Conserved Protein Domain Family
INTS11-like_MBL-fold
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cd16291: INTS11-like_MBL-fold 
Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1-Int14 (Integrator subunits). This subgroup includes Int11 (also known as cleavage and polyadenylation-specific factor (CPSF) 3-like protein, and protein related to CPSF subunits of 68 kDa (RC-68)). Integrator complex has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293849
Aligned: 24 rows
Threshold Bit Score: 314.199
Created: 23-Feb-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:active site [active site]
Evidence:
  • Comment:based on Pyrococcus horikoshii CPSF Ph1404 and human CPSF3 (CPSF-73) the active site is located at the interface of the MBL-fold metallo-hydrolase and beta-CASP domains
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                     #
Q5TA45      6 VTPLGAGQDVGRSCILVSIAG---KNVMLDCGMHmgf-ndDRRFPDFSYITQNGRl-------------tDFLDCVIISH 68   human
AAD12712    5 CLVLGAGQEIGKSCVVVTING---KKIMFDCGMHmgc-ddHNRYPNFSLISKSGDf-------------dNAISCIIITH 67   thale cress
NP_586250   3 VIPLGAGQDVGRSCILVSIKG---RTIMFDCGMHmgf-ndERRFPDFSYISKTKSf-------------dKVIDCIIISH 65   Encephalitozoon c...
EKX46018    5 VTPLGAGQDVGKSCILVTIGG---KNIMLDCGMHpgy-ndERRFPDFRYISKEGNf-------------tGLIDLVIISH 67   Guillardia theta ...
EED43849    3 VIPLGAGQDIGKSCIVVTIKN---KTIMFDCGIHlgy-ndSRKLPNFDYFNENHHg-------------rRPVDIIVISH 65   Enterocytozoon bi...
EDQ87993   12 VVPLGAGQDVGRSCVLVTMGG---RTIMFDCGMHmgy-ndARRFPDFTQVAQGPLt--------------DHIDLAIITH 73   Monosiga brevicol...
EJY68117    5 VIPLGAGQDVGRSCVIVELGG---RRLMFDCGIHmv---nQQQFPDFHFLQGSQQqpl---------dftNHIDCVLITH 69   Oxytricha trifallax
CCF73513    7 VCVLGAGQDVGRSCVIVTIGG---RKVMFDCGAHsgy-ndNRRYPLFSLLESKESpitvnssnktekisnFDIDCIILTH 82   Babesia microti s...
CEM02330    5 IKVLGAGQAVGRSCVVVTLGHsppRRVMFDCGVMlgarskEEKFPNFDQIPGMPMamatgssdgkrpdltSILDAVIVTH 84   Vitrella brassica...
ETO17782   22 VMVLGAGHEVGRSCIVVQFCEr--KTVMFDCGVHmgr-tdEKKFPDFDMLAQINKqak---------smnEIVDVVCISH 89   Reticulomyxa filosa

Feature 1      # ##                                                                           
Q5TA45     69 FHLDHCGALPYFSEMVGYDGPIYMThPTQAICPILLEDYRKIavdkkgean-------------------------ffts 123  human
AAD12712   68 FHMDHVGALPYFTEVCGYNGPIYMSyPTKALSPLMLEDYRRVmvdrrgeee-------------------------lftt 122  thale cress
NP_586250  66 FHLDHCGALPYFTEVCGYGGPIYMTlPTKEVCPVLLDDFRKIvagkgdsi---------------------------fty 118  Encephalitozoon c...
EKX46018   68 FHLDHCGSLPYFTEVLGYDGPMYAThPTKAIMPILLEDYRKIsverrgveek-----------------------dmfss 124  Guillardia theta ...
EED43849   66 FHIDHCGSLPYFVETTQFNGLIFMThPTKAALPIVLEDCKKIfenknqmekp------------------------lytt 121  Enterocytozoon bi...
EDQ87993   74 FHLDHCGALPYFTEQVGYDGPLYMTmPTRAIAQVLLEDYRKIavsrqgekn-------------------------fftr 128  Monosiga brevicol...
EJY68117   70 FHLDHCGALTYFTEGVGYHGPILATpPTKAIIPLMLEDFRKVssmqqgqkgggqgsggn---------qnsmnqdtafts 140  Oxytricha trifallax
CCF73513   83 FHIDHCGALPYFTENLGYDGPILMSyPTKALTPILLKDSCRVqslkhtkknpimdsdksfmallnenpaasyeeslnfte 162  Babesia microti s...
CEM02330   85 FHLDHCGALPKLTETYNYSGPIFMTyPTKALCPVLLRDMVNLstrisydgea------------------------iyel 140  Vitrella brassica...
ETO17782   90 FHLDHIGALPYFTEHLNYSNPILAShPTKYVSPLLLQDYCLIankgnlttkmslgttet----------darrgameyti 159  Reticulomyxa filosa

Feature 1                                          #                                   #      
Q5TA45    124 qmikdCMKKVVAVHLHQTVQVDd----eLEIKAYYAGHVLGAAMFQIKVGs---------------ESVVYTGDYNMTPD 184  human
AAD12712  123 thianCMKKVIAIDLKQTIQVDe----dLQIRAYYAGHVLGAVMVYAKMGd---------------AAIVYTGDYNMTTD 183  thale cress
NP_586250 119 qdisnCMKKVVTISMNETYKHDe----dFYITPYYAGHVLGAAMFHVVVGd---------------QSVVYTGDYSTTPD 179  Encephalitozoon c...
EKX46018  125 qqikdCMMKVTPCALEETIMIEe----dFEIRPYYAGHVLGAAMFYIRVGq---------------QSILYTGDYNMTPD 185  Guillardia theta ...
EED43849  122 eqinnCLSKVIALNMEETYEIEq----eFIIRPYYAGHVIGAAMFFVRYLd---------------ETVVYTGDFSTIPD 182  Enterocytozoon bi...
EDQ87993  129 ddiktCLNKATTIDLHQTVVIDq----dFEIKAYYAGHVLGAAMFYVRVGn---------------QSVVYTGDYNMSPD 189  Monosiga brevicol...
EJY68117  141 dmikaCIAKISTIQLHETQVIKg----dIKVTAYYAGHVLGACMFYVECNg---------------ESVVYTGDYNMTAD 201  Oxytricha trifallax
CCF73513  163 qsvekSLSRAIPLQLHSDTHIGd-----LTIRPYYAGHVLGASIFAVRYKsqlvvytgtnsfnairQKTIQLGDFNTMSD 237  Babesia microti s...
CEM02330  141 emverAIEKVRALMVHETATLPc----gIRVTPYYAGHVLGAALFHVEYGg---------------ESVVYTGDYSMTPD 201  Vitrella brassica...
ETO17782  160 ediesCMKKVQGVSLEERVTLFantkdeMIIECYYAGHVLGAVMFYIRMPhy------------dnVSVLYTGDYNMTSD 227  Reticulomyxa filosa

Feature 1                          
Q5TA45    185 RHLgAAWIDKCr-PNLLITES 204  human
AAD12712  184 RHLgAAKIDRLq-LDLLISES 203  thale cress
NP_586250 180 KHLgPASIKCIr-PDLLITES 199  Encephalitozoon cuniculi GB-M1
EKX46018  186 RHLgSARCDKLr-PDLLITES 205  Guillardia theta CCMP2712
EED43849  183 RYLrAATIDCLy-PDLLITES 202  Enterocytozoon bieneusi H348
EDQ87993  190 RHLgAAWIDRCe-PDVIISES 209  Monosiga brevicollis MX1
EJY68117  202 RHLgAAWIDKLr-PDVCITET 221  Oxytricha trifallax
CCF73513  238 KHLgPAKIPKLe-PDVLICES 257  Babesia microti strain RI
CEM02330  202 RHLgPARVPRLn-PDVVISES 221  Vitrella brassicaformis CCMP3155
ETO17782  228 RHLgSAKVPSNlqCDLLITES 248  Reticulomyxa filosa

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