Conserved Protein Domain Family
Joubert
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pfam15392: Joubert (this model, PSSM-Id:292035 is obsolete and has been replaced by 464699)
Joubert syndrome-associated
This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis.
Links
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Statistics
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PSSM-Id: 292035
Aligned: 18 rows
Threshold Bit Score: 342.099
Created: 1-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5XHZ1        117 QLQVTGLTDIADIIDDLITKRGVSSHELGLTEYQARNI--SRIQHPS-G-RRPQRTDEERREIKVWMKRKRKERMAEYLD 192  Norway rat
Q8CE72       2894 QLQVTGLTDIADIIGDLITKSGVSSHELGLTECQARSI--SRIQRPP-D-RGPRRTAEERREIKAWMRRKQKERMSEYLG 2969 house mouse
XP_003470328 2555 PLQMTGLTDIADIIDDLITNCGVSSKELGLTEQQAKSI--SRIPHSS-G-RCPQRTEKERREIQVWMKRKRKERMADYLN 2630 domestic guin...
ELW53479     2545 slrsdqnTAFPDIIDDLITKGGVSSEELGLTEQQARRI--SRVQHSY-S-RRPQRTEKEKREIRVWMKKKRKERMAEYLN 2620 Chinese tree ...
EGV97562      205 QLQVTGLTDIADIIDDLITKSGVSSEELGLTKKQARNI--SRIQQSS-G-RCPQRTEEERREIKIWMKRKRKERMAEYLN 280  Chinese hamster
XP_003759988 2838 dFQITGLTDVADIIGDLITESGVSREELGLTEHQAMKI--SRIHSTP-KkRKSQRTEKEKREIRAWMKRKRKERMAEYLA 2914 Tasmanian devil
XP_005060627 2849 PLQITGPSDVTDIVNDRVVESSTSLLELDLARTKTKDI--SRVLDSA-S-GHSQRTEKERKEIQTWMKRKQKERMREYLK 2924 collared flyc...
XP_001234077 3028 PLQITGLSDVTDIIRNLVTEGGISPMELGFPKTQAKKF--SRILDSA-F-RYSQKTEKEKKEIRAWMKRKQKERMREYMK 3103 chicken
XP_007666464 1984 PLQLTGLTDVADIIHDLVKDGGISAHDLGLTENQARKItsTRI-----T-RQPPRTEKEKKEIRAWMKRKQKERMVEYLG 2057 platypus
XP_007487628 2844 dLQISGLTDVADIINDLITESGISSEELGLTEYQAKKL--SRIHSTPkR-KKSQRTEKEKREIRAWMKKKRKERMAEYLA 2920 gray short-ta...

Q5XHZ1        193 QLAEKRGREHDPFCSRSSPFY-MTSRQIRQRQKMKHEKDRLQL-SNHYSQRISQAYSLMNELLSDSVQITKPADKPLGRR 270  Norway rat
Q8CE72       2970 QLAERRGRERNPFCPTSSPFY-MTSRQIRQRQKMKREKDRLQL-SKHYSQRLSQAYSLMNELLSDSAHITAPAENPLPPG 3047 house mouse
XP_003470328 2631 QLAEKRRQEHNPFCPRRNPFY-MTSREIRMRQKMKHEKDRLLL-SNHYSQRLSQAYSLMNELLAESAQLPATAQKPSPNK 2708 domestic guin...
ELW53479     2621 QLAEKRGQERDPFCHRSNPFY-MTSREIRLSQKMKHEKDRLLL-SDHYSRRISQAYSLMNELLSESVQLPATAQKPLPNK 2698 Chinese tree ...
EGV97562      281 QLAEKRGQERDPFCPRNSPFY-MTSRQIRQRQKMKHEKDRLLL-SNHYSQRISEAYHLMNELLSDSVQLTAPADQPLPNR 358  Chinese hamster
XP_003759988 2915 QLAQKREQEYEPFQPQRHPLC-MTSKEIRLCQRMKNEKDRLQL-SEHYDRRVAQAYSLMNELLFESAQVPRRCLKKPPGS 2992 Tasmanian devil
XP_005060627 2925 KLDEQRQKEHHPFNLGKNTHHhPTSKDIRIFQKKKEEKDKALL-SEHHRIRISQALSLMNEMLSETVPSPASDHRALSST 3003 collared flyc...
XP_001234077 3104 KVDEQRQKEHNPFNFKKYTHCrLTSKDIQLLKKKKEEKDKRLY-AEHHRMRVSQALSLMNEMLSESVMLPASEHRPWSRA 3182 chicken
XP_007666464 2058 KLAEQRAQEHNPFHSRRSANA-MTSREIRLSQKLKVEKDK-MLqSKHRSHRVSEAVTLMNELLSETVRLPTDESRPLSGT 2135 platypus
XP_007487628 2921 QLAVKREQEHEPFQSPRKQLC-MTSKEIRMCQKMKTEKDRLQL-SEHYHRRVAQAYNLMNELLVESAQTTGISPTKPPCG 2998 gray short-ta...

Q5XHZ1        271 ---------RQQCSSPKREN-A---QG--------------------QNLSSNRPAG-----GRHISGS-------R--- 302  Norway rat
Q8CE72       3048 py------rRQRGSSPKREN-A---HG--------------------QSLPVNRPGG-----DRHISRS-------S--- 3082 house mouse
XP_003470328 2709 rsta-rhcgQQRCPSPRREN-Q---HG--------------------HNF-LSRPGK-----VRCVSKS-------S--- 2747 domestic guin...
ELW53479     2699 rsta-qssrWQHYPRGKLKQ-FvfiGT--------------------ATFTIQKKGGgvkaaVRKAVKSpvtfqkdS--- 2753 Chinese tree ...
EGV97562      359 ppta-qhyrQQHCSSPRREN-P---HG--------------------QNFLINRPGR-----GRHISRS-------S--- 398  Chinese hamster
XP_003759988 2993 paksarisrKQYHLPPKGED-R---NI--------------------NTLSPNRNSK-----VRFASKP-------T--- 3033 Tasmanian devil
XP_005060627 3004 rspq-ayrrSNVASSP---------GG--------------------HLDSPVLAER-----SRIAAKP-------G--- 3038 collared flyc...
XP_001234077 3183 r-------sPQECRKNHIVStK---GG--------------------HPNNRVTSER-----SRTAVRP-------Rfgq 3220 chicken
XP_007666464 2136 pala-rglrRQLLPPPRGDN-P---HG--------------------HTLLTSQAEK-----IKFASKP-------A--- 2175 platypus
XP_007487628 2999 paksfristRQRHLPPRGVD-H---NIhtsspgrntkvrfapkptyiHARSPPRQHQ-----HSF-PRN-------T--- 3058 gray short-ta...

Q5XHZ1        303 ----H-------LRKGEplg----------------------------------rpHGSSQLR----------------- 320  Norway rat
Q8CE72       3083 ----H-------LCKGQp--------------------------------------RGSSQLR----------------- 3096 house mouse
XP_003470328 2748 ----Y-------Thtgkplgqpegsswprgtatftihs------------------------------------------ 2774 domestic guin...
ELW53479     2754 ----N-------A------------------------------------------------------------------- 2755 Chinese tree ...
EGV97562      399 ----R-------Lqkgkpleqsk--------------------------------------------------------- 410  Chinese hamster
XP_003759988 3034 ----Y-------Ihg----------------------------------------------------------------- 3037 Tasmanian devil
XP_005060627 3039 ----FgqkvqrfT------------------------------------------------------------------- 3047 collared flyc...
XP_001234077 3221 kghhF-------T------------------------------------------------------------------- 3226 chicken
XP_007666464 2176 ----Y-------AQKRSnls---------------------------------rgpQNSIWSTgaakfavqkqtrdak-- 2209 platypus
XP_007487628 3059 ----F-------VFSSFlisknawscrnavasylekehwvkkekdtkpqssffplvFENGFMLynyvksktriflsgmat 3127 gray short-ta...

Q5XHZ1        321 ---------------G------------------------------------------SNPP------------------ 325  Norway rat
Q8CE72       3097 ---------------G------------------------------------------SQPP------------------ 3101 house mouse
XP_003470328 2775 ------------------------------------raagakaavrkavqspgtswkasnaP------------------ 2800 domestic guin...
ELW53479     2756 -------------------------------------------------------------P------------------ 2756 Chinese tree ...
EGV97562      411 ---------------------------------------------------gssrrqgsntS------------------ 421  Chinese hamster
XP_003759988 3038 -----------------------------------------------------------rtP------------------ 3040 Tasmanian devil
XP_005060627 3048 -------------------------------------------------------------Pdlgltqsrgntcmilqks 3066 collared flyc...
XP_001234077 3227 -------------------------------------------------------------P------------------ 3227 chicken
XP_007666464 2210 atvrnaprspvtsrqNrmskvasretlpdlnedqphlqrpsrqqwklqegrpmaaipaSSYP------------------ 2271 platypus
XP_007487628 3128 vsikktnqvnkrmaqNassssd-------------------------------lsredFGYP------------------ 3158 gray short-ta...

Q5XHZ1        326 --------------------Y----------RSQQP--MRSHGAVGVVPLVQQACI------------------------ 349  Norway rat
Q8CE72       3102 --------------------C----------QSQKP--LRSRGAAGVGPPVQQACR------------------------ 3125 house mouse
XP_003470328 2801 --------------------G----------CSLQH--AKNHRHTGLTSVSQEMGI------------------------ 2824 domestic guin...
ELW53479     2757 --------------------Y----------HSLQQ--IKNHKSAGLAPQTKQVCI------------------------ 2780 Chinese tree ...
EGV97562      422 --------------------C----------QSLLH--TNSR---GVAPPKKQVCI------------------------ 442  Chinese hamster
XP_003759988 3041 --------------------L----------SQHQHpsQRNRKAATSVKKTTEVTRkparnvscfsdlssqdfsypprrt 3090 Tasmanian devil
XP_005060627 3067 tsrrqlrnatncpvdsrhsaE----------CRVSR--RSTQKPPQVTTAVQTEGV------------------------ 3110 collared flyc...
XP_001234077 3228 --------------------AlgsaqskaaeYRMSR--VSEQKYPAVSTAFETEGF------------------------ 3261 chicken
XP_007666464 2272 --------------------T----------PNVRY--LSSPGDP--VGSQSEADV------------------------ 2293 platypus
XP_007487628 3159 --------------------C----------PRARS--IKDSKTSSTTTNTE---------------------------- 3178 gray short-ta...

Q5XHZ1        350 ----------------EDEREDMVVSPWTLPSEIHKILHDRSGSLLQ-DM-SAADEEEP---EHSLAGGMDSVSESTGSI 408  Norway rat
Q8CE72       3126 ----------------EDEREEMVVSPWTLPSEIHRILHGRPESLLQ-DM-SPADEEEPe--PPLLAGGMDSVSESTGSI 3185 house mouse
XP_003470328 2825 ----------------EYEREEMVVSPWALPEEIHKILLESHSSLLQ-EL-PPTEENFE---PPFEVGGMDNISESTGSI 2883 domestic guin...
ELW53479     2781 ----------------EYEREETVVSPWTLPSEIHKILHESPSSLLQ-DL-SPAEEEQPr--TPFGMGGMDSMSESTGSI 2840 Chinese tree ...
EGV97562      443 ----------------EYEREDTVVSPWTLPSEIHRILHDRPKTLLQ-DIsPAEEEEPE---SSVLVAGMDSVSESTGSI 502  Chinese hamster
XP_003759988 3091 syvkssetststtnaeEYEREHDKMSSWTMADHADRILCRGPWSSLE-DF-SPAEDEK----FSVSINGLTSGSESTSSI 3164 Tasmanian devil
XP_005060627 3111 ----------------DLDTDRDVVSPWTVPDDIQRILQETHDSMFQ--A-SAAHSLSF---SPLGSTNTDSVSESTGSI 3168 collared flyc...
XP_001234077 3262 ----------------DHETGRDVESPWTVPDDIQRLLEDSHDTLFQ-DS-APL---SF---SPVVNHETDRISESTGSI 3317 chicken
XP_007666464 2294 ----------------AYERERDVVSPWTVPPEIHRILHDNHDPLFEgS------LILEdngSRLSVNGLDTISESTESI 2351 platypus
XP_007487628 3179 ----------------EYGRQHSLANSWALPEEIDKILSRSPNSSLE-DI-SPPEDEG----FPISINGLDSGSESTGSI 3236 gray short-ta...

Q5XHZ1        409 LSKLDWKAIEDMVASVEEK 427  Norway rat
Q8CE72       3186 LSKLDWKAVEDMVASVEDK 3204 house mouse
XP_003470328 2884 LSKLDWNAIEDMVAGVEDR 2902 domestic guinea pig
ELW53479     2841 LSKLDWNAIEDMVASVEDK 2859 Chinese tree shrew
EGV97562      503 LSKLDWRAIEDMVADVEDK 521  Chinese hamster
XP_003759988 3165 LSKIDWRAVDNMVAMVKNT 3183 Tasmanian devil
XP_005060627 3169 LSKLDWNAVEAMIADVEDK 3187 collared flycatcher
XP_001234077 3318 LSRLDWNAIEAMIADVEDT 3336 chicken
XP_007666464 2352 LSKLDWTAVDAMVASIEDK 2370 platypus
XP_007487628 3237 LSKIDWRAVDDMVASVENR 3255 gray short-tailed opossum
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