFDEACFYNSDY 669 Florida lancelet XP_002122339 646 LLTSVAANMNTNFLNRCRMNAIPGWQVFFPIPFSQYNPQIIFq--nGQVp---EQIDIKPSNGHFDLYSFDEVCFYNSDY 720 vase tunicate CBY14086 619 FLASPHADVNNDLFDRCRMNAIAGWQAYFPVPFTQFNKEIAPdvkeE--------IEIKGSTGHFDIYSFDETCFFNSDY 690 Oikopleura dioica XP_784212 597 YVTNVHLEINNDFLNRVRMNTIAGWQAFFPIPFAQFDPEIIYadspNP-----GTIDISKQVGRFDDSSYEHAAFYNSDY 671 purple sea urchin
Q7Z1Z1 654 MDvggFDTKIEgwgkEDv--------------DLFEKAIK-NGrLRVIRVPEPGLVHIYHPIHCDENMPTAQKDMCHGSK 718 Caenorhabditis ... NP_001135630 662 MA---ARRKMQ----SDrgereeeeeeeggytQLLELFLHfSE-LHVFRALEPALVQSFSLRPCSSHLSGDGYHRCVLSN 733 western clawed ... XP_002942593 679 MS---ARSKMS----ADaqenee----ilemlDIYEMFIRySG-LHVFRAVEPALLQQYRSRACNPRLSEEIYHRCVQSN 746 western clawed ... XP_003215028 688 MA---ARTRMA----ADaqdned----iletmDIYDLFVKySN-LHVFRAVEPALLQHYRPQSCNPRLSEEQYHRCVQSS 755 green anole XP_007234628 694 MA---ARTRMT----ADaqdnde----lleslDMFDVFVQySS-LHVFRAVEPALRQAYRNRTCDPQLSEDMFHRCLQST 761 Mexican tetra XP_001923418 680 MS---ARTRMP----GDlqenee----lleslDLYDVFVQySG-LHVFRAVEPALRQAYRNRTCDPRLSEDVFHRCLQST 747 zebrafish XP_002588920 670 MS---TRTELQ----KQrkened----vsetyNLYEMFLKhSN-LHVFRAVEPDLRQRYMPRTCNPHLSEDLYHSCLVSQ 737 Florida lancelet XP_002122339 721 MA---SRTKMAatvsaedske--slsdlvdtlEVYDIMIKySQ-LHVFRAVEPQLTRRYVHRNCNKRNGQEIFDRCERSN 794 vase tunicate CBY14086 691 MA---ARSKFAqksqknq--------dlidniDLYELFMEnSE-LHVFRAVEPALKRRWMLRQCSVKRGDGAVDRCERSN 758 Oikopleura dioica XP_784212 672 KT---ARKLWD----EKhpgvgtd--hiqsdeDLFDMFLN-CK-LHVFRAVDPAMKQHYQKRVCRPTMTEDRYHRCLASR 740 purple sea urchin
Q7Z1Z1 719 AASLASIDTL 728 Caenorhabditis elegans NP_001135630 734 LESLGSRSHL 743 western clawed frog XP_002942593 747 LEGLGSRSQL 756 western clawed frog XP_003215028 756 LEGLGSRAQL 765 green anole XP_007234628 762 HEGIGSRSQL 771 Mexican tetra XP_001923418 748 LESHGSRSQL 757 zebrafish XP_002588920 738 AEGLASKEQL 747 Florida lancelet XP_002122339 795 AEGLASRTQL 804 vase tunicate CBY14086 759 AEGLGTRTQL 768 Oikopleura dioica XP_784212 741 ADGLASRSQL 750 purple sea urchin
Jiyao W et al.(2023). "The conserved domain database in 2023.",