Conserved Protein Domain Family
RFX1_trans_act
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pfam04589: RFX1_trans_act (this model, PSSM-Id:309643 is obsolete and has been replaced by 461362)
RFX1 transcription activation region
The RFX family is a family of winged-helix DNA binding proteins. RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is to found N terminal to the RFX DNA binding region (pfam02257) in some mammalian RFX proteins, and is thought to activate transcription when associated with DNA. Deletion analysis has identified the region 233-351 in human RFX1 as being required for maximal activation.
Links
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Statistics
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PSSM-Id: 309643
Aligned: 14 rows
Threshold Bit Score: 153.947
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_009297596  122 SVSDSSPPAAVvQTGVPTQvvq--qvqSAQQRSVVQATSQttKTEPGTQLNVTSLQSVHLTQevqqQLQQV-PVQHV--- 195  zebrafish
OCA43044       93 GDSPSLKAGQA-QPLQLHG--------TQQERSVVQANPQ--KSSPVHQLTVQALQHVQGAA----EVQQL-QQVPVqhv 156  western clawe...
XP_011602212  127 sesvpdsnpppavvqtgvptqvvqqvqtaqqRSVVQATSQitKTEPGTQLSVTSLQPVHITPevqqqlSSV-PVQHV--- 202  torafugu
XP_011602214  129 SVPDSNPPPAVvQTGVPTQvvq--qvqTAQQRSVVQATSQitKTEPGTQLSVTSLQPVHITPevqqQLSSV-PVQHV--- 202  torafugu
XP_007562992  129 SVSDSSPPPAVvQTGVPTQvvq--qvqAAQQRSVVQATSQiaKTEPGTQLSVTNLQPVHITQevqqQLASV-PVQHV--- 202  Amazon molly
XP_012397563  218 gnSSTSKAGSV-QQLQVHSvqa---vpVTQERSVVQTTPQtpKSGPVQQLTVQGLQQVHVAQev-qQLQQV-PVQHV--- 288  Tasmanian devil
XP_008101931  276 NSSSAAKPGQV-QQLQLHGvqq---vpVAQERSVVQTTPSapKAGSVQQLAVQGLQQVHVTQev-qQLQQV-PVQHV--- 346  green anole
EGW00641      109 SKTAGAPAGTV-QQLQVHSvqq--svpVSQERSVVQATPQt-KAGPVQQLTVQGLQPVHVTQev-qQLQQV-PVSHV--- 179  Chinese hamster
XP_015220926    6 GGSDSAATVAl-RTSTSAQapvvqpvpASQQRVLVQATGSaqKGGQVQQLSVPRVQQVP---------QQVqQVQHV--- 72   spotted gar
XP_017161581   13 AASDPPTGVATlRTSSSAQapvvqpvpASQQRVLVQATGSaqKGGQ---VSVSR---VP---------QQ--QVQHV--- 72   guppy

XP_009297596  196 YTNQVQYV-EGGEANYTTSTIRSSSFPY-TETPLYTQSSAGQYYEATpASGSEAAspgtPLTVSVT-SGSPGVPMFVAGt 272  zebrafish
OCA43044      157 YPSQVQYV-EGTDATYTGSTIRSGSYPY-TETPLYTQATGSTYYEAQ-GATGQVS----SPTSSPAlASSPSVPMYVSG- 228  western clawe...
XP_011602212  203 YTNQVQYV-EGTDTNYTTSTIRSSTFPY-SETPLYTQTTPTQYYEGQqTPGSQAStpgtPLTVSVT-AGTTG------Gv 273  torafugu
XP_011602214  203 YTNQVQYV-EGTDTNYTTSTIRSSTFPY-SETPLYTQTTPTQYYEGQqTPGSQAStpgtPLTVSVT-AGTTG------Gv 273  torafugu
XP_007562992  203 YANQVQYV-EGGDTNYTTSTIRSSNFPY-TETPLYTQSTAAQYYEGQpTSGAQASspgtSLTVAVT-AGATG------Gv 273  Amazon molly
XP_012397563  289 YPSQVQYV-EGGDASYTASTIRSGTYPY-TETPLYTQNAGTSYYESQ-GTTAQVStpatSQAV----ASSGSVPMYVSG- 360  Tasmanian devil
XP_008101931  347 YPNQVQYV-EGGDASYTASTIRSNTYSY-TETPLYTQNAGANYYESQ-GTSTQVSspatSQTV----ASSGSVPMYVSG- 418  green anole
EGW00641      180 YSSQVQYV-EGGDASYTASAIRSSTYPY-PETPIYTQPAGTSYYEAS-GTAAQVStpatSQTV----ASSGSVPMYVSG- 251  Chinese hamster
XP_015220926   73 YPSQVQYV-EGGEAVYTNGTIR-TAYSYnPEAQLYSQGSGGTYFDSQ-AGGAQVTtvvsSA-SGVPpHGMVGIAMDVGG- 147  spotted gar
XP_017161581   73 YPTQVQYVgESGEAVYTNGTIR-TAYSYnPDSQLYGQGSGGAYFDSQ-AGGTHVTtvvsSASSGVPpHGMVGIAMDVGS- 149  guppy

XP_009297596  273 GQIVANPTTAAG 284  zebrafish
OCA43044      229 GQILTNTTQSAA 240  western clawed frog
XP_011602212  274 SMFVAQPTSATA 285  torafugu
XP_011602214  274 SMFVAQPTSATA 285  torafugu
XP_007562992  274 SMFVAQPTTAAG 285  Amazon molly
XP_012397563  361 GQIVTNSSGASS 372  Tasmanian devil
XP_008101931  419 GQIIANPSGGSS 430  green anole
EGW00641      252 SPIVASSSSSEA 263  Chinese hamster
XP_015220926  148 SQILSSGGAYLI 159  spotted gar
XP_017161581  150 SHIISSGSTYLL 161  guppy
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