Conserved Protein Domain Family
Sprouty
?
pfam05210: Sprouty (this model, PSSM-Id:310077 is obsolete and has been replaced by 461589)
Sprouty protein (Spry)
This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.
Links
?
Statistics
?
PSSM-Id: 310077
Aligned: 56 rows
Threshold Bit Score: 38.135
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q16G62        385 CRCEEC----QRPRQLP-SRwlcdktclCS-----AETIIDYASCLCCVKALFYHCS--KDHEleresdtVScadDPCS- 451 yellow fever m...
Q924S7        299 SRCVYCrdmfNHEENRR-GH--------CQdapdaVRTCIRRVSCMWCADSMLYHCMsdPEGD-------YT---DPCSc 359 house mouse
51_pfamImport   2 LHCVYCrdvfSPTQNRR-GQ--------CQeapdpVDTCIRRVSFMWCADSLLYHCMsdPEGD-------YS---DPCSc 62 
30_pfamImport   2 SRCVYCqdmfNQEDNGR-GR--------CHeapdpIQTCIRRVSFMWCADSLLYHCMsdPEGD-------YS---DPCSc 62 
17_pfamImport   2 SRCIYCremfNHEDNQR-GQ--------CQdapdpIKQCIYKVSCMLCAESMLYHCMsdSEGD-------FS---DPCSc 62 
24_pfamImport   1 SRCVYCrsvfSASENGR-GR--------CRdapdpALHCLRQWTCVWCAESLLYHCMsdSEGE-------FW---EPCSc 61 
26_pfamImport   1 SRCVYCrdvfNNEENGR-GQ--------CQdapdpIERCLYQVTCMWCAESMLYHCMsdSEGE-------FS---DPCSc 61 
36_pfamImport   2 SRCVYCqerfNHEENGR-GK--------CQdapdpIKRCIYQVSCMLCAESMLYHCMsdSEGD-------FS---DPCSc 62 
29_pfamImport   2 AQCEHCgeafYLSSNRR-GR--------CQdapdpVRTCIRRVSCMWLADTMLYHCMsdPEGD-------YS---DPCSc 62 
19_pfamImport   1 ARCVHCralfRRRADGRgGR--------CAeapdpGRLLVRRLSCLWCAESLLYHCLsdAEGD-------FS---DPCAc 62 

Q16G62        452 ------------CvphkrtTRWGCLAALSLPLPCLLCYWPMRGCVAICA 488 yellow fever mosquito
Q924S7        360 dts-----dekfC------LRWMALIALSFLAPCMCCYLPLRACHRCGV 397 house mouse
51_pfamImport  63 dps-----eehfC------LRWTALLGLSLIAPCMCCYAPLRACHRCAI 100
30_pfamImport  63 dtt-----derfC------LRWTALVGLSLLAPCMCCYAPLRACYRCGV 100
17_pfamImport  63 das-----eeqfC------VRWLALLGLSLLAPCLCCYPPLRLCHRCGE 100
24_pfamImport  62 ddsmggyphplcC------ARWLALLALSLFVPCMCCYLPLRACLRCGE 104
26_pfamImport  62 dpg-----hphfC------VRWLALVALSLVVPCMCCYLPLRACHRCGE 99 
36_pfamImport  63 dts-----ddkfC------LRWLALVTLSVIAPCMCCYLPLRACHHCGE 100
29_pfamImport  63 dggeg-sgggrlG------TRWLALFGLSLVAPCLCLYPPLHACHRVGL 104
19_pfamImport  63 epg-----hprpA------ARWAALAALSLAVPCLCCYAPLRACHWVAA 100
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap