2ZME,2ZME,1U5T,1W7P


Conserved Protein Domain Family
EAP30
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pfam04157: EAP30 (this model, PSSM-Id:309331 is obsolete and has been replaced by 461201)
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EAP30/Vps36 family
This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.
Links
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Statistics
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PSSM-Id: 309331
Aligned: 236 rows
Threshold Bit Score: 82.6527
Created: 17-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ZME_A         6 VGAGAIaKKKLAEAKykeRGTVLAEDQLA--QMSKQLDMFKtNLEEFASKHKQEIRK--N------PEF------RVQFQ 69  human
Q387W7       170 AGIAGLmRASAEKTA---QG-----ETLR--DIDDVMRNAS-SLVASIRNLQQKQQN--I------AGttkaed------ 224 Trypanosoma brucei
XP_015783316   3 hGIAGIeRKIKQQQA---ETDKNINEAFQ--DLSRLMEKAS-DMARLAQGMVQRLKE--KgnkeisQDE------TVLFK 68  two-spotted spi...
CCD80015     197 GGIGAIqRQQAARAV---ETDRNIAETFE--DLSQLMNNAS-EMVKLSRLLAKKVRD--T------KGSdlsaneIAELR 262 Schistosoma man...
XP_001009663 140 nmytgikdmqkkeeqkqqeqqkIVQSSFQkgDISSLFQNAR-ELKEISQYLKGNLSKvdK------QHE------QSDLD 206 Tetrahymena the...
EKG02941     192 AGIAGLmRASAEKVQ--------LRESLR--DIDDVMKKAS-SLVESIRHLRERQRG--G------Ekttned------- 245 Trypanosoma cruzi
XP_001465035 163 FGIAGVqQASAQSAA--------MSETLK--DIDDVMNKAS-KLVNDIRRLRERSEA--A------AAA------GSDAG 217 Leishmania infa...
XP_009032600  71 AGIAGLaRKRRAKRD---EAGALAAETRD--DVRALMAEAS-AVVSMLKKYQARADR--A------SG------------ 124 Aureococcus ano...
CDS26077     166 VGLSGIeRSILVQTV---SNDRSIAGAFA--DLTKLMENAK-EMVALSKSLSQRIRN--T------KAS------GGeve 225 Hymenolepis mic...
XP_013934284 312 AGIHGLeTLTSLKNS---EVSTFLNSSLG--DLQNLMDKSK-DLAKIGDDYRRMLMS--S------KTV------DKEVG 371 Ogataea parapol...

2ZME_A        70 D-----------MCATIG--V-----DPL------------ASgKGFWS----------EMLG------VGD-------F 96  human
Q387W7       225 ------nmtiesIEATLG--Lg----ATVrasgagwglvsaHA-G----------------------------------F 257 Trypanosoma brucei
XP_015783316  69 S-----------YLLNLG--InegleDLV------------TR-EKY--------------AN------DSH-------Y 95  two-spotted spi...
CCD80015     263 S-----------AMLSMG--V-----VEV------------VS-GGDDR----------GSSS------SSPsslsgttF 295 Schistosoma man...
XP_001009663 207 K-----------ILSDLG--Y-----FNV------------IT-KEEAG---------------------NS-------Y 227 Tetrahymena the...
EKG02941     246 ------etgiesIEATLG--Lg----AMV------------RA-Sstgs--------------------------sngrF 274 Trypanosoma cruzi
XP_001465035 218 setaverttiesIESTLG--Lg----AIV------------TR-Nhsng--------------------------sdsrF 252 Leishmania infa...
XP_009032600 125 ------------DDAALG-----------------------AA-Rqlgamrvaddd-------------aaavdagdgkL 155 Aureococcus ano...
CDS26077     226 edd---ttelrrAMLSMG-----------------------LE-Degesndyg------------------aasadaysF 260 Hymenolepis mic...
XP_013934284 372 Havell-srsrnSLKLLGnlLddr------------------etiNEANdfytveslnlLKQAggtqagSSL-------Y 425 Ogataea parapol...

2ZME_A        97 YYELGVQIIEV---CLAL---KHRNG-----------GLITLEELHQQVLKGRgkfaqDVSQDDLIRAIKKL-------- 151 human
Q387W7       258 HKELAWEIHSW---ITHEknhHVFGSm----------PLIPLIELFSLYNKARge-cdLVSTNDVLHACRALd------- 316 Trypanosoma brucei
XP_015783316  96 YRDLGKQVALV---IKPM---IEKSD-----------GIMALTDVFCAVNRSRgl--dLISSEDLLNACYTLk------- 149 two-spotted spi...
CCD80015     296 YIRLAHQVSSIlfpLLKG---QCSNHsadr----lhiGCIDLATAYCRVNRARgm--dLISPEDLLRACRYLd------- 359 Schistosoma man...
XP_001009663 228 LDQLSHQIYSI---CNEL---FPKLG-----------GIITLLDVFYFVNKKRqt--cLLNPQEVLDACSKFq------- 281 Tetrahymena the...
EKG02941     275 HQELAMELHSW---MTHKkneSVFGAm----------PIVPLIELFSLYNKARgg-sdLVSPSDVLLSCRAMt------- 333 Trypanosoma cruzi
XP_001465035 253 HRDLAVEMHTW---MTHEsnsKLFNDm----------PVVPLIELFALYNKARgg--dLVSPLDVLHACTYMaa------ 311 Leishmania infa...
XP_009032600 156 LADAAAAFASK---LLGAga----------------aKSVTLTDLWCRFNRARga-sgLVSPEDFADACGRYldrrspdf 215 Aureococcus ano...
CDS26077     261 HRQLAGQICRL---L---------LPlleqrtaeisgGCIDLTTAYCRVNRARgv--qLIAPDDLLQAARLMp------- 319 Hymenolepis mic...
XP_013934284 426 VEELSRQVYDF---IIQEnilRDKN------------GLVTALDLYCLFN-KRkg-fySVSPHNFLLATVSLkry---np 485 Ogataea parapol...

2ZME_A       152 -K-ALGtgfg-------iipVGgtylIQSV-PAELNMDH----TVVLQLAek---------nG-Y--------------- 192 human
Q387W7       317 qQ-EYAqytl------krlsSG----RYAL-QrKDPS------IVLKKLE------------H-Ilgprlcnekesgkft 365 Trypanosoma brucei
XP_015783316 150 nQ-KLGyslf-------kydSG----LMVI-QADNFNQE----NLNKETLkvieetcsdtvsP-G--------------- 196 two-spotted spi...
CCD80015     360 -KeNLPirlk-------gyaNG----LLVL-QLASEDEI----ETLKSTVelv-------ekRiS--------------- 400 Schistosoma man...
XP_001009663 282 aL-GLNaiv--------teyGN----VKVVeQTTFDTEK----DFQENIGkyi------thsV-G--------------- 322 Tetrahymena the...
EKG02941     334 kQ-AYSrytl------kqlsSG----RMAL-QhKDPS------LVLGKLA------------R-Ilgprfinpkdpasky 382 Trypanosoma cruzi
XP_001465035 312 kM-SGScydl------vtlpSG----RKAL-VnRDDS------LLLAKLT------------T-Vlgpqlvnakgssvqd 360 Leishmania infa...
XP_009032600 216 sR-DAPatlr-------vfrSG----VKVV-A---LADD----DTRARVV------------A-Haa------------- 249 Aureococcus ano...
CDS26077     320 sL-NLPlrlk-------tfpSG----LKVL-QlASESEE----TTLKSTC------------E-Lcasd----------- 358 Hymenolepis mic...
XP_013934284 486 dL-QLIelqlqslqkvegktAGettek-arslyAICSSTmnakSISRSIL------------E-Vlesgvs--------- 541 Ogataea parapol...

2ZME_A       193 --------------------------------------VTVSEIKASLKWETERARQVLEHLLKEGLAWLD 225 human
Q387W7       366 tsadsspihn---grdggvtqpvtqtavfpesssmlkgVNEVTFasvLHVTCSVSMDLLEELELQGYLCRS 433 Trypanosoma brucei
XP_015783316 197 --------------------------------------LTAHQLALRLGISLSLARQRLLNCENQGFACRD 229 two-spotted spider mite
CCD80015     401 --------------------------------------LSVDELALTVNLSPVLAKARLLAVEEVGLICRD 433 Schistosoma mansoni
XP_001009663 323 --------------------------------------ITAEQLGRKLNISPVICRIKLNKALKTGKLVID 355 Tetrahymena thermophila ...
EKG02941     383 qasg----------------dtvpttaafptswtllksIDEVQFaasIQVACSVAEDLLEELEAEGFLCRS 437 Trypanosoma cruzi
XP_001465035 361 awkktsshrqqqrsgdasslvrvpttsdfpkasrdlksVSDVSLaekMQVATEVAADILTLLMQKGYLCCV 431 Leishmania infantum JPCM5
XP_009032600 250 ------------------------------------ggATAMGLavaLAVPPALAAELLADAEHDGALCRD 284 Aureococcus anophagefferens
CDS26077     359 ----------------------------------nskgITPGELarkAGIASVLAKERLLLCEQKGMLCRD 395 Hymenolepis microstoma
XP_013934284 542 ---------------------------------ggysaLEFQNMcs-iQTNLLLLQSVLNVLTRDGVLCVD 578 Ogataea parapolymorpha DL-1
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